New drug shows promise for reversing liver damage in NASH patients
NCT ID NCT04929483
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new drug called BIO89-100 (Pegozafermin) in 222 adults with NASH, a serious fatty liver disease with liver scarring. Participants received weekly injections of the drug or a placebo for about 6 months. The goal was to see if the drug could reduce liver inflammation and fat without worsening scarring. Results showed some improvement in liver health, but more research is needed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
BIO89-100 (Pegozafermin)
What this could lead to
If successful, this could lead to a treatment that reverses liver inflammation and scarring in people with NASH, potentially preventing progression to cirrhosis.
What could go wrong
This is a Phase 2 trial with 222 participants, so results are still early. The drug may not work in larger, longer studies, and side effects are still being evaluated.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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89bio Clinical Study Site
Birmingham, Alabama, 35209, United States
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89bio Clinical Study Site
Birmingham, Alabama, 35211, United States
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89bio Clinical Study Site
Dothan, Alabama, 36305, United States
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89bio Clinical Study Site
Guntersville, Alabama, 35976, United States
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89bio Clinical Study Site
Madison, Alabama, 35758, United States
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89bio Clinical Study Site
Chandler, Arizona, 85224, United States
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89bio Clinical Study Site
Glendale, Arizona, 85036, United States
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89bio Clinical Study Site
Peoria, Arizona, 85306, United States
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89bio Clinical Study Site
Tucson, Arizona, 85712-4044, United States
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89bio Clinical Study Site
Tucson, Arizona, 85712-4046, United States
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89bio Clinical Study Site
Tucson, Arizona, 85741, United States
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89bio Clinical Study Site
Little Rock, Arkansas, 72205-6414, United States
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89bio Clinical Study Site
Little Rock, Arkansas, 72205, United States
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89bio Clinical Study Site
Chula Vista, California, 91911, United States
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89bio Clinical Study Site
Huntington Park, California, 90255, United States
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89bio Clinical Study Site
Long Beach, California, 90808, United States
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89bio Clinical Study Site
Orange, California, 92866, United States
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89bio Clinical Study Site
Panorama City, California, 91402, United States
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89bio Clinical Study Site
Rialto, California, 92377, United States
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89bio Clinical Study Site
Santa Ana, California, 92704, United States
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89bio Clinical Study Site
Englewood, Colorado, 80113, United States
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89bio Clinical Study Site
Boynton Beach, Florida, 33472, United States
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89bio Clinical Study Site
Bradenton, Florida, 34208, United States
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89bio Clinical Study Site
Fort Myers, Florida, 33912, United States
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89bio Clinical Study Site
Lakeland, Florida, 33805, United States
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89bio Clinical Study Site
Maitland, Florida, 32127, United States
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89bio Clinical Study Site
Miami, Florida, 33014, United States
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89bio Clinical Study Site
Miami, Florida, 33147, United States
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89bio Clinical Study Site
Miami, Florida, 33157, United States
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89bio Clinical Study Site
Miami Lakes, Florida, 33016, United States
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89bio Clinical Study Site
Ocala, Florida, 34471, United States
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89bio Clinical Study Site
Palmetto Bay, Florida, 33157, United States
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89bio Clinical Study Site
Pinellas Park, Florida, 33781, United States
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89bio Clinical Study Site
Port Orange, Florida, 32127, United States
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89bio Clinical Study Site
Sarasota, Florida, 34240, United States
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89bio Clinical Study Site
Viera, Florida, 32940, United States
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89bio Clinical Study Site
Athens, Georgia, 30607, United States
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89bio Clinical Study Site
Sandy Springs, Georgia, 30328, United States
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89bio Clinical Study Site
New Albany, Indiana, 47150, United States
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89bio Clinical Study Site
South Bend, Indiana, 46635, United States
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89bio Clinical Study Site
Iowa City, Iowa, 52246, United States
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89bio Clinical Study Site
Topeka, Kansas, 66606, United States
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89bio Clinical Study Site
Marrero, Louisiana, 70072-3151, United States
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89bio Clinical Study Site
Marrero, Louisiana, 70072-3155, United States
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89bio Clinical Study Site
Monroe, Louisiana, 71201, United States
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89bio Clinical Study Site
Shreveport, Louisiana, 71103, United States
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89bio Clinical Study Site
Glen Burnie, Maryland, 21061, United States
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89bio Clinical Study Site
Greenbelt, Maryland, 20770, United States
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89bio Clinical Study Site
St Louis, Missouri, 63033, United States
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89bio Clinical Study Site
Las Vegas, Nevada, 89119, United States
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89bio Clinical Study Site
Las Vegas, Nevada, 89121, United States
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89bio Clinical Study Site
Florham Park, New Jersey, 07932, United States
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89bio Clinical Study Site
New York, New York, 10033, United States
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89bio Clinical Study Site
Concord, North Carolina, 28027, United States
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89bio Clinical Study Site
Columbus, Ohio, 43210, United States
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89bio Clinical Study Site
Dayton, Ohio, 45414, United States
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89bio Clinical Study Site
Springboro, Ohio, 45066, United States
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89bio Clinical Study Site
Westlake, Ohio, 44145, United States
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89bio Clinical Study Site
Greenwood, South Carolina, 29646, United States
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89bio Clinical Study Site
Summerville, South Carolina, 29485, United States
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89bio Clinical Study Site
Chattanooga, Tennessee, 37411, United States
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89bio Clinical Study Site
Chattanooga, Tennessee, 37421, United States
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89bio Clinical Study Site
Hermitage, Tennessee, 37076, United States
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89bio Clinical Study Site
Austin, Texas, 78757-8051, United States
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89bio Clinical Study Site
Austin, Texas, 78757-8059, United States
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89bio Clinical Study Site
Beaumont, Texas, 77702, United States
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89bio Clinical Study Site
Dallas, Texas, 75234, United States
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89bio Clinical Study Site
Dallas, Texas, 75246, United States
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89bio Clinical Study Site
Edinburg, Texas, 78539, United States
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89bio Clinical Study Site
Fort Worth, Texas, 76104, United States
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89bio Clinical Study Site
Garland, Texas, 75044, United States
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89bio Clinical Study Site
Houston, Texas, 77030, United States
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89bio Clinical Study Site
Houston, Texas, 77099, United States
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89bio Clinical Study Site
San Antonio, Texas, 78209, United States
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89bio Clinical Study Site
San Antonio, Texas, 78215, United States
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89bio Clinical Study Site
San Antonio, Texas, 78229-4801, United States
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89bio Clinical Study Site
San Antonio, Texas, 78229-5069, United States
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89bio Clinical Study Site
Waco, Texas, 76710, United States
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89bio Clinical Study Site
Waco, Texas, 76712, United States
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89bio Clinical Study Site
Wichita Falls, Texas, 76301, United States
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89bio Clinical Study Site
Ogden, Utah, 84405, United States
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89bio Clinical Study Site
Sandy City, Utah, 84092, United States
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89bio Clinical Study Site
Manassas, Virginia, 20110, United States
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89bio Clinical Study Site
Richmond, Virginia, 23235, United States
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89bio Clinical Study Site
Richmond, Virginia, 23249, United States
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89bio Clinical Study Site
Roanoke, Virginia, 24014, United States
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89bio Clinical Study Site
Seattle, Washington, 98105, United States
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89bio Clinical Study Site
Spokane, Washington, 99202, United States
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89bio Clinical Study Site
San Juan, 00927, Puerto Rico