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At-home treatments may bring back smell for long COVID sufferers

NCT ID NCT05855369

Symptom relief Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two at-home treatments—smell training and a gentle nerve stimulation device—for people with long COVID who have lost or distorted their sense of smell. About 145 adults will do daily sessions at home and attend three clinic visits over 12 weeks. The goal is to see if these simple, non-invasive methods can improve smell function and quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 145 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * treatment-seeking for COVID-related persistent SL (anosmia, hyposmia, phantosmia or parosmia) * at least 1-month from SARS-coV-2 PCR-positive and/or rapid home-positive tests * normal sense of smell prior to COVID * naïve to both smell training (ST) and trigeminal nerve stimulation (TNS) * able to comprehend English and provide informed consent Exclusion Criteria: * history of head injury (e.g. sport, accident, combat blast) * sinonasal condition (e.g. upper respiratory infection, rhinosinusitis, polyps) * neurological disorder (e.g. epilepsy, neurodegenerative disorder, narcolepsy) * serious mental illness (e.g. schizophrenia, bipolar, or other psychotic disorder) * suicidal ideation within the last month * current (≤6 months) heavy cigarette smoker (heavy defined as ≥ 10 pack-years) * oral/nasal steroids or other intranasal medications within the last month * immunomodulatory medications * pregnant or trying to become pregnant

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Conditions

The condition(s) this trial relates to.

anosmia COVID-19 long COVID-19 olfactory nerve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Long COVID Olfactory disorder Smell dysfunction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.