CANCER

This study tests a new type of cancer vaccine made specifically for each person. The vaccine uses pieces of the patient's own tumor to teach their immune system to attack cancer cells. It is for people with solid tumors that have not spread or have spread to other parts of the bo…

This study offers continued treatment with atezolizumab (alone or with other drugs) to cancer patients who were benefiting from it in a previous Roche-sponsored trial but lack local access. Up to 1,000 participants will receive the therapy and be monitored for serious side effect…

This early-phase study tests a new drug, NTX-1088, which blocks a protein on cancer cells that helps them hide from the immune system. The trial includes about 90 adults with advanced solid tumors that have not responded to standard treatments. Participants receive NTX-1088 alone…

This study tests whether a special health assessment and personalized care plan can help older adults (65+) starting chemotherapy avoid severe side effects. About 70 participants will either receive the assessment-driven plan plus usual care, or usual care alone. The goal is to s…

This study tests the safety of a device called TheraSphere for men with localized prostate cancer. It uses tiny radioactive beads to deliver radiation directly to the tumor. The goal is to find the highest safe dose and see how well patients tolerate it. 36 participants will be f…

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with advanced cancers that have stopped responding to standard treatments. The goal is to see if the drug is safe and can help control the cancer. About 350 people with various cancer types, …

This study looks at whether having a cancer survivor's regular doctor work closely with their cancer team can better manage heart-related conditions like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers (like breast, prostate, or lung) an…

This study tests a web-based program that teaches parents skills to help their children—who have survived cancer—eat healthier and be more active. It includes 520 families with children aged 5-14 who are off cancer treatment for at least 6 months and have overweight or obesity. T…

This study compares two treatments for advanced head and neck cancer: the immunotherapy drug pembrolizumab (Keytruda) plus radiation versus standard chemotherapy (cisplatin) plus radiation. About 126 participants with p16-positive cancer will be enrolled. The goal is to see if th…

This study gives venetoclax to 165 people with blood cancers like leukemia and lymphoma who already benefited from the drug in earlier studies. The main goal is to track side effects and see how safe the drug is over a longer period. Participants must have tolerated the drug well…

This study offers continued treatment with the drug osimertinib to cancer patients who have already completed a previous study and are still benefiting from the drug. The main goal is to monitor safety and side effects. About 37 participants are expected to enroll.

This study tests a drug called RP1, which is injected directly into skin cancer tumors. It is for people who have had an organ or stem cell transplant and now have advanced skin cancer. The goal is to see if RP1 can shrink tumors safely without harming the transplanted organ. Abo…

This study tests a clinic-based program called ActivityChoice that helps cancer survivors become more physically active to lower their risk of heart disease. About 114 adult cancer survivors will be offered a choice of group in-person, group virtual, or self-monitored digital exe…

This study offers ongoing treatment with darolutamide to cancer patients who were already taking it in a previous Bayer-sponsored study and whose doctors believe they are still benefiting. About 402 participants will continue their same dose and attend regular check-ups. The main…

This study offers girls from birth to age 17 the chance to freeze their ovarian tissue before medical treatments like chemotherapy or radiation that could harm their fertility. The goal is to see if the frozen tissue can later be transplanted back to allow pregnancy and live birt…

This study looks at a new way of giving standard chemotherapy (R-CHOP) to older adults aged 75 and up with diffuse large B-cell lymphoma. The goal is to see if splitting the doses makes treatment easier to tolerate while still being effective. About 27 participants will receive t…

This study tests a new drug called RNDO-564, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like lung, bladder, or breast cancer) that no longer respond to standard treatments. The main goals are to check safety, find the best dose, and see if t…

This early-phase study tests a new cell therapy called ACIT-1 in adults with pancreatic or other cancers. The goal is to find the safest dose that can boost the body's immune system to fight cancer. About 34 people will take part, and researchers will monitor side effects and sur…

This early-stage study tests an experimental pill called HBI-2376 in people with advanced solid tumors (like lung, colon, or pancreatic cancer) that have specific gene changes (KRAS or EGFR mutations). The main goals are to find the safest dose and understand how the drug moves t…

This study tests a daily combination of sirolimus, celecoxib, and low-dose chemotherapy in 46 children whose solid or brain tumors have come back or not responded to standard treatment. The goal is to see if this approach can shrink tumors or stop them from growing. The treatment…

This early-phase study tested the safety and tolerability of an experimental drug called AZD6244, given as a capsule, in 58 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to identify side effects and determine how the drug …

This early-stage study tests an experimental drug called cofetuzumab pelidotin in 65 adults with a specific type of recurrent non-small cell lung cancer (NSCLC) that has a protein called PTK7. The drug is designed to deliver a toxin directly to cancer cells. The main goal is to s…

This early-stage study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic mutation called KRAS G12C. The main goals are to find a safe dose and understand how the drug moves through the body. About 44 adults …

This early-stage study tests a new drug called TT125-802 in about 50 adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check the drug's safety and find the best dose. Researchers will also watch for any tumor shrinkage an…

This study offers cancer patients who were already taking atezolizumab in a previous Roche-sponsored trial continued access to the drug. It includes about 382 participants and aims to monitor long-term safety and survival. The treatment continues until the cancer worsens, side ef…

This study tests a radioactive drug (177Lu PSMA) in people with advanced or spreading cancers that have a specific marker called PSMA. The goal is to see if the treatment is safe and can control the disease. 83 participants will receive up to 4 cycles of the drug, with doses adju…

This study offers continued treatment with durvalumab to cancer patients who have already completed a previous study and are still benefiting from the drug, as judged by their doctor. About 214 participants will be enrolled to monitor safety and side effects over time. The goal i…

This early-phase study tests a new drug called IMA401 in about 95 adults with advanced solid tumors (like lung or head/neck cancer) that came back or didn't respond to prior treatments. IMA401 is a special immune molecule that helps the body's T cells attack cancer cells. The stu…

This early-stage study tests a new drug, RP2, in 36 adults with advanced solid tumors that have not responded to standard treatments. The goal is to find the safest dose and see if RP2 works better when combined with another immunotherapy. The study focuses on safety and tumor re…

This study tests whether combining two immunotherapy drugs, atezolizumab and tiragolumab, can help control cancers where doctors cannot find the original tumor. About 4 adults whose cancer has not responded to chemotherapy will receive the drugs. Researchers will monitor side eff…

This trial is testing a new blood test called Galleri that looks for signs of many different cancers. Over 140,000 people aged 50-77 in the UK are taking part to see if adding this test to standard NHS screening helps find cancers at an earlier, more treatable stage. The study co…

This study tests a new radioactive imaging agent called [18F]-C-SNAT4 to see how it spreads in the body and whether it can help spot lung cancer on PET scans. It includes 5 healthy volunteers and 15 people with lung cancer. The goal is to check safety, radiation exposure, and whe…

This study looks at better ways to check for heart damage in adults who have had cancer. Researchers are testing if an AI-powered ECG and a simple blood test can find early signs of heart problems. The goal is to create a nationwide screening program to help cancer survivors stay…

This study is testing a new blood test that can detect many types of cancer early, before symptoms appear. About 35,000 people aged 50 and older will take the test, and those with a positive result will get follow-up exams to confirm if they have cancer. The goal is to see if the…

This study looks at two ways to encourage women who had childhood cancer and chest radiation to get regular mammograms. About 360 women aged 25-49 who haven't had a mammogram in two years will receive either tailored print materials plus a phone chat, or general health informatio…

This study tests a family program called Turtle Island Tales for American Indian families living in poverty. The program aims to prevent obesity and cancer by encouraging healthy eating, physical activity, less screen time, and better sleep. About 200 caregivers with children age…

This large study looked at whether taking daily vitamin D and omega-3 (fish oil) supplements can help prevent cancer, heart disease, and stroke in healthy older adults. Over 25,000 men and women aged 50+ took the supplements for about 5 years. The goal was to see if these common …

This study looks at whether adding a palliative care team early—before surgery—helps people with cancer feel better physically and emotionally. About 236 adults having certain abdominal cancer surgeries will either get standard care or standard care plus extra support from a pall…

This study looks at whether fasting for 24 hours before and after chemotherapy is safe and doable for people with lymphoma. About 40 patients will either fast or receive standard care. Researchers will track side effects, weight changes, and quality of life to see if fasting help…

This study looks at two different ways to manage symptoms in cancer patients who are new to palliative care. About 208 adults from Pennsylvania will be randomly assigned to one of two approaches. The goal is to see which method helps improve their quality of life more.

This study tests if a cooling mat, a non-drug option, can reduce hot flashes and night sweats in people receiving hormone therapy for breast or prostate cancer. About 40 participants will use the mat for 8 weeks and track their symptoms. The goal is to see if this simple approach…

This study looks at whether giving advanced cancer patients $1000 each month for a year can reduce their financial stress and improve their quality of life. About 250 people with stage 3 or 4 cancer who are on Medicaid will take part. They will receive the monthly payments and fi…

This study tests whether a telemedicine program, called tele-geriatric oncology, is practical for older adults (70+) with gastrointestinal or gynecological cancer. Participants meet with a nurse via video calls to discuss symptoms and aging-related needs. The goal is to see if th…

This study tests whether a mobile health program can help teens and young adults who finished cancer treatment become more physically active. About 287 participants in Alberta will either get educational materials alone or also receive a personalized activity plan, a fitness trac…

This study tests whether an 8-week digital health program called COBRA is safe and practical for older adults with cancer. The program focuses on balance and resistance exercises. Researchers will track how many participants stick with the program to see if it's a feasible option…

This study is testing whether a meditation-based support program, adapted for Black patients with advanced cancer, can help manage symptoms like pain and fatigue. Researchers will first interview patients and caregivers to tailor the program, then compare it to a standard educati…

This study looks at whether a progressive exercise program can reduce long-term nerve pain in veterans who have had lung cancer. Nine veterans aged 60-80 who finished treatment at least 6 months ago will take part. The goal is to see if exercise can ease pain and improve fitness,…

This study looks at whether cancer patients who are not expected to be cured benefit from being referred to a palliative care team when they visit the emergency room. About 240 adults with advanced cancer will be randomly assigned to either standard care or a direct referral to p…

This study looks at whether helping cancer patients with financial and social needs (like food, housing, or transportation) can improve their treatment and well-being. About 91 newly diagnosed cancer patients who report money problems will receive either one-on-one financial coun…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce common symptoms like memory problems, fatigue, insomnia, and anxiety in cancer patients and survivors. About 70 participants will receive either real or sham electroacupunct…

This study looks at whether using an activity tracker and a phone app can help people with cancer reach their exercise goals, like daily steps or weekly workout minutes. About 25 people currently in cancer treatment or survivorship will wear the tracker and use the app for 3 mont…

This study tests a 7-week group program led by trained peers (not doctors) to help cancer survivors reduce anxiety and depression after finishing curative treatment. 234 adults in Denmark who completed cancer treatment within the past year and have mild to severe symptoms are tak…

This study tests a special stress-reduction program for teens and young adults who have finished cancer treatment. The program teaches skills to manage stress and build resilience. Researchers want to see if it is practical and helpful for this group.

This study tests an electronic symptom management system called Nurse AMIE in 344 people with advanced cancer living in rural areas. The goal is to see if using the system improves survival and quality of life. Participants use the tool to report symptoms and get support, while r…

This study tests a digital program called EMBody designed to help young people aged 16-25 who have finished cancer treatment. The program aims to teach helpful ways of thinking about the body to improve health and quality of life. About 105 participants will use the program and r…

This study looks at whether support from a community health worker can help African American patients with advanced cancer feel better and plan their care. About 160 patients will either get standard care or extra help from a health worker. The goal is to see if this support impr…

This study tests a program to help Hispanic cancer survivors eat healthier and be more active. The goal is to reduce symptoms like pain, sleep trouble, and anxiety. About 187 survivors and their caregivers will take part. The program includes diet advice and physical activity tra…

This study tests a new approach to help childhood cancer survivors who struggle with memory, attention, and thinking after their treatment. Participants use a special light device on their head (called transcranial photobiomodulation) at home while doing computer brain games. The…

This small study tests whether a yoga program led by a Black or African American trainer can improve quality of life and reduce symptoms in Black cancer survivors. About 13 participants will attend yoga sessions and report how they feel. The goal is to see if this culturally tail…

This study looks at whether kava, a plant-based supplement, can safely help reduce anxiety and stress in people who have finished cancer treatment. About 43 cancer survivors with mild anxiety will take either kava or a placebo for 14 days, then switch after a break. The goal is t…

This study tests whether up to two doses of psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults who have both cancer and major depressive disorder. About 56 participants will receive either psilocybin or a placebo in a group setting with t…

This study tests a digital platform called ConnectedNest that helps cancer patients find and connect with community services for needs like housing, food, and financial help. About 400 adults with cancer from Minnesota clinics will use the platform for 90 days. The goal is to see…

This study looks at whether electroacupuncture (a type of acupuncture with mild electrical pulses) can help manage symptoms like pain, nausea, and trouble sleeping after a major cancer surgery. The researchers will test this in 20 people who have had cytoreductive surgery and hea…

This study tests a phone app called OnKO-Tips&Tricks designed for teens and young adults (ages 15-25) recently diagnosed with cancer. The app helps with daily check-ins, education, and direct contact with a nurse coordinator. Researchers want to see if using the app for 6 months …

This study tests a nutrition program for cancer survivors who are overweight or obese. It combines one-on-one dietitian counseling, behavioral skills training, and group support. The goal is to see if the program is practical and well-liked by participants and staff. About 73 adu…

This study tests a 12-week mobile health program for 304 young adult cancer survivors (ages 18-39) to help them increase physical activity and improve quality of life. The program includes optional features like e-coaching, a buddy system, and mindfulness training. Researchers wi…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help cancer patients feel more flexible in dealing with difficult thoughts and emotions. About 120 adults with breast, lung, or colorectal cancer will be split into three groups: on…

This study tests whether a special type of counseling called hope-focused motivational interviewing can improve hope, self-confidence, and self-compassion in cancer patients undergoing radiotherapy. About 46 adults with stage I-III cancer will be randomly assigned to receive this…

This study followed 492 adults with cancer who joined a supervised exercise program in community settings. The program included aerobic, strength, and functional training, offered in person or online. Researchers measured how often participants attended sessions, their quality of…

This pilot study explores whether chiropractic care can reduce chronic fatigue in adults who have finished cancer treatment and are now cancer-free. About 40 participants will be randomly assigned to receive chiropractic adjustments or continue usual care. The main goal is to see…

This study planned to look back at medical records to see how often people with lymphoma also had another cancer within six months. It aimed to find patterns and possible causes. The study was withdrawn before any patients were enrolled, so no results are available.

This study tracks 150 cancer patients to see how mind-body therapies like mindfulness, laughter yoga, and art therapy impact their quality of life and emotional distress. Participants complete one of these programs over about 8 weeks, and researchers measure changes using standar…

This study tests whether a "Patient Navigation 2.0 Checklist" helps Chinese adults in Chicago get recommended cancer screenings, vaccines, and help with social needs like housing or food. About 600 participants from Chinatown zip codes will use the checklist with a navigator. The…

This study looks at how certain cancers (head and neck, esophagus, and anal canal) change at the genetic and immune level when patients receive chemotherapy or immunotherapy. Researchers collect blood and tumor samples before and during treatment to track these changes. The goal …

This study tests whether using a visual consent form with pictures and simple language helps patients better understand research studies. Researchers will compare the standard consent process to a new visual version in studies on cancer and Alzheimer's disease. About 266 patients…

This small study tests whether frozen testicular tissue can be transplanted back into men to produce sperm. It includes men with infertility and healthy volunteers. The goal is to see if this approach could one day preserve fertility for boys who lose it due to cancer treatment.

This study collects blood, urine, and tissue samples from 500 adults with obesity to help researchers learn why people gain or lose weight, and why some regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up t…

This study follows 180 adults with cancer that has spread to the thigh bone and is at high risk of breaking. The goal is to see how well surgery (with or without radiation) or radiation alone helps patients walk, manage pain, and maintain quality of life over 6 months. The study …

This study involves 837 adult survivors of childhood cancer. Researchers are creating and testing a questionnaire to better capture symptoms and side effects that survivors may face years after treatment. The goal is to improve follow-up care and quality of life by giving doctors…

This study looks at how community cancer clinics ask patients about social needs like food, housing, or transportation. Researchers will work with 144 clinic staff to find out what helps or hinders these screenings. The goal is to create custom plans so clinics can better connect…

This early-phase trial is testing whether atorvastatin, a widely used cholesterol medication, can reduce levels of a faulty protein called p53 in people with various cancers, including solid tumors and acute myeloid leukemia. About 50 participants will take the drug for 1 to 4 we…

This study looks at how surviving cancer as a teen or young adult affects a person's sense of self, friendships, and family bonds. Researchers will interview and survey 300 survivors aged 15 to 25 who finished treatment at least 6 months ago. The goal is to learn what these survi…

This study collects fresh tumor samples from 416 adults with various cancers (bladder, kidney, colorectal, head and neck, liver, lung, skin, endometrial) to develop and train a live tumor diagnostic platform. The goal is to see how accurately the platform can predict whether a pa…

This study is testing better ways to take MRI pictures for people getting radiation therapy for solid tumors. The goal is to find the best scan settings to get clearer, more accurate images. Both cancer patients and healthy volunteers can take part. The study is currently on hold…

This study tests whether a quick, 30-second heart screening using a mobile ECG device can find hidden atrial fibrillation (an irregular heartbeat) in people aged 65 and older with cancer. About 480 participants will be randomly assigned to either the screening or usual care. The …

This study tests a new total-body PET scanner that may produce clearer images with less radiation. About 25 adults with cancer will get scanned on both the new and standard machines. The goal is to see if the new scanner works just as well or better, potentially making scans safe…

This study looks at whether older adults with cancer (age 65+) can use computer surveys to report their health and daily living needs. Researchers tested two different computer methods to see if they are reliable and easy to use. The goal is to make it simpler for doctors to asse…

This study looks at whether digital tools and telemedicine can help parents of children with cancer get genetic testing for themselves. The goal is to find family members who may have inherited a gene change that raises cancer risk. About 100 parents will take part, using a chatb…

This study collects health information from up to 75,000 people with cancer who received proton therapy or standard X-ray radiation at Loma Linda University Medical Center. By following participants for many years, researchers hope to learn which treatments are most effective and…

This study looks for clues in the blood that might help doctors predict which cancer patients will have serious side effects from immunotherapy drugs. Researchers are comparing patients who get immunotherapy with those who get standard chemotherapy. The goal is to find markers th…

This study looks at people and families who have a high chance of getting cancer because of their genes, family history, or environment. Researchers collect medical records, questionnaires, and samples to learn what causes cancer and how it runs in families. No treatment is given…

This study looks at whether using a Fitbit and a continuous glucose monitor is a practical way to track daily exercise in people with cancer or diabetes. About 35 adults who are not very active will wear these devices for a period of time. The goal is to see if people are willing…

This study was designed for adults with certain types of soft tissue sarcoma that have specific immune cell clusters (TLS). It aimed to test if adding a DNA repair inhibitor (olaparib) to immunotherapy (pembrolizumab) before surgery could boost the immune response. However, the s…

This study compares different outreach methods to see which works best for getting African Americans to join early phase cancer treatment trials. About 134 patients and their doctors will take part. The goal is to find ways to make cancer research more inclusive.

This study takes a piece of a patient's cancer and grows it in lab mice to test multiple drugs at once. The goal is to see if this approach can help doctors choose more effective treatments. It involves 40 people with advanced solid tumors who have not responded to standard thera…

This study brings together 265 experts to create clear, standard definitions for key measurements used in cancer clinical trials, such as how long patients live without their cancer getting worse. Currently, different trials define these measurements in different ways, making it …

This study looks at health records from 10,000 people with cancer to help researchers better understand the disease and improve treatments. No new drugs or procedures are tested. The goal is to use real-world data to make clinical trials smarter and support new drug approvals.

This study tests a digital self-management and peer mentoring program for young adults (ages 18-25) who survived childhood cancer. The goal is to help them take charge of their lifelong follow-up care as they move from pediatric to adult health services. The program aims to impro…

This study was designed to see if rotating a person horizontally could produce clear CT images for guiding cancer radiation therapy. It involved cancer patients who were already receiving radiation treatment. The approach used a fixed imaging system and a special rotation device,…

This study tests whether an educational video can help adults with serious cancer understand and use palliative care, which focuses on relieving symptoms and improving quality of life. About 172 participants will be split into two groups: one gets standard care plus brochures, th…

This study follows 150 cancer patients aged 65 and older who are receiving radiation therapy. Researchers will track how well they complete treatment, how their daily function changes, and any side effects they report. Participants fill out surveys and do physical and thinking te…

This study looks at whether a support program can help rural hospitals in Iowa meet national cancer care quality standards. Researchers will work with hospital staff to provide training and resources, then check if cancer treatment improves. About 31 hospitals and staff are invol…

This study looks at why some adults with advanced cancer are afraid to take opioids for pain, even when prescribed. Researchers will survey 50 patients to understand how fear, anxiety, and depression affect pain relief and medication use. The goal is to learn more about these bar…

This study compares how a single exercise session changes immune cells and inflammation in cancer patients undergoing chemotherapy and in healthy people of the same age. Researchers will measure natural killer cells and other immune markers before and after exercise. The goal is …

This study surveys 1,000 radiation oncology providers at Duke Cancer Center to understand their experience using telehealth instead of in-person visits during COVID-19. Researchers want to know if virtual visits led to missed appointments or more emergency room visits. The goal i…

This study was designed to track immune system recovery and test a pneumococcal vaccine (PCV-21) in people receiving CAR-T therapy for blood cancers or solid tumors. Participants would have had regular clinic visits and blood tests for up to 24 months. However, the study was with…

This study follows over 19,000 older adults who previously took part in a large aspirin trial. Researchers are monitoring long-term health outcomes like cancer, dementia, heart disease, and disability to see if aspirin has any delayed effects. No new medication is given—participa…

This study follows over 32,000 people who helped clean up the 2010 Deepwater Horizon oil spill or lived in affected areas. Researchers compare their health to people who were not exposed, using medical exams, lab tests, and phone interviews every two years. The goal is to learn a…

This study tests whether a computer character that talks and gestures can help cancer patients report their symptoms more completely. About 100 adults with gastrointestinal or head and neck cancer will use the system during treatment. The goal is to see if this approach reduces m…

This study tests an online questionnaire called CHAMP that older adults (65+) with cancer can fill out before their doctor visit. The tool helps doctors understand each patient's overall health to make better treatment decisions. About 180 participants from four hospitals will us…

This study looks at blood samples from 25 cancer patients receiving radiotherapy to find specific gene patterns that show how each person's body responds to radiation. Researchers will test these samples before and during treatment to identify markers that could help personalize …

This study tests new MRI guidance software (Philips iSuite) to see if it helps doctors place needles more quickly and accurately during biopsies and tumor ablations. About 12 people already scheduled for an MRI-guided procedure will take part. The goal is to compare this new soft…

This study collects blood samples from people who have unexpected or severe side effects from drugs they are taking as part of another NIH trial. The goal is to measure drug levels in the blood to better understand why side effects happen in some people but not others. Up to 100 …

This study examines how the COVID-19 pandemic impacted cancer diagnoses in Bavaria, Germany, by analyzing over 438,000 cases from 2018 to 2023. Researchers aim to identify which regions and cancer types saw the biggest drops in new diagnoses, especially for cancers with regular s…

This study is gathering health information from one million people across Africa to better understand diseases like heart disease, cancer, and diabetes. Researchers will look at risk factors such as weight, blood pressure, and smoking to see how they affect disease rates. The goa…

This study measures two substances in the blood, IGF-1 and IGF-1Ec, in 100 adults with solid tumors. Researchers want to see if higher levels of these markers are linked to larger tumors or more advanced cancer. The goal is to learn whether these blood tests could one day help do…

This study aimed to see if cancer patients' mindsets—their beliefs about their illness and body—could influence their physical and mental health during treatment. Researchers planned to follow newly diagnosed patients and test a short mindset intervention. However, the study was …

This study looks at whether a remote monitoring tool can help track symptoms and quality of life in people over 65 being treated for cancer. About 33 participants will fill out weekly questionnaires about side effects and complete surveys on their well-being. The goal is to see i…

This study looks at different ways to give people their genetic test results. Researchers want to see if using a website or chatbot is as good as talking to a genetic counselor by phone or video. About 2,500 adults from a biobank who have certain genetic changes linked to cancer …

This study looks at how often and when doctors talk with seriously ill patients about their care wishes. It includes up to 5,000 adults with cancer, heart failure, COPD, or dementia. The goal is to find ways to make these important conversations happen earlier and more often.

This study tests whether a wearable skin sensor can detect different levels of pain in 37 adults with cancer or COPD who have persistent pain. Participants wear the device for up to a week and report their pain levels. The goal is to create an algorithm that alerts caregivers whe…

This study follows up to 60 adults who have already received an experimental cancer treatment called SynKIR CAR T cells. The goal is to monitor long-term safety and check how well the therapy continues to work over time. Participants do not receive any new treatment in this study…

This study looks at information already collected from over 566,000 AARP members aged 50 to 71. Researchers want to find out how diet and lifestyle choices relate to cancer, chronic diseases, and death. No new participants are being recruited, and no treatments are being tested.

This study tests a training program called CASCADE for family caregivers of people newly diagnosed with advanced cancer. The goal is to see which parts of the training best help caregivers support their loved one in making medical decisions. 256 caregivers will receive different …

This study surveys 100 cancer patients at a pain clinic to understand how they use cannabis and CBD, including how often and why they use it (e.g., for pain or other symptoms), and where they get their information. The goal is to gather information, not to test a treatment. Parti…

This study looks at a program that lets cancer patients get hospital-level care at home. Researchers want to understand patients' experiences and see if the program improves quality of life. About 40 adults with cancer who are already in the program will answer questionnaires.

This study looks at whether eating nuts is linked to a lower risk of diseases like diabetes, heart disease, cancer, and dementia. Researchers will combine data from over 1 million adults worldwide to get clearer answers. The goal is to understand if nuts can help prevent these co…

This study was designed to measure how well the healthcare system supports adolescents and young adults (ages 12-39) living with advanced or recurrent cancer. Researchers planned to survey patients, caregivers, and clinicians about their experiences with emotional, spiritual, and…

This study looks at whether wearable devices (like smartwatches) can help cancer survivors track their symptoms at home. About 20 people will wear the device and report how they feel. The goal is to see if this approach is practical and can improve care.

This study is watching how the Galleri® blood test, which looks for many types of cancer early, works when used in regular doctor visits. About 14,000 adults who chose to take the test are taking part. The goal is to see how well the test finds cancer signals and how patients fee…

This study tests a new way to deliver radiation therapy for cancer using an MRI machine built into the radiation device. The goal is to see if real-time imaging can help doctors target tumors more precisely and reduce side effects. About 377 adults with any type or stage of cance…

This study looks at medical records of 50 cancer patients who say cannabis helped stop their tumor from growing or shrink it. Researchers want to see if there is real evidence behind these claims. The goal is to gather information, not to test a new treatment.

This study collects blood and urine samples from 1,000 adults who are getting radiation therapy for cancer. Researchers want to see how radiation changes genes in white blood cells, damages red blood cells, and alters hormone levels. Samples are taken before, during, and after tr…

This study provides standard cancer care to up to 10,000 patients at the National Cancer Institute. It collects medical information from participants to help researchers better understand cancer and improve future treatments. Participants receive routine treatments, not experimen…

This study looks at whether it is possible to track memory and concentration changes in adults aged 65 and older who are starting a type of cancer treatment called immune checkpoint inhibitors. Over six months, 30 participants will take simple memory and thinking tests every six …

This study tests whether a group education program can help medically underserved women and racial/ethnic minorities with BRCA 1 or 2 mutations better follow recommended cancer screenings and risk-reducing procedures. About 30 participants will take part to see if the approach is…

This study looks at whether the standard blood test given to pregnant women to check for fetal genetic conditions can also reveal signs of cancer in the mother. Researchers will analyze DNA from 300 pregnant women who have or develop cancer during pregnancy. The goal is to identi…

This study looks at how diet, lifestyle, and genetics influence the risk of getting endometrial cancer. Researchers will compare women who have or had the cancer with those who do not. The goal is to identify factors that may lead to the disease. About 1,315 women from New Jersey…

This study was designed to test a new imaging agent called 68Ga-FAPI-46 in people with solid tumors. The goal was to see if a PET/CT scan using this agent could predict how well a patient's tumor would respond to antibody-based therapy. The study was withdrawn before enrolling an…

This study aimed to see if adding simple visual summaries to consent forms helps cancer patients better understand and feel less anxious about joining clinical trials. It was designed for adults with cancer who were already considering a trial. However, the study was withdrawn be…

This study looks at whether a blood test (liquid biopsy) can find cancer mutations as well as the standard tissue biopsy in 1,500 advanced cancer patients. The goal is to see if the blood test helps doctors choose better treatments and saves healthcare money. Participants either …

This study looked at whether regular screening for prostate, lung, colorectal, and ovarian cancers can reduce deaths from these diseases. About 155,000 men and women aged 55-74 were randomly assigned to either get screened or receive usual care. Researchers tracked cancer cases a…

This study looks at whether a special health check for older adults (called a geriatric assessment) can help them and their caregivers talk more effectively with doctors about age-related concerns during cancer treatment. About 479 patients, caregivers, and clinic staff are takin…

This study looks at the cells and non-cellular material (stroma) inside benign and malignant tumors. Researchers will analyze samples from 7,000 patients collected since 2000 at Brest University Hospital. The goal is to describe what makes up the tumor environment, not to test a …

This study tests whether artificial intelligence (AI) can accurately summarize conversations between doctors and patients with advanced cancer about their care goals. About 60 patients from Dana-Farber Cancer Institute will have their serious illness talks summarized by an AI pro…

This study looks at why some African American women don't exercise often and tests whether teaching them to support a partner's exercise habits can help them become more active. About 80 sedentary women aged 18-65 will take part. The goal is to see if this buddy approach increase…

This study looks at how the immune system in the gut changes when people with cancer receive immunotherapy. Researchers will take small tissue samples from the gut and blood samples before and during treatment. The goal is to learn more about the body's response, not to test a ne…