CANCER

This trial tests whether two drugs already approved for certain skin and lung cancers can help people with rare cancers that have a specific gene change called BRAF V600. About 30 adults and children with various rare cancers will receive dabrafenib and trametinib. The goal is to…

This study tests whether lactulose, a type of sugar, can make immunotherapy more effective for people with advanced cancer. About 55 participants will take lactulose alongside their standard immunotherapy drugs. The goal is to see if lactulose increases helpful gut bacteria and i…

This study tests a new way to give radiation therapy for several pelvic cancers (prostate, endometrial, cervical, and rectal). The approach uses daily scans to adjust the radiation beam to the exact shape of the tumor, allowing for fewer but stronger treatments. The goal is to se…

This study tests whether a 16-week supervised exercise program can help prevent heart damage in breast cancer survivors. Many breast cancer treatments can harm the heart, and this trial aims to see if regular exercise can protect it. The study will include 44 women who finished c…

This trial tests a program called ONLOOP that reminds adult survivors of childhood cancer to get important screening tests. These tests can catch serious late effects like heart disease or second cancers early. About 900 survivors in Ontario will be randomly assigned to use ONLOO…

This study tests whether a pharmacist-led program can help adult cancer outpatients take their medications correctly and avoid errors. One hundred participants will receive either usual care or extra pharmacist counseling, medication review, and follow-up. The goal is to improve …

This early-phase trial tests the safety of a new drug, IM-1617, in about 175 adults with advanced solid tumors (colorectal, lung, breast, stomach, esophageal, or other cancers that have spread or can't be removed by surgery). The study first finds a safe dose, then checks how wel…

This early-stage trial tests an experimental drug called RP-001 in 66 adults with advanced solid tumors, including colorectal and pancreatic cancers. The main goal is to check the drug's safety and find the best dose. Researchers will also look for signs that the drug shrinks tum…

This early-phase study tests a drug called trastuzumab deruxtecan (T-DXd) combined with precise radiation (SRS) for people with HER2-positive breast cancer that has spread to the brain. The goal is to find the safest dose of the drug when given with radiation and to see how well …

This study tests whether artificial intelligence can guide how much fluid patients receive during major cancer surgery to keep their blood pressure more stable. About 176 adults having long cancer operations will be randomly assigned to either AI-guided fluid management or standa…

This study tests a new drug called GFH276 in people with advanced cancers that have RAS mutations, including pancreatic, lung, and colorectal cancers. The goal is to see if the drug is safe and can shrink tumors or slow disease. About 450 adults aged 18-75 will take part in two p…

This early-phase study tests a new mRNA treatment (NCP-IL-22BP mRNA) in 9 people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors to help the body fight cancer. The main goal is to check safety, and researche…

This study tests a new treatment for people with advanced head and neck cancer that cannot be removed by surgery. The treatment combines two immunotherapy drugs (iparomlimab and tuvonralimab) with a special type of radiation and standard chemotherapy. The goal is to see if this a…

This study tests a program called Primary Care Connect (PC2) for cancer survivors who also have heart-related conditions like high blood pressure, diabetes, or high cholesterol. The goal is to see if the program helps them stay connected to their primary care doctor and better ma…

This early-phase trial tests a protein from snake venom (crotoxin) given through an IV to people with advanced solid tumors that no longer respond to standard treatments. The main goal is to see if slowly increasing the dose can reduce side effects and allow higher, potentially m…

This study tests whether a computer program can help emergency doctors spot heart failure, COPD, and cancer from chest X-rays. About 25,000 adults will be included. The goal is to see if using the program leads to more early diagnoses compared to standard care.

This study will test a blood test called GRAIL Galleri that looks for signs of many different cancers. Researchers want to see how well it works in people who already have symptoms that might be cancer. About 100 adults will take the test, and the results will be compared to stan…

This study tests whether taking rosuvastatin (a statin) daily for one year can safely prevent life-threatening blood clots in people with cancer. About 4,000 adults with newly diagnosed or relapsed cancer who are at high risk for clots will receive either the drug or a placebo. T…

This study compares three simple topical treatments—sesame oil, aloe vera gel, and nitroglycerin ointment—to prevent phlebitis (vein inflammation) caused by chemotherapy. About 190 adults with breast or colon cancer receiving certain chemo drugs through a peripheral IV will be en…

This study tests whether a natural supplement called glutamine can prevent nerve damage caused by the chemotherapy drug vincristine in children and teens with cancer. About 70 participants aged 6 to 18 will take glutamine twice daily for 14 days during treatment. Researchers will…

This study looks at whether inhaling cardamom oil can reduce nausea, vomiting, and improve food intake in cancer patients undergoing chemotherapy, and compares it to peppermint oil. About 39 adults who have already had at least one round of chemo will take part. The goal is to fi…

This study tests whether personalized cooking and food guidance can help slow muscle loss and improve quality of life in adults with advanced cancer who are on chemotherapy. About 200 participants will be split into two groups: one gets standard nutrition care plus exercise advic…

This study tests a community-based program for 30 adults with cancer who want help managing daily activities. The program includes group workshops and hands-on activities to improve quality of life and well-being. Researchers want to see if it works in a real-world setting.

This study tests whether combining physical exercise with electrotherapy and exercise video games helps children and teens who have finished cancer treatment recover their strength, balance, and quality of life. About 45 participants aged 3 to 16 will be randomly assigned to diff…

This study tests whether a smartphone app that guides patients through exercises, nutrition tracking, and mood check-ins before cancer surgery can improve their physical function and reduce anxiety. Sixty adults scheduled for elective cancer surgery will either use the app or rec…

This study tests a smart home system (smart speaker, lights, and Wi-Fi router) that uses artificial intelligence to deliver insomnia therapy to young adult cancer survivors at home. The goal is to improve sleep and quality of life. About 74 participants aged 18-42 with a history …

This study looks at whether trained community health workers can reduce the stress and workload of people caring for older veterans with serious illnesses like dementia or cancer. About 480 rural caregivers will either get extra support connecting to resources or continue usual c…

This study tests a daily digital mindfulness program designed to reduce depressive symptoms in people who have finished treatment for early-stage breast, prostate, or colorectal cancer. About 76 participants will listen to short audio exercises each day for several weeks. The goa…

This study looks at whether a 12-week resistance exercise program can improve quality of life, reduce frailty, and boost mental health in people with multiple myeloma. Fifty patients will be split into two groups: one doing supervised exercise and the other doing the same exercis…

This study tests whether a specially designed chatbot can reduce stress and anxiety in adults recently diagnosed with cancer. Participants will use the chatbot for 12 weeks and complete questionnaires about their emotional well-being. The goal is to see if the chatbot offers extr…

This study looks at whether sildenafil (the drug in Viagra) can ease fatigue and thinking problems caused by cancer treatment. About 30 women with breast cancer will take the drug and report their symptoms. The goal is to see if it helps with memory, focus, and energy.

This study tests whether a supervised exercise program can improve muscle strength, muscle mass, and physical performance in women with cancer-related sarcopenia (muscle loss). Researchers will enroll 78 women who have completed primary cancer treatment and have low muscle streng…

This study looks at whether starting palliative care early during an unplanned hospital stay helps people with advanced cancer avoid harsh treatments near the end of life. About 493 adults with metastatic digestive, gynecological, ENT, or sarcoma cancers who are on palliative tre…

This study tests an online program called Finding My Way-UK for people who finished cancer treatment within the past year. About 60 participants will either use the four-week self-guided program or receive a list of support resources. The goal is to see if the program is easy to …

This study tests a support program (FamCASP) for adult family members of people with colorectal cancer. The program includes a digital screening tool and aims to reduce stress, improve coping, and meet family needs. Researchers will compare families who get the support with those…

This study tests a Traditional Chinese Medicine (TCM) regimen designed to ease a group of common symptoms in ovarian cancer patients, including trouble sleeping, fatigue, distress, and sadness. The trial will involve 316 participants and compare the TCM approach to a placebo to s…

This study looks at whether listening to calming music during the first radiation session can lower anxiety, stress, and pain in cancer patients. About 72 adults starting radiation will be split into two groups: one gets standard care, the other also hears 15-20 minutes of medita…

This study tests whether a digital platform called Beacon can help doctors better manage symptoms in people with advanced cancer. About 40 patients will wear a smartwatch and answer questions about how they feel. The platform combines this data to give doctors a clearer picture o…

This study tests whether virtual reality (VR) hypnosis can improve sleep in Chinese teens who have survived cancer. 186 participants aged 12-18 will be randomly assigned to VR hypnosis, standard sleep therapy (CBT-I), or VR relaxation. The goal is to see if VR hypnosis is a safe,…

This study looks at whether a structured exercise program can improve physical function, fitness, and quality of life in women with metastatic breast cancer. About 78 women currently undergoing treatment will take part. The program focuses on strength, endurance, and body composi…

This study tests whether a smartphone app called the Cancer Exercise app (CEA) can help cancer survivors become more physically active. 750 adults who have finished cancer treatment will either use the app for 12 weeks or receive usual care. The goal is to see if the app increase…

This study tests whether a small handheld device with bumps, called a Palm Stimulator, can help reduce pain, fear, and anxiety when cancer patients get an IV for chemotherapy. About 90 adults will be randomly assigned to either squeeze the device during the procedure or receive s…

This study tests a web-based program designed to help people with advanced cancer manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. About 40 patients and their partners will use the program to track symptoms and get person…

This study tests a new medicine called DS010 in 58 adults with cancer who are experiencing cachexia—a condition causing severe weight loss and muscle loss. The goal is to see if DS010 is safe and can help patients gain weight and improve muscle mass. The trial has two phases: fir…

This study tests whether a tailored program can help teens and young adults (ages 15-24) with cancer take their oral medications more consistently. Participants will use an electronic pill bottle to track adherence and complete surveys about their quality of life. The goal is to …

This study looks at whether having a detailed initial meeting with a psycho-oncology counselor soon after a cancer diagnosis can lower anxiety and depression and improve quality of life. About 148 newly diagnosed cancer patients will be randomly assigned to either receive this ex…

This study tests a guided self-help CBT manual called 'Khushi or Khatoon' for cancer patients with anxiety and depression. About 108 adults with cancer and moderate to severe distress will use the manual and be compared before and after treatment. The goal is to see if it improve…

This study tests whether a virtual exercise program with a peer buddy helps older adults (60+) who have had cancer become more active and feel better. Participants are split into three groups: one gets a peer plus guidance from exercise pros, one gets peer support only, and one g…

This study looks at whether virtual palliative care (video calls) works as well as in-person visits for adults with cancer. About 252 participants will be randomly assigned to one of two groups: virtual care or standard clinic care. The goal is to see if virtual care can improve …

This study looks at whether a respiratory rehabilitation (breathing exercise) program can improve quality of life for people with advanced non-small cell lung cancer who are on maintenance chemotherapy and immunotherapy. About 96 participants will either join the rehab program or…

This study tests a mobile health tool to help women on hormone therapy for breast cancer understand and manage side effects. Researchers will enroll 60 women to see if the app is easy to use and helps them stay on their medication. The goal is to improve quality of life and treat…

This study tests whether eating only within an 8-hour window each day (time-restricted eating) can reduce side effects and improve well-being in 50 adults with solid tumors starting adjuvant therapy after surgery. Participants will follow either the time-restricted eating plan or…

This study tests whether a mobile app called Tools for Coping with Cancer can help people with a history of cancer feel less distressed. About 50 adults who have had cancer in the last two years will use the app at home for 8 weeks. Researchers will check if the app improves mood…

This study will test whether a new method called Real-Time Image Guided Radiation Therapy (IGRT) can be used successfully in people with cancer. The goal is to see if the radiation beam can hit the tumor accurately in at least 85% of treatment sessions without causing unexpected …

This study tests whether a new collimator (a part that filters gamma rays) can improve whole-body scans in a special camera used for cancer imaging. 18 adults with multiple cancer spots will get an extra scan to see if the new part makes pictures sharper and more useful. The goal…

This study will translate and test a survey called PROFFIT, originally from Italy, to measure the financial burden of cancer treatment for Turkish patients. Researchers will enroll 320 adults who have had cancer treatment in the last three months. The goal is to ensure the survey…

This study is testing a new AI-powered chatbot designed to help cancer patients and their caregivers in rural areas get clear information about insurance, travel costs, and other financial aspects of cancer care. About 60 participants will be randomly assigned to use either a hyb…

This study looks at whether a simple 3-step program (assess, advise, refer) can help cancer survivors exercise more. About 1,800 people who finished cancer treatment in the last 5 years and have a higher body weight will take part. The goal is to see if this approach becomes a st…

This study aims to understand why few cancer patients in Martinique take part in clinical trials. Researchers will interview 30 patients and survey healthcare professionals to identify barriers and motivators. The goal is to improve participation and ensure better care for the lo…

This study aims to collect information about how and why cancer patients use cannabis. Researchers will track the type, dose, and effects of cannabis through a smartphone app. The goal is to better understand the needs and impact of cannabis use in this group. No treatment is pro…

This study will test a mobile app called RestoreMe that gives personalized nutrition advice and tracks activity for cancer patients. Researchers want to see if 150 patients find the app helpful and easy to use during or after their cancer treatment. The goal is to learn how well …

This study will collect blood samples from 100 adults with cancer who are about to start immunotherapy. Researchers will analyze the samples to find patterns in immune cells and molecules that might predict whether the treatment will work or cause side effects. The goal is to bet…

This study looks at tiny particles from tumors that can be found in the blood. The goal is to learn how these markers can help diagnose cancer, predict how well treatments will work, and understand why some cancers stop responding to therapy. About 620 adults with any type of can…

This observational study looks at how type 2 diabetes impacts quality of life in 920 cancer patients receiving immunotherapy. Participants will fill out surveys at the start, 3 months, and 6 months to track changes. The goal is to see if those with diabetes experience a greater d…

This study aims to collect health information and blood samples from 15,000 adults aged 40-70 over time. Researchers will use artificial intelligence to analyze molecular patterns in the blood to find early signs of diseases like heart disease, diabetes, cancer, and lung disease.…

This study looks at a new way to give recommended vaccines to adults with chronic diseases or weakened immune systems. Doctors will offer vaccines during hospital visits, admissions, or at discharge. The goal is to see how many patients accept and complete their vaccines, and to …

This study will follow 500 cancer patients starting or already on immunotherapy to better understand immune-related side effects (irAEs). Researchers will collect data on symptoms, lab tests, and treatments to find patterns that predict who gets side effects and how to manage the…

This study checks if a short questionnaire called G8 can accurately identify frailty in people aged 70 and older with solid tumors. Researchers will compare the G8 results with a full medical exam to see how well the tool works. The goal is to help doctors in Portugal quickly spo…

This study looks at how safe current blood thinner management is for 700 cancer patients who need surgery or medical procedures. Researchers will track bleeding and clotting problems within 30 days after surgery. The goal is to learn how to improve care and lower these risks in t…

This study aims to understand what helps people stay healthy as they get older. It will enroll 100,000 people aged 12 and up across the UK. Participants use smartphones or computers from home and may provide samples like blood or saliva. The goal is to learn how lifestyle, enviro…

This study tests whether AI-generated messages about alcohol and cancer risk can change how cancer survivors think about drinking and motivate them to cut back. About 850 adults who have had certain cancers and currently drink alcohol will receive either gain- or loss-framed mess…

This study tests an artificial intelligence tool that helps doctors and physicists review radiation treatment plans for prostate cancer before patients start therapy. The AI highlights differences in how providers plan treatments and points out warning signs to look for, aiming t…

This study looks at whether sending automated text messages to cancer patients after a hospital visit can help them use the right urgent care services instead of going to the emergency room. About 200 adults with active cancer will be randomly assigned to receive these messages o…

This study is building an AI tool called ACTIVATE that uses electronic health records to find which cancer patients might be eligible for clinical trials. Researchers will test the tool on data from up to 70,000 adults with cancer. The goal is to make it easier and faster to matc…

This study looks at whether wearable health trackers (like a Fitbit) can be easily used in a cancer clinic to monitor patients getting chemotherapy and radiation. About 20 adults with cancer will wear a device during their treatment and for 4 weeks after. The goal is to see if pa…

This study talks to 120 cancer patients in Texas to learn what makes it easier or harder to get timely cancer treatment. Researchers will interview people with breast, colorectal, lung, or prostate cancer, covering different insurance types. The goal is to identify key barriers a…

This study tests whether using a Fitbit and weekly symptom surveys can help doctors remotely monitor people with advanced melanoma who are starting immunotherapy. About 40 participants will be randomly assigned to use the digital monitoring tool or standard care. The goal is to s…

This study looks at how partnerships between universities and local health departments can help put cancer prevention programs into action. About 364 health workers and researchers will answer questions about their collaboration and the programs they offer. The goal is to find be…

This study looks at whether wearable sensors (like smartwatches) and electronic surveys are practical and acceptable for people taking part in early-phase cancer clinical trials. About 30 participants will wear a smartwatch and answer questions through a phone app for 4 weeks. Th…

This study looks at how platinum-based chemotherapy can cause permanent hearing loss in cancer patients, especially those from poorer backgrounds. Researchers will test hearing and thinking skills in 172 patients from North West England before and after treatment. The goal is to …

This study aims to discover rare genetic changes that make people more likely to develop cancer. Researchers will collect blood, saliva, and tumor samples from 100 people who have had multiple cancers or have a strong family history of cancer, along with their relatives. By seque…

This study reviews past cases of lower lip reconstruction in 20 adults who had skin cancer removed. Researchers will ask patients to rate their satisfaction with how the lip looks and works one year after surgery, and compare that with surgeons' opinions. The goal is to learn wha…

This study will test a more thorough cancer screening program for 100 veterans aged 35 and older who were exposed to burn pits during deployment. The goal is to see if this program is practical and satisfying for participants, and to find any early signs of cancer. Researchers wi…

This study will observe how adults receiving chemotherapy use digital media and how skilled they are at finding and understanding health information online. Researchers will survey 80 patients to learn about their digital habits and eHealth literacy. The goal is to better underst…

This study will follow one million adults aged 30-74 in Hubei, China, for up to 10 years. Researchers will collect health data and Traditional Chinese Medicine (TCM) body types to see how they relate to chronic diseases like heart disease, cancer, and diabetes. The goal is to cre…

This study tests a one-stop Lung Health Check for people aged 55-74 who smoke or used to smoke. It uses a low-dose CT scan plus blood tests, an ECG, and a breathing test to find lung cancer early and also spot other conditions like COPD, heart disease, and weak bones. The goal is…