Viral respiratory tract infection

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

This phase 2b trial tests several versions of an experimental flu vaccine that includes an adjuvant (MF59) to strengthen the immune response. The vaccine is made from cells, not eggs, and targets four flu strains. Around 1,000 adults aged 50 and older receive a single shot and ar…

This phase 3 study tested a single dose of an investigational RSV vaccine in 751 adults aged 60 and older, and those 50-59 at increased risk for severe RSV. The goal was to see how well the vaccine boosts the immune system and whether it is safe. Participants received either the …

This early-stage trial is testing a new mRNA flu vaccine in 50 healthy adults aged 18 to 49. The vaccine uses mRNA technology to target a specific flu strain. Researchers will compare its safety and immune response to a standard seasonal flu shot. The goal is to see if the new va…

This early-stage trial tests a single dose of a new mRNA flu vaccine (VRC H1ssF-3928) in 50 healthy adults aged 18 to 49. The vaccine aims to teach the body to fight a stable part of the flu virus. Researchers are checking for side effects and measuring immune responses, comparin…

This study tested an mRNA vaccine (mRNA-1345) against respiratory syncytial virus (RSV) in 360 pregnant women. The goal was to see if the vaccine is safe for mothers and their babies, and whether it triggers an immune response that could protect infants after birth. Participants …

This early-stage study tests a new mRNA vaccine designed to protect against avian influenza (bird flu) in 80 healthy adults aged 18-49. The vaccine uses mRNA technology to teach the body to recognize and fight the H5 flu virus. The main goal is to check the vaccine's safety and s…

Pfizer completed a study testing a new modified RNA (mRNA) flu vaccine in 1,202 healthy adults aged 18 and older. The goal was to see if the vaccine is safe and triggers a strong immune response. Participants received either the experimental mRNA vaccine or a licensed flu shot, a…

This study tested an experimental RSV vaccine in adults who had a lung or kidney transplant, as well as in healthy adults over 50. The goal was to see if the vaccine could safely boost their immune response against RSV, a common and potentially serious respiratory virus. Research…

This study tested a new mRNA-based flu vaccine in over 1,100 adults aged 50 and older. The vaccine targets multiple flu virus proteins to potentially provide stronger protection. Researchers compared it to standard flu shots and monitored safety and immune response for six months…

This large, final-stage study tested a new combination vaccine that aims to protect against both COVID-19 and the flu with a single shot. About 9,300 adults aged 65 and older took part, receiving either the combo vaccine or a standard high-dose flu vaccine. Researchers checked ho…

This study tested new mRNA-based seasonal flu vaccines in 776 healthy adults aged 18 and older. The goal was to see how safe the vaccines are and how well they boost the immune system. Researchers measured side effects and immune responses to find the best vaccine candidate.

This study tested an experimental RSV vaccine in adults aged 60 and older in China. The goal was to see if the vaccine produces a strong immune response similar to that seen in older adults from other countries, where the vaccine already proved effective. About 2,620 participants…

This completed Phase 3 trial tested whether an adjuvanted flu vaccine (FLUAD Quadrivalent) triggers a stronger immune response than a standard flu vaccine (FluQuadri) in 192 healthcare workers in Lima, Peru. Participants received one dose of either vaccine, and researchers measur…

This study tested a new nasal spray vaccine for respiratory syncytial virus (RSV), a common cause of serious breathing problems in babies and young children. The vaccine was given as nose drops to 88 healthy children aged 4 months to 5 years, including those who had and had not b…

This study tested a booster vaccine for H5N6 bird flu in about 260 adults. Some had previously received an H5N1 bird flu vaccine, while others had not. The goal was to see if the booster was safe and triggered a strong immune response. Participants received one or two doses of th…

This completed Phase 4 trial tested whether the Butantan Institute's seasonal flu vaccine is as safe and effective as the Sanofi vaccine. A total of 632 Brazilian adults aged 18 to 69 received one of the two vaccines. Researchers measured immune response through blood tests and t…

This study tested a single combination vaccine that aims to protect against both COVID-19 and influenza at the same time. About 980 adults aged 50 and older received either the combo shot, a flu shot alone, a COVID-19 shot alone, or both shots separately. Researchers monitored sa…

This study tested a single combination vaccine that targets both COVID-19 and influenza in adults aged 50 and older. About 980 participants received either the combo shot, the flu vaccine alone, the COVID-19 vaccine alone, or separate shots in each arm. Researchers monitored safe…

This early-stage study tested six different mRNA vaccine formulations against respiratory syncytial virus (RSV) in 240 healthy adults aged 18 to 49. The goal was to check safety and how well the vaccines trigger an immune response. Each participant received a single shot and was …

This study tested a new mRNA vaccine designed to protect against H5 pandemic flu strains. Researchers gave 276 healthy adults one of three doses or a placebo to check safety and immune response. The goal is to find the right dose for future studies.

This Phase 1 study tests a new vaccine that aims to protect against three respiratory viruses at once: RSV, hMPV, and PIV3. The trial involves 390 adults aged 60 and older and will check if the vaccine is safe and helps the body produce antibodies. Different combinations and dose…

This early-stage trial tested a new universal influenza vaccine called fH1/DSP-0546LP in 144 healthy adults aged 18 to 40. The goal was to check safety and how well the vaccine triggers an immune response. Participants received two shots three weeks apart, with different doses or…

This completed study in Japan checked the safety of the RSV vaccine Abrysvo in 497 pregnant women and their infants. Researchers tracked side effects in mothers for 28 days after vaccination and in babies from birth to 28 days old. The goal was to confirm the vaccine's safety in …

This early-stage trial tested a new self-amplifying mRNA vaccine (ARCT-2304) designed to protect against pandemic influenza. 212 healthy adults aged 18-80 received either two doses of the experimental vaccine or one dose of a licensed flu vaccine plus placebo. Researchers monitor…

This study tested a new vaccine for H7N9 bird flu, given through a small patch with tiny needles instead of a shot. Researchers wanted to see if it was safe and how the body reacted. The trial involved 267 healthy adults aged 18 to 50, who received two doses of the vaccine either…

Pfizer is testing a new type of flu vaccine called a self-amplifying RNA (saRNA) vaccine. This early study involves 440 healthy adults aged 18 to 49. Participants receive either the saRNA vaccine, a licensed flu shot, or a placebo. The main goal is to check safety and side effect…

This study tested a new vaccine designed to protect against two respiratory viruses: RSV and hMPV. It involved 646 healthy adults aged 60 and older who received either the vaccine or a placebo. The goal was to see if the vaccine is safe and triggers a strong immune response, with…

This study tested the safety and immune response of several Moderna mRNA vaccines for COVID-19, seasonal flu, RSV, and CMV in 308 healthy adults aged 18 to 75. Researchers monitored side effects and measured antibody levels after vaccination. The goal was to ensure the vaccines a…

This early-stage trial tested an experimental mRNA-based flu vaccine in 324 healthy younger (18-45) and older (60-80) adults. The main goal was to check safety and how well the vaccine triggers an immune response. Participants received one of several dose levels or a placebo, and…

This study tested a new mRNA-based flu vaccine from GSK in 845 healthy adults aged 18 to 85. The goal was to find the best dose and check how well it triggers the immune system and whether it is safe. Results will help decide if larger studies should move forward.

This study tested an experimental RSV vaccine in about 4500 adults aged 60 and older. Half received the vaccine and half received a placebo shot. The goal was to see if the vaccine could prevent lower respiratory tract disease caused by RSV, a common virus that can be serious in …

This study tested a new mRNA vaccine designed to protect against a future flu pandemic. Healthy adults aged 18-49 and 65-84 received either the experimental vaccine, a licensed flu shot, or a placebo. Researchers monitored safety and immune responses for about 13 months to see if…

This study tested an inactivated H1N1 flu vaccine in 122 kidney transplant recipients who were at least 6 months post-transplant and on triple immunosuppression. The goal was to see if the vaccine could safely trigger an immune response. Researchers measured antibody levels and t…

This early-stage study tested two experimental RSV vaccines given as nose drops in 60 children. Some children already had RSV antibodies (ages 1-5) and some did not (ages 6 months-2 years). The main goals were to check safety and whether the vaccines triggered an immune response.

This study tested an RSV vaccine in 378 older adults (60+) in Korea to see if it is safe and helps the body fight the virus. Participants received either the vaccine or a placebo and were monitored for side effects and immune response. The results showed the vaccine was well tole…

This study tested a new mRNA vaccine designed to protect against a potential pandemic of H5 bird flu. Nearly 1,000 healthy adults aged 18 to 85 received different doses to find the safest and most effective one. Researchers monitored side effects like pain, fever, and fatigue, an…

This study tested new modified RNA vaccines that target both influenza and COVID-19, given as a single shot. Over 2,600 healthy adults aged 18 and older took part, receiving either a flu vaccine, a COVID-19 vaccine, or a combination of both. The main goal was to check safety and …

This study tested a live, weakened RSV vaccine given as a nasal spray to infants and toddlers aged 6 to 24 months in Puerto Rico. The main goal was to see if the vaccine virus spreads from vaccinated children to others in the same household or daycare, and to check how long the v…

This early-stage study tested the safety and immune response of new vaccines that combine protection against flu, RSV, hMPV, and PIV3 in healthy adults aged 18 to 49. Participants received a single shot of one of several vaccine formulas. The goal was to see if these combination …

This study tested two different H5N8 bird flu vaccines in 1380 healthy adults to see how safe they are and how well they trigger the immune system. Participants received different doses of the vaccine with either AS03 or MF59 adjuvant. The goal is to find the best dose and adjuva…

This early-stage study tested an experimental flu vaccine called FluMos-v2 in 30 healthy adults aged 18 to 50. The vaccine is designed to protect against multiple flu strains at once, unlike current vaccines that target only one. Participants received two shots four months apart …

This study tested a new seasonal flu vaccine made from animal cells instead of eggs in over 3,200 adults aged 50 and older. Participants received either the new vaccine or a standard egg-based flu shot, and researchers measured their immune response and side effects. The goal was…

This large Phase 3 trial tested a new quadrivalent flu vaccine in over 2,700 healthy children aged 6 to 35 months. The study compared two doses of the experimental vaccine against a standard flu vaccine to see how well it triggers an immune response and whether it is safe. Resear…

This phase 3 study tested an mRNA vaccine called mRNA-1345 to protect against respiratory syncytial virus (RSV) in adults aged 50 and older. Over 3,300 participants received the vaccine alone, with a flu shot, or with a COVID-19 booster. The trial also looked at a booster dose on…

This completed phase 3 trial tested whether giving an RSV vaccine and a COVID-19 mRNA vaccine at the same time is as safe and effective as giving them separately. About 841 adults aged 50 and older took part. Researchers measured immune responses and side effects one month after …

This early-stage trial tested several experimental mRNA vaccines that aim to protect against both influenza and SARS-CoV-2 in a single injection. About 1,758 healthy adults aged 18 to under 80 took part. The main goals were to check safety and measure the immune response, with re…

This phase 2 study tested a non-adjuvanted H1N1 flu vaccine in 110 pregnant women to see if it is safe and triggers a good immune response. Participants received two doses of the vaccine and were monitored for side effects. The goal is to protect both mothers and their babies fro…

This study tested a new vaccine called IVX-A12 that targets two respiratory viruses: RSV and hMPV. It involved 264 healthy adults aged 60 to 85. The goal was to see if the vaccine is safe and boosts the immune system to fight these viruses.

This study tested a single combined vaccine that aims to protect against both COVID-19 and influenza. About 8,800 healthy adults received either the combo shot or separate vaccines. Researchers checked for side effects and measured immune responses over six months to see if the c…

This study tested a new combination vaccine called mRNA-1083 that aims to protect against both COVID-19 and the flu with a single shot. It involved 2,457 healthy adults aged 50 and older in Japan, Taiwan, and South Korea. The main goals were to check how well the vaccine triggers…

This study tested a new mRNA-based flu vaccine (mRNA-1010) in 172 healthy adults aged 18-50 and 65-80. The goal was to check its safety and how well it triggers the immune system compared to standard flu vaccines. Results help determine if the vaccine is safe and effective enough…

This study tested whether a new flu vaccine made in cells (instead of eggs) can prevent the flu. About 7,250 adults received either the vaccine or a placebo shot. Researchers then checked for flu infections over 6 months. The goal was to see if the vaccine protects against flu st…

This early-stage trial tested a new vaccine designed to protect against both RSV and hMPV, two common respiratory viruses. 385 healthy adults aged 60 to 75 received a single injection of different doses. The main goals were to check safety and measure the immune response. Results…

This study compared how well egg-based and non-egg-based flu vaccines trigger the immune system in adults aged 18 to 64. Researchers wanted to see if egg adaptation weakens the vaccine's effectiveness. Over two flu seasons, 366 participants received one of three vaccines: a stand…

This large phase 3 study tested an experimental RSV vaccine in over 25,000 adults aged 60 and older. The goal was to see if a single shot could prevent lower respiratory tract disease caused by RSV, a common virus that can be dangerous for seniors. Participants received either th…

This study tested whether giving the RSV vaccine (Abrysvo) and the shingles vaccine (Shingrix) at the same doctor's visit is safe and works as well as giving them separately. About 526 adults aged 50 and older took part. Researchers measured immune responses and tracked side effe…

This study compared three different flu vaccines: one made using eggs, one using cells, and one using a lab-made protein. The goal was to see which vaccine triggers the strongest antibody response, especially against a tricky flu strain called H3N2. 366 adults who hadn't had a fl…

This completed study looked at how well licensed RSV vaccines (Pfizer's Abrysvo or GSK's Arexvy) trigger an immune response in adults over 60 living in long-term care facilities compared to those living independently in the community. Researchers measured antibody levels before a…

This study tested a new combination vaccine called mRNA-1083 that aims to protect against both flu and COVID-19 in a single shot. About 1,320 adults aged 18 to 64 took part. Researchers measured the immune response and checked for side effects to see if the combo vaccine works as…

This study looked at whether adding special ingredients called adjuvants to two standard flu vaccines (Fluzone and Flublok) could make them work better. About 240 healthy adults aged 18 to 45 received either a regular flu shot or one with an adjuvant. Researchers checked for side…

This study tested a single shot that aims to protect against both COVID-19 and the flu. About 932 adults aged 50 to 64 received the experimental mRNA-1083 vaccine. Researchers checked for side effects and measured antibody levels one month after vaccination to see how well the va…

This early-stage trial tested a new type of flu vaccine called ARCT-2138, which uses self-amplifying mRNA technology to potentially provide stronger and longer-lasting protection. The study involved 139 healthy adults aged 18-49 and 65-85, who received either the experimental vac…

This Pfizer trial tested whether a single injection combining an updated COVID-19 vaccine and a flu vaccine is safe and triggers a strong immune response. The study involved 644 healthy adults aged 50 and older. Researchers measured side effects and antibody levels to see if the …

This study tested two different doses of an experimental H7 flu vaccine with an added booster (adjuvant) against a version without the booster. About 581 healthy adults aged 18 and older took part. The goal was to see which dose produced the strongest immune response and was safe…

This study tested an RSV vaccine in 453 healthy women aged 18-49. It compared a multidose vial with a preservative to a single-dose vial without one. The goal was to see if both versions are safe and produce a similar immune response. Participants received one shot and were follo…

This study tested an experimental RSV vaccine in about 1,500 adults. It compared the immune response and safety in younger adults (18-49 years) who are at increased risk for RSV disease to older adults (60 years and older). The goal was to see if the vaccine works as well in the …

This early-stage study tested a 'prime-boost' approach for a universal flu vaccine. Researchers gave an inactivated H5N1 flu shot to 32 healthy adults, some of whom had previously received other experimental flu vaccines. The goal was to see if this method could trigger broad imm…

This completed Phase 3 trial tested a quadrivalent (four-strain) influenza vaccine from Instituto Butantan in over 1,300 healthy infants and children aged 6 to 35 months. The study compared the immune response and safety of two doses (0.25ml and 0.50ml) against standard trivalent…

This Phase 1 study tested several versions of a quadrivalent recombinant influenza vaccine, some with an adjuvant, in 210 healthy adults aged 18-30 and 50+. The main goals were to check safety and measure antibody responses against flu strains. Researchers compared different H3 a…

This study tested a quadrivalent influenza vaccine in 652 healthy children aged 3-8 years. Researchers compared immune responses after one dose versus two doses, and also checked for side effects. The goal was to find the best way to protect children against flu.

This early-stage trial tested a new mRNA-based flu vaccine in 233 healthy adults aged 18 and older. The study compared three different doses of the experimental vaccine to a standard high-dose flu shot. Researchers monitored safety and immune responses over time to see if the new…

This large Phase 3 trial tested an experimental mRNA-based flu vaccine (mRNA-1010) against standard flu shots in over 40,000 adults aged 50 and older. The goal was to see if the new vaccine is safer and better at preventing flu-like illness caused by influenza A or B. Researchers…

This study tested a seasonal flu vaccine made with a modified manufacturing process in healthy adults aged 18 and older. The goal was to see if the new process produces a vaccine that works as well as the current version and is as safe as a licensed flu vaccine. About 1,928 parti…

This completed Phase 1 trial tested a new flu vaccine that includes an extra H3 strain, aiming to improve protection against influenza. The study involved 400 healthy adults aged 18-49 and 60+, comparing the new vaccine to standard flu shots. Researchers checked for side effects …

This early-stage trial tested an experimental mRNA vaccine designed to protect against two respiratory viruses: RSV and hMPV. Healthy adults aged 18 to 49 and 60 years and older received a single injection of the vaccine at different doses. The main goals were to check safety and…

This early-stage trial tested a new mRNA vaccine that combines protection against seasonal flu and COVID-19 in a single shot. Researchers gave the vaccine to 106 healthy adults aged 18-64 to check for side effects and measure immune responses. The goal is to see if a combined vac…

This early-stage trial tests a new mRNA-based flu vaccine in 159 adults aged 18-49 and 60+. The vaccine uses modified mRNA to target a specific flu strain (H3N2). Researchers compare its safety and immune response to a standard flu shot. The goal is to gather data to improve futu…

This phase 3 trial tested a new recombinant flu vaccine (RIV4) against a standard inactivated flu vaccine (IIV4) in 301 healthy adults aged 18 and older in South Korea. The study measured antibody levels and safety over 29 days. The goal was to see if the new vaccine triggers a s…

This study tested a live-attenuated RSV vaccine given as a nasal spray in 259 infants and toddlers aged 6 to 18 months. The main goals were to check safety and measure the immune response. Researchers also looked at how much vaccine virus was shed and how well the vaccine worked …

This study tested a recombinant flu vaccine (RIV4) in over 1,300 people aged 9 to 49. The goal was to see if the immune response in children and teens (9-17) was as good as in adults (18-49). Researchers measured antibody levels before and 29 days after vaccination. The trial als…

This study tested a new universal flu vaccine (INFLUENZA G1 mHA) in 170 healthy adults aged 18-45. The goal was to check if it is safe and triggers an immune response. Participants received either the vaccine with or without an adjuvant, or a placebo. Results will show if this ap…

This completed Phase 2/3 trial tested whether adding baloxavir to standard oseltamivir treatment helps hospitalized flu patients clear the virus faster. Fifteen adults with confirmed influenza were randomly assigned to receive either the combination or oseltamivir alone. The main…

This study tested a new mRNA booster shot (mRNA-1345) in 507 adults aged 60 and older who had already received a licensed RSV vaccine at least a year earlier. The goal was to see if the booster is safe and boosts the immune system's ability to fight RSV. Researchers measured side…

This study tested a new flu medicine called ZX-7101A in 169 children aged 2 to 11. The medicine was given as a single oral dose, and researchers compared it to a standard 5-day treatment (oseltamivir). The main goal was to check safety and how well it relieved flu symptoms. The t…

This study looked at the safety and how the body processes two doses of nirsevimab, a medicine to prevent RSV, given 5 to 6 months apart. It included 33 Japanese infants up to 12 months old with heart or lung disease, weak immune systems, Down syndrome, or who were born early. Re…

This early-phase study tested a new oral drug called CC-42344 in 80 healthy adults to see if it is safe and how the body processes it. The drug is designed to stop the influenza A virus from multiplying. The study did not treat actual flu patients, but the results will help decid…

This study tested whether the antiviral drug Amizon (enisamium iodide) can help adults with colds or flu feel better faster. One hundred adults aged 18 to 60 took either Amizon or a placebo pill for 7 days, starting within a day of their first symptoms. Researchers tracked sympto…

This study tested whether a daily supplement called Immulina, made from Spirulina, can help healthy people fight off upper respiratory viruses like the flu. Researchers measured natural killer cell activity and other immune markers in 492 healthy adults aged 18-59 and 65+. Partic…

This study tested whether a special infant formula containing lactoferrin and human milk oligosaccharides (HMOs) could improve immunity in newborns. 240 healthy full-term babies were randomly assigned to receive either the test formula, a standard formula, or breast milk for 12 m…

This small pilot study tested whether a sustained-release ammonium chloride formula (with vitamin D) can reduce virus levels in adults with mild or moderate COVID-19 or influenza. 32 participants took either the active formula or a vitamin D-only control twice daily for 10 days. …

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This study looked at whether the flu vaccine can reduce inflammation in people with stable coronary artery disease. Inflammation plays a key role in heart disease progression. The trial involved 47 adults aged 60 and older with stable heart disease, who received the flu vaccine e…

This study tested a new flu medicine called ZSP1273 in 72 children aged 2 to 17 with influenza A. The goal was to see how safe it is, how the body processes it, and whether it helps reduce flu symptoms. The trial took place in China and has already been completed.

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested an experimental oral drug called EDP-323 in 142 healthy adults who were deliberately infected with RSV. The goal was to see if the drug is safe and can reduce the amount of virus in the nose compared to a placebo. Results will help determine if EDP-323 could be …

This study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…

This study tested a new flu medicine called ADC189 in 190 children aged 2 to 11 with influenza. The medicine is given as a single dose, either as a tablet or granules. The goal was to see if it is safe and works well in younger children, who currently have limited treatment optio…

This study tested two new rapid tests that use a single nose swab to detect COVID-19, influenza A/B, and RSV. Researchers checked how accurate the tests are compared to standard lab methods and whether healthcare workers find them easy to use. The study involved 589 people with s…

This study collected nasal swabs, throat swabs, and saliva samples from 79 people with symptoms of flu, RSV, or COVID-19. The samples were used to help evaluate a point-of-care device called LumiraDx, which aims to quickly and accurately detect these viruses. The study focused on…

This study checked how well a new rapid test (LumiraDx) detects COVID-19 and flu A/B from a simple nose swab. Over 1,000 people with symptoms took part at clinics. The test aims to give fast results at the point of care, helping doctors tell these illnesses apart quickly.

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study checked how accurate two rapid tests (LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV-2 & Flu A/B) are at detecting COVID-19 and flu in people with symptoms. 716 participants provided nasal swabs at clinics. The results were compared to standard lab tests to measure…

This study tested a new rapid test (LumiraDx Influenza A/B + RSV Test) that uses a nasal swab to quickly detect flu A, flu B, and RSV. Over 500 people with cold or flu-like symptoms took part. The test was performed by healthcare workers at point-of-care sites and compared to sta…

This study tested whether giving general practitioners a rapid C-reactive protein (CRP) test helps them decide when antibiotics are truly needed for patients with respiratory infections. 140 patients with symptoms like cough, fever, or sore throat took part. Doctors in the test g…

This study checked how well a new test called VitaSIRO solo™ detects COVID-19, flu, and RSV in people with respiratory symptoms. Over 1,200 participants provided nose and throat swabs. The test's accuracy was compared to standard lab methods.

This study tested a new rapid test that checks for flu A, flu B, COVID-19, and RSV using one nasal swab. Over 1,100 people with respiratory symptoms took part. The goal was to see how well the test works compared to standard lab tests.

This study checked how well a new rapid test (iHealth COVID-19/Flu A&B) can detect COVID-19 and flu A and B in people with respiratory symptoms. About 588 people with two or more symptoms provided nose swabs. The test's results were compared to a standard lab test to see how accu…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study looked at whether FebriDx, a rapid fingerstick test, can accurately tell bacterial from non-bacterial acute respiratory infections when used by people without lab training. Researchers compared results from untrained operators to trained ones in 800 patients with fever…

This large study tested whether an enhanced flu vaccine (Fluad) works better than standard flu shots in adults aged 65 and older. Over 38,000 participants received either Fluad or a regular vaccine. The goal was to see if Fluad prevents confirmed flu cases more effectively. Resul…

This study tested a new medicine called CD388, given as a single set of three shots, to see if it can prevent the flu in healthy adults aged 18 to 64. Over 5,000 participants received either CD388 or a placebo. Researchers measured how many people got the flu over the next 24 wee…

This study tested several types of flu vaccines in over 1,800 adults aged 65-82 in Hong Kong over four years. The goal was to see which vaccine or combination of vaccines provides the strongest and longest-lasting immune protection. Researchers measured antibody levels and immune…

This study looked at two new ways to prevent RSV, a serious lung infection in babies: a vaccine given to pregnant women and an antibody shot given to infants. Researchers wanted to see how well each method works alone or together. 181 mother-infant pairs took part, and the study …

This study tested a new medicine called clesrovimab in over 1,000 infants and children at high risk for severe RSV disease. The goal was to see if it is safe and works as well as or better than the current standard treatment, palivizumab. Participants received either clesrovimab …

This study tested whether giving families educational materials, alcohol-based hand sanitizers, and surgical face masks could reduce the spread of colds and flu among household members. Researchers followed 2,788 people in 450 households in Northern Manhattan for 15 months. They …

This study looked at how well the seasonal flu vaccine works in adults who are hospitalized with severe flu-like illness. Researchers compared vaccinated and unvaccinated patients across a network of French hospitals to see if the vaccine reduced confirmed flu cases. The goal is …

This study tested whether a new vaccine against certain E. coli bacteria (ExPEC9V) can be given at the same time as a high-dose flu shot in adults aged 65 and older. The goal was to see if the immune response to both vaccines remains strong when given together. About 959 particip…

This study tested a single dose of nirsevimab, a lab-made antibody, in 800 healthy preterm and term infants in China to see if it could prevent serious lung infections caused by RSV. The goal was to reduce doctor visits and hospital stays during the RSV season. Results showed the…

This study tested whether sending text message reminders to patients and nudging their doctors could increase flu vaccination rates. Over 26,000 adults aged 50 and older took part. The approach used simple, low-cost tools like pre-visit texts and automatic vaccine orders in the e…

This study tested an injection called TNM001 in over 2,200 babies under 1 year old to see if it could prevent serious lung infections caused by RSV. The goal was to reduce the number of babies who get sick enough to need medical care. The study compared the shot to a placebo to c…

This study tested a new medicine called TNM001 to prevent severe RSV lung infections in high-risk infants under 1 year old. About 201 babies received either the antibody or a placebo, and were monitored for 270 days. The goal was to see if the antibody could safely reduce serious…

This large study tested a new medicine called clesrovimab to prevent RSV, a serious lung infection, in healthy babies born early or full-term. Over 3,600 infants received either the medicine or a placebo. The goal was to see if the medicine could reduce the number of babies who g…

This study looked at whether a single shot of nirsevimab (Beyfortus) can prevent RSV and other respiratory infections in infants under 1 year old. Researchers reviewed medical records from 816 babies at seven hospitals in China, comparing those who got the shot to those who did n…

This study tested whether far-UVC light, a safe type of ultraviolet light, can reduce respiratory infections like flu and COVID-19 in long-term care facilities. The trial involved 550 elderly residents who are at higher risk due to age and health conditions. The light was used as…

This study checked the safety of a quadrivalent flu vaccine in over 42,800 people aged 3 and older. Researchers looked for side effects within 30 minutes, 7 days, and 28 days after vaccination. The goal was to find any very rare adverse reactions. Results help confirm the vaccine…

This study tested whether the dietary supplement MitoQ could prevent severe viral infections, like COVID-19, in adults who had close contact with a sick person. Eighty asymptomatic adults were given MitoQ or no treatment and monitored for illness. The goal was to see if the suppl…

This study tested different strategies to increase RSV vaccination among 50 pregnant people. The goal was to find the best way to encourage vaccination at the right time during pregnancy to protect newborns from severe RSV. The study compared early and late vaccination timing alo…

This study tested whether a high-dose flu vaccine works better than the standard dose in adults aged 50 to 64. About 1,180 participants received either the high-dose or standard-dose shot, and researchers measured their immune response 28 days later. The goal is to see if the str…

This study tested the H1N1 flu vaccine in 439 people with cystic fibrosis to see if it prevents the flu and is safe. Participants included adults, children, pregnant women, and lung transplant recipients. Researchers measured immune response and tracked flu symptoms, using antivi…

This study looked at over half a million older adults in Taiwan who were hospitalized for a bone fracture. Researchers compared those who had received a flu vaccine in the past year to those who had not. They found that vaccinated patients had fewer infections and a lower chance …

This study looked at how well a single dose of BEYFORTUS (nirsevimab) protects infants from serious RSV infections that require a doctor visit or hospital stay. Researchers followed nearly 50,000 babies during their first RSV season. The goal was to see if the shot reduces cases …

This study tested a single injection of nirsevimab in over 8,000 healthy infants under 1 year old to see if it could prevent hospitalizations from RSV, a common respiratory virus. Babies received either the shot or no intervention and were followed for up to 6 months. The goal wa…

This study tested whether sending a one-time text reminder to parents could increase flu vaccination rates among children. Over 228,000 patients aged 6 months to 18 years at Children's Hospital of Philadelphia were included. Researchers compared vaccination rates 30 days after th…

This study tested a high-dose flu vaccine in 165 healthy adults aged 65 and older in Taiwan. Researchers compared the immune response and safety of the high-dose shot to a standard-dose flu vaccine. The goal was to see if the stronger dose could provide better protection against …

This study tested a high-dose flu vaccine against a standard-dose one in 2,100 adults aged 60 and older in Japan. The goal was to see if the high-dose version triggers a stronger immune response. Participants received one shot and were followed for 28 days to measure antibody lev…

This phase 3 study tested a quadrivalent (four-strain) influenza vaccine against two trivalent (three-strain) vaccines in over 7,100 Chinese participants aged 6 months and older. The goal was to see if the quadrivalent vaccine triggers a stronger immune response and provides broa…

This study tested whether a high-dose flu vaccine (QIV-HD) works better than the standard-dose vaccine in adults aged 60 and older. Over 1,500 healthy volunteers received either the high-dose or standard shot. Researchers measured immune responses 28 days later to see if the high…

This study combines data from two large trials in Denmark and Spain involving over 466,000 older adults. It compares the high-dose flu vaccine (Efluelda/Fluzone High-Dose) to the standard-dose flu shot to see which better prevents severe outcomes like hospitalization for flu or p…

This study looked at whether it's safe and effective to give a high-dose flu vaccine and a Moderna COVID-19 booster at the same time to adults 65 and older. 306 volunteers who had already received two Moderna shots took part. Researchers measured side effects and antibody levels …

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This large study tested whether a high-dose flu vaccine works better than the standard-dose shot in adults 65 and older. Over 332,000 participants were randomly assigned to receive either the high-dose or standard-dose vaccine. Researchers tracked hospitalizations for flu, pneumo…

This study tested whether treating private well water with ultraviolet (UV) light can prevent stomach and respiratory infections in children under 5. Researchers gave 28 Pennsylvania households either a real UV device or a fake one and tracked illness symptoms via weekly texts. T…

This study looked at whether taking a probiotic called LP28 can help older adults fight off colds and feel better. 102 people who had at least two colds in the past year took part. Researchers measured cold symptoms and immune cell levels to see if the probiotic made a difference…

This study compared a single dose of baloxavir marboxil to a 5-day course of oseltamivir in 100 Chinese children aged 1 to 12 with flu symptoms. The main goal was to check safety, including side effects. Researchers also measured how quickly symptoms like cough and fever improved…

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This completed study looked at how two different Robitussin cough syrup regimens affect quality of life in 244 adults with coughs from the common cold. One group used a single daytime/nighttime syrup, while the other used separate daytime and nighttime syrups. Researchers measure…

This study looked at whether taking probiotics can reduce a protein in the blood linked to acne inflammation. Researchers measured this protein in 50 adults with mild to moderate acne before and after probiotic treatment. The goal was to see if probiotics could help ease acne sym…

This study tested whether a stellate ganglion block (an injection near nerves in the neck) can improve distorted sense of smell (parosmia) caused by COVID-19. 48 adults with long-term smell issues after COVID took part. Half received the nerve block, half got a placebo (saline). …

This Phase 3 trial tested whether a single pill containing paracetamol (pain reliever/fever reducer), fexofenadine (antihistamine), and phenylephrine (decongestant) works better than a placebo for treating cold and flu symptoms. 567 adults in Brazil took the combo pill or a place…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

This study looks at how regular winter swimming—bathing in cold open water during winter—affects blood cells, blood flow, and stress-fighting enzymes in healthy men. Researchers compare winter swimmers to a control group who never swim in cold water and have a sedentary lifestyle…

This study tested a drug called suzetrigine, which blocks a specific nerve channel (NaV1.8) involved in pain signaling. In 67 healthy volunteers, tiny amounts were injected into the skin alongside a placebo and lidocaine. Participants received six different types of brief pain (e…

This study measured levels of mannose-binding lectin (MBL), a protein involved in immune response, in 97 ICU patients with severe H1N1-related acute respiratory distress syndrome (ARDS). Researchers wanted to see if higher or lower MBL levels were linked to a higher risk of death…

This study tracks how many infants in Germany receive nirsevimab, a long-acting antibody that helps protect against severe RSV disease. Researchers will survey parents of babies born during three RSV seasons (2024–2027) to measure immunization rates. The goal is to see how well t…

This study tracked 241 ICU patients with severe influenza to see how many developed a fungal lung infection called IAPA. Researchers collected blood and fluid samples to identify risk factors. The goal is to help doctors spot high-risk patients earlier.

This study looked at why some older adults (age 50 and up) maintain flu-fighting antibodies longer after getting the flu vaccine. Researchers enrolled 510 people and measured their immune response over time. The goal was to understand factors that help maintain protection, not to…

This study looked at 537 patients with respiratory infection symptoms to see how the types of viruses and bacteria changed from the COVID-19 pandemic period to after it. Researchers used a special PCR test to detect multiple germs at once. The goal was to understand how pandemic …

This study looked at how the immune system of healthy adults aged 65-75 responds to RSV, a common cause of chest infections. Researchers gave volunteers a mild RSV infection and took blood and nose samples to find immune markers linked to protection. The goal is to use these find…

This study from the University of Sao Paulo looked at whether measuring blood pressure during an exercise test can help predict outcomes in adults with flu-like symptoms, especially those who are unvaccinated. Researchers enrolled 62 participants and followed them for 30 days. Th…

This completed study in Hong Kong enrolled 977 adults aged 18-45 to understand how getting the flu vaccine year after year changes the body's immune response. Participants received either the Flublok vaccine or a saline placebo. Researchers measured antibody levels and looked for…

This study followed 241 adults hospitalized with the flu to see how the infection impacts the heart. Researchers tracked heart complications like new or worsening heart failure, heart attacks, and cardiac arrest. The goal was to better understand the link between influenza and he…

This completed study gave 11 healthy adults a specially made H3N2 flu virus via nasal spray to see how their immune systems reacted. Participants were quarantined for at least 8 days in a hospital-like setting. The goal was to learn more about flu infection and immune response, n…

This completed study from France compared over 1,500 ICU patients on ventilators to see if those with COVID-19 develop more lung infections than patients with influenza or no viral pneumonia. Researchers tracked cases of ventilator-associated pneumonia and tracheobronchitis. The …

This completed study tested different doses of an influenza A H3N2 virus in 33 healthy adults aged 18 to 55. The goal was to find a dose that safely causes mild flu symptoms, so this virus strain can be used in future trials to test new vaccines or treatments. Participants were m…

This study looked at how bacteria living in the nose and gut influence the immune response to a nasal flu vaccine in 201 children aged 6 to 17. Half got the vaccine right away, half waited 28 days. Researchers collected samples before and after vaccination to measure antibodies a…

This study tested whether electronic alerts and structured messages from an antibiotic stewardship team could reduce antibiotic use in hospitalized patients with suspected pneumonia. 107 adults were enrolled, and those with test results suggesting viral infection were randomly as…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study looked at how children's immune systems respond to the seasonal flu vaccine. Researchers collected nasal and finger-prick blood samples from 65 kids aged 2-17 before and after they got their flu shot. The goal was to understand both systemic and nasal immunity, which c…

This study looked at how adults aged 18 and older experienced a trivalent recombinant influenza vaccine. Over 1,000 participants completed a short online survey about their injection experience, side effects, and willingness to get vaccinated again. The goal was to better underst…

This study looked at why the live attenuated influenza vaccine (LAIV), given as a nasal spray, is less effective in adults than in children. Researchers measured antibody levels in 51 healthy adults after vaccination to understand the immune response. The goal is to use these ins…

This study checked how accurate a new test (Xpert Expanded Respiratory Panel) is at finding respiratory infections. Researchers tested nose swabs from 3,200 people with symptoms and compared results to other tests. The goal was to see if the new test works well enough for routine…

This study tested whether adding infectious disease experts to primary care teams helps reduce unnecessary antibiotic use. Over 1,300 patients from six clinics in Spain took part. Doctors in the expert-advised group could call or meet with specialists to discuss tricky cases. The…

This study followed over 3,800 women who had received an RSV vaccine or a placebo in a previous pregnancy to see if it was safe in later pregnancies. No new vaccine was given—researchers just tracked pregnancy outcomes and baby health up to 42 days after birth. The goal was to de…

This study looked at whether new RSV prevention medicines given to infants or pregnant women reduced hospitalizations for RSV in children under 2. Researchers analyzed health records from over 2,700 children in the Australian Capital Territory. The goal was to see if the 2025 pre…

This study tested whether measuring a protein called MxA in the blood can help doctors decide when to stop antiviral drugs in patients with flu or COVID-19. Researchers enrolled 86 adults and compared standard care to MxA-guided treatment. The goal was to see if the test could re…

This study surveyed 5,000 German adults to find out how many people got their flu shot during the current respiratory season. The focus was on adults aged 60 and older, as well as those with chronic illnesses. By collecting this data, researchers hope to help public health offici…

This study gave healthy adults a nasal flu vaccine to safely mimic a mild flu infection. Researchers then measured virus levels and immune responses in nasal samples. A small group also had lung function tests. The goal was to create a reliable model for studying flu without caus…

This completed study analyzed over 230,000 adults in France who had lower respiratory tract infections like pneumonia, bronchitis, or flu. Researchers used anonymous electronic health records from 2015 to 2024 to describe patient characteristics, how often antibiotics were prescr…

This study looked at how well the 2023 and 2024 flu vaccines protect against influenza A. Researchers gave the 2023 vaccine to 23 healthy adults between May and June 2024, when the vaccine was about to expire, to compare their immune responses with people who got the 2023 vaccine…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…

This study looked at how the immune system of older adults (ages 60-75) responds to a controlled infection with respiratory syncytial virus (RSV). Researchers gave 28 healthy volunteers a weakened form of the virus via nasal drops and monitored their symptoms and immune reactions…

This study looked at how the flu virus changes the types of bacteria living in the nose and throat, and how the body's immune system reacts. Researchers gave 17 healthy adults either a flu vaccine nasal spray or a saltwater mist, then tracked bacterial changes and immune response…

This study tested whether taking the statin drug atorvastatin changes the body's immune response to the flu vaccine. 63 adults took either a statin or a placebo for four weeks before and after getting the flu shot. Researchers measured antibody levels and checked for side effects…

This study reviewed records from 542 adults in 20 ICUs across China who had severe flu (Influenza A) and breathing failure. Researchers divided patients into those who also developed a fungal lung infection (aspergillosis) and those who did not, to understand risk factors and sur…

This study looked at 32 adults in the ICU on ECMO life support who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole behaves in the body to find the best dose for these very ill pat…

This study tested a computer tool that helps nurses decide when antibiotics are needed for common respiratory infections like colds and sore throats. The tool, built into the electronic health record, calculates a patient's risk and suggests appropriate care. Researchers measured…

This study tracked 289 healthcare workers in short-stay hospital wards to see how often they caught the flu, both with and without symptoms. Participants gave blood samples and nasal swabs to confirm infections. The goal is to understand how many silent flu cases occur among staf…

This study looked at how well different licensed flu vaccines trigger an immune response in adults aged 65 to 74. About 179 participants received one of four flu vaccines over two flu seasons, and researchers measured their antibody levels at several time points. The goal was to …

This study followed 919 pregnant women in Paris to see how often they caught H1N1 flu during the 2009 pandemic and what happened to their pregnancies. Researchers also checked if the flu vaccine was safe. The goal was to better understand the risks of flu during pregnancy.

This early-phase study involved 36 healthy Thai adults to see if getting a COVID-19 booster and flu vaccine together is as effective and safe as getting them separately. Researchers measured immune responses and side effects over one month. The goal was to gather information to p…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study looked at 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers collected fluid from the lungs to study the virus and the body's immune response. The goal was to learn more about what causes severe illness, not to test a new treatment.

This completed study looked at 227 adults and children in the intensive care unit with severe flu. Researchers wanted to see if a specific blood marker (soluble HLA-G5) could predict which patients would develop severe breathing failure. They also collected respiratory samples to…

This study followed over 1,000 adults with confirmed or suspected COVID-19 who were admitted to intensive care units (ICUs) across France. Researchers tracked their treatments, complications, and survival at 28 days. The goal was to learn how these patients are managed and what f…

This study looked at 73 people who were hospitalized with severe COVID-19 pneumonia to see if their lungs still had problems 4 months later. The main focus was on how well oxygen moves from the lungs into the blood. The goal was to better understand these lasting issues so doctor…

This study tested how well the flu vaccine works and if it's safe for people with inflammatory bowel disease (IBD). Researchers compared 228 adults with IBD who were either taking immunosuppressive drugs or not. The goal was to see if the vaccine triggers a strong immune response…

This study looked at whether the seasonal flu vaccine works as well in people with sarcoidosis as it does in healthy people. Researchers gave the flu shot to 190 adults with sarcoidosis and compared their immune response to a group of healthy volunteers. The goal was to see if th…

This study looked at whether a dietary fiber from baker's yeast (beta-glucan) can improve how well the flu vaccine works in healthy adults aged 50 and older. 78 participants took either the supplement or a placebo before getting their flu shot. Researchers measured antibody level…

This study followed 38 adults who survived severe breathing failure from the 2009 H1N1 flu. Researchers compared those who needed a machine to oxygenate their blood (ECMO) with those who did not. They measured lung function, quality of life, and mental health at least 9 months af…

This study looked at how a new medicine called nirsevimab affected RSV infections and hospital stays in children under 2 years old in the Australian Capital Territory. Researchers used routine health data from over 2,300 kids to compare RSV cases and emergency visits before and a…

This study tested a patient engagement tool (PET) designed to encourage COVID-19 and flu vaccination among underserved populations in East London, including minority ethnic groups, migrants, and low-income individuals. Over 5,900 adults from six GP practices were randomly assigne…

This completed study collected blood, urine, and nasal swab samples from 249 adults—some with COVID-19, some with the flu, and healthy controls—at two time points. Researchers used a systems biology approach to analyze the data, aiming to understand why people respond differently…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults aged 65 and older who received the 2020-2021 flu vaccine. The samples were sent to experts at the WHO, CDC, and FDA to help decide which flu strains to include in future vaccines. T…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults 65 and older after they received their seasonal flu vaccines. The samples were sent to health authorities to help decide which flu strains to include in future vaccines. The study d…

This study collected blood samples from 90 children (6 months to under 9 years) and adults 65 and older after they received the 2019-2020 flu vaccine. The samples were sent to health agencies like the WHO and CDC to help them decide which flu strains to include in future vaccines…

This study tracked nearly 2,500 adults who came to the emergency room during flu season to see how many actually had the flu. By testing everyone with a nasal swab, researchers aimed to find flu cases that might otherwise go unnoticed. The goal is to give hospitals a clearer pict…

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…

This completed study looked at how 147 healthy hospital workers responded to the seasonal flu vaccine and the H1N1 pandemic vaccine. Researchers measured antibody and cellular immune responses, focusing on how age and previous flu vaccinations affected those responses. The goal w…

This completed study looked at how well the seasonal flu vaccine worked during the 2012-2013 flu season in adults who were hospitalized with flu-like symptoms. Researchers compared vaccinated and unvaccinated patients across a network of French hospitals to see if the vaccine red…