Can a Blood-Derived gel help you smell again?
NCT ID NCT07151703
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether a person's own platelet-rich plasma (PRP) can improve smell when placed in the nose on a gel sponge versus being injected. Sixty adults with smell loss lasting over three months will receive one treatment and then do smell training for three months. Researchers will compare smell test scores and comfort between the two methods.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- autologous platelet-rich plasma (PRP)
- What this could lead to
- If it works, this could offer a simple, office-based treatment to help restore smell in people with persistent loss of smell.
- What could go wrong
- This is a small, early-phase trial with only 60 participants. PRP is not a proven treatment for smell loss, and the benefit may be modest or no better than current care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2025
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged between 18 and 80 years, regardless of sex * Subjective complaint of olfactory dysfunction with confirmed hyposmia or anosmia based on standardized olfactory testing * History of at least 3 months of prior olfactory training but with persistent olfactory complaints Exclusion Criteria: * Congenital anosmia * Diagnosed neurological or structural brain abnormalities (e.g., brain tumor, major head trauma, stroke) with low likelihood of olfactory recovery * Inability or unwillingness to comply with study procedures or follow-up assessments
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Taipei Veterans General Hospital
Taipei, 112201, Taiwan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Shocking the nose back to life: new combo therapy for Parkinson's smell loss
- Sniff and sweat: new study tests simple ways to keep aging brains sharp