Blood test may tell which oral cancer patients need more chemo
NCT ID NCT07296250
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether a blood test that finds circulating tumor cells (CTCs) can help decide if oral cancer patients need extra chemotherapy after standard treatment. About 100 patients who have completed surgery and chemoradiotherapy will be tested. If their CTC count is high, they will receive low-dose oral chemotherapy for up to a year. The goal is to see if this approach improves survival and creates a new standard for monitoring the disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- low-dose oral chemotherapy
- What this could lead to
- If successful, this could provide a standard way to detect remaining cancer cells in the blood and guide personalized chemotherapy, potentially improving survival for oral cancer patients.
- What could go wrong
- This is a small, early-phase trial with only 100 participants. The approach is experimental, and it is not yet known if using CTC counts to guide treatment truly improves outcomes or causes side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2025
- Expected to finish
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Jul 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 months to 90 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Participants with Cancer: 1. Aged between 18 and 90 years. 2. Histologically confirmed diagnosis of head and neck squamous cell carcinoma (HNSCC). 3. Completed surgical treatment and identified as having high-risk factors, followed by concurrent chemoradiotherapy. 4. Willing to continue follow-up visits at the hospital after completion of treatment. Exclusion Criteria: 1. Presence of psychiatric disorders. 2. Deemed unsuitable for participation by the attending physician. 3. Unwilling to participate in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Linkou Chang Gung Memorial Hospital
RECRUITINGTaoyuan City, 333423, Taiwan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Re-irradiation plus cetuximab targets head and neck tumors that return
- Sharper tumor maps: PET scans could tighten radiation beams
- Lighting up oral cancer: dye may help surgeons see tumor edges
- Five days of radiation instead of weeks: a new test for head and neck cancer