CANCER

This early-stage trial tests a personalized mRNA cancer vaccine designed by artificial intelligence. It is given as a shot directly into tumors for people with advanced solid cancers who have run out of standard options. The main goal is to check safety and find the right dose, w…

This program offers a personalized cancer vaccine to patients with solid tumors that have spread or are locally advanced. It is for people who have run out of standard treatment options or cannot take them, and who have a less than 50% chance of surviving 5 years. The vaccine is …

This early-phase study tests a new drug called TTX-080, which blocks a protein (HLA-G) that helps tumors hide from the immune system. It is given alone or with other cancer drugs (pembrolizumab, cetuximab, or FOLFIRI plus cetuximab) to people with advanced solid tumors, including…

This study looks at whether a low dose of a common steroid (prednisolone) can effectively treat liver inflammation (hepatitis) that occurs as a side effect of cancer immunotherapy. About 63 cancer patients who develop moderate to severe liver inflammation will receive the low-dos…

This study tests whether adding a breathing muscle training device to standard pre-surgery exercise (Prehab) helps people with lung cancer recover better after surgery. About 100 adults with lung cancer who are scheduled for surgery will take part. The goal is to see if the breat…

This study tests a new drug, IMC-R117C, for people with advanced colorectal, esophageal, stomach, or ovarian cancers that have a specific protein (PIWIL1) and a certain immune type (HLA-A*02:01). The goal is to see if the drug is safe and can shrink or control tumors. About 600 p…

This study tests a pill called abemaciclib in people with advanced solid tumors that have certain gene changes (in CCND1, CCND2, CCND3, CDK4, or CDK6). The goal is to see if the drug can stop or slow cancer growth. About 38 participants will receive the drug and be monitored for …

This study tests a 6-month program of supervised exercise, heart risk management, and online support for young cancer survivors (ages 18-45) who have mild heart dysfunction after cancer treatment. The goal is to see if this program improves fitness, heart function, and quality of…

This study provides ongoing treatment with Roche investigational cancer drugs for up to 100 people who were already in a Roche-sponsored study and still need the therapy. Participants will continue their current treatment regimen, and researchers will track side effects and safet…

This study looks at whether removing a brain tumor and the nearby area causing seizures can reduce or stop those seizures. About 100 people aged 8 and older with brain tumors and related seizures will have surgery and be followed for up to a year. The goal is to see if surgery im…

This study tests whether a mobile health program can help young adults (ages 18-39) who have survived cancer and are now overweight or obese lose weight. Participants will either get a full smartphone-based weight management program or just digital tools and support. The goal is …

This early-stage study tests whether using high-intensity focused ultrasound to destroy tumors from the inside can boost the effects of immunotherapy drugs (ipilimumab and nivolumab) in adults with advanced cancer that has stopped responding to standard treatments. The main goals…

This early-phase trial tests an experimental drug called ALTA2618 in about 110 adults whose advanced solid tumors (like breast or endometrial cancer) have a specific AKT1 E17K gene change. The main goal is to check the drug's safety and find the right dose. Participants must have…

This study is for people with advanced liver, kidney, or bladder cancer that has spread. It combines a special type of radiation (PULSAR) with drugs that boost the immune system to fight the cancer. The goal is to see if this combination is safe and helps keep the cancer from gro…

This study tests a new way to help men who lost fertility due to cancer or autoimmune treatments. Doctors will transplant frozen testicular tissue back into the patient to see if it can restart sperm production. The main goal is to check if the procedure is safe and possible. Onl…

This study tests a drug called alectinib, already approved for some lung cancers, in people with other rare cancers that have a specific gene change (ALK). About 30 adults, teens, and children will receive the drug to see if it shrinks tumors or stops cancer growth for at least 2…

This study tests a new drug, MBRC-101, in people with advanced solid tumors that have stopped responding to standard treatments. The drug is designed to deliver a chemotherapy-like agent directly to cancer cells. The trial aims to find the safest and most effective dose, and to s…

This early-stage trial tests a new drug called DXP-106 in about 54 people with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and see if the drug works alone or with chemotherapy. Participants receive the drug by IV, and t…

This study tests if a new version of the drug olaparib (DWZ2501) works the same as the current version (DWC202510) in people with advanced ovarian cancer linked to a BRCA gene mutation. About 40 adults who are already stable on olaparib will take both versions at different times …

This study aims to see if giving people healthy prepared meals and education helps them eat better compared to just physical activity coaching. It involves 120 adults in Anson County who have or are at risk for chronic conditions like obesity, diabetes, or heart disease. Particip…

This study looks at whether cancer survivors who had temporary heart damage from chemotherapy can safely stop taking heart failure medications once their heart function has recovered. About 335 adults who finished cancer treatment at least 6 months ago and are currently on heart …

This study tests a three-drug combination (isatuximab, lenalidomide, dexamethasone) at lower-than-standard doses in 50 adults newly diagnosed with multiple myeloma. The goal is to see if the lower doses can still control the cancer while reducing common side effects. Participants…

This program provides access to an experimental drug called AVM0703 for people with various solid tumors or blood cancers who have not responded to other treatments. It is available in the US upon a doctor's request. So far, 37 patients have received the drug, and side effects ha…

This study tests whether the drug larotrectinib can make thyroid cancer cells more sensitive to radioactive iodine therapy. It includes children and adults with a specific genetic change (NTRK fusion) whose cancer has spread to the lungs. The goal is to see if this combination ca…

This study offers continued access to an investigational cancer drug for patients who were already benefiting from it in a previous study. The main goal is to monitor long-term safety. Participants must have completed an earlier Lilly study and still be getting benefit from the d…

This study looks at the long-term safety of nivolumab and other cancer drugs in people with different types of cancer. It is for patients who have already taken part in a Bristol-Myers Squibb trial and may continue treatment. The goal is to track side effects and see how well the…

This program offers an experimental oral medication, sevabertinib, to adults with advanced non-small cell lung cancer that has a specific HER2 gene mutation and has stopped responding to other treatments. Participants must have a life expectancy of at least 12 weeks and be in rel…

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them from growing back. About 46 adults with cancer that has spread to the brain will take part. The goal is to improve tumor control, not to cure the disease…

This study looks at whether starting nutritional support early can help cancer patients on palliative chemotherapy maintain their weight, muscle mass, and quality of life. Researchers will compare 200 participants with lung, colorectal, ovarian, or pancreatic cancer to a historic…

This early-phase study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. AGX101 is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to find the safest dose and to check for sid…

This early-phase study tests an experimental drug called WTX212A in 12 people with advanced solid tumors. The drug is given alone or with radiotherapy to see if it shrinks tumors and is safe. The goal is to find the best dose and understand side effects.

This early-stage study tests an experimental pill called CID-078 in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. About 220 adults with cancers like lung, breast…

This early-stage trial tests a new drug called ALTA3263 in adults with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a KRAS mutation. The main goals are to check safety and find the right dose. About 188 people whose cancer has worsened after stand…

This study tests a program that helps smokers with cancer quit smoking. About 1,448 participants will either get a personalized quit plan with supportive text messages or just brief advice. The goal is to see if the app-based approach leads to more people successfully quitting, c…

This study tests a new approach for people with liver metastases (cancer that has spread to the liver from another part of the body). Doctors will deliver the drug bevacizumab directly into the liver along with standard chemo during a procedure called TACE. The goal is to see if …

This study tests atezolizumab, a drug already approved for some cancers, in people with rare cancers that have high tumor mutational burden (TMB), high microsatellite instability (MSI), or a specific DNA repair defect (CMMRD). About 30 adults, teens, and children will receive the…

This study tests whether a blood thinner called apixaban can safely prevent dangerous blood clots in cancer patients at moderate risk. About 996 adults with solid tumors or lymphoma will be randomly assigned to take a standard twice-daily dose, a simpler once-daily dose, or no bl…

This study tests whether adding sarilumab to standard chemotherapy can clear leftover cancer cells in people with triple negative breast cancer, a fast-growing type. The trial has two parts: first, finding the safest dose in people with advanced cancer; second, testing that dose …

This study tests an experimental drug called zotiraciclib for people with a specific type of brain tumor (glioma) that has returned after treatment. The tumors must have a mutation in the IDH1 or IDH2 gene. The goal is to see if the drug can slow or stop tumor growth. Participant…

This study is for adults with advanced solid tumors that have stopped responding to standard treatments. It tests an experimental drug called INV-1120, given alone or together with the immunotherapy pembrolizumab. The main goals are to find the safest dose and to watch for side e…

This early-phase trial tests CPO301, a drug that delivers a cancer-killing agent directly to tumor cells, in adults with advanced solid tumors (including lung cancer) that have not responded to other treatments. The main goals are to find a safe dose and check for early signs of …

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have lost a specif…

This study aims to help men who became infertile after childhood cancer treatment. Researchers will transplant the patient's own testicular tissue, which was frozen before treatment, back into the scrotum. The goal is to see if the tissue can start producing sperm again. Only 5 m…

This study is for women with a certain type of breast cancer (ER+HER2-) who have already had radiation once and now need a second lumpectomy. Researchers want to see if giving radiation again is safe and helps prevent the cancer from coming back. About 114 participants will be fo…

This study tests a two-step treatment for people with large, relapsed solid tumors that cannot be removed by surgery. First, a special type of radiation is given, followed by standard radiation combined with two immunotherapy drugs (iparomlimab and tuvonralimab). The goal is to s…

This study tests whether adding a special type of high-dose radiation (adaptive pulse radiotherapy) to standard immunotherapy can help control advanced solid tumors better than immunotherapy alone. About 35 adults with various cancers who are already receiving or planning to rece…

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay, and improve their quality of life. About 100 cancer survivors who finished treatment at least 6 months ago will either get the telehealth program or usual ca…

This study tests a new treatment for gastrointestinal cancers using a patient's own immune cells that are specially engineered to attack cancer. About 100 people with certain cancer markers will receive these cells to see if they are safe and can shrink tumors. The goal is to con…

This study tests a new treatment called EBNK-001, which uses donor immune cells (natural killer cells) to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive these cells alon…

This trial tests a personalized therapy where a patient's own immune cells are engineered to recognize and attack cancer. Up to 100 adults with various cancers whose tumors show specific markers can join. The goal is to check safety and whether the cells can shrink tumors, but on…

This early-phase study tests a new drug called JMT108 in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Participants receive JMT108 by IV every t…

This study tests a drug called entrectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change (ROS1 fusion). About 30 adults and children with these rare tumors will receive the drug. Researchers will measure if tumors shrink …

This early-phase trial tests an investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers will also look for signs that the …

This early-phase trial tests an experimental drug called IMA402 in about 145 adults with advanced solid tumors that have returned or not responded to standard treatments. IMA402 is a bispecific T-cell engager designed to direct the immune system to attack cancer cells carrying a …

This study tests a new treatment for people with solid tumors that have come back or not responded to standard care. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer cells. Some participants will also receive an immunotherapy drug …

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if their tumors shrink or stop growing for at least 24 weeks. The goal is to fi…

This early-phase study tests a new drug, IMC-P115C, designed to help the immune system find and attack cancer cells that have a protein called PRAME. It is for people with advanced solid tumors who have a specific genetic marker (HLA-A*02:01) and have tried other treatments. The …

This study offers boys aged 0-17 the chance to freeze testicular tissue before starting treatments like chemotherapy or radiation that could cause infertility. The goal is to use this tissue later to help them have biological children. Researchers will track how many pregnancies …

This expanded access study offers balstilimab alone or combined with zalifrelimab to cancer patients who previously received these drugs in a clinical trial and saw benefit. The goal is to allow continued treatment for those who qualify. Participants must have completed the earli…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study tests a treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen based on a biopsy of the tumor or a blood test. The goal is to see if this approach is safe and can shrink or control advanced solid t…

This early-stage study tests a single injection of umbilical cord blood cells (XJ-MK-002) in 16 adults aged 18-75 who have low platelets from cancer therapy. The main goal is to check safety and find the best dose. Researchers will monitor side effects and platelet counts for 28 …

This study tests if abatacept, a drug used for arthritis, can prevent serious heart problems in cancer patients who develop heart inflammation from immunotherapy. About 390 adults hospitalized with this condition will receive either abatacept or a placebo. The goal is to see if t…

This study tests a combination of two drugs, nab-sirolimus and letrozole, in people with advanced or recurrent endometrioid endometrial cancer. The goal is to see if the combination can shrink or control tumors. About 29 participants will receive the treatment, and researchers wi…

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if FOG-001 is safe and can shrink tumors or slow their growth. The trial focuses on several cancer types, including colorectal, pro…

This study tests whether giving a drug called selpercatinib for 6 months before radioactive iodine therapy can improve treatment outcomes in children, teens, and young adults (ages 2-25) with a specific genetic form of thyroid cancer (RET fusion). The goal is to make the cancer a…

This study tests whether inhaling a drug called tranexamic acid can help cancer patients who have severe lung bleeding and are on a breathing machine. The goal is to see if it lowers the chance of death within 28 days compared to standard care. About 60 adults with blood cancers …

This study is testing two new blood tests designed to help detect cancer in people who have symptoms that might be caused by cancer. Researchers will enroll 1,650 adults aged 45 and older who are already undergoing medical tests for possible cancer. The goal is to see how well th…

This study is testing whether analyzing DNA and proteins in urine can help detect urothelial cancers of the bladder and kidney. Researchers will collect urine samples from 500 adults—some with known or suspected cancer and some healthy controls—to see if this non-invasive approac…

This study aims to create a blood test that can find many types of cancer early, before symptoms appear. Researchers will analyze DNA from blood samples of 6,000 people, including those with and without cancer, to train an artificial intelligence platform. The goal is to improve …

This early-phase study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on PET-MR scans. Researchers want to see if it can safely and accurately find clots anywhere in the body, including in the heart of people with atrial fibrillation. The study in…

This study is developing and testing an artificial intelligence (AI) model to detect whether cancer has spread to lymph nodes. Researchers will compare the AI's accuracy against standard pathology reports from doctors. The goal is to see if the AI can help diagnose lymph node met…

This study tests an injectable dye called NC527-X that makes tumors glow during surgery, helping surgeons see and remove them more precisely. About 400 adults with solid tumors who are scheduled for surgery will take part. The goal is to find the best dose and timing for the dye …

This study tests a health workshop for Latino parents with children ages 6 to 12 living in rural Florida. The workshop teaches healthy eating, physical activity, and sun safety to reduce cancer risk. Researchers will see if families find the program useful and if it helps them ma…

This early-stage study tests an inhaled form of fentanyl, a strong painkiller, for cancer patients. About 100 adults with malignant tumors will receive the inhaled spray and an IV injection at different times to compare how the drug moves through the body and its safety. The goal…

This study tests whether testosterone replacement therapy can reduce fatigue and improve sexual function in men aged 55 and older who have cancer and low testosterone. About 230 participants will receive either testosterone or a placebo for several months. The goal is to see if t…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older Veterans with cancer maintain their physical function. About 188 participants aged 55 and older with early-stag…

This study explores whether virtual reality (VR) can help people with cancer manage chronic pain and reduce their need for opioid medications. Researchers will work with 25 adults who have active cancer and moderate to severe pain to develop and test a VR program. Participants wi…

This study tests a video-based program for older adults (65+) with cancer and mild memory problems, along with their spouse or caregiver. Participants attend six 60-minute video sessions and complete surveys to see if the program reduces distress and improves well-being. The goal…

This study tests whether a virtual reality (VR) program can help cancer survivors manage ongoing symptoms like pain, fatigue, anxiety, and depression. About 30 adults who finished cancer treatment at least 3 months ago will use either VR or a simple audio recording at home for 4 …

This study tests whether adding motivational counseling to a virtual exercise program helps cancer survivors stay active. About 236 people who finished cancer treatment within the last 5 years will join a 6-month program with supervised exercise and either standard or enhanced co…

This study tests whether a digital avatar can help reduce anxiety and improve quality of life for adults with cancer who are receiving a stem cell transplant as an outpatient. About 90 participants will be randomly assigned to either the avatar program or usual care. The goal is …

This study tests ways to help Black women who have finished cancer treatment stay physically active over the long term. Researchers will track activity levels, fatigue, and quality of life in 260 participants. The goal is to find simple, lasting strategies that improve health and…

This study tests a program that gives cancer patients free legal help with issues like insurance denials, disability benefits, and financial aid. About 50 adults with advanced cancer will receive legal navigation and be followed for 6 months. Researchers want to see if this reduc…

This study looks at how different group exercise programs affect fitness and muscle strength in women who have finished breast cancer treatment. About 15 women will try one of four supervised resistance training routines. The goal is to see which approach best improves heart heal…

This study tests a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) for chronic nerve pain caused by cancer or its treatment. 60 adults will receive both real and sham (placebo) stimulation in random order to see if real rTMS provides better pain …

This study tests a 4-month coaching program called SONATA for people aged 60 and older with advanced cancer. The program helps patients build a support network of family and friends to improve treatment adherence and quality of life. About 330 participants will take part, along w…

This study explores whether a special type of writing, called compassionate expressive writing, can help people living with or after cancer feel better emotionally. About 50 adults who have experienced body changes from cancer will write for 20 minutes in four sessions. Researche…

This study tests whether an internet-based pain coping skills program can help cancer survivors manage ongoing pain. About 456 adults who have finished or are still receiving cancer treatment will take part. The program teaches skills to cope with pain and is compared to standard…

This study is testing an 8 to 12 week exercise program for people who have or had cancer. The program includes supervised exercise classes, either online or in person, twice a week. The goal is to help participants increase their physical activity and reduce cancer-related sympto…

This study tests whether a nature-based healing meditation can help friends and family who cared for a loved one with cancer cope with grief after the death. Researchers will enroll 70 adults who recently lost someone to cancer. Participants will practice a guided nature meditati…

This study tests whether a tailored exercise and support program before cancer treatment helps adults with cancer feel better and function better. About 60 people referred to UNC will be randomly assigned to the program or usual care. The goal is to see if this approach improves …

This study tests a short counseling program for young adults (ages 25-39) with cancer and their caregiving partners. The goal is to see if the program helps them cope with stress and maintain their relationship. The study will enroll 20 couples and measure how many people join an…

This study tests whether creating and sharing a short digital story about their cancer journey can reduce depressive symptoms and improve self-esteem and quality of life in Chinese childhood cancer survivors aged 13 to 18. Participants attend four 2.5-hour workshops in small grou…

This study looks at whether writing about their experiences can improve the health of Asian American breast cancer survivors. Researchers will enroll 192 adults who have finished their main cancer treatment within the last 5 years. Participants will write about their experiences,…

This study explores whether using virtual reality (VR) can lower anxiety and improve the treatment experience for cancer patients receiving radiotherapy. About 150 adults with cancer who are getting radiation at the University of Miami will be randomly assigned to watch a standar…

This study looks at whether massage therapy can improve sleep for children aged 12 to 21 who are in the hospital for cancer treatment or a stem cell transplant. About 70 participants will either receive standard care or add massage therapy to their routine. Researchers will track…

This study tests a special type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it can shrink tumors better and with fewer side effects than standard radiation. About 37 adults with advanced solid tumors will receive this tre…

This study looks at whether live, online group exercise classes help cancer survivors become more physically active compared to watching recorded workout videos. About 300 people who had cancer in the last 5 years will join a 12-week program and be followed for 9 months. Research…

This study is testing a virtual reality (VR) device that uses cognitive behavioral therapy to help people with long-term cancer pain. About 40 adults with cancer and chronic pain will try the VR device or watch a 2D video. The goal is to see if the VR device is easy to use, safe,…

This study looks at whether acupuncture can help young women (ages 15-40) whose periods stopped after chemotherapy for cancer. Researchers will check if it's practical to offer acupuncture and whether it helps restart menstruation and improve quality of life. Participants will re…

This study is testing a short program called Positive Affect Treatment (PAT) to improve the wellbeing of people caring for a loved one with advanced cancer. About 150 caregivers will take part, using phone or internet. The goal is to see if the program helps reduce stress and imp…

This study tests whether a smartphone app called ARTCan can help young adults (ages 18-25) who survived childhood cancer feel better emotionally. Participants will use the app for 6 weeks to do art therapy activities and answer weekly surveys about their mood. The goal is to see …

This study tests whether an artificial intelligence (AI) app can improve quality of life and reduce anxiety and depression in people with cancer who are already receiving psychotherapy. About 60 participants will be randomly assigned to either get the AI app alongside their usual…

This study tests whether a program of resistance training (like lifting weights) plus a high-protein drink after workouts can help women with breast cancer maintain muscle and reduce fat while they undergo chemotherapy. About 30 women will be randomly assigned to start the progra…

This study tests different combinations of education, counseling, and peer support for Chinese cancer patients and survivors. Researchers want to see which mix is practical and helps improve quality of life. The study involves 64 participants who speak Mandarin and live in New Yo…

This study tests whether the drug ustekinumab can control diarrhea and colon inflammation caused by immune checkpoint inhibitors in cancer patients. Ten adults with solid tumors who have moderate to severe symptoms will receive the drug and be monitored for side effects. The goal…

This study looks at whether nerve transfer surgery can improve facial movement and quality of life for cancer patients who have facial paralysis after treatment. About 40 adults who are scheduled for this surgery will take part. Researchers will track side effects and measure cha…

This study tests how well naldemedine works for constipation caused by opioid painkillers in cancer patients. About 100 adults with cancer who take opioids and still have constipation despite laxatives will receive naldemedine. Researchers will track symptom changes and patient e…

This study looks at whether a virtual, group-based writing program can improve the quality of life for people who survived cancer as adolescents or young adults. About 30 survivors will take part in online writing sessions. The goal is to see if this approach is helpful and pract…

This study looks at how two different supportive care programs affect the emotional health and quality of life of people with advanced cancer and their family caregivers. About 400 patient-caregiver pairs will take part. The goal is to find better ways to ease depression and impr…

This study tests a brief motivational program to help 84 cancer survivors from the World Trade Center Health Program increase their physical activity. Participants will wear a Fitbit to track activity, and the goal is a 25% boost in moderate-to-vigorous exercise. The program focu…

This study tests if acupuncture on the tongue can ease taste problems caused by chemotherapy in people with gynecologic cancer. About 75 participants will receive either real acupuncture, a fake version, or standard dietary advice. The goal is to see if acupuncture can reduce unp…

This study looks at whether doing resistance exercises at home using a digital program works as well as doing them in a supervised studio for people who have finished cancer treatment. The goal is to see if the home-based option helps more people stick with exercise and improves …

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants must have poor sleep for at least 2 week…

This study looks at whether a program called enCompass Humana can help family caregivers of people with cancer and diabetes feel more supported and less stressed. About 162 caregivers will be randomly assigned to receive the program or usual care. The program offers coaching and …

This study looks at whether using the Calm meditation app for 10 minutes a day can help people with blood cancer who have trouble sleeping. About 276 patients will use the app for 8 weeks, and researchers will track their sleep, mood, fatigue, and signs of inflammation. The goal …

This study tests if a supervised stationary cycling program can reduce nerve pain and improve daily function in people who have chemotherapy-induced peripheral neuropathy (CIPN). Thirty adults with cancer who have mild CIPN will cycle for 30-60 minutes twice a week for 12 weeks. …

This study tests a smartphone app that teaches mindfulness to cancer survivors who have finished their main treatments. The goal is to see if using the app for 4 weeks helps reduce stress. About 345 adults who have had any type of cancer will take part, with some getting the app …

This study looks at how safe and helpful a computer-assisted vacuum procedure is for removing blood clots in the lungs of cancer patients. About 25 adults with cancer and a moderate-risk pulmonary embolism will take part. The goal is to see if the procedure improves quality of li…

This study is testing an online educational program called On-Trac (Online Training After Cancer) to help adult cancer survivors cope with anxiety. The program teaches strategies based on cognitive-behavioral therapy and acceptance commitment therapy. Researchers will enroll 80 p…

This study tests if a smartphone app called Resilience PRO can improve quality of life for cancer patients receiving treatment. About 1,458 adults with any stage cancer will either use the app plus usual care, or just usual care. The app asks about symptoms and alerts the care te…

This study tests a computer tool called C-SCAT that helps adolescents and young adults with cancer track and manage their symptoms. About 126 participants will either use the tool or receive usual care. The goal is to see if the tool improves their confidence and ability to manag…

This study compares two approaches to supportive cancer care: one using technology and one using a redesigned team-based model. About 3,000 adults with newly diagnosed or recurring solid tumors will participate. The goal is to see which method better improves quality of life over…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can help cancer survivors who feel depressed or anxious. Twenty adults who have finished cancer treatment and have no brain tumors will receive the drug in a controlled setti…

This study tests a program called Mindset Moments for young adults (ages 19-25) who have finished cancer treatment. Participants attend 8 weekly online group sessions and do short daily activities on an app to help with stress and emotional strength. The goal is to see if the pro…

This study tests a new 5-session phone therapy called CARE for older adults (70+) with cancer who feel depressed or distressed. It compares CARE to standard supportive counseling. The goal is to see which approach better improves mood and reduces anxiety.

This study looks at whether smelling essential oils (aromatherapy) combined with hypnosis can reduce anxiety and improve comfort for cancer patients during uncomfortable procedures like blood draws or dressing changes. About 66 adults with cancer who are also under palliative car…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can safely reduce depression in people with cancer. Researchers will enroll 86 adults with cancer-related depression. Participants will receive either electroacupuncture or a control tre…

This study looks at two different exercise programs—flexi band resistance training and whole-body electrical muscle stimulation—to see which better helps cancer patients maintain muscle strength, reduce inflammation, and improve quality of life during treatment. About 100 adults …

This study looks at whether guided play sessions can help children aged 10 to 18 with acute lymphoblastic leukemia better tolerate pain and control their emotions while receiving chemotherapy. Over four weeks, some children will take part in therapeutic play during their treatmen…

This study looks at whether a one-year, home-based exercise program can help older adults (60+) who are undergoing cancer treatment. Participants will be randomly assigned to either the exercise program or usual care. Researchers will measure walking speed, balance, muscle streng…

This study tests whether group counseling and peer support can help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain feel less stigma about their health. About 195 adults will join counseling sessions and report how stigma affects their li…

This study is testing a digital program designed to help adolescent and young adult cancer survivors (ages 15-39) manage symptoms of depression. The program includes educational content and four evidence-based strategies. Researchers want to find out which parts of the program wo…

This study compares three types of support for parents who lost a child to cancer. It tests whether Meaning-Centered Grief Therapy, Supportive Counseling, or Enhanced Usual Care better reduces grief and depression. About 415 parents with high grief levels will take part. The goal…

This study looks at whether a food farmacy (free healthy food) plus online cooking classes can help cancer survivors who struggle to afford food. About 80 survivors will take part, and researchers will check if the program is safe and easy to use. The goal is to improve nutrition…

This study looks at whether it is safe and helpful to stop taking statins (cholesterol-lowering drugs) in people with advanced cancer who are in palliative care. Many patients continue taking these preventive medications even when they are near the end of life, which can cause si…

This study tests whether a mobile health exercise program can improve physical function, reduce fatigue, and enhance quality of life in 170 older adults (age 60+) with myeloid neoplasms who are receiving outpatient chemotherapy. Participants will be randomly assigned to either th…

This study tests if using a small ultrasound scanner helps nurses place an IV drip on the first try more often than the traditional touch-and-feel method. About 98 adults with cancer who need IV treatment will take part. The goal is to reduce discomfort and improve the treatment …

This small pilot study tests whether using a hand-held vibration device for just 3 minutes each day can safely reduce nerve pain and numbness caused by chemotherapy. Sixteen adults who finished certain chemo drugs at least 60 days ago will try the therapy at home. The main goal i…

This study looks at whether expressive writing can help Chinese American cancer survivors cope with their feelings. About 108 people who finished cancer treatment within the last 5 years will write about their experiences in Chinese. Researchers will check if this reduces depress…

This study is testing a 7-week online program called My Wellbeing Guide to see if it can reduce depression and anxiety in cancer patients. About 6,500 adults with cancer and high depressive symptoms will be randomly assigned to use the program or a control app with resource links…

This study tests whether using virtual reality (VR) headsets is safe and helpful for cancer patients who feel anxious, depressed, or stressed during treatment. About 24 patients will use VR to explore calming scenes like forests or oceans. The goal is to see if this can improve t…

This study tests a mobile app called Moodivate to help treat depression in people with incurable cancer. About 279 participants will either use the app or not for 12 weeks. The goal is to see if the app reduces depressive symptoms and improves quality of life. Risks include frust…

This study looks at whether combining exercise with cognitive rehabilitation can improve memory and thinking in older adults who have finished cancer treatment. About 40 people aged 65 and older will be assigned to one of four groups: exercise only, brain training only, both, or …

This study tests a program that lets cancer patients report symptoms from home using a digital questionnaire. A nurse then gives tailored advice. The goal is to see if this improves quality of life and reduces emergency visits. About 1055 adults with cancer will take part.

This study is testing a yoga program designed to fit different cultures for cancer patients who are in the hospital for a stem cell transplant. The goal is to see if the program helps reduce symptoms of depression. About 60 adults from India, Tanzania, and the United States will …

This study tests a combined exercise and cognitive rehabilitation program delivered via mobile health for older cancer survivors (age 60+) who have memory or thinking concerns after treatment. The goal is to see if the program is feasible and improves cognitive function. The stud…

This study tests a mobile health app designed to help cancer patients remember to take their oral medications and report symptoms. Researchers will enroll 35 English- or Spanish-speaking adults with cancer who are starting or recently started oral anticancer therapy. The goal is …

This study adapts a therapy called FORT for parents of children who survived cancer. Many parents have high fear that the cancer will return, which affects their quality of life. The study will test if the therapy is acceptable and helpful for 36 parents across Canada. Parents wi…

This study tests a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage symptoms like pain, fatigue, and emotional distress, and encourages engagement with recommended follow-up care. Researchers will enroll 260 people …

This study tests if digital courses can improve the health and quality of life of people recently diagnosed with cancer. About 440 participants will be randomly assigned to one of two online programs and will fill out questionnaires, complete modules, and provide blood samples fr…

This study tests whether a 30-minute cycling session right before chemotherapy or immunotherapy can help cancer patients maintain their fitness. 80 adults with breast, ovarian, or colorectal cancer will either receive standard exercise advice or also do supervised cycling on trea…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goal is to…

This study tests an online self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. The program teaches mental strategies to manage worry. Researchers will see if it is easy to use and helps reduce fear in 4…

This study compares three standard pain management methods used during minimally invasive cancer surgery. 48 adults having surgery for cancers of the liver, stomach, pancreas, or other organs will be randomly assigned to one of three groups. The goal is to see which method provid…

This study looks at whether Reiki, a non-invasive therapy where a practitioner lightly places hands near the body, can help adults with cancer who feel very tired from immunotherapy. Twelve participants will either receive six weekly Reiki sessions or wait, then switch. Researche…

This study tests whether a structured care plan, based on patient-reported symptoms, can improve quality of life for adults with advanced cancer. Participants will either receive standard palliative care or a tailored plan that triggers specific support based on their needs. The …

This study tests a therapy called EMDR Toolbox to see if it can improve the emotional well-being of people with cancer. The therapy helps process past stressful events that may make coping with cancer harder. Researchers will enroll 46 adults with early-stage cancer and compare t…

This study tests whether MDMA-assisted therapy can help cancer patients and their close loved ones cope with adjustment disorder—a condition causing severe emotional distress after a cancer diagnosis. Twenty participants (10 patient-loved one pairs) will receive two doses of MDMA…

This study tests a new text-message program designed to help cancer survivors who feel depressed connect with mental health care. Researchers will enroll 60 cancer survivors who have signs of depression and own a cellphone. The program sends tailored texts and a referral link to …

This study looks at whether adding chaplain-led spiritual care or psychotherapy/meditation to usual palliative care can help people with advanced, incurable cancer live longer and have a better quality of life. About 854 adults with metastatic cancer and a life expectancy of one …

This study tests whether a smartphone app called iCANSleep can help cancer survivors with insomnia sleep better. The app uses a proven therapy called Cognitive Behavioural Therapy for Insomnia (CBT-I). Researchers will compare 146 cancer survivors who use the app to those on a wa…

This study tests a program called Dyadic Life Review for people aged 65+ with advanced cancer and their caregivers. The program helps them talk about their lives together to improve their relationship and emotional well-being. The study will enroll 60 patient-caregiver pairs and …

This study looks at whether giving cancer patients personalized diet advice and palliative care counseling can improve their quality of life, energy levels, and nutrition. About 215 adults with cancer in Bangladesh will be split into two groups: one gets the extra support, the ot…

This study is testing whether a Maitake mushroom supplement can improve immune function in people receiving chemotherapy or CDK4/6 inhibitors for cancer. Researchers will measure changes in blood neutrophil counts and other immune markers. The trial involves 40 adults with solid …

This study is creating and testing a nurse-led program to help women who go through early menopause after cancer treatment. The program offers personalized education, decision support, and skills to manage symptoms. About 117 women will take part in video sessions and fill out qu…

This study tests whether an herbal formula called MZRW can help cancer survivors who have constipation. About 70 adults who have finished cancer treatment at least a month ago will take either MZRW or a placebo pill for 2 weeks. Researchers will check if bowel movements improve a…

This study looks at whether giving cancer patients healthy groceries and nutrition advice can improve their diet, reduce symptoms, and boost quality of life. One hundred adults with any type of cancer living in four Maine counties will be split into three groups: some get groceri…

This study looks at whether a digital art activity can help cancer patients better express their distress, symptoms, and experiences. Researchers will enroll 60 adult cancer patients who are currently receiving treatment. Participants will use a digital tablet to create art and t…

This study looks at whether hearing aids can improve the quality of life for cancer patients who develop hearing problems from platinum-based chemotherapy. About 52 adults currently receiving such chemotherapy and experiencing hearing loss will be offered a hearing aid. Researche…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study tests whether a drug called NPX-5 (psilocybin) combined with talk therapy can reduce severe anxiety in people who have been diagnosed with cancer. About 87 adults aged 18 to 80 will receive one of three doses (25 mg, 10 mg, or 1 mg) during an 8-hour therapy session. Th…

This study tests whether immersive virtual reality exercises can improve thinking skills in people with cancer who have memory and attention problems after chemotherapy. About 60 participants will either do virtual reality activities or continue usual care. The goal is to see if …

This study tests whether a mobile app that tracks symptoms and sensor data can help people receiving chemotherapy feel better and stay connected with their care team. About 50 adults with solid tumors will use the app and a Fitbit for 90 days. The goal is to see if the app is eas…

This study tests whether a physiotherapist navigator can help cancer patients manage side effects like fatigue and strength loss. 26 adults recently diagnosed with cancer will either receive usual care or extra support from a physiotherapist navigator for 12-18 weeks. The navigat…

This study tests a tele-exercise program called RISE-YA to reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants must be 6 months to 5 years past curative treatment and currently get little exercise. The program is delivered remote…

This study asks 300 adolescents and young adults (ages 15-39) who have or had cancer to fill out surveys. The goal is to find out what topics—like exercise, sexual health, fertility, money issues, and clinical trials—they feel they didn't get enough education about. No treatment …

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. Researchers will measure changes in food security, di…

This study creates a registry of 500 children, teens, and young adults (ages 1-39) diagnosed with cancer. Researchers will collect health surveys, physical tests, and blood samples over time to understand how cancer and its treatment affect aging and quality of life. The goal is …

This study tests whether a web portal with a virtual health educator helps Black and Hispanic cancer patients in Florida learn about and sign up for clinical trials. About 350 adults will be randomly assigned to either a standard educational website or one with a virtual coach. T…

This study is testing whether wearable devices that track heart rate and other vital signs can help doctors spot infections earlier and better predict how long a person with advanced cancer has to live. About 120 hospice patients will wear a small ECG patch while receiving end-of…

This study tests a communication program called COACH-Cog for older adults who have both Alzheimer's or related dementia and cancer. About 300 people (patients, their care partners, and doctors) will take part. The goal is to see if the program helps patients and their families f…

This study collects blood samples from people receiving stem-cell transplants for blood cancers and from their donors. Researchers will analyze these samples to understand how the immune system recovers after transplant and why some patients develop graft-versus-host disease. The…

This study is testing a new imaging agent called 68Ga-NYM096 to see how well it shows up in various cancers, including tumors that have spread. About 120 adults with confirmed cancer will receive the tracer and undergo a PET/CT scan. The goal is to measure how strongly the tracer…

This study collects medical information and biological samples (blood, tissue, stool) from 1,000 cancer patients receiving immunotherapy drugs called immune checkpoint inhibitors. The goal is to understand why some patients develop inflammatory side effects (immune-related advers…

This study follows 10,000 people who survived childhood cancer to learn about their long-term health. Researchers want to understand what health problems may appear years after treatment and what factors might protect against them. Participants are at least five years past their …

This study collects and freezes testicular tissue from boys and young men who are about to undergo treatments like chemotherapy or radiation that could cause permanent infertility. The tissue is stored in a special bank, with the hope that future medical advances will allow it to…

This study is testing a special PET-CT scanner that takes detailed pictures of cancer tissue right after it is removed during surgery. Researchers want to see if these images match the standard lab analysis and if they help doctors make better decisions. About 850 people with pro…

This study tests whether data from smartphones and smartwatches can help identify teens and young adults with cancer who are at risk for depression and other mental health issues. About 25 participants aged 10-25 will use an app and wear a smartwatch for two months. The goal is t…

This study follows people who have already received gene transfer therapy for cancer or other conditions. Researchers will collect health information and blood samples over up to 15 years to monitor long-term safety and any side effects. No new treatment is given; the goal is to …

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study looks at the immune cells and genetic changes in thymic epithelial tumors (TETs). Researchers will analyze tumor tissue and blood from 50 adults who have not yet been treated. The goal is to better understand these rare tumors, not to test a new treatment.

People with serious mental illness often have undiagnosed physical problems like heart disease, diabetes, or cancer. This study adds routine health checkups to psychiatric clinics to see if they catch these hidden conditions better than usual care. About 2,800 adults with psychot…

This study tests a program called 'My Care My Voice' that helps people with cancer talk to their doctors about palliative care. Palliative care focuses on quality of life and symptom relief, and can start early alongside cancer treatment. The study will include 271 participants a…

This study collects and analyzes genetic material (DNA, RNA) and tissue samples from 500 adults with cancer to identify markers and causes of the disease. Researchers will build a biobank to explore better ways to prevent, detect, and treat cancer. Participants must have a confir…

This study looks at whether group educational sessions can help veterans with newly diagnosed cancer make better plans for their future medical care. About 50 veterans will take part, and researchers will check if this group approach works better than the usual one-on-one care pl…

This study looks at whether a short nutrition and exercise program before cancer treatment is practical and helpful for American Indian patients. About 30 adults with any cancer type will eat walnuts and increase their walking for at least 3 weeks before starting treatment. Resea…

This study aims to understand the different types of fatigue people experience, whether from cancer, lupus, ME/CFS, or other conditions. Researchers will compare fatigued and non-fatigued adults using interviews, questionnaires, physical tests, and optional brain scans. The goal …

This study collects tumor samples from 2,000 people with various cancers to learn how to predict who will respond to immunotherapy. Participants donate tissue during a routine biopsy. The goal is to understand tumor biology and improve future treatment decisions, not to test a ne…

This study is testing a mobile app called Mio-App designed to help children and teenagers with cancer improve their thinking and physical abilities. The app includes games and questions to strengthen metacognition—the ability to think about one's own thinking. Researchers will st…

This study is testing a values assessment tool for women with metastatic breast cancer and their caregivers. The goal is to see if using the tool helps patients and caregivers feel less conflicted about decisions and improves communication with their cancer doctors. About 40 peop…

This study looks at how to better support adults aged 65 and older who are receiving chemotherapy. Researchers will measure each person's resilience and create a personalized care plan to meet their needs. The goal is to see if this approach helps reduce hospital stays and emerge…

This study aims to understand how the trillions of bacteria living in our bodies (the microbiome) are linked to cancer and heart disease. Researchers will collect samples and health information from 16,000 adults over age 40. The goal is to build a large database that can help fu…

This study aims to learn how the COVID-19 pandemic impacts patients with cancer by asking them to fill out surveys and participate in phone interviews. Researchers will track how many people take part over 12 months. The goal is to gather information, not to test a treatment.

This study collects personal writings from teenagers and young adults being treated for cancer. Researchers will analyze these stories to understand their emotions, struggles, and needs. The goal is to use these insights to improve how doctors and hospitals care for young patient…

This study aims to understand how gene changes in metastatic pancreatic cancer relate to treatment response. Researchers will analyze tumor samples from 190 adults starting chemotherapy. The goal is to see if returning genetic results within 8 weeks is feasible, which could help …

This study looks at whether exercise can help prevent cancer from coming back in adults who have already had cancer. Researchers will review data from 1,000 cancer survivors to compare those who exercise with those who don't. The goal is to see if staying active is linked to bett…

This study tests a new device called STING-MARK that helps doctors mark the exact location of a tumor for treatments like radiation. Researchers will use donated organ samples (not live patients) to see if the marker is easy to place, stays in place, and shows up clearly on scans…

This study follows 200 adults with advanced cancer who are receiving immunotherapy. Researchers want to understand their physical and emotional distress, financial burden, and care needs over one year. The goal is to create a tool that can predict who is at high risk for severe s…

This study is testing whether an artificial intelligence tool can help match cancer patients to clinical trials they might be eligible for. Researchers will enroll up to 50,000 people with various types of cancer and use the AI to suggest trials. The goal is to see if this approa…

This study is looking at whether certain markers in the blood can help predict side effects in cancer patients receiving immunotherapy (immune checkpoint inhibitors). Researchers will collect blood samples and health data from 200 participants during their regular check-ups. The …

This study is a registry that gathers information from adult cancer patients receiving routine care at participating clinics. Researchers will collect data on treatments, outcomes, and patient surveys to better understand how cancer is managed in the real world. The goal is to im…

This study aims to improve methods for freezing and thawing ovarian tissue, and for maturing eggs in the lab, so that people at risk of early menopause—often due to cancer treatment—might still be able to have a genetically related child. Up to 300 females aged 0-45 who are preme…

This study looks at how tumors and healthy tissues change during a course of radiotherapy. About 250 cancer patients and 10 healthy volunteers will have special MRI scans and give blood or urine samples. The goal is to find patterns that could help doctors target tumors more prec…

This study asks cancer patients how satisfied they are after a special team assessment at the hospital. About 309 adults will fill out an anonymous survey after meeting with a pharmacist, dietitian, psychologist, social worker, and other care providers. The goal is to find out wh…

This study trains high school students to become health advocates and encourage their adult family members to get screened for cancer. Researchers will see if this youth-led approach increases screening rates among adults who are overdue. About 84 teens and their adult relatives …

This study looks at how interested people are in using telehealth and digital tools for cancer genetic testing. About 360 adults who meet guidelines for genetic testing will be offered online counseling and digital options. The goal is to see if these tools help more people compl…

This study is creating a large collection of human biological samples and health information, called a biobank. Researchers will use these materials to study the causes of diseases like cancer, heart disease, and diabetes. Up to 10,000 participants will provide samples and data t…

This study is gathering information from up to 10,000 cancer patients to see if choosing treatments based on the unique genetic makeup of their tumor leads to better outcomes and fewer side effects. Researchers will review medical records and may test leftover tissue or blood sam…

This study is collecting blood and urine samples from 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze genes, proteins, and immune cells to find patterns that predict disease progression, complications, or response to t…

This study explores how the brain processes chronic breathlessness in people with advanced cancer, COPD, or heart failure. Researchers will use brain scans (fMRI) and virtual reality to see if different diseases cause different breathlessness patterns. The goal is to learn if cur…

This study is testing a new approach called xDRIVE that combines lab tests on tumor samples with artificial intelligence to suggest personalized cancer treatments. It involves 210 Florida patients with cancers that have come back or not responded to standard therapy, including ch…

This study aims to find out if a more detailed genetic analysis of tumors can help doctors choose better treatments for people with advanced cancer. About 8,000 adults with metastatic or locally advanced solid tumors will have their tumor DNA analyzed in two ways: a standard test…

This study tests a new care model for cancer survivors who experience late effects from treatment. Patients fill out a questionnaire before their visit, which guides a conversation with their doctor to create a personalized plan. The goal is to see if this approach helps more pat…

This study is testing a new tool called CANoPy that predicts the risk of chronic nerve pain in cancer patients. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer who are about to start treatment. The goal is to give doctors a simple way to …

This study looks at why some cancer patients develop autoimmune problems after treatment with immune checkpoint inhibitors. Researchers will analyze blood samples and health records from 600 adults with cancer who are prescribed these drugs. The goal is to find genetic and immune…

This study tests whether a nurse-led program using online questionnaires and phone calls can help cancer patients transition safely from hospital to home. About 50 adults with cancer who own a smartphone or tablet will participate. The goal is to see if this follow-up approach is…

This study records short videos and voice clips of 200 cancer patients (some in pain, some not) to create a secure database. The goal is to help future artificial intelligence tools learn how to recognize pain from facial expressions and speech. No new treatments or tests are inv…

This study is testing whether cancer patients undergoing chemotherapy can monitor their own blood counts at home instead of traveling to the hospital for every blood draw. About 265 adults with cancer from Denmark, Poland, and Germany will participate. The goal is to see if home …

This study is collecting blood samples from up to 2050 cancer patients to look for tiny pieces of tumors (called biomarkers) in the blood. The goal is to learn how well blood tests can detect these markers, not to change or test any treatments. Participants will give blood sample…

This study looks at whether getting genetic counseling for hereditary cancer online works as well as meeting with a counselor in person. About 1000 adults who are at risk for inherited cancer will either use a web-based program or have standard counseling. The goal is to see if t…

This study follows up to 700 people who have already received radiation therapy for cancer. Researchers will collect information from routine check-ups to learn about long-term side effects and how the disease progresses over time. No new treatments or procedures are given—the go…

This study follows over 1,500 cancer patients in China to see how their nutritional status during chemotherapy and radiation affects their quality of life, treatment side effects, and survival. Researchers will track changes in diet, weight, and blood markers over time. The goal …

This study is testing a new screening tool called SOCS-OTS to see if it correctly identifies cancer survivors who need occupational therapy. About 80 adults from a cancer rehab clinic will take the screening, and researchers will compare it to a standard measure. The goal is to m…

This study is for adults with aggressive cancers that have a poor outlook. Researchers want to see if using a detailed analysis of a person's tumor (their 'molecular profile') can help doctors choose a more effective, personalized treatment. The study will enroll 400 people and t…

This study looks at what motivates people aged 70 and older with cancer to be physically active and eat well. Researchers will first group participants based on their motivation patterns, then use that information to design a personalized program to help them improve their activi…

This study looks at whether having access to a specialized palliative care clinic helps cancer patients feel more secure and reduces unnecessary hospital visits. Researchers will compare patients who use the clinic with those who do not, and also ask family members about their ex…

This study tests a 4-session virtual coaching program to help young adults (ages 26-39) who have survived cancer better understand their health insurance, reduce financial stress, and keep up with important follow-up screenings. About 300 participants will be randomly assigned to…

This study looks at why cancer patients who have needs like help with transportation, food, or housing choose not to accept support services. Researchers will survey 500 adults and interview a smaller group to understand their reasons. The goal is to improve how hospitals offer h…

This study looks at whether a special genetic test can help doctors pick the right dose or type of medicine for people with cancer. About 120 adults with gastrointestinal or other cancers who are already getting a standard genetic test will also receive a broader test. The goal i…

This study aims to improve how we measure metabolism—the rate your body burns calories—by looking at body shape and composition. Researchers will compare healthy volunteers and people with conditions like diabetes, obesity, or cancer. Participants spend two days in the hospital f…

This study looks at whether people with multiple myeloma who have achieved a very deep remission (called MRD-negative) and have been on maintenance therapy for at least two years can stop that therapy without their cancer coming back. Researchers will follow 70 participants for u…

This study is a large registry that collects health information from up to 10,000 people who received or were evaluated for radiation therapy for cancer or benign tumors at UT Southwestern since 2000. Researchers will analyze quality of life and compare outcomes with national dat…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep issues. Researchers will track insomnia over the first year using questionnaires to see how it develops and what factors—like treatment or emotional distress—may trigger or worsen it. The goal is to…

This study is testing whether wearable devices like smartwatches can help detect infections early in children receiving cancer treatment. About 150 children aged 5-18 will wear a device for 4 weeks to track heart rate, activity, and other health signs. The goal is to use this dat…

This study is building a registry of 10,000 adults interested in inherited cancer research. Participants fill out a consent form and questionnaires every two years, and may be invited to other studies. There is no treatment or cure involved—just observation and data collection to…

This study tests a device that measures fluid in the body to see if it can better track swelling (edema) in cancer patients. Researchers will include 46 people with breast cancer or other cancers who have fluid buildup after treatment. Participants will have body measurements, bl…

This study tracks 30 adults with rare cancers or rare genetic changes who are already taking a Health Canada-approved targeted therapy that isn't yet covered nationally. Researchers will measure how long patients live, their quality of life, and how well the treatment works. The …

This study looks at how well different fertility preservation methods work for people with cancer or other illnesses that may harm their ability to have children. Researchers will review medical records of 100 patients aged 0-50 who used fertility preservation services. The goal …

This study is an early test of a new drug called LY4066708 in 104 healthy adults. The main goal is to check for side effects and see how the drug moves through the body and brain. Participants will be followed for up to 24 weeks. This study does not aim to treat any disease.

This study surveys 200 adult cancer patients who have had CAR-T cell therapy to learn how it affects their fertility. The goal is to gather information that can help doctors improve future treatment plans and fertility preservation options. No new treatments are being tested—just…

This study looks at whether using video calls for geriatric checkups before cancer treatment can lower the number of unplanned hospital readmissions in patients aged 75 and older who live far from specialists. About 500 participants will be randomly assigned to either standard ca…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…

This study is for people with advanced cancer. Researchers will use a special genetic test on tumor samples to look for changes that might guide treatment. The goal is to see if this approach helps doctors choose more effective therapies. Up to 1000 participants will be enrolled.

This study is for 100 cancer patients whose treatments have some evidence of working, but doctors aren't sure how much they help or if they're worth the cost. Researchers will track how long patients live and how they feel day-to-day using simple quality-of-life surveys. The goal…

This study looks at whether a simple ultrasound of the thigh muscle can detect muscle loss (sarcopenia) in people who have finished cancer treatment. About 55 adults aged 18-74 with certain cancers will have an ultrasound and a standard DEXA scan to compare results. The goal is t…

This study aims to understand how skin conditions related to cancer or cancer treatments impact the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to learn how to better treat these skin i…

This study is for adults 18 and older who want to learn about their personal risk of developing cancer. Researchers will collect information on diet, exercise, smoking, alcohol use, family history, and body composition. The goal is to understand risk factors and guide people towa…

This study is testing a mobile app called EveryDose that helps cancer patients remember to take their oral chemotherapy pills on time. About 25 adults with cancer who are starting a new oral chemo drug will use the app for 12 weeks. Researchers will track how often patients use t…

This study aims to learn how genes and environmental factors cause rare tumors and cancer in individuals and families. Up to 500 people of any age with unusual tumors, a family history of cancer, or certain exposures can join. Participants provide medical history, samples, and ma…

This study follows 600 black and white adults with solid tumor cancer who use cannabis or not. Researchers use a smartphone app and surveys to track pain, symptoms, and cannabis, opioid, and tobacco use over a year. The goal is to understand how cannabis affects pain and whether …

This study looks at whether a tool called TrialTalk™ helps improve conversations between cancer patients and their doctors. About 30 patients and their providers will fill out questionnaires before and after a regular clinic visit. The goal is to see if the tool makes communicati…

This study is a registry that collects information from 2000 adults with metastatic cancer who are receiving radiation therapy as part of their standard care. The goal is to gather clinical data and patient-reported outcomes to help researchers better understand how radiation the…

This study is for cancer patients who have a blood clot and are taking blood thinners. These medicines can cause dangerous bleeding. Researchers want to see if a special blood test (thrombin generation assay) can predict who is at higher risk of bleeding. The study will follow 21…

This study looks at new blood and urine tests to find cancer early in firefighters. About 2,000 firefighters will give samples to see how well these tests work. The goal is to improve early detection and save lives.

This study is testing a new device that takes detailed PET-CT pictures of a tumor right after it is removed during surgery. The goal is to help surgeons see if any cancer cells are left behind, so they can remove more tissue if needed. About 50 adults with solid tumors will take …

This study tests a digital platform called the Genetics Navigator, designed to help patients and parents of children who are offered genetic testing. The goal is to see if using the platform reduces distress and improves the overall experience. About 170 adults will participate, …

This study collects genetic and health information from 3,000 people to help doctors choose the right medications and avoid side effects. Participants include those taking multiple medications or specific drugs for blood pressure or depression. The goal is to learn how genes affe…

This pilot study tests a program to help young female cancer survivors in rural Imperial County, California, get reproductive health care that matches their personal goals. About 64 women who have had cancer will receive screening, counseling, and telehealth consultations. The go…

This study looks at whether a community-based program can help cancer survivors and their loved ones eat healthier and exercise more. About 100 adults in the Birmingham area who have had cancer or are close to a cancer survivor will take part. The program adapts proven health tip…

This study looks at whether changing people's automatic, unconscious feelings about exercise can help them become more active. Researchers will work with 120 adults who are overweight and currently inactive. Participants will wear a Fitbit and answer quick smartphone surveys to m…

This observational study will enroll 100,000 adults aged 35 and older to build a registry and biorepository. Researchers will collect health records, questionnaires, and blood, saliva, and stool samples over five years, with five more years of follow-up. The goal is to identify b…

This study looks at how the bacteria in your gut might cause diarrhea during cancer treatment. Researchers will follow 150 adults starting cancer therapy, collecting stool and blood samples to see which bacteria are linked to diarrhea. The goal is to understand the connection so …

This study looks at whether a digital visual communication tool can help newly diagnosed cancer patients, their caregivers, and doctors better understand treatment choices. About 86 adults with breast or head and neck cancer will use the tool and then report their satisfaction. T…

This study tests a special tool called UR-GOAL that helps older adults (age 60+) with acute myeloid leukemia and their caregivers make informed treatment decisions. About 1,020 participants will be randomly assigned to use the tool or receive standard information. The main goal i…

This study tests a Clinical Trials Navigator (CTN) program that helps cancer patients, families, and doctors find and enroll in clinical trials outside their local cancer centre. The program will be rolled out to 20 centres across Canada over 12 months. Researchers will measure i…

This study is gathering tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to learn how often certain genetic changes occur and to store participants' own immune cells for possible future use in making …

This study collects and stores tumor, tissue, and blood samples from up to 10,000 cancer patients treated at the Arizona Cancer Center. The samples are kept in a secure database and used by researchers to better understand cancer. Participation is open to all cancer patients unde…

This study explores the link between gut bacteria, fatigue, and thinking problems in people with cancer. Researchers will collect stool samples and measure cognitive function in 250 adults receiving standard cancer treatment. The goal is to better understand these connections, no…

This study follows 450 adults with cancer who are receiving immunotherapy (a type of treatment that helps the immune system fight cancer). Researchers want to see if using cannabis helps or harms symptom management, such as pain, sleep, anxiety, and fatigue. Participants will com…

This study will collect genetic information and health records from 25,000 people who have cancer or are at risk for it. The goal is to learn more about what drives cancer and how to better tailor treatments. Participants will not receive a new therapy, but their data may help fu…

This study looks at how cancer patients in palliative care feel about stopping medications that are not for their cancer. About 120 participants will fill out questionnaires, watch an educational video, and read a brochure. Then they will answer questions again to see if their vi…

This study looks at why certain cancer patients—especially those from minority backgrounds, lower-income areas, or with decision-making challenges—are less likely to join research studies. Researchers will survey 300 adults with cancer and map patient data to find barriers and im…

This study follows 5,500 Canadian cancer patients whose tumors have rare genetic changes. Researchers will collect data on how these cancers behave and how well different treatments work, including newer targeted drugs. The goal is to learn more about these uncommon mutations to …

This study surveys 100 young adults (ages 18-39) receiving cancer treatment at a hospital to compare their satisfaction in two different infusion spaces. Participants fill out surveys and may join interviews about their experience with the room design and mental health staff. The…

This study looks at muscle loss (sarcopenia) and cognitive problems (chemobrain) in people who have finished cancer treatment. Researchers will collect data from 100 adults aged 18-74 with certain cancers to see how common these issues are. The goal is to better understand and ma…

This study interviews 20 cancer patients, their caregivers, and healthcare providers to understand their thoughts on receiving hospital-level care at home. The goal is to learn what people like and worry about, so future home care programs can be designed better. No treatment is …

This study looks at 380 cancer patients getting chemotherapy for ovarian, lung, stomach, or pancreatic cancer. Researchers will take extra blood samples during routine chemo visits to measure clotting markers. The goal is to find out which patients are most likely to develop dang…

This study looks at how weight loss changes the way people with advanced cancer feel about their bodies. Researchers want to understand if these feelings differ between men and women, and across countries. The goal is to create better, fairer nutrition advice for patients. About …

This study is testing a new virtual reality (VR) tool called Life at 100.4 to help teenagers and young adults with cancer, along with their caregivers, learn about their diagnosis and treatment. The tool uses an immersive social VR environment to make education more engaging. Res…

This study aims to find new genetic changes that increase the risk of inherited cancers in both children and adults. Researchers will analyze DNA from up to 1,500 people who have or may develop hereditary cancer. The goal is to discover new susceptibility genes, which could lead …

This study looks at whether improving the clarity of instructions helps cancer patients attend all their scheduled radiation sessions and feel more at ease. Researchers will update patient materials and track missed treatments, unplanned clinic visits, and patient comfort. The st…

This study is for people with advanced cancers who are taking targeted treatments for months or years. Researchers will interview 75 participants to understand their experiences and needs. The goal is to find better ways to support patients living with chronic cancer treatments.

This study is testing a blood test called Galleri® that looks for signals of many types of cancer at once. Researchers want to see if using this test in people aged 50 and older with Medicare can help find cancers earlier and reduce the number of late-stage (stage IV) cancers. Th…

This study looks at whether adding a special helper called an oncology research navigator (ORN) to standard cancer care helps patients learn about and join clinical trials and support services. About 686 adults with new cancer appointments at UNC Medical Center will take part. Th…

This study follows 3,000 adult cancer patients who take oral anticancer drugs at home. Researchers want to understand how well these drugs work in real life and identify any problems, like side effects or dosing issues. The goal is to improve patient care and safety through bette…

This study is creating a large collection of blood and tissue samples and health information from 100,000 cancer patients. The goal is to provide researchers with high-quality materials to study cancer and develop better diagnostic tests. Participants must be 18 or older and able…

This study looks at whether a short video can help people with early-stage cancer living in rural Vermont feel more in control of their care. About 40 patients will either get the video right away or after a few months. Researchers will check if the video improves patients' under…

This study tests whether a special clinic that checks your genes and medications can lower the chance of harmful drug interactions. About 1,300 adults with cancer or mental health conditions who take multiple medications will participate. Researchers will compare how well the cli…

This study compares two procedures—thoracentesis (draining fluid) and pleuroscopy (taking a tissue sample)—to see which one gives a clearer diagnosis faster for people with fluid around the lungs that may be caused by cancer. About 98 adults with suspected cancer will be randomly…

This study is a disease registry that collects information from about 700 people with advanced non-small cell lung cancer that has a specific genetic change called METex14 skipping. The goal is to track what treatments people receive in everyday practice and how well they work, a…

This study is collecting blood samples from 1,500 cancer patients who are receiving FDA-approved immunotherapy. Researchers will analyze immune-related markers in the blood to see if they can predict whether the treatment will work. The goal is to better understand why some patie…

This study watches how cancer patients with superficial vein clots (clots in veins near the skin) respond to different blood thinners prescribed by their doctors. About 1,576 adults with active cancer and a recent vein clot will be followed for 3 months to see which treatment wor…

This study is for 500 adults with cancer who are willing to give extra blood samples over time. Researchers will look for tiny bits of tumor DNA in the blood to see how cancer changes during and after standard treatment. The goal is to learn more about cancer, not to test a new t…

This study aims to find and measure special immune cells that can recognize and attack cancer. Researchers will collect blood samples from 300 cancer patients whose immune system may be reacting to their disease or treatment. The goal is to better understand how the body fights c…

This study looks at whether whole-body MRI, ultrasound, and a new blood test can find cancer early in firefighters. Firefighters have a higher risk of cancer due to job exposures. The study will enroll 800 active firefighters aged 35 and older with at least 10 years of service. I…

This study follows 540 adults with solid cancers to track how anxiety and depression change over time. Researchers will look at factors like age, cancer type, and coping style to predict who needs extra support. No new treatment is given—the goal is to learn and improve care.

This study is testing whether a new type of imaging (HyperSight CBCT) and adaptive planning (Ethos) can better track changes in tumors and nearby organs during radiation therapy for children with non-brain cancers. Twenty children aged 18 or under will receive standard radiation …

This study looks at whether a special team of cancer experts, called a Molecular Tumor Board, can help doctors choose better treatments based on the genetic makeup of a patient's tumor. About 192 adults with cancer will have their tumor genes analyzed, and the board will suggest …

This study asks 50 people — including cancer patients, doctors, and industry workers — whether a 1939 UK law that bans advertising cancer treatments is still useful. The goal is to understand how people use online and social media for cancer information and whether the law should…

This study aims to collect and store blood, tissue, urine, and stool samples from up to 10,000 cancer patients across Texas. Researchers will use these samples to study how the immune system responds to cancer treatments and find markers that predict which therapies work best. Th…

This study is testing a new way to help teenagers and young adults with hard-to-treat cancer, along with their parents and doctors, have better conversations about what the future may hold. The goal is to see if this personalized approach is practical and helpful for everyone inv…

This study looks at how tumors and nearby healthy organs change in size and shape during and after radiation therapy. By analyzing scans from 500 people who have already completed radiation, researchers hope to learn more about these changes. The goal is to use this information t…

This study is checking whether new molecular markers (biological clues from tumors) can be used in everyday care for people with rare adrenal cancers. Researchers want to see if these markers can be reported quickly after surgery and if they help doctors make better treatment dec…

This study tests a program called CTNow that helps cancer patients and doctors in rural areas learn more about clinical trials. The program uses education and teleconference tools to make it easier for patients to find and join trials. About 50 adults with cancer from Hawaii, Kau…

This study is creating a large databank of blood, imaging, and tissue samples from 5,000 cancer patients and healthy volunteers. The goal is to find links between biological markers and how well treatments work, including tumor control, side effects, and quality of life. Particip…

This study looks at whether digital rehabilitation (like online exercise or therapy) is practical and helpful for cancer patients during and after treatment. About 300 people from Denmark, Sweden, Germany, Poland, and Lithuania will take part. The goal is to learn what helps or h…

This study looks at whether cancer patients do better when they go to the emergency department at their own cancer hospital versus another hospital. Researchers will track 2,000 adults with active cancer or recent remission to see how many days they spend alive and out of the hos…

This study collects online surveys from 15,000 people who have been diagnosed with cancer or who have cared for someone with cancer. The goal is to learn about the emotional, physical, social, and financial challenges they face. Findings will help improve programs and policies fo…

This study looks at whether having a radiopharmacist review a patient's full medication list before they receive targeted radionuclide therapy (TRT) can prevent drug-related problems. TRT uses radioactive drugs to kill cancer cells while sparing healthy tissue. The study will inc…

This study looks at the gut bacteria of 16 people with advanced solid cancers who are already receiving immunotherapy. Researchers want to see if certain bacteria are linked to how well the treatment works. No new treatment is given; the goal is to learn more about the connection…

This study aims to understand what helps or gets in the way of a good hospital experience for Asian cancer patients at MD Anderson. Researchers will survey 520 former patients and interview healthcare providers. The goal is to identify barriers and find ways to improve care for t…

This study looks at whether cancer survivors can use a smartwatch and a phone app to regularly report their symptoms and quality of life. About 50 adults who have finished cancer treatment and have controlled disease will wear a smartwatch for 4 months and answer weekly questionn…

This study is testing a computer program that uses interactive stories and artificial intelligence to help teenagers aged 15-17 who already drink alcohol make healthier choices. About 200 teens will use the program during their regular clinic visits. The goal is to see if the pro…

This study looks for new genetic causes of cancer in people diagnosed at a young age (under 40, or under 30 for breast cancer). Standard genetic tests often miss the cause, so researchers will use a more detailed method called exome sequencing to search for hidden risk factors. T…

This study tests a new tool that lets cancer patients report any issues that might delay their treatment. Researchers want to see if this tool can help identify and address problems sooner, especially for racial groups that often face longer delays. The study will enroll 240 adul…

This study looks at whether sending a text message to check for depression is a good way to screen cancer survivors. About 60 people who have had cancer and own a cellphone will take part. The goal is to see if this method is easy to use and works better than the usual way of scr…

This study looks at whether adding patient navigators and easy-to-understand educational materials can increase the number of Black and Latino cancer patients who are referred to and enroll in cancer clinical trials. About 500 patients from community oncology clinics will take pa…

This study aims to help preserve fertility in females under 40 who face infertility due to treatments like chemotherapy or radiation. Participants will have an ovary surgically removed and frozen for future use. Researchers will also study how to improve the freezing and maturati…

This study is collecting information from 500 adults with solid tumors who are receiving proton therapy, a type of radiation that may cause fewer side effects than standard radiation. The goal is to gather real-world data on how well proton therapy controls cancer and its side ef…

This study tests whether community outreach, navigation help, and digital tools can increase the number of Black and Hispanic patients enrolling in cancer treatment trials at Moffitt Cancer Center. About 7,600 community members, doctors, and staff will take part. The goal is to m…

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a camera in a pill) to screen for early growths or cancer. The goal is to see how well this test finds precancerous or cancerous lesions in the small bowel. Results …

This study tests a telehealth program designed to help young cancer patients (ages 0-50) get fertility care that matches their personal goals. Researchers will track whether the program increases the number of patients who receive fertility counseling or preservation services. Th…

This study looks at why cancer patients feel very tired during chemotherapy and radiation. Researchers will collect blood and stool samples from 125 adults with different cancers before, during, and after treatment. They aim to find links between fatigue and changes in genes and …

This study looks at how to help people in Zimbabwe who have both cancer and HIV stay engaged in their HIV care while they are being treated for cancer. Researchers will first observe 150 patients to understand the barriers, then develop and test strategies to overcome them with a…

This study looks at whether the amount of vitamin D in your blood affects your chance of developing thyroid problems while receiving a common type of cancer immunotherapy (PD-1/PD-L1 inhibitors). Researchers will measure vitamin D and thyroid function before and during standard c…

This study is creating a registry of 1000 adults with cancer who use cannabis. Participants use a secure app to track their symptoms, cannabis use, and how they feel after using it. The goal is to collect real-world data to help patients and doctors make informed decisions about …

This study tests whether digital messages (texts, emails, or apps) can encourage teens and young adults who survived childhood cancer to schedule and attend their long-term follow-up appointments. About 530 survivors aged 15-29 who are overdue for care will receive different sequ…

This study aims to learn more about what causes cancer and how to prevent it. Researchers will follow 200,000 adults aged 30–70 who have never had cancer, collecting health surveys, blood, urine, and saliva samples over many years. By studying lifestyle, genetics, and medical his…

This study tracks 5,000 cancer patients receiving chemotherapy or targeted drugs to detect heart-related side effects early. Researchers use regular heart tests and blood markers to build a system that predicts serious heart problems. The goal is to improve patient safety and qua…

This study follows about 50,000 people who survived childhood cancer (diagnosed before age 21 between 1970 and 1999) and 10,000 of their siblings. Researchers want to learn how cancer treatments like radiation, chemotherapy, and surgery affect health years later. Participants com…

This study tests a new way to help people with cancer, especially those from African American, Hispanic, or underserved areas. The program provides extra support and resources to reduce distress and improve quality of life. About 375 adults with suspicious cancer findings or a ca…

This study from Mayo Clinic is watching how a blood test that can detect many types of cancer is used in everyday doctor visits. About 500 adults who have already had or are scheduled for this test will take surveys about their feelings, satisfaction, and the costs that follow. T…

This study looks at whether cancer patients are willing to answer questions about their social and economic circumstances, such as income, education, and housing. Researchers want to understand how these factors affect access to healthcare and participation in clinical trials. Ab…

This study looks at why some childhood cancer survivors continue to have symptoms like fatigue, pain, and trouble sleeping. Researchers will ask 600 survivors aged 8-18 about their symptoms and collect stool samples to study gut bacteria. The goal is to find links between gut hea…

This study listens to cancer survivors to understand how they experience and talk about fatigue. Researchers will interview 80 survivors and their doctors to create a visual poster that helps patients describe their fatigue better. The goal is to improve communication and help pe…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…