New combo pill aims to halt liver scarring in NASH patients
NCT ID NCT05327127
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 2 study tested whether a combination of two experimental drugs, K-877-ER and CSG452, can improve liver health in adults with nonalcoholic steatohepatitis (NASH) and liver fibrosis. The 228 participants received either the combination or a placebo. The main goal was to see if the treatment reduced liver disease activity without worsening scarring.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
K-877-ER and CSG452 tablets
What this could lead to
If successful, this combination could offer a new treatment option to reduce liver damage and slow fibrosis progression in people with NASH.
What could go wrong
This is an early Phase 2 trial with a moderate number of participants. The results may not confirm benefit, and side effects are still being evaluated.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for NASH are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Adobe Clinical Research, LLC
Tucson, Arizona, 85712, United States
-
Alliance Clinical Research
Poway, California, 92064, United States
-
Arcare Center for Clinical Research
Little Rock, Arkansas, 72205, United States
-
Arizona Liver Health
Tucson, Arizona, 85712, United States
-
Asahikawa Medical University Hospital
Asahikawa, Hokkaido, 078-8510, Japan
-
Boston Medical Center Boston University Chobanian & Avedisian School of Medicine
Boston, Massachusetts, 02118, United States
-
CINME - Centro De Investigaciones Metabolicas
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1056ABJ, Argentina
-
Centricity
Suffolk, Virginia, 23435, United States
-
Centricity Research
Columbus, Georgia, 31904, United States
-
Clinical Trials Research
Lincoln, California, 95648, United States
-
Clínica de Endocrinologia e Metabologia Ltda
Brasília, Brasilia DF, 71625-009, Brazil
-
Complejo Hospitalario Universitario A Coruna
A Coruña, 15001, Spain
-
DSI Research Northridge, LLC
Dayton, Ohio, 45414, United States
-
Digestive Health Research of Central Texas, LLC
Waco, Texas, 76712, United States
-
ENCORE Borland Groover Clinical Research
Jacksonville, Florida, 32256, United States
-
Ecogene-21
Chicoutimi, Quebec, G7H 7K9, Canada
-
Ehime University Hospital
Tōon, Ehime, 791-0295, Japan
-
Endeavor Clinical Trials
San Antonio, Texas, 78240, United States
-
Fujita Health University Hospital
Toyoake, Aichi-ken, 470-1192, Japan
-
Fukui-ken Saiseikai Hospital
Fukui-shi, Fukui, 918-8503, Japan
-
GI Alliance Research
Flowood, Mississippi, 39232, United States
-
GI Alliance Research
Cedar Park, Texas, 78613, United States
-
GI Alliance Research
Dallas, Texas, 75246, United States
-
GI Alliance Research
Garland, Texas, 75044, United States
-
GI Associates Research, LLC
Columbia, Missouri, 65201, United States
-
GI Select Health Research
Richmond, Virginia, 23236, United States
-
GLRI McAllen Research
Pharr, Texas, 78577, United States
-
Gastrointestinal Specialists of Georgia, PC
Marietta, Georgia, 30060, United States
-
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
Hiroshima, Hiroshima, 730-8619, Japan
-
Hospital Alianca Rede D 'Or
Salvador, Estado de Bahia, 41920-900, Brazil
-
Hospital General Universitario Gregorio Maranon
Madrid, 28007, Spain
-
Hospital Italiano de Buenos Aires
Ciudad Autónoma de Buenos Aires, Buenos Aires, 1199, Argentina
-
Hospital Italiano de La Plata
La Plata, Buenos Aires, 1900, Argentina
-
Hospital Provincial del Centenario
Santa Fe, Rosario, S2002KDS, Argentina
-
Hospital Universitario Austra
Pilar, Buenos Aires, B1629ODT, Argentina
-
Hospital Universitario Marques de Valdecilla
Santander, Cantabria, 39008, Spain
-
Hospital Universitario Puerta De Hierro
Madrid, 28222, Spain
-
Hospital Universitário João de Barros Barreto
Belém, Pará, 66073-000, Brazil
-
Hospital de Clinicas de Porto Alegre
Porto Alegre, Porto Alegre RS, 90035-903, Brazil
-
Impact Research Institute
Waco, Texas, 76710, United States
-
Instituto de Investigaciones Clinicas de Mar del Plata
Mar del Plata, Buenos Aires, B7600FZN, Argentina
-
Iowa Digestive Disease Center
Clive, Iowa, 50325, United States
-
JCHO Hokkaido Hospital
Sapporo, Hokkaido, 062-8618, Japan
-
Japanese Red Cross Musashino Hospital
Musashino, Tokyo, 180-8610, Japan
-
Jefferson City Medical Group
Jefferson City, Missouri, 65109, United States
-
Kanazawa University Hospital
Kanazawa, Ishikawa-ken, 920-8641, Japan
-
Kawasaki Medical School General Medical Center
Okayama, Okayama-ken, 700-8505, Japan
-
Liver Institute Northwest
Seattle, Washington, 98105, United States
-
Lucas Research, Inc.
Morehead City, North Carolina, 28557, United States
-
McGill University Health Centre
Montreal, Quebec, H4A 3J1, Canada
-
Miami Clinical Research
Miami, Florida, 33155, United States
-
Mid-Atlantic GI Research, LLC
Greenbelt, Maryland, 20770, United States
-
NHO Kure Medical Center and Chugoku Cancer Center
Kure Shi, Hiroshima, 737-0023, Japan
-
NHO Takasaki General Medical Center
Takasaki Shi, Gumna, 370-0829, Japan
-
Nagano municipal Hospital
Nagano, Nagano, 381-0006, Japan
-
Nagoya University Hospital
Nagoya, Aichi-ken, 466-8560, Japan
-
Nature Coast Clinical Research, LLC
Inverness, Florida, 34452, United States
-
Nippon Medical School Hospital
Bunkyō City, Toyko, 113-8603, Japan
-
North Richmond Health Research
Richmond, Virginia, 23229, United States
-
Northeast Clinical Rsearch of San Antonio
San Antonio, Texas, 78233, United States
-
Ocala GI Research
Ocala, Florida, 34471, United States
-
Ogaki Municipal Hospital
Ōgaki, Gifu, 503-8502, Japan
-
Oita Cardiovascular Hospital
Ōita, 870-0837, Japan
-
Penn State Health/Penn State College of Medicine
Hershey, Pennsylvania, 17033, United States
-
SHIN-YURIGAOKA General Hospital
Kawasaki, Kanagawa, 215-0026, Japan
-
Saga University Hospital
Saga, Saga-ken, 849-8501, Japan
-
Saiseikai Niigata Hospital
Niigata, Niigata, 950-1104, Japan
-
Sensible Healthcare Clinical Research, LLC
Ocoee, Florida, 34761, United States
-
Shinshu University Hospital
Matsumoto Shi, Nagano, 390-8621, Japan
-
St. Marianna University School of Medicine
Kawasaki, Kanagawa, 216-8511, Japan
-
Tandem Clinical Research, LLC
Marrero, Louisiana, 70072, United States
-
Tohoku Rosai Hospital
Sendai, Miyagi, 981-8563, Japan
-
United Clinical Research Institute
Los Alamitos, California, 90720, United States
-
University of Calgary
Calgary, Alberta, T2N 4Z6, Canada
-
University of Michigan
Ann Arbor, Michigan, 48109, United States
-
Velocity Clinical Research
Los Angeles, California, 90057, United States
-
Yokohama City University Hospital
Yokohama, Kanagawa, 236-0004, Japan