CANCER

This early-stage study is testing whether taking lactulose, a common sugar, can improve the effectiveness of immunotherapy drugs for people with advanced cancer. Researchers believe lactulose may help by changing the types of bacteria in the gut. The study will enroll about 55 ad…

This UK trial is testing whether two already-approved cancer drugs, dabrafenib and trametinib, can effectively treat rare cancers or common cancers with a rare genetic change called a BRAF V600 mutation. The study will enroll about 30 adults and children with various cancers that…

This study is testing whether a supervised exercise program can help protect the hearts of breast cancer survivors. Many life-saving cancer drugs can damage the heart over time. Researchers will compare heart health in women who complete a 16-week exercise program against those w…

This early-stage study is testing the safety of combining a targeted cancer drug (Trastuzumab Deruxtecan) with precise radiation therapy for people with HER2-positive breast cancer that has spread to the brain. The goal is to see if this combination can better control the cancer …

This study is testing whether a personalized support program can help teenagers and young adults with cancer take their oral medications as prescribed. Researchers will compare the personalized program to standard care in 160 participants aged 15-25. The goal is to see if the tai…

This study is testing a new program called ONLOOP that reminds adult survivors of childhood cancer in Ontario to get important health screenings. Many survivors are at higher risk for heart problems, breast cancer, or colon cancer due to their past cancer treatments, but often mi…

This study is testing a new system to help cancer survivors manage their weight through exercise. Doctors will use a simple 3-step plan (assess, advise, refer) to connect eligible patients with a weight management program. The goal is to see if this structured approach gets more …

This study is testing a new drug called GFH276 in adults with advanced cancers that have a specific genetic change called a RAS mutation. The main goals are to find a safe dose and see if the drug can shrink tumors in cancers like pancreatic, lung, and colorectal cancer. It is an…

This study is testing whether using an artificial intelligence (AI) system to guide how much fluid patients receive during major cancer surgery leads to more stable blood pressure and better recovery. Researchers will compare the AI-guided approach to standard fluid management in…

This study tests whether a new care coordination program helps cancer patients better manage chronic conditions like high blood pressure, diabetes, and high cholesterol during cancer treatment. Researchers will compare patients who receive the new program to those getting usual c…

This study tests a personalized care program for adults 65 and older who are receiving chemotherapy. Researchers will create individual support plans based on each person's health needs and check in weekly for 12 weeks. The goal is to help manage treatment side effects better and…

This study aims to see if a computer program using artificial intelligence (AI) can help emergency room doctors find early signs of lung cancer, COPD, and heart failure on chest X-rays. It will compare how many new cases are found when doctors use the AI tool versus when they don…

This study aims to test a new, more comprehensive health check for people at higher risk of lung cancer. It will offer 500 eligible adults in Glasgow a single clinic visit that includes a low-dose CT lung scan, a blood test, a heart trace, and a breathing test. The goal is to see…

This study is testing a new type of PET scanner to see if it can take better pictures of cancer inside the body. Researchers will compare images from the new scanner to those from a standard machine in 25 adult cancer patients. The goal is to see if the new technology can provide…

This study is testing a blood test called Galleri that looks for signs of many different cancers. It will enroll about 100 adults who have symptoms that could be cancer. The main goal is to see how well this test works compared to standard diagnostic methods for finding cancer in…

This study is testing if glutamine, a common amino acid supplement, can prevent nerve damage (neuropathy) caused by the chemotherapy drug vincristine in children and teens with cancer. Researchers will give glutamine to some participants and compare their rates of nerve damage an…

This study aims to create and test a practical system for hospitals to offer and give recommended vaccines to adults with chronic diseases or weakened immune systems. It will involve 1,500 patients, offering vaccines during their hospital visits or stays. The goal is to see if th…

This trial aims to see if a daily cholesterol-lowering pill (rosuvastatin) can safely prevent life-threatening blood clots in people with cancer. It will involve 4,000 patients who are at higher risk for clots but are not taking blood thinners. The study compares the statin to a …

This study aims to find the best topical treatment to prevent phlebitis, a painful inflammation of the veins, in patients receiving chemotherapy. Researchers will compare three substances—sesame oil, aloe vera gel, and nitroglycerin ointment—applied to the skin where the IV is pl…

This study aims to see if a special breathing and exercise program can improve the quality of life for people with advanced non-small cell lung cancer. The program is for patients who are already receiving ongoing immunotherapy and chemotherapy to control their cancer. Researcher…

This study aims to see if inhaling cardamom or peppermint essential oils can help reduce the nausea and vomiting that often comes with chemotherapy. It will compare the two scents to see which one works better at controlling these side effects and helping patients maintain their …

This study is testing whether a self-guided mobile app can help people with a history of cancer manage emotional distress. Researchers want to see if the app is easy to use and if it improves mood, coping skills, and quality of life. Participants will use the app for 8 weeks and …

This study is testing a new, easy-to-use mindfulness program delivered by daily text messages. It aims to help people who have finished treatment for early-stage breast, prostate, or colorectal cancer and are experiencing mild to moderate depression. The goal is to see if this br…

This pilot study aims to test three different programs designed to help older cancer survivors who are experiencing memory and thinking problems after finishing their cancer treatments. Researchers will compare an exercise program, a brain training program, and a combined program…

This study is testing whether adding a wearable device, like a smartwatch, to an existing remote symptom-tracking program helps cancer patients and their care teams. It aims to see if the device is easy for patients to use and if the data it collects relates to the symptoms patie…

This study aims to see if a Traditional Chinese Medicine (TCM) regimen can help ease a cluster of common and distressing symptoms in ovarian cancer patients, including fatigue, poor sleep, distress, and sadness. About 316 participants will be randomly assigned to receive either t…

This study aims to help children and teenagers who have finished cancer treatment recover their physical strength and overall well-being. Researchers will test whether combining different types of therapy—including guided exercise, video game workouts, and muscle stimulation—work…

This study is testing whether a specialized form of psychotherapy called the EMDR Toolbox Method can improve the psychological wellbeing of people diagnosed with cancer. It will compare this new method to standard EMDR therapy in 46 participants to see which is more feasible and …

This study aims to see if a 12-week physical exercise program can improve the quality of life, reduce frailty, and help with mental health for people being treated for multiple myeloma, a type of blood cancer. Researchers will compare a supervised exercise group with a home-based…

This study aims to see if listening to calming music during a patient's first radiation therapy session can make the experience easier. Researchers will compare 72 cancer patients receiving standard care to those who also get a 15-20 minute music therapy session. They will measur…

This study is testing whether a supervised exercise program can help women with breast or gynecological cancer who have lost significant muscle mass and strength (a condition called sarcopenia). Researchers will compare the effects of exercise on muscle strength, body composition…

This study is testing whether a 10-week virtual exercise program with peer support can help older adults with cancer become more physically active and improve their well-being. Researchers will compare three groups: one gets a peer buddy plus a coach, one gets just a peer buddy, …

This study will test a support program and a digital screening tool designed to help family members of colorectal cancer patients. The goal is to see if this support reduces psychological distress, improves coping skills, and meets family needs better than usual care. Researchers…

This study is testing whether a remote monitoring system using a Fitbit and weekly symptom surveys can help patients better manage side effects during cancer immunotherapy. Researchers want to see if this digital tool is easy for patients to use and if it improves their quality o…

This study is developing an online program called On-Trac to help adult cancer survivors learn skills to manage anxiety. The program uses techniques from established talk therapies and is delivered through group video sessions and individual coaching. Researchers will test if the…

This study aims to see if palliative care delivered through scheduled video calls is as helpful as traditional in-person visits for adults with cancer. Palliative care focuses on improving quality of life, managing symptoms, and providing support for patients and families. Resear…

This study is testing a mobile phone app designed to help women taking hormone therapy for early-stage breast cancer. The app helps them track and manage treatment side effects, with the goal of helping them stay on their medication as recommended. Researchers will enroll 60 wome…

This study examines whether involving palliative care specialists early during unplanned hospitalizations helps patients with advanced cancer. It focuses on reducing aggressive treatments near the end of life and improving quality of life. The research will compare outcomes for n…

This study will test if a guided self-help workbook based on Cognitive Behavioral Therapy (CBT) can help cancer patients manage anxiety and depression. About 108 adult cancer patients in Pakistan who can read Urdu and are experiencing psychological distress will participate. The …

This study is testing whether a simple handheld device can make it easier for cancer patients to get their IV chemotherapy. Patients will squeeze a palm-sized device with bumps during the needle insertion to see if it reduces pain and fear. The goal is to provide a drug-free, eas…

This study is testing whether personalized cooking and nutrition advice can help slow muscle loss in people with advanced cancer. About 200 adults on chemotherapy will receive either standard nutrition care or that care plus tailored food guidance based on their taste changes and…

This study aims to help family and friends who care for seriously ill older veterans living in rural areas. It will test whether connecting these caregivers with a trained community health worker for six months can reduce their stress and improve their satisfaction with care. The…

This study is testing a new at-home system designed to help young adult cancer survivors who have trouble sleeping. The system uses a smart speaker, lights, and Wi-Fi router to deliver a proven sleep therapy program without needing a screen or an in-person therapist. Researchers …

This study is testing whether sildenafil, a medication commonly known as Viagra, can help prevent or reduce the 'brain fog' and severe fatigue that often come with cancer treatment. It will involve 30 women with a specific type of breast cancer who are receiving standard chemothe…

This study is testing if a supervised 30-minute bike ride, done right before a patient's chemotherapy or immunotherapy infusion, is a safe and practical way to help them maintain their fitness and energy levels during treatment. It will involve 80 adults with certain types of bre…

This study is testing a new AI chatbot tool designed to help cancer patients and their caregivers, especially those living in rural areas, manage the high costs of care. About 60 participants will try one of two chatbot versions to get information on insurance, travel expenses, a…

This study is testing whether a virtual reality (VR) hypnosis program can improve sleep for young people who have survived childhood cancer. Researchers will compare the VR hypnosis to standard talk therapy (CBT-I) and a simple VR relaxation program in 186 participants. The goal …

This study is testing a 4-week online self-help program designed to support the mental and emotional well-being of people who have recently finished curative cancer treatment. It will see if the program is easy to use and acceptable, and if it shows early signs of improving feeli…

This study is testing if a phone app can help people scheduled for cancer surgery get stronger and feel less anxious before their operation. About 60 adults will use the app for weekly walking tests and daily check-ins on exercise, nutrition, and mood. Researchers will compare th…

This study aims to understand how having type 2 diabetes affects quality of life for cancer patients receiving immunotherapy. Researchers will follow 920 patients for six months, comparing quality-of-life changes between those with and without diabetes. Participants will complete…

This study aims to understand the real-world challenges and supports for getting timely cancer treatment. Researchers will conduct interviews and group discussions with about 120 Texas residents who have breast, colorectal, lung, or prostate cancer. The goal is to identify the ma…

This study aims to understand the quality of care young adults with advanced cancer receive, especially near the end of life. Researchers will survey and interview 70 patients, their caregivers, and clinicians to measure unmet needs in emotional support, communication, and sympto…

This study aims to find the best ways for universities and local health departments to work together to bring proven cancer prevention and control programs to communities. It will involve 28 partnerships across the U.S., testing whether providing tailored support helps these team…

This study is testing whether wearable health devices (like smart watches) can be easily used to monitor patients during combined chemotherapy and radiation treatment for cancer. Researchers want to see if collecting daily health data (like heart rate and steps) helps doctors and…

This study aims to identify where young adults with cancer feel they lack information and support. Researchers will ask 300 people, diagnosed between ages 15-39, to complete questionnaires about their experiences. The goal is to find gaps in education on topics like fertility, ex…

This study aims to test different AI-generated messages about alcohol use and cancer risk. Researchers want to see if certain message styles can change cancer survivors' perceptions about alcohol harm and their intentions to reduce drinking. The study involves 850 adult cancer su…

This study aims to develop a blood test to predict which cancer patients are most likely to develop dangerous blood clots during chemotherapy. Researchers will track 380 patients with lung, ovarian, pancreatic, or stomach cancer, taking blood samples at four points during their t…

This study is testing a new AI tool designed to help match cancer patients with clinical trials they might be eligible for. The tool scans electronic health records to identify patients whose cancer is progressing and suggests relevant trials to their doctors. The goal is to see …

This study aims to understand if cancer patients are willing to share information about their social and economic backgrounds during clinical trials. Researchers will ask 1,000 participants about factors like income, education, housing, and experiences with discrimination. The go…

This study is testing a new computer tool that uses artificial intelligence (AI) to help doctors and medical physicists review radiation treatment plans for prostate cancer. The tool highlights potential errors and differences in how doctors plan treatments, aiming to catch mista…

This study is testing a digital app designed to help cancer patients understand their genetic test results. The goal is to see if using the app reduces patient distress and improves knowledge compared to receiving standard information from pamphlets or videos. The study will invo…

This study aims to find markers in the blood that can predict how well a cancer patient will respond to immunotherapy and what side effects they might experience. Researchers will collect blood samples from 100 adults with cancer who are starting immunotherapy treatment. The goal…

This study is testing a program called 'My Care My Voice' designed to make it easier for patients with advanced cancer and their doctors to talk about palliative care. Palliative care focuses on managing symptoms and improving quality of life, and earlier conversations about it c…

This study aims to test if a simple electrical device can accurately measure fluid buildup (swelling) in the arms or legs of cancer patients. It will involve 46 patients in Denmark who have swelling after chemotherapy or radiation. Researchers will compare the device's readings a…

Healthspan Connect is a large UK research programme aiming to understand what helps people stay healthy as they age. It will follow 100,000 participants, aged 12 and up, to explore how lifestyle, environment, genetics, and social factors influence long-term health and wellbeing. …

This study will follow one million adults in China for up to 10 years to learn how Traditional Chinese Medicine (TCM) concepts of body types relate to the development of modern chronic diseases like heart disease, cancer, and diabetes. It is an observational study, meaning resear…

This study aims to see if an intensive, yearly cancer screening program is practical and acceptable for veterans who were exposed to burn pits during military service. It will enroll 100 veterans to undergo multiple screening tests over three years. The research will also explore…

This study aims to understand how satisfied patients are with the look and function of their lower lip after reconstructive surgery, which is often needed after cancer removal. Researchers will look back at the experiences of 20 patients and also gather opinions from their surgeo…

This study aims to see if simple blood tests can detect cancer markers as effectively as invasive tissue biopsies. Researchers will enroll 620 patients with various cancers, focusing on lung cancer, to compare blood test results with traditional biopsy methods. The goal is to dev…

This study is testing a Turkish version of a survey designed to measure the financial burden and stress (often called 'financial toxicity') experienced by cancer patients. Researchers will ask 320 Turkish-speaking adult cancer patients who are currently receiving treatment to com…

This study aims to collect information about how cancer patients use cannabis products. Researchers will follow 45 patients who report using cannabis, asking them to track their usage in a smartphone app. The goal is to better understand why patients use cannabis, what types they…

This study aims to learn more about the side effects that can occur when cancer patients receive immunotherapy drugs. It will follow 500 adult patients with various cancers to track when these side effects happen, how severe they are, and how they are managed. The goal is to gath…

This study aims to understand why cancer sometimes runs in families. Researchers will collect blood, saliva, and tumor samples from people with cancer and their relatives to look for inherited genetic changes. The goal is to find new genetic links to cancer risk that could help f…

This study aims to understand why cancer patients and healthcare professionals at a hospital in Martinique do or do not participate in clinical trials. Researchers will interview 30 patients and survey doctors and nurses to identify the main barriers and motivators. The goal is t…

This study aims to understand how safe current practices are for managing blood thinners in people with cancer who need surgery or medical procedures. Researchers will observe 700 patients to measure how often serious bleeding or dangerous blood clots happen after surgery. The go…