New allergy shot strategy aims to stop sneezing and sniffling for good

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Voluntary signing of the informed consent form 2. Commitment to abide by the research procedures and cooperate throughout the implementation of the research 3. Diagnosis conforms to the ARIA guidelines. The basis for the diagnosis is as follows: a. Symptoms: Paroxysmal sneezing, clear nasal discharge, nasal itching, and nasal congestion occur for 2 or more times, with symptoms persisting or accumulating for more than 1 hour each day, accompanied by tearing, eye itching, and eye redness and other ocular symptoms; b. Signs: Commonly, the nasal mucosa is pale and edematous, and nasal watery secretions are present; c. Allergen testing: Positive results for dust mite allergens SPT and/or serum-specific IgE, or positive nasal challenge test, requiring Der p and Der f to be positive (SPT results of ++ or higher, serum sIgE ≥ 2 grades), and other allergens in the allergen test to be negative 4. History of allergic rhinitis caused by atopic dust mite allergens 5. Infertile women must ensure they do not become pregnant during the treatment period 6. Age must be between 5 and 60 years old Exclusion Criteria: 1. Allergic to the excipients of Arrogel (aluminum hydroxide) or the rescue medication epinephrine 2. Suffering from respiratory system diseases other than stable asthma 3. Pulmonary dysfunction (NYHA grade II or above, or FeV1 \< 70%) or having irreversible pathological changes in the reactive organs such as emphysema or bronchiectasis 4. Severe acute or chronic diseases (including malignant diseases), inflammation and fever 5. Multiple sclerosis 6. Immune system diseases (autoimmune diseases, immune diseases caused by antigen-antibody complexes, immune deficiencies, etc.) 7. Active pulmonary tuberculosis 8. Severe mental disorders 9. Obvious cardiac dysfunction 10. Patients who have received immunotherapy within the last 1 years (subcutaneous injection or sublingual administration of allergen-specific immunotherapy, etc.) 11. Patients who used experimental drugs or participated in other clinical studies within 30 days before treatment 12. Patients who received IgE monoclonal antibody (mAb) treatment in the past 4 months 13. Patients taking beta-blockers 14. Patients who have insufficient understanding of the trial 15. Patients whose age is not between 5 years old and 65 years old 16. Patients who are pregnant or breastfeeding during the study period, or have plans to get pregnant 17. Patients who cannot undergo tonsil injection due to acute or chronic tonsillitis, small tonsils, previous tonsillectomy, overly sensitive pharyngeal reflex and inability to cooperate with treatment 18. Patients with aphthous stomatitis