Milk thistle extract shows promise for fatty liver in new study

NCT ID NCT05051527

Completed Disease control Sponsor: Mylan Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at whether Legalon, a milk thistle extract, can help lower liver enzymes in people with non-alcoholic fatty liver disease (NAFLD) who also have metabolic syndrome. Over 360 adults took Legalon along with diet and exercise. The goal was to see if this combination improves liver health. Results may help doctors decide if Legalon is a useful addition to lifestyle changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Legalon (silymarin, milk thistle extract)
What this could lead to: If effective, Legalon could become a standard add-on to diet and exercise for managing NAFLD and reducing liver enzyme levels.
What could go wrong: This is an observational study without a placebo group, so results may be less reliable. The effect may be modest, and long-term benefits are unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

Contacts and locations

Locations

Phramongkutklao Hospital, 315 Ratchawithi Rd, Thung Phaya Thai, Ratchathewi

Bangkok, 10400, Thailand

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