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Can a chaplain or therapist extend life in advanced cancer? large trial aims to find out

NCT ID NCT07290491

Symptom relief Sponsor: The Methodist Hospital Research Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether adding chaplain-provided spiritual care or psychotherapy/meditation to standard palliative care can improve survival and quality of life in people with advanced, non-curable cancer. About 854 participants with a life expectancy of one year or less will be randomly assigned to one of three groups: standard care plus palliative measures, standard care plus chaplain spiritual sessions, or standard care plus psychotherapy/meditation. The study aims to see if emotional and spiritual support can make a real difference in how long patients live and how they feel.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
chaplain-provided spiritual care or psychotherapy/meditation
What this could lead to
If it works, this could show that spiritual and emotional support alongside standard care helps people with advanced cancer live longer and feel better.
What could go wrong
This is a large phase 3 trial, but the intervention is behavioral, not a drug, so survival benefits may be modest or hard to prove. Results may not apply to all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 854 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

May 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients are eligible to be included in the trial only if all of the following criteria apply * The patient provides written informed consent for the trial. * Male or female ≥18 years of age on the day of informed consent signing. * Histologically confirmed metastatic disease with life expectancy of one year or less. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3. * Willing and able to comply with the protocol for the duration of the trial including undergoing scheduled visits and interventions. Exclusion Criteria: Patients are excluded from the trial if any of the following criteria apply: * Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. If a patient develops a psychiatric disorder after baseline, he/she will not be taken off the trial. * Mobility limitations that would interfere with cooperation with the requirements of the trial. * Confirmed positive pregnancy test in women of child bearing potential.

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Conditions

The condition(s) this trial relates to.

cancer metastatic malignant neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Houston Methodist Neal Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

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