Milk thistle extract shows promise for fatty liver in new study
NCT ID NCT05051527
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at whether Legalon, a milk thistle extract, can help lower liver enzymes in people with non-alcoholic fatty liver disease (NAFLD) who also have metabolic syndrome. Over 360 adults took Legalon along with diet and exercise. The goal was to see if this combination improves liver health. Results may help doctors decide if Legalon is a useful addition to lifestyle changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Legalon (silymarin, milk thistle extract)
What this could lead to
If effective, Legalon could become a standard add-on to diet and exercise for managing NAFLD and reducing liver enzyme levels.
What could go wrong
This is an observational study without a placebo group, so results may be less reliable. The effect may be modest, and long-term benefits are unproven.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Phramongkutklao Hospital, 315 Ratchawithi Rd, Thung Phaya Thai, Ratchathewi
Bangkok, 10400, Thailand