New shot shows promise against fatty liver disease

NCT ID NCT05989711

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a weekly injection called pemvidutide in 212 adults with NASH, a serious liver condition linked to fat buildup. The goal was to see if the drug could reduce liver fat and scarring without worsening the disease. Participants received either the drug or a placebo for 24 weeks, and researchers measured changes in liver health through biopsies and scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Pemvidutide (a weekly injection)

What this could lead to

If successful, this could provide a new treatment to reduce liver fat and scarring in people with NASH, potentially preventing progression to cirrhosis.

What could go wrong

This is an early Phase 2 trial with only 212 participants. The drug may not work better than placebo, and side effects are possible. Results need confirmation in larger studies.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Altimmune Clinial Study Site

    Tucson, Arizona, 85704, United States

  • Altimmune Clinical Study Site

    Chandler, Arizona, 85224, United States

  • Altimmune Clinical Study Site

    Peoria, Arizona, 85345, United States

  • Altimmune Clinical Study Site

    Tucson, Arizona, 85701, United States

  • Altimmune Clinical Study Site

    North Hollywood, California, 33019, United States

  • Altimmune Clinical Study Site

    Panorama City, California, 91402, United States

  • Altimmune Clinical Study Site

    Englewood, Colorado, 80110, United States

  • Altimmune Clinical Study Site

    Bradenton, Florida, 34201, United States

  • Altimmune Clinical Study Site

    Fort Myers, Florida, 33912, United States

  • Altimmune Clinical Study Site

    Hialeah Gardens, Florida, 33018, United States

  • Altimmune Clinical Study Site

    Miami Lakes, Florida, 33014, United States

  • Altimmune Clinical Study Site

    Port Orange, Florida, 32123, United States

  • Altimmune Clinical Study Site

    Sarasota, Florida, 34240, United States

  • Altimmune Clinical Study Site

    West Palm Beach, Florida, 33401, United States

  • Altimmune Clinical Study Site

    Dalton, Georgia, 30720, United States

  • Altimmune Clinical Study Site

    Marietta, Georgia, 30006, United States

  • Altimmune Clinical Study Site

    Bastrop, Louisiana, 78602, United States

  • Altimmune Clinical Study Site

    Shreveport, Louisiana, 71101, United States

  • Altimmune Clinical Study Site

    Clarksville, Tennessee, 37040, United States

  • Altimmune Clinical Study Site

    Germantown, Tennessee, 38138, United States

  • Altimmune Clinical Study Site

    Austin, Texas, 73301, United States

  • Altimmune Clinical Study Site

    Bellaire, Texas, 77401, United States

  • Altimmune Clinical Study Site

    Edinburg, Texas, 78539, United States

  • Altimmune Clinical Study Site

    Edinburg, Texas, 78540, United States

  • Altimmune Clinical Study Site

    Georgetown, Texas, 78626, United States

  • Altimmune Clinical Study Site

    Houston, Texas, 77036, United States

  • Altimmune Clinical Study Site

    San Antonio, Texas, 78201, United States

  • Altimmune Clinical Study Site

    San Antonio, Texas, 78204, United States

  • Altimmune Clinical Study Site

    West Jordan, Utah, 84081, United States

  • Altimmune Clinical Study Site

    San Juan, 00901, Puerto Rico

  • Austin Health

    Heidelberg, Victoria, 3084, Australia

  • Box Hill Hospital

    Box Hill, Victory, 3128, Australia

  • Fiona Stanley Hospital

    Murdoch, Western Australia, 6150, Australia

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042, Australia

  • Liverpool Hospital

    Liverpool, New South Wales, 2170, Australia

  • Monash Hospital

    Clayton, Victory, 3168, Australia

  • Princess Alexandra Hospital/ Translational Research Institute

    Woolloongabba, Queensland, 4102, Australia

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, 2050, Australia

  • Sir Charles Gairdner Hospital

    Nedlands, Western Australia, 6009, Australia

  • St. Vincent's Hospital Melbourne

    Fitzroy, Victoria, 3065, Australia