Fatty liver disease

This study tests whether a daily probiotic lysate supplement can reduce fat and stiffness in the liver of adults with non-alcoholic fatty liver disease (NAFLD). Participants take either the supplement or a placebo for three months, and doctors measure changes using MRI and ultras…

This study tests whether a daily capsule containing fragments of a probiotic bacterium (L. rhamnosus) can reduce liver fat and improve blood markers in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). Participants take either the supplement or a place…

This study investigates whether a nutrition education program and omega-3 supplements can help people with non-alcoholic fatty liver disease (NAFLD) lose weight, improve liver enzymes, and lower cholesterol. Participants are randomly assigned to receive nutrition guidance, omega-…

This completed Phase 2 study tested whether a combination of two experimental drugs, K-877-ER and CSG452, can improve liver health in adults with nonalcoholic steatohepatitis (NASH) and liver fibrosis. The 228 participants received either the combination or a placebo. The main go…

This study tested an experimental drug called HSK31679 in 186 Chinese adults with non-alcoholic steatohepatitis (NASH), a serious liver condition. Participants took either 80 mg, 160 mg, or a placebo daily for 52 weeks. The goal was to see if the drug could improve liver damage a…

This early-stage trial tested a new drug, LY3849891, in 115 people with fatty liver disease who carry a specific gene variant (PNPLA3 I148M). The main goal was to check safety and how the body processes the drug. Researchers also looked at changes in liver fat and inflammation us…

This study tested whether regularly removing blood (like donating blood) can lower iron levels and improve diabetes control and fatty liver disease. 132 adults aged 40-75 with prediabetes or diabetes took part. The treatment group gave blood several times, while the control group…

This study tested a new medication called efinopegdutide in 124 adults with fatty liver disease (also called MASLD). The goal was to see if taking the drug every two weeks or every week could safely reduce liver fat. After 28 weeks, the drug helped lower liver fat, and researcher…

This study tested whether Mediterranean or DASH diets improve liver function in people with nonalcoholic fatty liver disease (NAFLD). 75 adults with mild to moderate liver enzyme elevations were split into three groups: one following general dietary guidelines, one on a Mediterra…

This study tested three different doses of HPG1860, an experimental oral drug, against a placebo in 89 adults with nonalcoholic steatohepatitis (NASH), a type of fatty liver disease. The main goals were to check safety and see if the drug could lower liver fat content measured by…

This study tested a weekly injection called pemvidutide in 212 adults with NASH, a serious liver condition linked to fat buildup. The goal was to see if the drug could reduce liver fat and scarring without worsening the disease. Participants received either the drug or a placebo …

This study tested different doses of vitamin E in 200 adults with nonalcoholic fatty liver disease (NAFLD) to find the best dose for improving liver health. Participants took vitamin E or a placebo for 24 weeks, and researchers measured changes in a key liver enzyme (ALT). The go…

This study tested whether taking phytosterols (plant-based supplements) for 3 months can improve liver health, cholesterol, and insulin levels in people with nonalcoholic fatty liver disease (NAFLD). 27 participants took either phytosterol pills or a placebo. Researchers measured…

This study looked at how well adults with obesity or complicated overweight could stick to different very low-calorie ketogenic diets (VLCKD) in a real-world clinic. Participants chose one of four diet plans, ranging from all-natural foods to all meal replacements, and followed a…

This Phase 2 trial tested a drug called DD01 in 67 overweight or obese adults with a type of fatty liver disease (MASLD/MASH). The goal was to see if DD01 could safely reduce liver fat by at least 30% over 48 weeks compared to a placebo. The study is completed, and results will s…

This study tests a medicine called survodutide in adults with overweight or obesity and a liver condition called NASH. Participants receive weekly injections of survodutide or a placebo for about a year, along with diet and exercise advice. The goal is to see if the drug reduces …

This study tested whether a device that measures liver fat at home can motivate people with non-alcoholic fatty liver disease (NAFLD) to stick with diet and exercise. Ten adults with NAFLD used the device and received standard care. The goal was to see if home monitoring leads to…

This early-phase study tested an oral drug called idebenone in 53 adults with non-alcoholic steatohepatitis (NASH) and mild-to-moderate liver scarring. The main goal was to check safety and tolerability, while also looking for signs that the drug might reduce liver stiffness and …

This study tested two versions of a low-calorie Mediterranean diet, each with different carb and fat levels, combined with moderate aerobic exercise in 36 adults with obesity and fatty liver disease (NAFLD). The goal was to see if one diet plan worked better than the other at red…

This study looked at whether a diet rich in tomatoes could improve liver health, gut function, and blood sugar in people with non-alcoholic fatty liver disease (NAFLD). Eighty participants either ate a tomato-free diet or one with added tomatoes and sauce for six weeks. Researche…

This study tested whether a combination of two drugs, dasatinib and quercetin, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD) and fibrosis. Thirty adults with biopsy-confirmed liver scarring took either the drug combo or a placebo in cycles ove…

This study looked at whether changing the amount of methyl donor nutrients (like folate and choline) in the diet could help people with non-alcoholic fatty liver disease (NAFLD). The goal was to reduce liver fat and improve liver function. 51 participants completed the study, and…

This study looked at whether adding rice bran to nutrition education helps people with fatty liver disease. 58 overweight or obese adults with moderate fatty liver were split into two groups: one got nutrition education alone, the other got nutrition education plus rice bran. Res…

This study looked at whether a class of diabetes drugs called SGLT2 inhibitors can improve fatty liver disease in people with type 2 diabetes. 150 adults took the drugs for 6 months, and researchers measured changes in liver stiffness, fat levels, and blood sugar control. The goa…

This study tested a drug called BI 770371 in 28 people with compensated cirrhosis caused by MASH, a liver disease linked to metabolism. Participants received either the drug or a placebo as an infusion every 3 weeks for 12 weeks. The main goal was to see how well the drug is tole…

This study looked at whether eating 400 grams of fresh oranges daily for a month could improve metabolism in 60 adults with metabolic-associated fatty liver disease (MAFLD). Participants either ate oranges or other fruits. Researchers measured changes in liver fat and blood fats.…

This study looked at whether a Mediterranean diet, with or without added exercise, could help people with a type of fatty liver disease called MASLD. The goal was to see if the diet could reduce fat and scarring in the liver. 96 adults took part, and researchers used special MRI …

This study tested whether ornithine aspartate granules work better than silymarin capsules for non-alcoholic fatty liver disease (NAFLD). 237 adults with NAFLD and elevated liver enzymes took one of the two treatments for a period. The main goal was to see if liver fat levels imp…

This completed Phase 2 trial tested LAENNEC, a substance made from human placenta, in 49 adults with chronic liver disease. The study aimed to check if the treatment is safe and whether it can improve liver function, measured by a drop in ALT levels. Participants received either …

This study tested three different probiotics (Pediococcus pentosaceus, Lactobacillus lactis, and Lactobacillus helveticus) in 89 adults with non-alcoholic fatty liver disease. Participants took probiotic capsules or a placebo daily for 8 weeks, along with a standard liver supplem…

This study tested a team-based approach for people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a type of fatty liver linked to heart problems. 286 adults received either standard care or extra support from a liver doctor, a nutritionist, and a psycholog…

This phase 2 trial tested elobixibat, a drug that blocks bile acid absorption in the gut, in 47 adults with nonalcoholic fatty liver disease (NAFLD) or its more severe form NASH. Participants received either elobixibat or a placebo for 16 weeks. The main goal was to see if the dr…

This study looked at whether ketotifen, a medicine used for allergies, is safe and helpful for people with non-alcoholic fatty liver disease (NAFLD) who do not have cirrhosis. Sixty adults with NAFLD took part. The main goal was to see if ketotifen could improve liver scarring (f…

This completed phase 4 trial compared two common diabetes drugs, dapagliflozin and empagliflozin, added to metformin in 108 adults with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Participants took one of the two drugs daily for six months. Researchers used live…

This study tested whether a probiotic called L. lactis CKDB001 can improve liver enzyme levels in people with nonalcoholic fatty liver disease (NAFLD). 95 adults with mildly elevated liver enzymes took either the probiotic or a placebo daily for 12 weeks. The goal was to see if t…

This study tested an experimental drug called efinopegdutide in 381 adults with non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. The main goal was to see if the drug could help the liver heal (resolve NASH) without making scarring worse. Participants r…

This study tested three dietary strategies—low-carb, Mediterranean, and standard nutritional advice—in 173 overweight adults with MASLD (fatty liver disease) over 6 months. Researchers measured changes in liver fat and damage using scans and blood tests. The goal was to see which…

This study looked at whether aspirin or a diabetes drug called an SGLT2 inhibitor (like dapagliflozin) can improve liver health in people with type 2 diabetes and non-alcoholic fatty liver disease. Researchers measured liver enzymes, cholesterol, and liver stiffness (using FibroS…

This study tested a new drug called BIO89-100 (Pegozafermin) in 222 adults with NASH, a serious fatty liver disease with liver scarring. Participants received weekly injections of the drug or a placebo for about 6 months. The goal was to see if the drug could reduce liver inflamm…

This pilot study tested a drug called ibutamoren in 12 adults with nonalcoholic fatty liver disease (NAFLD). The goal was to see if it could lower fat in the liver. Participants took the drug for 6 months, and researchers measured liver fat using special MRI scans. The study was …

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This phase 2 trial tested an oral drug called MGL-3196 in 125 adults with non-alcoholic steatohepatitis (NASH), a fatty liver disease that can lead to scarring and liver failure. The main goal was to see if the drug could reduce liver fat measured by MRI after 12 weeks compared t…

This study tested a drug called TRO19622 in 22 adults with NASH, a type of fatty liver disease. Participants took the drug or a placebo for one month to see if it improved liver enzyme levels and was safe. The goal was to gather early information on whether the drug might help co…

This early-stage trial tested a new oral drug called J2H-1702 in 100 healthy men to see if it is safe and how the body processes it. The drug is being developed for non-alcoholic steatohepatitis (NASH), a type of liver disease. The study was completed and used a placebo for compa…

This study tested a new drug called J2H-1702 in 87 adults with non-alcoholic steatohepatitis (NASH), a type of fatty liver disease. The goal was to see if the drug is safe and if it can reduce liver fat and scarring after 12 weeks compared to a placebo. Participants were randomly…

This study tested whether taking curcumin (from turmeric) daily for 12 weeks could improve cholesterol, blood sugar, hormones, and liver health in women with both PCOS and nonalcoholic fatty liver disease. 74 women participated in a double-blind, placebo-controlled trial. The goa…

This early-stage trial tested an experimental drug called BI 3006337 in 64 adults who are overweight or obese and have fatty liver disease. Participants received weekly injections of either the drug or a placebo for about 4 months. The main goal was to check safety and tolerabili…

This phase 2 trial tested whether semaglutide (a diabetes drug) combined with cilofexor and firsocostat (two experimental liver drugs) can improve liver scarring and resolve NASH in people with cirrhosis. 457 participants with compensated cirrhosis due to NASH were randomly assig…

This completed study tested whether the diabetes drug semaglutide (Rybelsus) could help 60 adolescent girls with PCOS and obesity reduce liver fat and improve insulin sensitivity, compared to a weight loss diet. Participants took a daily oral tablet for 4 months or followed a pre…

This study tested a drug called tesamorelin in 51 obese adults with nonalcoholic fatty liver disease (NAFLD). The drug is designed to increase growth hormone levels, which may help reduce liver fat and inflammation. Researchers measured changes in liver fat using special scans an…

This study looked at whether eating only during a set window each day (time-restricted eating) combined with supervised exercise can reduce fat in the liver and improve heart health in adults with obesity. 187 people took part. The goal was to see if the combination works better …

This study tested whether combining a new liver drug (NNC0194-0499) with semaglutide (a diabetes/weight-loss drug) can reduce liver scarring in people with NASH, a serious fatty liver disease. About 700 adults received weekly injections of either the drug combo, a different combo…

This study tested whether a virtual reality (VR) diet program is a practical way to help people with fatty liver disease lose weight. Twenty adults with fatty liver were randomly assigned to receive diet counseling either in person or through a VR headset. The VR program, called …

This study tested a drug called BOS-580 (efimosfermin) in 231 obese adults with or at risk for NASH, a serious fatty liver disease. Participants received either the drug or a placebo as a shot under the skin. The main goal was to check safety and side effects. The trial is now co…

This study tested a monthly injection called AZD2693 in 220 adults with non-alcoholic steatohepatitis (NASH) and liver scarring, who carry a specific genetic risk factor. The goal was to see if the drug could reverse liver inflammation and scarring without making it worse. The tr…

This phase 2b trial tested whether saroglitazar magnesium can help people with nonalcoholic steatohepatitis (NASH) and liver fibrosis. 189 adults took either a 2 mg or 4 mg dose of the drug or a placebo daily for several months. The main goal was to see if the drug could resolve …

This study tested a single dose of the experimental drug GSK4532990 in 61 adults with NASH, a type of fatty liver disease. Researchers measured how the drug moves through the body and affects liver proteins, while also checking for safety. The goal is to see if the drug can help …

This study looked at whether drinking a mineral water rich in bicarbonate, sulfate, calcium, and magnesium could help people with a type of fatty liver disease called MASLD. 87 adults with MASLD either drank the mineral water daily plus followed a healthy diet, or just followed t…

This study tested whether a 4-week program of inspiratory muscle training (using a POWERbreathe® device) could improve diaphragm thickness, reduce fatty liver, and increase aerobic capacity in 30 healthy men aged 60-80. Participants were split into a training group and a control …

This study tested an experimental drug called ARO-HSD in 50 healthy volunteers and people with NASH, a serious fatty liver disease. The main goal was to check safety and how the drug moves through the body. It's an early step to see if ARO-HSD might be a future treatment for NASH…

This completed study looked at whether Legalon, a milk thistle extract, can help lower liver enzymes in people with non-alcoholic fatty liver disease (NAFLD) who also have metabolic syndrome. Over 360 adults took Legalon along with diet and exercise. The goal was to see if this c…

This study tested whether motivational interviewing, a type of counseling that boosts a person's own desire to change, can help people with non-alcoholic fatty liver disease (NAFLD) lose weight. Over 200 adults with NAFLD and a BMI of 25 or higher took part. Some received four mo…

This study tested whether alternate day fasting (eating only 600 calories on fast days) combined with regular aerobic exercise can reduce liver fat in people with non-alcoholic fatty liver disease (NAFLD). Eighty obese adults aged 18–65 with NAFLD participated. The goal was to se…

This study looked at whether an 8-week 5:2 intermittent fasting diet could help people with fatty liver disease. Eighty adults with excess liver fat followed the diet, eating normally for 5 days and restricting calories to 500 kcal on 2 non-consecutive days each week. Researchers…

This completed trial tested whether drinking Jing-Si Herbal Tea twice daily for 24 weeks can improve markers of non-alcoholic fatty liver disease (NAFLD). 108 adults with moderate NAFLD were randomly assigned to receive the tea or a placebo. Researchers measured changes in blood …

This study tested a drug called cotadutide in 54 adults with a type of fatty liver disease that includes liver scarring but not cirrhosis. Participants received either the drug or a placebo as a daily injection. The main goal was to check safety and tolerability, with results hel…

This study tests a computer program called NIMIT-AI that analyzes routine blood test results over multiple doctor visits to detect liver scarring in people with fatty liver disease (MASLD). Unlike the current standard method (FIB-4), which often misses cases and fails with incomp…

This study tests whether a device called Fibroscan can diagnose fatty liver disease (steatosis) without needing a biopsy. Researchers will measure liver stiffness and viscosity in 72 people, including healthy volunteers and patients with confirmed fatty liver. Results will be com…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study looked at whether giving doctors the results of a blood test called ELF helps them better diagnose advanced liver scarring (fibrosis) in people with fatty liver disease. About 450 patients were randomly assigned to have the ELF test or not during their liver clinic vis…

This study looked at over 1,200 adults with metabolic fatty liver disease (MASLD) to see if a new digital test, called FibroNest Ph-FCS, can predict who will develop serious liver complications. The test uses computer analysis of standard liver biopsy images to measure scarring. …

This study tested a new, fully automated MRI technique to diagnose liver fibrosis and inflammation without needing a needle biopsy or contrast dye. Researchers scanned 200 adults with chronic liver disease and compared the MRI results to standard biopsy findings. The goal is to p…

This study tested whether a special ultrasound, called ShearWave Elastography, can measure liver stiffness without needing a needle biopsy. Over 1,200 adults with chronic liver disease, liver transplants, or heart failure had a quick scan during a regular clinic visit. The goal w…

This study tested a new ultrasound software that measures liver fat in children and teens aged 5 to 21 with or at risk for fatty liver disease. Researchers compared the ultrasound results to standard MRI scans to see if the ultrasound could accurately detect liver fat. If it work…

This study by Mayo Clinic tested whether analyzing chemicals in a person's breath could help diagnose or predict the course of liver disease, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants and looked for unique patterns of volatile organic c…

This study compared two methods of taking a liver tissue sample: one using an endoscope with ultrasound (EUS) and the other using a needle through the skin (percutaneous). Researchers wanted to see which method provides better samples for diagnosing liver disease. The trial invol…

This study tested whether artificial intelligence (AI) could more accurately predict liver scarring (fibrosis) in people with metabolic-associated fatty liver disease (MAFLD). Researchers compared AI models using FibroScan and clinical data against standard noninvasive scores lik…

This study tested a new blood test called LLIFT to see if it can accurately diagnose fatty liver disease and its severe form, NASH, without needing a liver biopsy. Researchers enrolled 158 people at high risk for metabolic syndrome. The LLIFT test combines patient information lik…

This study tested whether special software on standard ultrasound machines can accurately measure liver fat in people with non-alcoholic fatty liver disease (NAFLD). Researchers compared the ultrasound results to the Fibroscan CAP method in 25 adults. The goal was to see if the u…

This study looked at two different needle sizes used to take liver tissue samples during an endoscopy procedure. The goal was to see which needle gives better samples for diagnosing liver disease. 82 patients with unexplained high liver enzymes took part, and each had samples tak…

This study tested whether an artificial intelligence (AI) program can accurately measure liver fat using regular ultrasound images in children aged 8 to 18 with fatty liver disease. The AI's results were compared to MRI scans, which are the current gold standard. The goal is to p…

This study tested how well a special MRI scan called LiverMultiScan can measure liver fat, iron, and scarring. 61 adults with various liver diseases had up to 6 scans on different machines. The goal was to see if the results are consistent when repeated on the same scanner or on …

This study looked at whether two blood tests, eLIFT and FibroMeter, can accurately detect liver fibrosis (scarring) in people with type 2 diabetes. The researchers compared these blood tests to standard methods like FibroScan and liver biopsy. The goal is to find a simpler, less …

This study looked at over 1,000 people with non-alcoholic fatty liver disease (NAFLD) to see if simple blood tests and ultrasound-based devices can accurately detect liver scarring (fibrosis) without needing a liver biopsy. The goal is to develop reliable, non-invasive tools to i…

This study tested whether a special ultrasound technique can accurately measure liver fat in children with non-alcoholic fatty liver disease (NAFLD). Researchers compared ultrasound results to MRI scans in 90 children aged 6 to 18. If it works, this could offer a faster, radiatio…

This study tested whether a personalized home exercise program (walking three times a week and strength training with elastic bands twice a week) could improve fitness and strength in 30 adults waiting for a liver transplant. The goal was to see if better fitness before surgery c…

This study tested whether using a lidocaine spray along with a low dose of a muscle relaxant (cisatracurium) can make placing a breathing tube easier and safer during ERCP, a procedure for bile duct problems. 186 adults with liver issues were randomly assigned to receive either t…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This completed Phase 1 study looked at how the drug tirabrutinib is processed in people with mild, moderate, or severe liver impairment compared to healthy volunteers. Forty participants took a single oral dose, and researchers measured drug levels and safety. The goal was to und…

This observational study investigates whether a substance in the blood called nociceptin is linked to overactive nerves in people who have both type 2 diabetes and metabolic fatty liver disease. Researchers will compare 50 patients with both conditions to 50 healthy volunteers, m…

This study analyzed health records of over 118,000 adults with obesity, type 2 diabetes, and related heart, kidney, and liver conditions. Researchers compared people who added a second type of diabetes drug (GLP-1 or SGLT2) early to those who did not. The goal was to see if early…

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This study looked at how the body processes a single dose of the drug etavopivat in people with mild, moderate, or severe liver disease compared to those with healthy livers. 48 adults took part. The goal was to understand how liver function affects drug levels and safety, which …

This study looked at 180 people with liver cancer (hepatocellular carcinoma) who also had cirrhosis caused by either fatty liver disease or alcohol use. Researchers compared immune cells and gut bacteria in the liver to understand why cancer develops. The goal was to gather knowl…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This completed study observed 40 people with type 2 diabetes to find blood markers that could identify those at risk for a serious liver condition called NASH. Researchers measured liver stiffness and calculated scores like FIB-4 and ELF to see which patients might have liver sca…

This study looked at a new method to measure pressure in the liver's blood vessels during an endoscopic ultrasound. Researchers tested it in 100 adults with liver disease to see if it is safe and works well. The goal was to gather information, not to treat the disease.

This completed study collected blood or saliva samples from 213 people with rare liver diseases to extract and store their DNA. The goal was to create a genetic resource that scientists can use in future studies to explore the causes, biomarkers, and genetic factors of these cond…

This study looked at how obesity affects the way children's bodies process common acid reflux medications like lansoprazole and pantoprazole. Researchers gave a single dose of these drugs to 76 children aged 6-21, both with and without obesity, and measured how long the drugs sta…

This study looked at how a single dose of MY008211A tablets moves through the body in people with different levels of liver function. 24 adults (some with liver problems, some without) took part. The goal was to understand safety and how the liver affects drug levels, not to trea…

This study looked at 315 HIV-positive adults to build models that predict fatty liver disease and liver scarring. Researchers used ultrasound and FibroScan tests to track liver changes over time. The goal was to better understand and identify liver problems early in people living…

This completed study tested different ways to use an ultrasound machine to measure liver fat in 35 healthy adults. The goal was to find the most reliable technique for non-invasively diagnosing fatty liver disease, a common condition linked to obesity and diabetes. By standardizi…

This completed Phase 1 study looked at how the experimental cholesterol-lowering drug enlicitide is processed in the body of people with mild or moderate liver impairment compared to healthy volunteers. Twenty participants received a single oral dose, and researchers measured dru…

This completed study followed 1,681 people with steatotic liver disease (fatty liver) in Germany to observe how the condition progresses over time. Researchers measured liver stiffness, inflammation, and tracked whether participants developed heart problems or tumors. The goal wa…

This study looked at how the drug LY3502970 enters the bloodstream and leaves the body in people with different levels of liver function. 29 participants, including healthy volunteers and those with mild to severe liver impairment, took a single dose. The goal was to understand d…

This study looked at how the drug MCI-186 (also called edaravone) behaves in people with mild or moderate liver impairment compared to those with healthy livers. Twenty-two participants received a single dose of the drug. The goal was to see if liver problems affect how the drug …

This study tested whether a version of the Mediterranean diet made with Asian ingredients is acceptable to people with non-alcoholic fatty liver disease (NAFLD). 30 participants in Singapore tasted meals from a 4-week menu and rated them. The goal was to see if people liked the f…

This study followed over 7,300 people with nonalcoholic fatty liver disease (NAFLD) and its more severe form, NASH, in regular doctor visits. Researchers aimed to understand how the disease progresses and what treatments doctors are using, since no drugs are officially approved f…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study tested whether a pop-up alert in the electronic medical record could help doctors remember to refer patients with fatty liver disease (NASH) to a liver specialist. Thirty doctors from internal medicine, family medicine, and endocrinology took part. The goal was to see …

This completed study used leftover liver tissue from 36 adults who had surgery to create lab models of early infection. Researchers want to learn how bacteria and viruses first take hold in the liver, which could lead to new ways to prevent or treat serious bloodstream infections…

This study looked at how a single dose of the drug AZD2693 moves through the body in people with liver impairment compared to healthy volunteers. Researchers measured drug levels in the blood to understand safety and processing differences. A total of 35 adults took part. The goa…

This study looked at how the body processes a drug called ESK001 in people with different levels of liver function. Researchers gave a single dose to 32 adults, including healthy volunteers and those with mild, moderate, or severe liver impairment. The goal was to measure drug le…

This completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…

This early-stage trial looked at how a single 50mg dose of pyroglutamate rongliflozin capsules behaves in 32 adults with mild or moderate liver damage and type 2 diabetes, compared to healthy volunteers. Researchers measured drug levels in the blood and tracked side effects to un…

This completed Phase 1 study looked at how moderate and severe liver impairment changes the way the body handles a single dose of palovarotene, compared to healthy people. Thirty-one participants were split into three groups based on liver function and received up to 10 mg of the…

This study looked at how the hormone glucagon affects the liver's ability to break down proteins and fats in people with obesity, type 2 diabetes, and fatty liver disease. Researchers wanted to understand if the body becomes resistant to glucagon in these conditions. A total of 2…

This early-stage study tested a single 4 mg dose of the drug elpipodect (MK-8189) in 14 people—some with mild or moderate liver problems and some healthy. Researchers measured how much drug stayed in the blood and for how long. The goal was to see if liver impairment changes drug…

This study looked at how common Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is among 459 adults in Turkey who are at risk due to being overweight, having diabetes, or other metabolic issues. Researchers used a special ultrasound to measure liver fat and stiff…

This completed study in 130 adults with type 2 diabetes and fatty liver disease tested whether a blood marker called adiponectin can predict how well certain diabetes drugs reduce liver fat. Participants received either an SGLT2 inhibitor, a GLP-1 receptor agonist, or both for si…

This study looked at how people with chronic liver disease (like hepatitis B, C, or fatty liver) respond to COVID-19 vaccines. About 233 adults had three visits over a year to check their immune response and see if they got COVID-19. The goal was to understand if liver disease af…

This study aimed to find new blood markers that can show liver damage in people with anorexia nervosa. Researchers compared blood samples from 19 patients with and without signs of liver injury. The goal is to improve detection and understanding of liver problems in this conditio…

This study looked at 10,000 older adults (age 60+) with fatty liver disease to find out what increases their risk for serious liver problems like scarring, cirrhosis, or liver cancer. Researchers used medical records and yearly check-ups to build a computer model that predicts th…

This study compared two procedures for getting a liver biopsy and measuring liver pressure in people with chronic liver disease or cirrhosis. One method uses a scope through the mouth (endoscopic ultrasound), the other goes through a vein in the neck (transjugular). The goal was …

This study looked at how common liver scarring (fibrosis) is in people with anorexia nervosa. Researchers used a special scan called Fibroscan to measure liver stiffness in 43 patients when they were admitted to the hospital. The goal was to learn more about liver health in this …

This study looked at how consistent FibroScan, a non-invasive device that measures liver stiffness and fat, is when used by different operators on different days. 108 adults with fatty liver or alcohol-related liver disease had multiple scans and blood tests over two visits. The …

This study tested whether a mobile health app called EL-FIT could help people with nonalcoholic steatohepatitis (NASH) exercise safely at home. Seventeen adults with NASH used the app and a Fitbit to do daily exercise as they wished. The main goal was to see if it was feasible an…

This study compared how patients feel about two ways to take a small sample of liver tissue: one using a needle through the skin (percutaneous) and another using a thin tube through the mouth (EUS-guided). 102 adults with chronic liver disease were randomly assigned to one method…

This study looked at 38 adults with non-alcoholic fatty liver disease to see if gut bacteria are getting too close to the gut lining, which might worsen liver health. Researchers used a sigmoidoscopy to take tissue samples and measured the distance of microbes from intestinal cel…

This study collected blood, stomach, liver, intestine, and fat tissue from 360 severely obese patients undergoing bariatric surgery. The goal was to better understand how obesity and surgery affect the body, especially the digestive system. Researchers hope this knowledge will le…

This completed study examined immune semaphorin proteins in the liver and fat tissue of 148 obese patients with non-alcoholic fatty liver disease (NAFLD). Researchers aimed to understand how these proteins relate to inflammation and liver damage. The study did not test any treatm…

This completed study looked at whether eating only during a specific daily window (time-restricted eating) can slow the aging process in 176 adults who are overweight or have early fatty liver disease. Participants followed a Mediterranean diet with or without calorie restriction…

This study looked at whether fatty liver disease can be an early warning sign for heart disease, separate from known risk factors. Researchers measured blood markers of blood vessel damage in 63 people aged 50-69 who were already at high risk for heart problems. The goal was to b…

This study examined medical records of 263 adults with NASH to see how factors like age, other health problems, and medications relate to the severity of liver scarring. The goal was to identify which patients are at higher risk for advanced fibrosis. The findings may help doctor…

This study looked at whether a computer analysis of liver biopsy images (called FibroNest Ph-FCS) can predict future liver complications in people with a type of fatty liver disease called MASLD. Researchers reviewed medical records from 1,578 patients to see if the digital score…

This study looked at how the body handles a single shot of fazirsiran in 34 people with mild, moderate, or severe liver problems, compared to those with healthy livers. Participants were followed for 6 months after the injection. The goal was to measure drug levels and check for …

This study used online questionnaires to understand how well healthcare providers and people with or at risk for MASH (a liver disease) understand the links between MASH and heart, kidney, and metabolic conditions. About 1,330 participants completed the 25-minute survey. The goal…

This study looked at how the body processes a single dose of the drug AMG 133 in people with different levels of liver impairment compared to those with healthy livers. Thirty-six adults took part, and researchers measured drug levels in the blood and checked for side effects. Th…

This study tested new MRI and MRE techniques that let children breathe normally during scans, instead of holding their breath. The goal was to measure liver fat and stiffness more comfortably and accurately in kids with fatty liver disease. 135 children aged 6-17 took part, and t…

This study looked at how the drug varegacestat moves through the body in people with liver problems compared to healthy people. About 35 adults took a single dose, and researchers measured drug levels and side effects. The goal was to understand if liver impairment changes how th…

This completed study examined 292 people with non-alcoholic fatty liver disease (NAFLD) to see if liver scarring is linked to heart disease risk. Researchers used non-invasive tests like the coronary calcium score and liver elastography. The goal was to better understand how to s…

This study looked at whether a 4-week moderate resistance training program could improve diaphragm thickness, liver fat, and quality of life in healthy men aged 60-75. Thirty participants were split into an exercise group or a control group that kept their normal routine. Researc…

This study looked at how the drug BPN14770 is handled by the body in people with mild, moderate, or severe liver impairment compared to healthy people. A total of 32 adults took a single dose of the drug. Researchers measured drug levels in the blood and checked for side effects.…

This completed Phase 1 study looked at how the drug MK-8527 moves through the body in people with mild or moderate liver impairment compared to healthy volunteers. Researchers measured drug levels in the blood over time to understand how liver function affects the drug. The study…

This study followed 922 adults with metabolic fatty liver disease (MASLD) for up to 2 years. Researchers tracked changes in liver health and looked for clinical and metabolic factors that predict worsening disease, including liver scarring, serious liver events, heart problems, a…

This early-stage study tested the safety of a new drug called ACT500 in 72 healthy Chinese adults. Participants received either the drug or a placebo, and researchers monitored side effects and how the drug moved through the body. The goal was not to treat disease but to gather e…

This study tested whether video-based education helps liver transplant patients adapt to their disease and use medications correctly. 90 adult patients were split into three groups: two received different video trainings, and one got standard care. Researchers measured adaptation…

This study tested a single injection of a new drug (NNC0194-0499) for non-alcoholic fatty liver disease in 33 people with various degrees of liver impairment and healthy volunteers. The goal was to see how the liver processes the drug and whether it is safe. Results will help det…

This study looks at how moderate liver problems change the way the body handles sevabertinib, an experimental cancer drug for tumors with HER2 mutations. About 20 people—10 with liver impairment and 10 healthy volunteers—will take a single dose and have their blood levels measure…

This completed study looked at 300 liver transplant cases to understand why donor livers with fatty liver disease are more likely to be injured after transplantation. Researchers compared genetic activity in archived tissue samples from 50 cases, using advanced techniques to iden…

This study tested whether adding a quick, painless liver scan (Fibroscan®) to standard screening questions could better identify people at risk for liver disease caused by both alcohol and excess weight. Fourteen English- or Spanish-speaking adults from underserved communities to…

This completed Phase 1 study looked at how the drug HRS-5965 behaves in people with mild or moderate liver impairment compared to those with normal liver function. Twenty-four adults took a single 50 mg dose of the drug. The goal was to measure drug levels in the blood and check …

This study examined whether menopausal hormone therapy (MHT) can improve liver function and reduce fat buildup in the liver in postmenopausal women. 44 women were split into two groups: 22 received MHT and 22 did not. After 6 months, researchers measured liver enzymes, fat levels…

This completed Phase 1 study looked at how the drug bulevirtide (Hepcludex) behaves in the body of people with normal liver function and those with liver impairment. Researchers measured drug levels in the blood and how quickly it is cleared. The study involved 74 participants an…

This study tested a new ultrasound feature that measures liver fat and compared it to the standard MRI method. About 60 adults with or at risk for fatty liver disease had two ultrasounds and one MRI. The goal was to see if the ultrasound could accurately estimate liver fat, which…

This completed Phase 1 study looked at how the drug golcadomide is processed in the body of people with moderate or severe liver impairment compared to healthy volunteers. 29 adults received a single dose, and researchers measured drug levels and safety. The goal is to understand…

This study looked at 325 people with fatty liver disease and early-stage liver scarring to see if a non-invasive scan (measuring liver and spleen stiffness) could predict which patients have dangerous veins in the esophagus that might bleed. Currently, patients often need a camer…

This completed Phase 1 study from Columbia University enrolled 18 overweight or obese adults with insulin resistance and non-alcoholic fatty liver disease (NAFLD). Researchers used a technique called a pancreatic clamp to carefully control insulin levels and measure how blood sug…

This study looked at how camlipixant, an experimental drug for chronic cough, behaves in people with liver problems compared to healthy volunteers. 32 adults aged 18-75 took part to see if liver impairment changes drug levels or safety. The goal is to help doctors decide the righ…

This study tested whether a drug called diazoxide, which lowers high insulin levels, can help researchers understand how fatty liver disease develops. Twenty-four adults with overweight or obesity and insulin resistance took either a low or high dose of diazoxide or a placebo for…

This study looked at different ultrasound techniques to measure liver stiffness in 72 adults with chronic liver disease. The goal was to see how newer methods compare to an established one. No treatments or interventions were given; it was purely a comparison of measurement tools…

This study looked at how paracetamol (a common painkiller) is processed in the body after major liver surgery. Researchers measured paracetamol levels in the blood over five days in 90 patients who had different amounts of liver removed. The goal was to understand if patients wit…

This study looked at 150 adults having gallbladder surgery to see if fatty liver disease (MAFLD) makes a special imaging technique less clear. The imaging uses a dye to help surgeons see bile ducts. Researchers found that fatty liver can reduce image quality and created a way to …

This study looked at 1,000 people aged 40-80 with type 2 diabetes or obesity to find the best way to screen for advanced liver scarring (fibrosis) from fatty liver disease. Researchers tested combinations of blood tests and a special ultrasound (FibroScan) to see which approach m…

This study looked at how a single dose of the antifungal drug fosmanogepix is processed in the bodies of 28 adults with varying degrees of liver impairment. Participants took one pill by mouth, and researchers measured drug levels in the blood over time. The goal was to see if li…

This early-stage trial tested the safety and tolerability of a single dose of J2H-1702 in 16 healthy women. The drug is being developed for non-alcoholic steatohepatitis (NASH), a serious liver condition. Researchers measured how the body processes the drug and its effects, but t…

This study looked at how common and severe fatty liver disease is in people with type 2 diabetes. Researchers used advanced MRI scans to measure liver fat, inflammation, and scarring. 317 patients were checked twice, three years apart, to see how the disease changes over time. Th…

This study tests how the experimental drug cagrilintide, being developed for weight management, is processed by the body in people with different levels of liver function. It involves 32 participants, including those with liver impairment and healthy volunteers. The goal is to se…

This study looked at 67 adults with type 2 diabetes and fatty liver disease who were starting a type of diabetes medication called SGLT2 inhibitors. Researchers used ultrasound and blood tests to measure changes in liver stiffness and fat after 6 months of treatment. The goal was…

This study used advanced MRI scans to look for organ damage in 693 adults who had recovered from COVID-19. Researchers focused on the heart, kidneys, and liver to see how often and how severely these organs were affected. The goal was to better understand the long-term health imp…

This study looked at how the drug divarasib is processed in the bodies of 31 people with different levels of liver function, from healthy to severely impaired. Participants received a single dose, and researchers measured drug levels in the blood over time. The goal was to unders…

This completed study looked at the economic burden of non-alcoholic fatty liver disease (NAFLD) in 73 adults in Flanders, Belgium. Researchers measured healthcare costs, patient expenses, and quality of life using questionnaires. The goal was to understand the financial impact of…

This study looks at how the drug BI 1015550 is absorbed and processed in the blood of people with mild or moderate liver problems compared to those with healthy livers. About 28 adults took a single dose and had blood samples taken over several days. The goal is to understand if …

This study tested a new drug called AZD4076 in 40 healthy men to see if it is safe and how the body processes it. The drug is being developed for non-alcoholic steatohepatitis (NASH), a serious liver condition. This is an early, first-in-human trial, so it focused only on safety …

This completed Phase 1 study tested a single 50 mg dose of the drug KP-001 in 24 adults, some with healthy livers and others with different levels of liver impairment. The goal was to see how liver function affects the drug's levels and safety in the body. Results could help guid…

This study looked at how different levels of liver impairment affect the way the body processes a single dose of the drug evobrutinib. Twenty-four participants with either normal liver function or mild to moderate liver impairment took one dose of the drug. Researchers measured d…

This study looked at how the drug efinopegdutide behaves in people with moderate to severe liver damage compared to healthy people. A total of 22 adults took a single dose, and researchers measured drug levels and safety. The goal was to understand dosing needs for patients with …

This study looked at how the drug olpasiran is processed by the body in people with mild, moderate, or severe liver problems compared to those with healthy livers. A total of 25 adults took a single dose of the drug. The goal was to understand safety and how the liver affects dru…

This completed Phase 1 study looked at how a single dose of the drug AZD5004 moves through the body in people with mild, moderate, or severe liver impairment compared to healthy volunteers. The goal was to measure drug levels and check safety. 33 adults aged 18-80 took part. The …

This study looked at 20 teens aged 13-20 with severe obesity who were scheduled for bariatric surgery. Researchers measured liver fat and how the body processes energy before and one year after surgery. The goal was to understand how the surgery affects liver health and metabolis…

This early-stage study tested a new medicine called NNC0581-0001 in 48 adults, including healthy volunteers and people with fatty liver (hepatic steatosis). The main goal was to check safety and how the drug moves through the body after a single injection under the skin. Particip…

This study looked at how a single dose of the drug repotrectinib stays in the blood of people with moderate or severe liver impairment compared to healthy volunteers. 18 adults took part to help understand if liver problems change drug levels. The results will guide dosing for pa…

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This study looked at how the drug AZD2389 behaves in people with liver impairment compared to healthy volunteers. 35 adults took a single dose, and researchers measured drug levels in the blood to check safety and processing. The goal is to understand if liver problems change how…

This completed Phase 1 study looked at how a single 0.5 mg dose of the drug cenerimod is processed in 24 people — some with mild or moderate liver impairment and some healthy. The goal was to see if liver problems change drug levels or safety. Participants were monitored for side…

This completed Phase 1 study looked at how olomorasib, an oral drug, enters the bloodstream and leaves the body in people with mild, moderate, or severe liver impairment compared to healthy volunteers. 46 participants received a single dose. The goal is to understand if liver fun…

This study looked at how the drug fexinidazole, used for sleeping sickness, is processed by the body in people with mild or moderate liver impairment compared to those with normal liver function. Twenty-one adults took a single 1200 mg tablet, and researchers measured drug levels…

This study looked at 200 patients with early-stage pancreatic cancer who had Whipple surgery. Researchers found that some patients developed fatty liver within six months after surgery, which may affect nutrition, blood sugar control, and long-term survival. The goal is to help d…

This completed study looked at 217 adults with chronic hepatitis B to see how common fatty liver and fatty pancreas are in obese versus lean patients. Researchers used ultrasound and a special liver stiffness test to measure fat and scarring. The goal was to learn more about how …

This early-stage study looked at how a single dose of venglustat is processed in people with mild, moderate, or severe liver problems compared to healthy adults. Twenty-six participants received one tablet and were monitored for about three weeks. The goal was to see if liver fun…