New drug shows promise against fatty liver and scarring

NCT ID NCT05011305

Completed Disease control Sponsor: Zydus Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2b trial tested whether saroglitazar magnesium can help people with nonalcoholic steatohepatitis (NASH) and liver fibrosis. 189 adults took either a 2 mg or 4 mg dose of the drug or a placebo daily for several months. The main goal was to see if the drug could resolve liver inflammation without worsening scarring.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

saroglitazar magnesium

What this could lead to

If successful, this could point toward a treatment that reduces liver inflammation and scarring in people with NASH, potentially slowing or stopping disease progression.

What could go wrong

This is a mid-stage trial with only 189 participants, so results may not confirm effectiveness or safety. The drug may not improve fibrosis or could cause side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Fibrosis fibrotic liver disease metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FIBROSIS NONALCOHOLIC STEATOHEPATITIS

Contacts and locations

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Locations

Zydus AR001

CABA, C1056ABJ, Argentina
Zydus AR002

Ramos Mejía, Argentina
Zydus AR003

CABA, CP143CKE, Argentina
Zydus AR004

Buenos Aires, B1629ODT, Argentina
Zydus AR005

CABA, C1264AAA, Argentina
Zydus AR006

CABA, C1221ADC, Argentina
Zydus AR007

CABA, C1199ABB, Argentina
Zydus AR008

CABA, C1425AGC, Argentina
Zydus AR009

Mar del Plata, B7600, Argentina
Zydus AR010

Rosario, S2002KDS, Argentina
Zydus AR011

Mar del Plata, Argentina
Zydus AR012

CABA, C1426ABP, Argentina
Zydus AR013

CABA, C1180AAX, Argentina
Zydus TR001

Ankara, 06800, Turkey (Türkiye)
Zydus TR002

Ankara, 06230, Turkey (Türkiye)
Zydus TR003

Adana, 01240, Turkey (Türkiye)
Zydus TR004

Bursa, 16059, Turkey (Türkiye)
Zydus TR005

Gaziantep, 27310, Turkey (Türkiye)
Zydus TR006

Izmir, 35150, Turkey (Türkiye)
Zydus TR007

Izmir, 35100, Turkey (Türkiye)
Zydus TR008

Istanbul, 34760, Turkey (Türkiye)
Zydus TR009

Istanbul, 34093, Turkey (Türkiye)
Zydus TR010

Kocaeli, 41000, Turkey (Türkiye)
Zydus TR011

Kayseri, 38039, Turkey (Türkiye)
Zydus TR012

Mersin, 33110, Turkey (Türkiye)
Zydus TR013

Rize, 53020, Turkey (Türkiye)
Zydus TR014

Trabzon, 61080, Turkey (Türkiye)
Zydus US001

Maitland, Florida, 32751, United States
Zydus US002

Arlington, Texas, 76012, United States
Zydus US003

Lakeland, Florida, 33803, United States
Zydus US004

Winter Park, Florida, 32789, United States
Zydus US005

Houston, Texas, 77058, United States
Zydus US007

Miami, Florida, 33014, United States
Zydus US008

San Antonio, Texas, 78240, United States
Zydus US009

Cincinnati, Ohio, 45267-0595, United States
Zydus US010

Cincinnati, Ohio, 45044, United States
Zydus US011

Hermitage, Tennessee, 37067, United States
Zydus US012

Panorama City, California, 91402, United States
Zydus US013

Huntington Park, California, 90255, United States
Zydus US014

Marrero, Louisiana, 70072, United States
Zydus US015

Charleston, South Carolina, 29401, United States
Zydus US016

Lakewood Rch, Florida, 34211, United States
Zydus US017

Boston, Massachusetts, 02215, United States
Zydus US018

Asheville, North Carolina, 28801, United States
Zydus US019

Wyoming, Michigan, 49519, United States
Zydus US020

Indianapolis, Indiana, 46202, United States
Zydus US021

Richmond, Virginia, 23298, United States
Zydus US022

Los Angeles, California, 90027, United States
Zydus US023

Murrieta, California, 92563, United States
Zydus US024

Miami, Florida, 33135, United States
Zydus US025

Tucson, Arizona, 85712, United States
Zydus US027

Charlotte, North Carolina, 28204, United States
Zydus US028

Nashville, Tennessee, 37232, United States
Zydus US029

Tucson, Arizona, 85724, United States
Zydus US030

Charleston, South Carolina, 29425, United States
Zydus US031

San Antonio, Texas, 78215, United States
Zydus US032

Birmingham, Alabama, 35294, United States
Zydus US034

Miami, Florida, 33136, United States
Zydus US035

Cleveland, Ohio, 44109, United States
Zydus US036

San Antonio, Texas, 78229, United States
Zydus US038

Miami, Florida, 33136, United States
Zydus US039

Aurora, Colorado, 80045, United States
Zydus US041

Fresno, California, 93720, United States
Zydus US043

San Antonio, Texas, 78234, United States
Zydus US047

Phoenix, Arizona, 85013, United States
Zydus US049

Kansas City, Kansas, 66160, United States
Zydus US051

Austin, Texas, 78745, United States
Zydus US052

Orange, California, 92868, United States
Zydus US053

Philadelphia, Pennsylvania, 19141, United States
Zydus US054

Miami, Florida, 33173, United States
Zydus US057

Fort Myers, Florida, 33907, United States
Zydus US060

Hershey, Pennsylvania, 17033, United States
Zydus US061

Fort Worth, Texas, 76104, United States
Zydus US062

Los Angeles, California, 90033, United States
Zydus US065

La Jolla, California, 92037, United States
Zydus US066

New York, New York, 10033, United States
Zydus US067

Houston, Texas, 77030, United States
Zydus US069

Manhasset, New York, 11030, United States
Zydus US070

Manassas, Virginia, 20110, United States
Zydus US071

Houma, Louisiana, 70363, United States
Zydus US072

Springboro, Ohio, 45066, United States
Zydus US073

Columbia, South Carolina, 29204, United States
Zydus US074

Columbia, Missouri, 65201, United States
Zydus US075

Greenwood, South Carolina, 29646, United States
Zydus US076

Wichita Falls, Texas, 76301, United States
Zydus US077

Sparta, New Jersey, 07871, United States
Zydus US078

Waco, Texas, 76712, United States
Zydus US079

Homewood, Alabama, 35209, United States
Zydus US080

Long Beach, California, 90808, United States
Zydus US081

Ocala, Florida, 34471, United States
Zydus US082

Richmond, Virginia, 23236, United States
Zydus US085

Orlando, Florida, 32806, United States
Zydus US087

Tucson, Arizona, 85712, United States
Zydus US088

Ogden, Utah, 84405, United States
Zydus US089

Bellaire, Texas, 77401, United States
Zydus US090

Long Beach, California, 90815, United States
Zydus US092

Chesterfield, Michigan, 48047, United States
Zydus US094

Lancaster, California, 93534, United States
Zydus US095

Edinburg, Texas, 78539, United States
Zydus US096

Hialeah Gardens, Florida, 33016, United States
Zydus US097

San Juan, Puerto Rico, 00927, Puerto Rico
Zydus US098

Miami Lakes, Florida, 33016, United States
Zydus US099

Naples, Florida, 34102, United States
Zydus US100

West Des Moines, Iowa, 50652, United States
Zydus US101

Austin, Texas, 78757, United States
Zydus US102

San Antonio, Texas, 78229, United States
Zydus US103

San Antonio, Texas, 78222, United States
Zydus US104

Port Orange, Florida, 32127, United States
Zydus US105

Brownsville, Texas, 78520, United States
Zydus US106

Edinburg, Texas, 78539, United States
Zydus US107

Dalton, Georgia, 30720, United States
Zydus US108

Hallandale, Florida, 33009, United States
Zydus US109

Houston, Texas, 77030, United States
Zydus US110

Houston, Texas, 77079, United States
Zydus US111

Gardena, California, 90247, United States
Zydus US112

Summerville, South Carolina, 29485, United States
Zydus US113

Gainesville, Georgia, 30501, United States
Zydus US114

Marietta, Georgia, 30060, United States
Zydus US115

Saint Paul, Minnesota, 55101, United States
Zydus US116

Reno, Nevada, 89511, United States
Zydus US117

Katy, Texas, 77084, United States
Zydus US118

Chula Vista, California, 91911, United States
Zydus US119

Savannah, Georgia, 31406, United States
Zydus US120

Kansas City, Missouri, 64131, United States
Zydus US121

Miami, Florida, 33155, United States
Zydus US122

Clearwater, Florida, 33761, United States
Zydus US123

West Monroe, Louisiana, 71291, United States
Zydus US124

Maitland, Florida, 32751, United States
Zydus US125

Largo, Florida, 33777, United States