Could less radiation be enough for HPV throat cancer? new trial aims to find out.
NCT ID NCT06902623
First seen Apr 24, 2026 · Last updated Jun 23, 2026 · Updated 10 times
Summary
This study is testing whether people with early-stage HPV-positive throat cancer can be treated with radiation alone at a lower dose, instead of the usual full-dose radiation plus chemotherapy. The goal is to see if this gentler approach can keep the cancer from coming back while causing fewer long-term side effects. The trial will enroll 30 adults with stage I-II HPV-positive oropharyngeal cancer.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Medstar Georgetown University Hospital
RECRUITINGWashington D.C., District of Columbia, 20007, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Medstar Southern Maryland Hospital Center
RECRUITINGClinton, Maryland, 20735, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy (66 Gy)
What this could lead to
If successful, this could show that many patients with early HPV-positive throat cancer can skip chemotherapy and receive a lower radiation dose, reducing long-term side effects while still controlling the cancer.
What could go wrong
This is a small, early-phase study with only 30 participants, so results may not apply to everyone. Lowering treatment intensity could increase the risk of cancer recurrence, and long-term safety data are not yet available.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.