New drug combo aims to stop advanced nose cancer from coming back

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Voluntary participation and signed informed consent. * Age 18-65 years, male or non-pregnant female. * Pathologically confirmed non-keratinizing nasopharyngeal carcinoma (differentiated or undifferentiated type, i.e., WHO type II or III). * Previously untreated patients with no history of other malignancies; initial treatment for nasopharyngeal carcinoma. * Stage III: TanyN3M0 / T4N0-2M0 (9th AJCC/UICC staging system). * ECOG performance status 0-1, with no severe dysfunction of vital organs (heart, lung, liver, kidney, etc.). * Hemoglobin (HGB) ≥90 g/L, white blood cell count (WBC) ≥4.0×10\^9 /L, platelet count (PLT) ≥100×10\^9/L. * Liver function: ALT and AST \<2.5× upper limit of normal (ULN); total bilirubin \<2.0×ULN. * Renal function: serum creatinine \<1.5×ULN. Exclusion Criteria: * Patients with recurrent or distant metastatic nasopharyngeal carcinoma. * Pathologically confirmed keratinizing squamous cell carcinoma (WHO type I). * Receipt of systemic or topical glucocorticoid therapy within 4 weeks prior to enrollment. * Participation in another clinical trial of an investigational drug within 3 months prior to treatment. * Known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation. * Patients with idiopathic pulmonary fibrosis, drug-induced pneumonitis, organizing pneumonia (i.e., bronchiolitis obliterans), radiation pneumonitis that is clinically symptomatic or requires steroid therapy, active pneumonitis, or other moderate-to-severe pulmonary diseases that significantly affect lung function. * Comorbidities requiring long-term immunosuppressive medication or systemic/topical corticosteroids at immunosuppressive doses. * Prior use of anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibodies (or any other antibodies targeting T-cell co-stimulatory or checkpoint pathways) with documented disease progression at the time of study entry. * Presence of any active autoimmune disease or history of autoimmune disease (including but not limited to: interstitial pneumonia, uveitis, enteritis, hepatitis, hypophysitis, nephritis). Patients with vitiligo or childhood asthma that has completely resolved and requires no intervention in adulthood may be included; patients requiring bronchodilators for medical management of asthma are excluded. * HIV-positive; HBsAg-positive with detectable HBV DNA copy number (quantitative detection ≥1000 cps/mL); positive hepatitis C antibody (HCV Ab) with detectable HCV RNA. * Receipt of any anti-infective vaccine (e.g., influenza vaccine, varicella vaccine) within 4 weeks prior to enrollment. * Positive pregnancy test in women of childbearing potential, or lactating women. * Inability to comply with scheduled follow-up due to psychological, social, family, or geographical reasons.