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Asthma drug could stop cat allergy sneezes in their tracks

NCT ID NCT06069063

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This small Phase 2 trial tests whether a single dose of zafirlukast, an asthma drug, can prevent nasal symptoms caused by cat dander. Twelve adults with cat allergies will receive either the drug or a placebo before being exposed to cat dander in a controlled setting. Their symptoms will be tracked for four hours to see if the drug makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Zafirlukast
What this could lead to
If it works, this could point toward a new way to prevent allergy symptoms from cats using an already-approved asthma drug.
What could go wrong
This is a very small early-stage trial with only 12 people. It may not work as hoped, and results may not apply to real-world cat exposure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Active nonsmoking males and females between the ages of 18-65 with allergic rhinitis triggered by cat dander exposure. * Concomitant medication limited to "as needed" including for mild asthma. * Baseline resting blood pressure les than or equal to 140/90 mm Hg. * Baseline resting heart rate less than or equal to 100 beats/min. * Baseline NIFR must be ≥ 50 L/min. * Females of childbearing age may participate only if they have a negative urine pregnancy test, are non-lactating, and agree to practice an adequate birth control method (abstinence, combination barrier and spermicide, or hormonal) for the duration of the study. * The ability to give informed consent and comply with study procedures. Exclusion Criteria: * Receiving immunotherapy for cat allergy * Predictable seasonal allergy during the study period * Newly (\< 2 weeks) diagnosed with Corona Virus Disease (COVID-19) * Regular use of controller medication for moderate to severe asthma * Subject works with cats or keeps a cat as a pet. * Inability or unwillingness to give written informed consent. * History of upper/lower respiratory tract infection, requiring systemic steroids, antibiotics, and or emergency room (ER) visit or urgent care within 6 weeks of screening visit. * History of adverse reaction or allergy to Zafirlukast * History of neurological, hepatic, renal, diabetic mellitus, thyroid disorder, psychiatric, addiction or other medical conditions that may interfere with the interpretation of data or the patient's participation in the study or may increase safety concerns per investigator discretion. * History of cardiovascular diseases including uncontrolled hypertension (blood pressure \>160/100 mmHg), ischemic heart disease, congestive heart failure (New York Heart Association III or IV), valvular heart disease or cardiomyopathy (e.g., depressed left ventricular ejection fraction by echo, arrhythmias). * Known allergy or sensitivity to atropine or ipratropium bromide. * Documented or self-reported current history of alcoholism or drug abuse. * Baseline Spirometry Forced Expiratory Volume in first second (FEV1) \<70% of predicted * Participated in another research trial and received investigational drug within 30 days or 5 half-lives, whichever is longer * Unwillingness or inability to comply with study procedures.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The official record

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    Open the record ↗

  2. A doctor treating you

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