Asthma drug could stop cat allergy sneezes in their tracks
NCT ID NCT06069063
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This small Phase 2 trial tests whether a single dose of zafirlukast, an asthma drug, can prevent nasal symptoms caused by cat dander. Twelve adults with cat allergies will receive either the drug or a placebo before being exposed to cat dander in a controlled setting. Their symptoms will be tracked for four hours to see if the drug makes a difference.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Zafirlukast
- What this could lead to
- If it works, this could point toward a new way to prevent allergy symptoms from cats using an already-approved asthma drug.
- What could go wrong
- This is a very small early-stage trial with only 12 people. It may not work as hoped, and results may not apply to real-world cat exposure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 12 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Active nonsmoking males and females between the ages of 18-65 with allergic rhinitis triggered by cat dander exposure. * Concomitant medication limited to "as needed" including for mild asthma. * Baseline resting blood pressure les than or equal to 140/90 mm Hg. * Baseline resting heart rate less than or equal to 100 beats/min. * Baseline NIFR must be ≥ 50 L/min. * Females of childbearing age may participate only if they have a negative urine pregnancy test, are non-lactating, and agree to practice an adequate birth control method (abstinence, combination barrier and spermicide, or hormonal) for the duration of the study. * The ability to give informed consent and comply with study procedures. Exclusion Criteria: * Receiving immunotherapy for cat allergy * Predictable seasonal allergy during the study period * Newly (\< 2 weeks) diagnosed with Corona Virus Disease (COVID-19) * Regular use of controller medication for moderate to severe asthma * Subject works with cats or keeps a cat as a pet. * Inability or unwillingness to give written informed consent. * History of upper/lower respiratory tract infection, requiring systemic steroids, antibiotics, and or emergency room (ER) visit or urgent care within 6 weeks of screening visit. * History of adverse reaction or allergy to Zafirlukast * History of neurological, hepatic, renal, diabetic mellitus, thyroid disorder, psychiatric, addiction or other medical conditions that may interfere with the interpretation of data or the patient's participation in the study or may increase safety concerns per investigator discretion. * History of cardiovascular diseases including uncontrolled hypertension (blood pressure \>160/100 mmHg), ischemic heart disease, congestive heart failure (New York Heart Association III or IV), valvular heart disease or cardiomyopathy (e.g., depressed left ventricular ejection fraction by echo, arrhythmias). * Known allergy or sensitivity to atropine or ipratropium bromide. * Documented or self-reported current history of alcoholism or drug abuse. * Baseline Spirometry Forced Expiratory Volume in first second (FEV1) \<70% of predicted * Participated in another research trial and received investigational drug within 30 days or 5 half-lives, whichever is longer * Unwillingness or inability to comply with study procedures.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.