Viral respiratory tract infection

This phase 3 trial is investigating whether giving a repeat dose of the RSVpreF vaccine to immunocompromised adults is safe and triggers a strong immune response. Participants, aged 18 and older, will receive one shot and be monitored for about a year. The study aims to find the …

This Phase 1 trial tests experimental mRNA vaccines designed to protect against many types of influenza A by targeting a stable part of the virus. Healthy adults aged 18 to 59 receive one or two doses of the vaccine candidates, alone or in combination. The study checks for side e…

This early-stage trial tests an experimental mRNA vaccine called mRNA-1365 in healthy adults aged 60 and older. The vaccine is designed to trigger immunity against two respiratory viruses—RSV and hMPV—which can cause severe illness in older people. Researchers will evaluate the v…

This trial is testing a new vaccine called rBCG-N-RSV, which is based on the BCG vaccine (used for tuberculosis) but modified to also target respiratory syncytial virus (RSV). The study involves 200 adults over 60 years old, who will receive either this new vaccine or the standar…

This early-stage trial tests an experimental mRNA vaccine called YKYY025 designed to protect against respiratory syncytial virus (RSV). Healthy adults aged 18 and older receive a single injection of either the vaccine or a placebo. Researchers monitor safety, side effects, and im…

This study will test a new RSV vaccine in 60 adults aged 20 and older. Researchers want to understand how the vaccine triggers the immune system to create strong antibodies and memory T cells. The goal is to learn how to make RSV vaccines more effective.

This study tests a new mRNA vaccine called IN006 to see if it is safe and helps the body fight RSV, a virus that can cause serious breathing problems. About 200 healthy adults, both younger (18-59) and older (60-79), will receive one or two shots of the vaccine or a placebo. Rese…

This study is checking the safety of a high-dose flu vaccine called Efluelda in adults aged 65 and older in South Korea. About 670 participants will receive one shot and be monitored for side effects for about a month. The goal is to see how often reactions like injection site pa…

This early-stage study tests a new vaccine (MKK900) against respiratory syncytial virus (RSV) in 120 healthy women aged 18 to 49. The main goal is to check if the vaccine is safe and triggers a strong immune response. Participants will receive either the new vaccine or an active …

This early-stage trial compares an experimental flu vaccine called H1ssF with the standard seasonal flu vaccine (Flucelvax). About 112 adults aged 18-70 will take part, including some who have had flu shots before and some who have never had one. The main goal is to check safety …

This study will check how well a new RSV vaccine (RSVpreF) works when given to pregnant women in Brazil. Researchers will follow 5,000 infants up to 6 months old who are hospitalized or seen in clinics for respiratory illness. By comparing babies whose mothers got the vaccine to …

This early-stage trial will test the safety of a new RSV mRNA vaccine in 60 healthy adults aged 18 and older. Participants will receive either a low dose, high dose, or a placebo (saline) shot. The study aims to see if the vaccine causes any side effects, paving the way for large…

This early-stage trial tests a new influenza vaccine that includes a special booster called BK-01 adjuvant. The goal is to see if it is safe and triggers a strong immune response in adults 18 and older. 160 volunteers will receive either the new vaccine, a standard flu vaccine, o…

This study is checking the safety of a high-dose flu vaccine called Efluelda Tetra in adults aged 65 and older in South Korea. About 670 participants will receive one dose and be monitored for side effects for about a month. The goal is to see how often reactions like injection s…

This study tests whether personalized ventilator settings can reduce lung injury in adults with severe respiratory failure who are on ECMO (a heart-lung machine). Researchers will use esophageal manometry or electrical impedance tomography to tailor the ventilator's positive pres…

This study looks at whether the RSV vaccine given in late pregnancy can help protect babies born to mothers with HIV. RSV is a leading cause of infant hospitalization, and babies exposed to HIV are at higher risk. Researchers will measure antibody levels in mothers and infants to…

This study looks at the real-world effectiveness of the RSV vaccine Abrysvo in adults. Researchers will analyze health records from over 290,000 people to compare those who got the vaccine with those who did not. The goal is to see if the vaccine reduces hospitalizations and othe…

This study tests whether taking a short course of the drug sirolimus (Rapamycin) can improve how well older adults on hemodialysis respond to flu and RSV vaccines. Sixty participants will receive the vaccines plus sirolimus at different times. The goal is to see if this approach …

This study tests whether a single dose of the RSV vaccine (Arexvy) can reduce moderate-to-severe COPD flare-ups in people who have frequent attacks. Researchers will enroll 320 high-risk patients aged 50+ and follow them for one year. Half will get the vaccine plus standard care,…

This study tests whether a single oral dose of TRX-100 can prevent influenza infection in healthy adults aged 18 to 55. Participants will be deliberately exposed to the flu virus in a controlled setting. The trial is randomized, double-blind, and placebo-controlled, meaning neith…

This phase 3 trial will test whether adding low or moderate doses of the corticosteroid methylprednisolone to standard care can lower the death rate in adults with severe influenza pneumonia in the ICU. About 496 participants will be randomly assigned to receive either saline (pl…

This study tests whether the RSV vaccine Abrysvo can help blood cancer patients who have had a stem cell transplant or CAR-T therapy build immunity against RSV. Researchers will measure antibody levels before and after vaccination in 30 adults. The goal is to see if the vaccine t…

This early-stage study tests a single dose of a new drug called AVM0703 in 16 adults with severe breathing failure (ARDS) caused by COVID-19 or the flu. The main goal is to check if the drug is safe and how the body processes it. Participants are randomly assigned to receive the …

This study evaluates a new digital test that people can use at home to detect COVID-19 and influenza A and B from a nasal swab. Participants with symptoms will use the test themselves and compare the results to a standard lab PCR test. The goal is to see if the test is accurate e…

This study will test a new at-home rapid test that checks for flu A, flu B, and COVID-19 using a nasal swab. About 200 people with symptoms will use the test themselves, and their results will be compared to standard lab PCR tests. The goal is to see if the test is accurate and e…

This study tests whether analyzing chemicals in a person's breath can quickly identify serious respiratory infections like COVID-19, flu, and Legionella in hospitalized patients. Researchers will collect breath samples from 777 adults using a simple bag, then analyze them in a la…

This study aims to see if analyzing chemicals in a person's breath can rapidly detect respiratory infections like COVID-19 or the flu. Researchers will collect breath samples from 1,665 adults with symptoms and healthy volunteers. If successful, this non-invasive test could offer…

This study will test a new at-home diagnostic test that aims to detect five respiratory viruses—COVID-19, influenza A and B, RSV, and rhinovirus—from a single nose swab. About 2,000 people with cold or flu symptoms will provide samples in simulated home environments. The test's a…

This study tests whether a rapid PCR test done right in the clinic can help doctors diagnose and treat acute respiratory infections faster. Over 16,000 adults at risk of severe illness will take part. The goal is to see if this approach lowers rates of respiratory failure and hos…

This trial tests whether offering a needle-free flu vaccine (FLUMIST) for self-administration at home, picked up from a pharmacy, increases flu vaccination rates compared to usual care. Households with children aged 2 to 17 in Burlington, Ontario, are randomly assigned to either …

This phase 3 trial is testing whether a single dose of the antiviral drug sebaloxavir marboxil can prevent influenza in household members (ages 2 and up) who live with someone recently diagnosed with the flu. Participants are randomly assigned to receive either the drug or a plac…

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This study tests whether a chatbot delivered through WhatsApp can help mothers decide to get their children aged 3-6 vaccinated against seasonal flu. Mothers are randomly assigned to receive either a chatbot that tailors its messages to their readiness to vaccinate or a standard …

This study will compare two enhanced flu vaccines—one with an adjuvant (MF59) and one with a higher dose—in 350 adults living with HIV. The goal is to see which vaccine triggers a stronger immune response. Participants will receive one shot and have their antibody levels checked …

This large trial will study whether flu and pneumonia vaccines can reduce serious flare-ups and medical costs in people aged 45-80 with COPD. About 7,000 participants will be split into four groups: flu vaccine, pneumonia vaccine, both, or no vaccine. Researchers will track lung …

This trial tests a handheld light device (RD-X19) to see if using it for 5 minutes every other day can prevent upper respiratory infections like COVID-19 and flu. It involves 130 military personnel and their families at a single base. Half will get the real device, half a sham de…

This study tests whether a single dose of nirsevimab, an antibody that targets RSV, can prevent respiratory infections in Aboriginal and Torres Strait Islander children aged 6 months. Around 1,000 children will be randomly assigned to receive either the antibody or standard care.…

This study tests two nasal protective devices (Noseguard and Noseguard Night) in 2000 adults to see if they can reduce the risk of catching respiratory infections like COVID-19 and influenza. Participants will use the devices as directed for 8 weeks, and researchers will track in…

This study tests a new medicine called SIBP-A16 to see if it can safely prevent RSV in infants under 1 year old, including those born early. About 36 babies will receive either the new drug, a placebo, or an existing RSV drug. The main goal is to check for side effects and how th…

This study tests a new flu vaccine in 1,200 adults aged 60 and older to see how well it boosts immunity and if it's safe. Participants receive one dose of either the new vaccine or a current one, and researchers check antibody levels and side effects for 30 days. The goal is to f…

This study tests whether a special fish oil (Omega Cold) can help healthy adults avoid or recover faster from colds, flu, and COVID-19. Four hundred participants aged 18–80 will take either the fish oil or a placebo daily for four months during flu season. They will report any sy…

This trial tests whether simple nudges (reminder messages) and motivational interviewing can increase flu vaccination among 4,050 healthcare workers in Chinese community hospitals. In phase 1, hospitals get either standard nudges, personalized nudges with a chatbot, or no reminde…

This study looks at whether a special pillow that combines cold therapy and arm elevation can help children aged 7 to 12 feel less anxious and more comfortable after surgery for a broken arm. About 80 kids will be randomly assigned to use either the special pillow or standard car…

This study tests a new herbal blend designed to shorten the duration and reduce the severity of common cold symptoms. Researchers will enroll 300 healthy adults in Australia who get frequent colds. Participants will take the herbal product or a placebo whenever they feel a cold c…

This study looks at how well and how safely SIROPSEDAL syrup works for acute cough caused by colds or upper respiratory infections. About 124 children and adults will take the syrup as prescribed by their doctor and report their cough severity over one week. The main goal is to s…

This study looks at how well RHINOSEDAL works for people aged 8 and older with a stuffy nose caused by colds, allergies, or sinus issues. About 126 participants will use the treatment as prescribed and report their symptoms over 6 days. The goal is to see if it provides meaningfu…

This study looks at whether a traditional Chinese herbal drink (Xuanfei Jiangzhuo Decoction) can help older adults (60+) recover faster from a COPD flare-up caused by the flu. About 300 participants will either take the herbal drink plus standard flu medicine or standard flu medi…

This study looks at whether a fast, bedside test (SPOTFIRE) can help doctors better treat children with respiratory infections in the emergency department. About 720 children aged 2 months to 18 years will be randomly assigned to either get the rapid test or standard care. The go…

This phase 3 trial tests whether a single dose of baloxavir helps non-hospitalized adults with mild-to-moderate influenza recover faster compared to a placebo. About 264 participants will be enrolled within 5 days of symptoms and tracked until they feel fully recovered. The study…

This study looks at how well a saltwater (saline) nasal spray works and how safe it is for infants and toddlers aged 3 months to 4 years with stuffy noses from colds, flu, or allergies. About 83 children will use the spray for up to 14 days, and parents will report symptom change…

This study looks at whether changing climate patterns are shifting when winter respiratory viruses, like the flu, peak each year. Researchers will review medical records of 5,000 patients who tested positive for these viruses and compare infection rates with weather data from the…

This study investigates how the immune system inside the nose responds to the FluMist nasal flu vaccine in healthy adults aged 18 to 65. Participants receive a single dose of the vaccine, and researchers collect nasal swabs and gentle saline washes before vaccination and again tw…

This study examines data from up to 70,000 patients hospitalized with respiratory tract infections in Dutch hospitals between 2018 and 2026. Researchers will analyze how long patients stay, how many need intensive care, and the overall costs. The goal is to help improve hospital …

This study looks at health records of babies born in Scotland to see if those whose mothers received the RSV vaccine (ABRYSVO) during pregnancy have fewer hospital visits for RSV. No new participants are enrolled; researchers will analyze existing data. The goal is to understand …

This study follows 150 adults aged 60 and older who have a respiratory infection (flu, RSV, or COVID-19) or who test negative. Researchers will measure specific immune markers in the blood over 60 days to see how they change from early infection to recovery. The goal is to better…

This study looks at vitamin D levels in 63 critically ill children (ages 1 month to 12 years) admitted to the ICU with severe breathing infections. Researchers will measure vitamin D in the first 24 hours and compare it to how severe the infection is and the risk of death. The go…

This study will follow 1,440 women aged 20 to 45 who had a respiratory viral infection within six months before pregnancy or early in pregnancy. Researchers will track pregnancy complications like gestational diabetes and preterm birth to see if these infections increase risks. T…

This study will look at 5,900 hospitalized adults aged 60 and older to find out which viruses cause severe lung infections. Researchers will test respiratory samples to track common and emerging viruses like flu, RSV, and COVID-19. The goal is to better understand how often these…

This study will observe 65 children, aged 1 to 24 months, hospitalized with bronchiolitis at Assiut University Hospital. Researchers will collect information on family, social, and medical factors to identify what makes the illness more severe. The goal is to help doctors predict…

This study looks at whether the types of bacteria in a child's gut can influence how sick they get from RSV, a common virus that can cause severe breathing problems in infants. Researchers in Vietnam will compare the gut bacteria and immune responses of 250 children with mild ver…

This study looks at how different features of an AI system affect the way primary care doctors diagnose and treat respiratory infections. About 3,000 doctors in China will use a web-based tool with various AI features, such as automated data entry or stepwise medication suggestio…

This study follows 270 preterm babies (born before 32 weeks) from birth to age 3. Researchers will regularly swab their noses to analyze the bacteria and other microbes living there. The goal is to see if the nose microbiome can predict which babies will develop bronchopulmonary …

This study will examine gut bacteria, immune markers, and nutrient levels in 120 children with different respiratory health conditions, including pneumonia and recurrent infections, compared to healthy kids. By analyzing stool samples and health data, researchers hope to understa…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This follow-up study checks if taking TUDCA or fatty acid supplements during a flu vaccine helps older adults (ages 60-70) keep their immunity longer. Researchers will measure antibody levels and immune cells about 8 months after vaccination. No new treatment is given—just one bl…

This study will observe up to 4,000 children under 5 years old who test positive for RSV and visit emergency departments in Turkey. Researchers will track how many children need to be admitted to the hospital or intensive care, and what treatments they receive. The goal is to bet…

This study aims to understand how influenza transmits from person to person. Healthy volunteers, called Recipients, will spend time in a controlled environment with people infected with the flu (Donors) while performing everyday activities like playing cards. The study involves d…

This study will track 10,000 adults in Hong Kong with respiratory symptoms to measure how often RSV causes illness and how severe it gets. Researchers will collect nose and throat samples and blood tests over several weeks. The goal is to fill knowledge gaps about RSV in adults a…

This phase 1 trial aims to safely and reliably cause mild flu symptoms in healthy adults using a lab-made H3N2 influenza virus. By carefully monitoring 32 volunteers, researchers hope to establish a controlled human infection model (CHIM) that can be used in future studies to tes…

This study will test if a new health awareness video can teach public transportation drivers in Lebanon about preventing respiratory infections like colds and flu. About 160 drivers will be split into two groups: one watches the health video, the other watches a neutral video abo…

This study will observe 300 children and young adults (ages 0-20) with respiratory tract infections to see if chest ultrasound can predict their outcomes, such as need for hospitalization or ICU care. Researchers will use an ultrasound score and combine it with clinical data to s…