Musculoskeletal system disorder

This trial tests a treatment strategy for adults with acute myeloid leukemia (AML) that did not respond to standard induction chemotherapy. Participants receive clofarabine and intermediate-dose Ara-C chemotherapy, followed by a reduced-intensity allogeneic stem cell transplant u…

Researchers test a reduced-intensity conditioning regimen before allogeneic stem cell transplant in adults with high-risk AML, MDS, or ALL who cannot tolerate standard intensive treatment. The regimen combines clofarabine, busulfan, and thymoglobulin. The trial measures relapse r…

This trial tests whether a spinal cord stimulator, implanted surgically, combined with intensive motor rehabilitation can help people with spinal cord injury regain the ability to stand and step. Ten adults with complete or incomplete spinal cord injury who cannot currently stand…

Researchers are testing an experimental antibody drug called verekitug in adults with chronic rhinosinusitis with nasal polyps, a condition where inflamed tissue grows inside the nasal passages and causes congestion. Participants receive either verekitug or a placebo injection wh…

This early-phase trial tested two cancer drugs—imatinib mesylate and cyclophosphamide—given daily by mouth to 26 people with rare, advanced tumors that had no standard treatment. The main goal was to find the safest dose of imatinib when combined with a fixed dose of cyclophospha…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

Researchers compare two common mouthwashes to see which reduces dental plaque more effectively in young patients with gum inflammation. Sixty patients aged 15 to 25 use either a chlorhexidine rinse or an essential oil rinse twice daily for three months. The team measures plaque o…

Researchers test whether antimicrobial photodynamic therapy, a light-activated treatment, can reduce bacteria in infected baby front teeth better than standard root canal cleaning. The trial enrolls children aged 2 to 5 with a single-rooted front baby tooth that has died from dee…

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

This study tests whether a substance produced by umbilical cord cells can help control moderate rheumatoid arthritis. Participants receive weekly injections of either the cell substance or a placebo for six weeks, alongside their usual medication. The goal is to see if it improve…

This phase 2 trial tested vamorolone, a drug similar to steroids, against a placebo in 46 males with Becker muscular dystrophy. The goal was to check safety and tolerability over 24 weeks, while also looking for early signs of benefit. The study is complete, but results are not y…

This phase 3 trial tests an oral drug called brepocitinib in 241 adults with dermatomyositis, a rare disease causing muscle weakness and skin rash. Participants receive either the drug or a placebo for 52 weeks to see if it improves symptoms. The study is active but no longer rec…

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This study will test a gentler way to fix cavities in children's permanent molars using the Hall Technique, which places a stainless steel crown without drilling or numbing shots. Ten children will get either the Hall Technique or the standard method (with drilling and anesthesia…

This trial investigates whether using a socket sealing abutment, with or without bone graft material, helps preserve bone and soft tissue after immediate molar implant placement. Adults aged 18-45 with non-restorable molars will receive the implant right after extraction, and the…

NUTRIREA-3 compares two feeding strategies for adults on ventilators with shock. One group receives low-calorie low-protein feeding for the first week, while the other receives standard-calorie standard-protein feeding. Researchers track survival and time to leave the ICU to see …

Researchers at Al-Azhar University are testing whether a diode laser combined with a green dye and a remineralizing agent can reduce the surface area of white spot lesions on teeth. The trial enrolls 90 people aged 13 to 40 who have good oral hygiene and no other health condition…

This study tested whether adding extra dental checkups and video calls with a dentist could improve oral hygiene in children with cleft deformities. Sixty children aged 3 to 15 took part. The program included a longer dental visit and teleconsultations every two months. Researche…

Researchers are testing whether adding tocilizumab, a drug that blocks an inflammation signal called IL-6, to standard chemotherapy helps adults with high-risk acute myeloid leukemia. Participants receive idarubicin and cytarabine, the usual induction chemotherapy, plus a single …

Researchers are testing a combination of the experimental antibody MEDI5752 and stereotactic body radiotherapy in people with metastatic soft tissue sarcoma that has spread to the lungs. MEDI5752 targets two immune checkpoints, PD-1 and CTLA-4, and the radiation is aimed at one l…

This study looks at whether the drug eplontersen can reduce abnormal protein buildup in the heart for people with a condition called ATTR-CM. About 150 participants from a larger trial will get heart scans after 140 weeks of treatment. The goal is to see if the drug helps clear t…

This study is a follow-up to an earlier trial, testing the long-term safety and effects of a drug called AOC 1001 in adults with myotonic dystrophy type 1 (DM1), a genetic muscle disease. 37 participants who completed the first study received multiple doses of AOC 1001 by IV infu…

Researchers are testing whether apremilast helps people with early psoriatic arthritis that affects only a few joints. Participants have had symptoms for five years or less and still have joint pain and swelling despite stable treatment with NSAIDs or one conventional DMARD. The …

Braces make it harder to clean teeth, which can lead to swollen, bleeding gums. Researchers are comparing two common oral care routines in 60 adults aged 18 to 35 who wear fixed braces. One group brushes with triclosan toothpaste, another brushes and rinses with chlorhexidine mou…

Researchers are testing whether giving radiation therapy before sipuleucel-T, a personalized immunotherapy vaccine, works better than the vaccine alone in men with hormone-resistant prostate cancer that has spread. The trial enrolls about 51 participants and randomly assigns them…

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

Researchers are testing whether a liposomal chemotherapy drug called CPX-351 works better than standard chemotherapy before an allogeneic stem cell transplant in adults with higher-risk myelodysplastic syndromes (MDS) or oligoblastic acute myeloid leukemia (AML). The trial enroll…

Researchers are studying a spinal implant called the EVOS Lumbar Interbody System, which uses PEEK-OPTIMA HA enhanced cages, in adults with degenerative disc disease or grade 1 spondylolisthesis in the lower back. The study follows participants who receive the device during spina…

This study is testing the long-term safety and effectiveness of bimekizumab, a drug that reduces inflammation, in 508 adults with active axial spondyloarthritis (including ankylosing spondylitis). Participants who completed earlier trials will receive the drug for an extended per…

Researchers compare two powered toothbrushes, one with a side-to-side motion and one with an oscillating-rotating motion, to see which removes more dental plaque and reduces gingivitis. About 295 healthy non-smoking adults, aged 18 to 59, brush twice daily with their assigned too…

This study tests whether watching a video about brushing and flossing is as effective as a hands-on demonstration with a 3D model for people with gingivitis (early gum disease). Eighty adults with gingivitis will receive either a video link or a live demo, and their gum health wi…

This study tests three different fluoride treatments—silver diamine fluoride gel, a special fluoride varnish, and a standard fluoride gel—to see which one best stops early childhood cavities. Ninety healthy children with at least one active cavity will receive one of the treatmen…

Researchers are testing an experimental drug called sonelokimab in adults with active psoriatic arthritis, a condition that causes painful, swollen joints along with skin psoriasis. The trial compares sonelokimab injections with placebo injections, and also includes a third group…

This trial tests two treatments for a jaw joint condition called TMJ disc displacement with reduction, where the disc that cushions the joint slips out of place but returns to normal when the mouth opens. Researchers will compare injecting hyaluronic acid, a natural lubricant, ag…

This study tests whether adding metformin, a diabetes drug, to standard methotrexate therapy helps more people with rheumatoid arthritis achieve disease control. About 128 adults with active RA who have not recently taken methotrexate will receive either methotrexate plus metform…

This trial compares root canal treatments using one, two, three, or four rotary files to see if the number of instruments affects how well dentists can reach a tricky second canal in upper molars and how much pain patients feel afterward. Adults with asymptomatic apical periodont…

This study tested a procedure that uses a patient's own growth factors to help rebuild lost jawbone. Eleven people with severe bone loss in the upper jaw received a bone graft mixed with plasma rich in growth factors. After 6-9 months, enough bone had grown to place dental implan…

This early-phase trial tests a new drug called IMM01-STEM, made from stem cell secretions, in 28 people with muscle wasting due to knee osteoarthritis. The main goal is to check safety and find the right dose. Participants receive injections and are monitored for side effects ove…

This trial tests whether patient-specific PEEK implants, custom-made plastic pieces, can rebuild the bone under the eye after surgery to remove part of the upper jaw due to tumors. The goal is to keep the eye in its natural position and avoid a sunken appearance or vision problem…

Researchers are testing whether a combination of venetoclax and a three-day course of decitabine works better than the standard pairing of venetoclax and azacitidine for older or unfit adults newly diagnosed with acute myeloid leukemia. The trial enrolls 154 participants and comp…

This study tested a special spinal implant (the Keos Lumbar Interbody Fusion Device) in 25 adults with degenerative disc disease or related spine conditions. The goal was to see how well the device helped bones fuse and how it affected pain and quality of life. Participants had s…

This phase 2 study tests a combination of two nucleoside drugs, doxecitine and doxribtimine, in 47 people with thymidine kinase 2 (TK2) deficiency, a rare genetic disorder that weakens muscles. Participants already receiving nucleoside therapy continue treatment to see if the dru…

This trial tests whether an injectable, tooth-colored filling material works as well as a conventional one for repairing cavities in back teeth. Researchers will place both types of fillings in the mouths of 38 healthy young adults, each person getting both materials in different…

This trial tests whether blood-flow-restriction (BFR) training, done before knee replacement surgery, can reduce pain and boost strength. BFR uses a cuff to partially block blood flow during low-weight exercise, which may build muscle without heavy loads. About 19 people schedule…

This trial tests whether 3D-printed dentures work as well as conventionally made ones for people who have lost all their teeth. Each participant will wear both types of dentures for a set period, and researchers will measure how accurately each fits, how much force they can bite …

This study tests a chemotherapy drug called CPX-351 in people under 60 with secondary acute myeloid leukemia (AML), a type of leukemia that develops after other blood disorders or cancer treatments. The goal is to see how well the drug can make the cancer disappear or improve blo…

This trial evaluates the long-term safety and effectiveness of mexiletine in children aged 6 to 18 with myotonic disorders, conditions where muscles have trouble relaxing after contraction. Participants, who previously completed a study of mexiletine, receive the drug for about 8…

This study tests two calcium silicate-based dental cements, Biodentine and NeoPutty, for treating irreversible pulpitis (severe tooth nerve inflammation) in adults. Sixty participants with deep cavities and spontaneous pain will receive a single-session pulpotomy, where the infla…

This study tested whether a custom digital surgical guide helps dentists perform crown lengthening more accurately than the usual method. Twenty-four adults with gummy smiles due to a condition called altered passive eruption took part. The digital guide uses 3D scans and imaging…

This study tracks 245 adults aged 18 to 60 who receive a Vivacit-E liner during hip replacement surgery. The liner is a plastic cup that fits inside the hip socket to allow smooth movement. Researchers measure how long the liner stays in place without needing removal, and they ch…

This study looked at the long-term safety and effectiveness of bimekizumab in adults with active psoriatic arthritis. Over 1,100 people who completed earlier studies received the drug and were monitored for side effects and disease symptoms. The goal was to see if bimekizumab rem…

This early-stage trial evaluates an experimental drug called ZB002, given as an injection under the skin. In the first part, healthy volunteers receive a single dose to check safety and how the drug moves through the body. In the second part, people with rheumatoid arthritis rece…

This trial compares two attachment systems, OT-Equator and Ball and Socket, used to hold a lower denture in place with a single dental implant. Researchers will measure how much force is needed to pull the denture off, along with gum health and bone levels, over 12 months. The go…

This trial tests whether combining two bone-building drugs, teriparatide and cinacalcet, works better than teriparatide alone for men with low bone mass. Researchers will give one group the combination and another group teriparatide plus a placebo for 11 months. They will measure…

This trial is testing an experimental drug called eplontersen in people with transthyretin-mediated amyloid cardiomyopathy (ATTR CM), a condition where abnormal protein builds up in the heart and leads to heart failure. The study aims to see if the drug, given as a regular inject…

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This early-phase trial tested the drug enasidenib in 17 people with low-risk myelodysplastic syndrome or a related leukemia who had anemia and did not have a specific gene mutation. The goal was to see if the drug could safely improve red blood cell counts and reduce the need for…

This trial tests whether a single injection of ICM-203, a gene therapy, can safely help people with mild-to-moderate knee osteoarthritis. The therapy delivers a gene into the knee joint that may encourage cartilage growth, reduce inflammation and pain, and improve daily movement.…

This study tests whether bimekizumab works better than risankizumab for adults with active psoriatic arthritis (PsA), a condition causing joint pain and skin lesions. About 684 participants will receive one of the two drugs for 16 weeks. The main goal is to see who gets at least …

This pilot study tested whether a butyrate supplement, a type of short-chain fatty acid, could change the gut microbiome and immune responses in people with rheumatoid arthritis who didn't respond well to methotrexate. Twenty participants took the supplement for up to two months.…

This trial tests whether repairing an isolated cleft palate at 6 months of age leads to better speech than waiting until 12 months. About 650 infants across the UK, Scandinavia, and Brazil will be randomly assigned to one of the two surgery times. Doctors will measure how well th…

This trial tests whether applying hyaluronic acid gel to exposed tooth roots during gum surgery improves healing compared with surgery alone. Researchers plan to enroll 80 adults with periodontitis who have suprabony defects, meaning bone loss that leaves pockets at least 5 mm de…

This trial tests whether regular walking with a robotic exoskeleton can improve bone health and quality of life in people with spinal cord injury. Participants will train three times a week for 26 weeks, aiming for an hour of continuous walking each session. Researchers will meas…

This trial tests whether screening for anemia at the time a patient consents to hip or knee replacement surgery, which is usually 4 to 6 months before the operation, leads to better outcomes than the standard approach of testing only 2 to 4 weeks before surgery. About 800 adults …

This trial tests whether adding venetoclax to a standard chemotherapy pair (cytarabine and mitoxantrone) can help adults with acute myeloid leukemia that has relapsed or not responded to initial treatment. In the first phase, researchers find the highest safe dose of cytarabine w…

This trial tests whether older adults with knee osteoarthritis can improve balance and mobility through a smartphone-based rehabilitation program at home, compared with the same exercises done in person at a clinic. Both groups follow a six-week program with four sessions per wee…

This study tested the drug RINVOQ in 69 adults with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Participants took RINVOQ as prescribed by their doctor and were followed for up to a year. The goal was to see how safe and effective the drug is in real…

This trial tests whether adding a laser procedure to standard deep cleaning improves gum health and quality of life in people with periodontitis. Researchers will compare two groups: one receiving scaling and root planing alone, and another receiving the same cleaning plus laser-…

This trial tests whether placing a graft made from the patient's own tooth and blood components into an extraction socket improves bone healing compared with letting the socket heal on its own. Adults with non-restorable teeth will receive either the graft or no graft, and resear…

This phase 3 trial tests an experimental drug called AOC 1001 in 159 adults with myotonic dystrophy type 1, a genetic condition that causes muscle weakness and stiffness. Participants receive either the drug or a placebo by intravenous infusion. The main goal is to see if the dru…

This trial tests whether injecting platelet-rich fibrin (a substance made from the patient's own blood) into the jaw joint, along with botulinum toxin (Botox) into a nearby muscle, improves symptoms of anterior disc displacement, a common TMJ disorder. The study includes 39 peopl…

This trial tests whether a structured early mobilization program helps people recover faster after abdominal surgery. Half of the 130 participants will follow a gradual schedule of getting out of bed within the first 24 hours after surgery, while the other half receives routine c…

This trial tests whether a gel made from fucoidan, a compound found in seaweed, can improve healing and bone regrowth in people with gum disease. The study enrolls 5 systemically healthy adults aged 25 to 55 who have periodontitis with bone defects around teeth or implants. After…

This study tests a new motorized spinal rod (ASTS) in 5 children aged 4-10 with severe early-onset scoliosis. The rod is implanted and can be lengthened remotely to correct the spine curve over time. The goal is to see if the device is safe and works as intended, potentially redu…

This trial tests whether digital tools can help people with mild to moderate hip or knee osteoarthritis manage their condition without surgery. Participants receive one of three options: usual care with a handout, a physical activity prescription from a doctor using a smartphone …

This study tested a plastic meniscus implant in 115 adults aged 30-75 who still had knee pain after having part of their meniscus removed. The goal was to see if the implant is safe and helps reduce pain and improve knee function. Participants were followed for up to 5 years afte…

This trial tests a device called the NUsurface Meniscus Implant for people with a damaged or removed meniscus in the knee. The implant is designed to act like a natural meniscus, cushioning the knee and reducing pain. Researchers will measure changes in knee pain and function usi…

This trial tests whether a 4-week prehabilitation program before total knee replacement can improve recovery. The program includes physical therapy, breathing exercises, psychological support, and targeted treatments based on each person's osteoarthritis type. Researchers will co…

This trial tests whether a graft made from a patient's own extracted tooth can preserve the jawbone that normally shrinks after tooth removal. Researchers compare four approaches: no graft, dentin graft alone, dentin graft combined with platelet-rich fibrin (PRF) from the patient…

This study looks at whether dupilumab, an injectable medication, can improve lung function and reduce symptoms in adults with COPD who have a specific type of inflammation. The researchers are reviewing medical records from patients who received dupilumab as part of routine care,…

This trial is testing whether combining certolizumab pegol, an injectable biologic, with methotrexate, a standard oral medication, can help adults with early active rheumatoid arthritis achieve and maintain remission. Participants are newly diagnosed, have not yet taken disease-m…

This trial tests whether combining certolizumab pegol (Cimzia) with methotrexate can help adults with early, active rheumatoid arthritis achieve and maintain low disease activity without flare-ups. Participants who already responded well to this combination in a prior study conti…

This trial is testing an implantable wireless brain-computer interface (BCI) called NEO in people with tetraplegia caused by cervical spinal cord injury. The device is designed to let participants control external equipment using their brain signals, potentially improving their a…

This trial tests whether applying a gel made from a patient's own blood—called injectable platelet-rich fibrin (i-PRF)—to the surgical site after gum removal surgery (gingivectomy) improves healing. In a split-mouth design, one side of the mouth receives i-PRF, while the other si…

This study tests whether an AI-guided exercise program done at home can be as good as traditional in-person physiotherapy for patellofemoral pain syndrome, a common cause of front knee pain in active adults. Adults aged 18-40 with this condition will be randomly assigned to eithe…

This study looks at whether placing an antibiotic paste directly into the infected bone during surgery can cure foot bone infections. Adults with foot osteomyelitis will receive the paste instead of six weeks of intravenous antibiotics, followed by a short course of oral antibiot…

This trial tests a new, less invasive surgical approach for treating advanced periodontitis (stage III). Instead of lifting the gum, doctors access the damaged bone through a small pinhole, clean the area, and place a bone graft to encourage regeneration. The study includes adult…

This phase 2 trial is testing whether adding venetoclax, a pill taken daily for 12 months, can reduce the number of leukemia stem cells that remain in the bone marrow of people with chronic myeloid leukemia (CML) who are already in deep molecular remission on standard TKI therapy…

This trial tests whether rinsing with coconut oil can reduce plaque and gum inflammation as effectively as a standard chlorhexidine mouthwash. Eighty adults with plaque-induced gingivitis will be split into two groups: one using coconut oil daily and the other using chlorhexidine…

This study is testing whether applying a silver diamine fluoride gel followed by a fluoride varnish can stop cavities in children's baby teeth. Researchers will follow 237 children for a year to see how many cavities become inactive and whether parents are satisfied with the trea…

This phase III trial is testing whether taking oral azacitidine as a maintenance therapy after an allogeneic stem cell transplant can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Participants are randomly assigned to receive…

This early study tests an implanted device called the Intelligent Spine Interface (ISI-C) in people with spinal cord injuries. The device is designed to bridge the gap in the spinal cord, picking up signals from above the injury and sending them to nerves below. The goal is to un…

This study compares two supervised exercise programs—motor control retraining and close kinetic chain exercises—to see which better reduces pain, improves knee function, and strengthens a key thigh muscle in people with patellofemoral pain syndrome (pain around the kneecap). Fift…

This trial asks whether a newer filling material called zirconomer holds up better than a standard glass ionomer cement when repairing cavities in children's baby molars. About 30 children aged 5 to 7 with a cavity in a back baby tooth will receive one of the two fillings. Resear…

This trial tests three types of tooth-colored fillings in children's baby molars to see which performs best. It compares a preheated bulk-fill composite with two indirect composite systems, looking at how well they hold up, how they look, and whether they cause any problems. The …

This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participa…

This trial tests whether adding a posterior column osteotomy—a small cut in the spinal joints—during standard scoliosis surgery improves spine straightening in adolescents. Half of the participants will receive the extra procedure, and half will not. The study measures curve corr…

This study compares two types of tooth-colored fillings—alkasite and glass ionomer—for cavities in baby molars. Children aged 5 to 7 with decayed molars will receive one of the two materials, and the fillings will be checked over time for signs of new decay, color match, and how …

This early-phase trial tests a new type of immunotherapy for people who develop a rare blood cancer called post-transplant lymphoproliferative disease (PTLD) after a solid organ transplant. The treatment uses the patient's own immune cells (T-cells) that are engineered to resist …

This trial compares two types of surgical tools used during total hip replacement: single-use (disposable) reaming instruments and conventional reusable ones. The main focus is on the overall cost of surgery, including sterilization, materials, and operating room time. Researcher…

This trial tests three different injection combinations for people with a painful jaw joint condition called TMJ internal derangement. Participants receive one injection of hyaluronic acid mixed with either platelet-rich plasma, tenoxicam, or a corticosteroid. The study measures …

This trial looks at whether children with juvenile spondyloarthritis who have stable, inactive disease can safely reduce or stop their TNFi medication without causing a flare. Participants are randomly assigned to continue their usual TNFi dose, take it less frequently, or stop i…

This trial tests whether a spinal implant that delivers electrical stimulation, combined with robot-assisted rehabilitation, can improve walking ability in people with chronic spinal cord injury. Participants will have a device implanted and then undergo months of training. The g…

This pilot trial is asking whether injecting magnesium sulfate into the jaw joint after a standard washout procedure (arthrocentesis) can reduce pain and improve jaw function better than the usual treatments. It compares magnesium sulfate against hyaluronic acid (a common injecti…

This trial tests whether dupilumab, an injectable drug that blocks certain inflammatory signals, can reduce sinus swelling and improve symptoms like loss of smell and runny nose in adults with chronic sinusitis who do not have nasal polyps. Participants receive either dupilumab o…

This trial tests whether photodynamic therapy (PDT) using methylene blue can control early-stage pericoronitis, a painful gum infection around partially erupted wisdom teeth. Thirty-four healthy young adults with early pericoronitis will receive either standard irrigation or PDT,…

This study compares two types of dental implants in people who need a short-span fixed bridge (fewer than four implants). One implant has a lateralized design intended to preserve the crestal bone around it, while the other is a standard version. The goal is to see whether the la…

This trial tests whether short dental implants can work as well as standard implants placed after sinus surgery for people with limited bone height in the upper back jaw. Participants have partial tooth loss and a shallow sinus floor that would normally require a sinus lift proce…

This trial tests whether a plastic meniscus implant can outperform non-surgical treatments for people with persistent knee pain after a partial meniscus removal. Participants who had the surgery more than six months ago and are between 30 and 75 years old are randomly assigned to…

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This trial compares two types of dental implant surfaces—Nanotite and Osseotite—to see which one integrates more successfully when placed by graduate students learning implant surgery. The study includes adults who already need dental implants for missing teeth. The goal is to fi…

This study looks at whether a specific dental implant can hold a temporary bridge right after being placed, so patients don't have to wait months for a permanent restoration. Researchers will follow 75 adults with missing back teeth who need a short bridge. The main question is w…

This trial tests whether a dental implant with a special lateralized design (Osseotite Certain Prevail) preserves more bone around the implant than a standard version. About 100 adults who need a short fixed bridge to replace missing teeth will receive one of the two implant type…

This study tracks about 450 adults with active psoriatic arthritis who are prescribed upadacitinib (RINVOQ) by their doctor. Researchers will follow participants for up to 24 months to see how well the drug controls joint and skin symptoms when used alone or with methotrexate in …

This trial is testing the long-term safety and tolerability of the drug filgotinib in people with rheumatoid arthritis who have already completed an earlier filgotinib study. Researchers are monitoring side effects, lab abnormalities, and vital signs over an extended period. The …

This study looks at two surgical options for people with stage II Kümmell's disease, a condition where a spinal bone collapses after a minor injury. Researchers are comparing standard vertebroplasty (injecting bone cement) against a newer method that combines cement with small sc…

This trial tests whether a brief vocational rehabilitation program can help people with arthritis who are worried about losing their jobs. Participants, all currently employed and living or working in eastern Massachusetts, will work with a physical or occupational therapist to i…

This trial tests whether efgartigimod, an injected drug that blocks certain immune antibodies, can improve muscle strength and function in adults with active idiopathic inflammatory myopathy — a group of rare autoimmune diseases that cause muscle inflammation and weakness. About …

This trial investigates whether two common osteoporosis medications, denosumab and alendronate, can reduce liver fat and scarring in postmenopausal women who also have nonalcoholic fatty liver disease (NAFLD). The study will compare changes in liver fat and stiffness over 12 mont…

This trial investigates whether a single injection of platelet-rich plasma (PRP), made from a person's own blood, can reduce pain and improve function in chronic patellar tendinopathy (knee tendon pain). The study includes 29 adults aged 18–65 who have had tendon pain for over th…

This trial investigates whether people with knee osteoarthritis who also have a bowleg deformity (tibia vara) experience different pain relief after a partial knee replacement compared to those without the deformity. The study will measure medial knee pain using a standard pain s…

This study tests whether adding blood flow restriction training (BFRT) to standard exercise can improve pain, function, and quality of life in people with tennis elbow. BFRT uses a cuff around the upper arm to partially restrict blood flow during low-load exercises, aiming to mim…

This study looks at whether adding a statin (atorvastatin or rosuvastatin) to standard osteoporosis treatment can improve bone density in postmenopausal women. Participants are women aged 55 and older with osteoporosis who also have high cholesterol. The trial compares standard t…

This phase 3 trial tests whether risankizumab, an injectable biologic, can reduce joint pain and swelling in adults with moderately to severely active psoriatic arthritis who have not responded to or cannot tolerate other biologic treatments. Participants receive either risankizu…

This study tests whether adding the targeted drug venetoclax to standard chemotherapy helps more adults with acute myeloid leukemia (AML) achieve remission. It enrolls people aged 18 to 65 with intermediate- or high-risk AML who have not yet been treated. The main goal is to see …

This trial compares standard knee replacement surgery to surgery using custom cutting blocks designed from each patient's anatomy. The goal is to see if these personalized tools lead to better knee function, less bleeding, shorter surgery time, and lower overall costs. About 95 p…

This phase 2 trial tests whether the drug abatacept can safely and effectively treat severe heart inflammation (myocarditis) caused by immune checkpoint inhibitors, a type of cancer immunotherapy. The study enrolls adults with any cancer who develop this rare but often fatal hear…

This study investigates whether a collagen hydrogel called H42 can help treat deep gum pockets caused by periodontitis or peri-implantitis. Researchers will measure changes in pocket depth, plaque, gum attachment, and bleeding over 90 days in adults aged 25 to 65 with 1 to 5 gum …

This study tracks the safety and effectiveness of bosutinib (Bosulif) in people with chronic myelogenous leukemia (CML) who are either newly diagnosed or have not responded to or tolerated prior treatments. Researchers will monitor side effects and how well the drug controls the …

This study compares the safety of baricitinib, an oral medication, against TNF inhibitors (injectable drugs like etanercept and adalimumab) in people with rheumatoid arthritis. The main focus is on the risk of venous thromboembolism (blood clots in veins). Participants include th…

This study tests whether a three-month resistance training program using ankle weights can improve leg strength, balance, pain, and quality of life in people who have had knee replacement surgery for osteoarthritis. Twenty-four participants are randomly assigned to either the res…

This trial tests whether a collagen-based injection (Fibroquel) works as well as a standard hyaluronic acid injection (Synvisc) for knee osteoarthritis. About 32 adults with moderate knee OA will receive three weekly injections of one treatment. The study measures knee function a…

This trial investigates whether a single dose of antibiotics before hip replacement surgery prevents joint infections as effectively as multiple doses. The study involves about 20,000 adults with osteoarthritis undergoing hip replacement at hospitals across Denmark. Researchers w…

This study investigates whether a passive stretching program can reduce muscle and tendon stiffness in people with type 2 diabetes. Diabetes can cause muscles and tendons to become stiffer, making walking harder and increasing energy use. The trial compares stiffness in people wi…

This phase 2 trial is testing whether combining two drugs, ponatinib and 5-azacitidine, can improve survival in people with advanced chronic myeloid leukemia (CML). The study includes adults whose CML has progressed to an accelerated phase or a more aggressive blast crisis. Parti…

This study tests whether adjusting the daily dose of the leukemia drug dasatinib based on a patient's blood levels can improve safety and effectiveness. Adults newly diagnosed with chronic phase chronic myeloid leukemia (CML) will receive either standard dosing or a dose tailored…

This phase 2 trial tests whether adding pioglitazone (a diabetes drug) to the standard leukemia medication imatinib can eliminate remaining cancer cells in people with chronic-phase chronic myeloid leukemia (CML). Participants must have been on imatinib for at least two years and…

This trial tests whether adding the targeted drug ponatinib to standard chemotherapy (cytarabine) can help prevent relapse in adults with a specific, high-risk genetic form of acute myeloid leukemia (FLT3-ITD AML) who are already in first remission. The study includes two age gro…

This trial investigates whether adjusting the dose of imatinib (Gleevec) based on the drug's level in the blood can improve outcomes for people newly diagnosed with chronic phase chronic myeloid leukemia (CML). Participants whose imatinib blood level is low after 28 days are rand…

This trial tests whether taking probiotics by mouth, along with standard root canal medications, can reduce pain and improve healing in people with chronic tooth infections. Participants will receive either a probiotic capsule or a placebo for 21 days, combined with one of three …

This trial studies a device called coflex, a small implant placed in the spine after decompression surgery for lumbar spinal stenosis (a narrowing of the spinal canal that causes back and leg pain). The study includes 40 adults with moderate to severe stenosis and low back pain. …

This study tests whether a device called BB-02, which delivers pulsed electromagnetic fields, can slow cartilage damage in people with early knee osteoarthritis. Researchers will use MRI scans to measure changes in cartilage and track pain levels. The goal is to find a non-surgic…

This study compares different exercise programs for adolescents with idiopathic scoliosis who have undergone spinal fusion surgery. Participants are divided into three groups: one doing body awareness therapy plus core stabilization, one doing core stabilization alone, and a cont…

This study compares standard Schroth exercises with a virtual reality version of the same exercises in teens aged 10–15 with mild adolescent idiopathic scoliosis (curves of 10–30 degrees). The goal is to see if adding VR improves spinal alignment, trunk rotation, and mobility mor…

This study tested whether adding photodynamic therapy (a light-activated treatment) to standard sodium hypochlorite irrigation better kills bacteria in root canals. 64 adults needing root canal treatment were randomly assigned to receive either sodium hypochlorite alone or with p…

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This study looks at how well the SAGITTA EVL R hip implant works over the long term—7 to 10 years after surgery. Researchers are checking how many implants survive without needing another revision, how satisfied patients are, and what complications arise. The study includes adult…

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This study looked at whether using a soft hip brace (abduction splint) for two months in one-month-old babies with mild hip dysplasia (stable hips but abnormal ultrasound) improves hip development. 90 infants were enrolled. The goal was to see if the brace makes hip ultrasound me…

This study tested a chemotherapy drug called CPX-351 in 59 adults aged 60 to 75 with a high-risk form of acute myeloid leukemia (AML). The goal was to see how well it could put the cancer into remission. Participants received the drug through an IV, and some also had a stem cell …

This completed Phase 4 study compared the safety of baricitinib (a daily pill) to TNF inhibitors (injections) in over 2,600 adults with rheumatoid arthritis. The main goal was to see if baricitinib had a higher risk of blood clots. Participants had to be at least 60, have a histo…

This study tests whether certolizumab pegol (Cimzia), a drug already used for arthritis, can reduce flares of anterior uveitis—a painful eye inflammation—in people with axial spondyloarthritis who have had uveitis before. About 89 adults with active axial spondyloarthritis and a …

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This trial tests whether CardiolRx, a pharmaceutical cannabidiol, can improve heart recovery in adults with acute myocarditis (heart muscle inflammation). Participants receive either CardiolRx or a placebo for 12 weeks. The study uses heart MRI scans to measure changes in heart t…

This study investigates whether adding a contract-relax physical therapy technique to standard respiratory care can improve diaphragm function in patients who develop diaphragmatic paresis after cardiac surgery. The trial enrolls adults who have undergone heart surgery with a hea…

Researchers compare two devices, Amy Check and Osstell, for measuring the stability of dental implants placed during a graftless closed sinus lift. The trial enrolls 30 adults who need tooth replacement in the upper back jaw and have limited bone height. Each participant receives…

This study is testing a portable ultrasound device called POROUS R4C that measures bone in the lower leg without radiation. Researchers want to see if it can estimate bone mineral density as accurately as the standard X-ray method (DXA). The study will include 350 healthy men and…

This study is testing whether a radiation-free ultrasound system called Scolioscan can accurately screen for scoliosis in school children. Researchers will compare ultrasound results with standard X-rays in 160 children referred for screening. If the ultrasound proves reliable, i…

This study aims to develop new imaging methods to better detect and understand myofascial pain, a common muscle pain condition. Researchers will compare 52 participants—some with myofascial pain and some healthy—using MRI, muscle electrical activity, and fiber-optic imaging. The …

This study is testing a new device that uses near-infrared light to measure pelvic floor muscle fitness in women with myofascial pelvic pain, a condition that affects up to 26% of women. The goal is to create a simple, non-invasive diagnostic tool that could replace the need for …

Researchers are testing whether ultrasound can reliably show joint damage and inflammation in people with septic arthritis, a painful joint infection. The trial follows 28 adults with septic arthritis in the shoulder, elbow, wrist, hip, knee, or ankle. Participants receive standa…

This study tests whether a 3D intraoral scanner can accurately measure dental plaque compared to the traditional method of applying a dye and visually scoring. Twenty adults with at least 20 natural teeth and visible plaque will be scanned before and after plaque disclosure and a…

Researchers at Emory University are testing whether shear wave elastography, an ultrasound technique that measures tissue stiffness, can tell the difference between healthy tendons and painful ones. The study enrolls about 56 people, some with tendinopathy and some without, and s…

This study looked at whether certain proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers collected saliva from 60 people and measured three specific biomarkers. The goal is …

Researchers at Izmir Katip Celebi University are testing a deep learning model called UNet to automatically outline bone sequestra, pieces of dead jawbone, on panoramic dental X-rays. The study uses 120 anonymized X-rays with 134 marked lesions from patients who had radiotherapy,…

This trial tests whether contrast-enhanced ultrasound can detect spinal cord injury during decompression surgery for chronic spinal cord compression. Researchers inject an ultrasound contrast agent before, during, and after the procedure to visualize blood flow changes in the spi…

This study tests whether a special PET/CT scan can measure changes in amyloid deposits in organs of people with systemic amyloidosis. Participants receive an injection of a radiolabeled peptide that binds to amyloid, then undergo imaging at different times. Researchers compare th…

This study explores whether gas samples from the mouth can be collected and analyzed up to 7 days later to diagnose halitosis (bad breath). Researchers will take breath samples from 100 adults with gum disease and measure volatile sulfur compounds—the molecules responsible for ba…

This trial tests whether an ultra-low-dose CT scan, using a new image reconstruction algorithm, can produce images good enough for diagnosing lung, abdominal-pelvic, and bone lesions, compared to a standard-dose CT scan. About 116 adults will receive both scans as part of their u…

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study looks at whether substances in the blood from a tooth's pulp can help dentists tell the difference between reversible pulpitis (a mild inflammation that can heal) and irreversible pulpitis (severe damage needing a root canal). Researchers will collect a small sample of…

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study investigates whether three common lab tests — blood levels of ESR and CRP, plus a leukocyte esterase dipstick test on joint fluid — can reliably diagnose chronic infection in people who have had a total joint replacement. The researchers will compare the test results a…

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This study explores whether ultrafast ultrasound can accurately assess diaphragm function in adults with known or suspected diaphragm dysfunction. Researchers will compare ultrasound measurements with standard tests like pressure measurements and electrical signals from the diaph…

This study tested a new 3D bone scan camera (VERITON-CT) that takes only 25 minutes and uses less radiation than standard scans. Researchers compared it to conventional 2D scans in 146 people with suspected or known bone metastases. The goal was to see if the new method could acc…

This study tested whether a special PET scan using 68Ga-DOTATOC can detect inflammation in the heart muscle of people with myocarditis. 33 adults with suspected acute myocarditis and normal angiograms received the scan. The goal was to see if this method is as good as or better t…

Researchers are testing whether a toothpaste containing proteins, enzymes, and fluoride improves gum health and reduces plaque more than a standard fluoride toothpaste. The study enrolls healthy adults aged 18 to 70 with mild gum inflammation. Participants use one of the two toot…

Researchers at the University of Barcelona are testing whether a mouthwash made from bioflavonoids can reduce dental plaque and gum inflammation as effectively as a standard chlorhexidine mouthwash. The trial enrolls 24 adults with at least 20 teeth and no severe gum disease. Par…

Researchers are testing whether giving azacitidine, a chemotherapy drug, together with donor lymphocyte infusions after a stem cell transplant can prevent relapse in people with high-risk acute myeloid leukemia or myelodysplastic syndrome. About 30 patients will receive the combi…

Female college athletes tear their ACL more often than men, and hormones may play a role. This study enrolls women who play basketball, soccer, or volleyball at two universities, some taking a common birth control pill and some not. Researchers measure relaxin levels in the blood…

About 25% of people who have knee replacement surgery develop persistent pain that can last for months. This trial tests whether taking a CBD-dominant oil before and after surgery can reduce that risk. Researchers will randomly assign about 40 adults to receive either CBD oil or …

This trial tests whether educating primary care health professionals can improve prevention of repeat fractures in older adults. It involves 40 primary health care centers in Stockholm, where some clinics receive special training and referral support for patients who have had a f…

This study tests whether a brief form of talk therapy called acceptance and commitment therapy (ACT) can help prevent chronic pain after lumbar spine surgery. Adults scheduled for back surgery will attend a one-day workshop and a follow-up phone session before their operation. Re…

This trial tests whether giving azithromycin—a common antibiotic—twice a year to young children in Niger can reduce deaths. It compares giving the drug to all children aged 1-59 months versus only to infants 1-11 months, who are at highest risk. The study also checks how these ap…

Researchers are studying whether injecting platelet-rich plasma (PRP), a concentrated mix made from a patient's own blood, into the knee can reduce pain and improve movement in people with moderate knee osteoarthritis. The study enrolls adults over 50 with persistent knee pain an…

Researchers compare spinal anesthesia and general anesthesia for people having hip or knee replacement surgery for osteoarthritis. The trial checks whether patients can safely walk 5 meters within 6 hours after surgery and how they feel in terms of pain, nausea, dizziness, confus…

Researchers are testing whether an online exercise and self-massage program can lower jaw pain and improve jaw movement in adults with bruxism, the habit of grinding or clenching teeth. Participants complete eight sessions over four weeks, either exercising live with a physical t…

Researchers are testing whether a 12-week Taekwondo training program can help adults with ankylosing spondylitis and axial spondyloarthritis. The trial enrolls 21 adults aged 19 to 59 who have stable treatment or no medication for at least three months. Participants join either a…

Researchers are studying ozone therapy in adults who have a herniated lumbar disc and are on a waiting list for discectomy or microdiscectomy. Participants receive ozone injections and are followed for up to two years. The study measures changes in sciatic and lumbar pain, how ma…

This study tests whether a special nano calcium fluoride varnish, a diode laser, or both together can reduce tooth sensitivity. Thirty adults with sensitive teeth will receive one of the treatments and rate their pain on a scale. The goal is to see which approach provides the bes…

Researchers at Sohag University are studying a minimally invasive spine surgery called MI-TLIF for people with degenerative lumbar and lumbosacral spine diseases. The trial enrolls about 30 adults with conditions such as degenerative spondylolisthesis, disc herniation, or recurre…

Researchers compare two dental implant connection designs to see how each affects the bone around implants that hold lower dentures. Fourteen fully edentulous men, aged 45 to 60, receive two implants in the lower jaw, with one group getting internal tri-lobe implants and the othe…

Researchers at Ain Shams University are testing whether aloe vera gel, placed inside a tooth after root canal cleaning, reduces inflammation and pain better than the standard calcium hydroxide dressing. The trial enrolls 33 adults with dead or dying teeth and infection around the…

Parents of children with complex medical conditions often feel unsure about managing their child's symptoms at home. This trial tests whether a mobile app with nurse support can help. Ninety-six parents receive either the app, which offers health checks, monitoring, education, an…

Researchers are testing a home-based program called action observation and motor imagery (AOMI) training for adults with spinal cord injury. Participants watch exercise videos and imagine themselves doing the movements without actually moving. The trial aims to see if this traini…

Researchers are testing whether showing adults with gingivitis personalized 3D images of possible future gum changes helps them brush and clean between their teeth more consistently. The study enrolls 88 adults aged 18 to 60 with gingivitis, divided into three groups. One group r…

Researchers compare three ways to preserve the jawbone after a tooth is removed. Participants are randomly assigned to receive no bone graft, a graft made from their own extracted tooth, or a synthetic bone substitute called beta-tricalcium phosphate. The trial measures changes i…

Researchers are testing a biodegradable nasal dressing called OCEAN that releases the steroid mometasone furoate. The dressing is placed in the nose after endoscopic sinus surgery in adults with chronic rhinosinusitis, with or without nasal polyps. The trial checks safety by coun…

This study tested a more precise dental surgery for people with persistent root infections after standard treatment. Using a 3D-printed guide, surgeons aimed to remove infected tissue more accurately, reduce surgery time, and improve quality of life. The trial involved 70 adults …

This study tested whether rinsing the tooth with cold saline (cryotherapy) or placing metformin (a diabetes drug) inside the tooth can reduce pain after root canal treatment. 80 adults with infected lower premolars were randomly assigned to receive one of four treatments. Pain wa…

This study tests two treatments for tennis elbow (lateral epicondylitis) in 60 adults aged 18-65. One group gets ultrasound-guided dry needling, the other gets shock wave therapy, both once a week for five weeks. Everyone also does a home exercise program. The goal is to see whic…

Researchers are comparing two single injections for knee osteoarthritis: an experimental polyacrylamide hydrogel gel and a standard hyaluronic acid shot called Synvisc-One. The trial enrolls about 238 adults aged 40 and older with mild to moderate knee arthritis confirmed by X-ra…

This study tests whether an 8-week program combining exercise and health education can reduce muscle pain and improve well-being in textile workers. Thirty-eight volunteers from a Spanish textile factory will attend weekly workshops and do two online exercise sessions per week vi…

This study compares two types of nerve blocks—SFIB and PENG—to see which one controls pain better after hip replacement surgery. Sixty patients will be randomly assigned to receive one of the blocks. The main goal is to measure how much morphine they need in the first 24 hours af…

This study tests whether adding an injection called Tropho Tend to standard physical therapy helps reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Sixty adults with shoulder pain lasting at least six weeks will be randomly assigned to receive e…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This study looks at whether walking football—a low-impact, no-running version of soccer—is safe and helpful for people with axial spondyloarthritis, a long-term inflammatory spine condition. Twelve participants will play twice a week for 12 weeks. Researchers will measure pain, s…

This study tested whether adding virtual reality exercises to standard physical therapy helps people with partial shoulder tendon tears. 49 adults with shoulder pain did either regular rehab or rehab plus VR. Researchers measured pain, movement, and quality of life to see if VR m…

This study looks at whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the knee can reduce pain and improve movement in people with knee osteoarthritis. The trial involves 110 adults over 35 with knee arthritis. Researchers are…

Researchers at the University of Porto studied 30 adults with myofascial temporomandibular disorder who still had jaw muscle pain after using a stabilization splint for at least five years. All participants kept using their splints and received four weekly 30-minute acupuncture s…

Researchers are testing whether combining extracorporeal shockwave therapy with injections of hyaluronic acid or platelet-rich plasma eases pain and improves knee function better than shockwave therapy alone in people with moderate to severe knee osteoarthritis. The trial enrolls…

This trial compares two ultrasound-guided pain-relief techniques for children aged 1 to 12 undergoing surgery on the front or side of the thigh. One group receives a fascia iliaca nerve block, while the other gets caudal analgesia, both given after general anesthesia. The goal is…

Plantar fasciitis causes heel pain from irritation of the thick band of tissue on the bottom of the foot. This trial compares two common treatments: kinesiotaping, where a flexible tape is applied to the foot, and lower limb stretching exercises that target the calf and hamstring…

Researchers compare the GDS Muscle and Joint Chains Method with conventional physiotherapy in adults with frozen shoulder. Thirty participants receive eight 50-minute sessions over four weeks. The trial measures changes in shoulder range of motion and pain intensity to see whethe…

Researchers are testing whether short, repeated sessions of mild low oxygen (mild intermittent hypoxia) can strengthen upper airway muscles and improve sleep apnea treatment. Adults with newly diagnosed obstructive sleep apnea and prehypertension or stage 1 hypertension, includin…

Researchers are testing whether cooling local anesthetic before injecting it into the tooth's pulp reduces pain during root canal treatment. The trial enrolls 40 people with painful, inflamed lower molars who need a root canal. Each participant receives the anesthetic at either c…

Calcific tendinitis of the rotator cuff causes long-lasting shoulder pain when calcium builds up in the tendon. Standard treatment flushes the deposit with fluid, but the calcium often dissolves slowly. Researchers are testing whether injecting sodium thiosulfate, a chemical that…

Researchers compare two root canal file systems, ProTaper Gold and ProTaper Ultimate, to see if they differ in how much pain patients feel afterward. The trial enrolls 40 adults with permanent lower molars diagnosed with symptomatic irreversible pulpitis and apical periodontitis.…

Calcific tendinitis of the rotator cuff causes long-lasting shoulder pain when calcium builds up in a tendon. A common treatment is ultrasound-guided needling and lavage to break up and flush out the deposit, often followed by a corticosteroid injection to prevent a pain flare. R…

Researchers compare two treatments for long head of the biceps brachii tendinopathy, a common cause of shoulder pain. One group receives a single ultrasound-guided injection of triamcinolone acetonide and lidocaine around the tendon. The other group receives transcutaneous electr…

Researchers compare three sealers used during root canal treatment, Totalfil, NeoSealer, and AH-Plus, to see how much pain patients feel afterward. The study includes 39 people with painful, inflamed lower molars that need a root canal. Each participant receives one of the three …

Bariatric surgery helps people with severe obesity lose weight, but it also strips away muscle and bone. Many men who have the surgery also have low testosterone, which worsens muscle loss. This trial tests whether testosterone replacement, combined with exercise and diet counsel…

Researchers compare two materials used in pulpotomy, a procedure that removes inflamed pulp from a tooth and covers the remaining tissue. Adults with deep cavities and signs of pulp inflammation in lower first or second molars receive either BIO MTA+ or Well-Root PT. The study me…

Children with spinal cord injury often struggle to sit upright because their trunk muscles are paralyzed. Researchers are testing a device that sends electrical pulses through the skin to the spinal cord, called transcutaneous spinal stimulation, to see if it can improve sitting …

Researchers at the University of Louisville are testing whether combining activity-based locomotor training with non-invasive spinal stimulation can improve sitting posture and trunk control in children with chronic spinal cord injuries. The trial enrolls 14 children, ages 3 to 1…

Newborns with complete bilateral cleft lip and palate often wear a custom molding appliance for a few months before surgery to bring the upper jaw segments closer together. This trial compares two versions: a vomer molding appliance and a conventional molding appliance. Researche…

This study tested two types of magnetic brain stimulation (iTBS and rTMS) combined with robotic walking therapy in 30 people with chronic spinal cord injury. The goal was to see if these treatments could improve leg strength, walking ability, and daily independence. All participa…

Boys with hemophilia often miss out on games and activities because of concerns about bleeding and joint damage. Researchers developed a 12-week muscle-strengthening exercise programme with input from children, parents, and physiotherapists. The DOLPHIN-II trial compares this pro…

This study tested a special carbon fiber plate and screws to treat hallux rigidus, a condition that causes stiffness and pain in the big toe joint. 18 adults who needed surgery for this condition took part. The surgery removed damaged cartilage and fused the bones together using …

Researchers at Ataturk University are testing whether watching nature videos through virtual reality glasses can improve sleep quality and mental well-being in people with multiple sclerosis. The trial enrolls 42 adults aged 18 to 80 who have MS and are not in an attack. One grou…

This study looks at whether adding special balance training to standard scoliosis exercises can improve balance in teenagers with mild scoliosis. About 72 teens aged 10-17 will either use a high-tech platform that gives real-time feedback or do simple balance exercises at home. T…

This small pilot study is testing whether using heat (radiofrequency ablation) to disable a nerve in the heel can relieve chronic pain from plantar fasciitis or heel spurs. The 31 participants have had pain for over 6 months and tried at least four other treatments without succes…

Researchers are testing whether a hybrid cardiac rehabilitation programme can help adults recover after heart surgery. Participants start with two weeks of supervised exercise at the hospital, then continue training at home for six weeks using heart-rate monitors, a cloud care pl…

This pilot study tests whether a minimally invasive technique called percutaneous needle electrolysis can reduce groin pain and improve hip function in male ice hockey players aged 18 to 21. Six players will receive three ultrasound-guided treatments to the hip capsule. Researche…

This study tests whether custom-made 3D-printed masks fit children better than standard commercial masks for non-invasive ventilation (NIV). Fifteen children aged 8-12 who already use NIV but have poor adherence will try a custom mask made from a 3D facial scan. Researchers will …

Researchers want to know if a wireless peripheral nerve stimulator, already implanted in some patients for chronic arm pain, can also make paralyzed muscles contract. The trial enrolls adults with stroke or spinal cord injury who have the device on nerves in the arm. Participants…

Researchers at Rigshospitalet in Denmark are testing whether adults newly diagnosed with acute myeloid leukemia can safely measure their own blood counts and give themselves blood and platelet transfusions at home. The study trains and certifies 22 participants to use a home bloo…

This study tests whether a manual therapy called Mobilization with Movement (MWM) can reduce pain and inflammation in people with knee osteoarthritis. Forty adults with moderate to severe knee OA will receive either MWM or a sham treatment twice a week for four weeks, plus standa…

This study tests whether physical therapy, combined with motivational support and planning, can help older adults with chronic hip, knee, or back pain become more physically active. Participants work with physical therapists to set personal goals and adapt activities to their con…

Cervical spondylosis is age-related wear and tear in the neck that can cause pain, stiffness, and weakness. This trial compares two manual therapy techniques, Gong's mobilization and Maitland mobilization, in 50 adults aged 40 to 60 with the condition. Each participant receives o…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This trial tests whether S(+) ibuprofen, a purified form of the common painkiller, can reduce pain in people with knee or hip osteoarthritis better than a standard ibuprofen product. Researchers will compare the two treatments in about 176 adults aged 18 to 75. Participants will …

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This study tests a new treatment called BRC-OA, made from donated human fat tissue, for people with mild to severe knee osteoarthritis. The goal is to see if it safely reduces pain and improves knee function. About 42 adults aged 18-80 will receive one of two doses or a control, …

This study tested whether a mobile application could help nurses and caregivers better manage pressure injuries (bedsores) in people receiving home care. Thirty participants were followed for 28 days, with caregivers using the app to track wound healing and receive reminders. The…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This phase 2 trial tests whether pitolisant, a wake-promoting drug, can reduce excessive daytime sleepiness in adults aged 18 to 65 with myotonic dystrophy type 1. Participants receive either pitolisant or a placebo for a period, and researchers measure changes in sleepiness, fat…

This study compares two ultrasound-guided procedures that target nerves around the knee to relieve chronic osteoarthritis pain that has not improved with standard care. One procedure uses heat from radiofrequency to disable the nerves, while the other uses a chemical called pheno…

This study tests whether a guided exercise program done at home before knee replacement surgery can help people recover better. 84 adults scheduled for knee replacement will be asked to do simple exercises daily from the day they are admitted until surgery. Researchers will measu…

This study compares two hands-on treatments—Integrated Neuromuscular Inhibition and Active Release Technique—for people with neck pain caused by trigger points in the upper trapezius muscle. About 64 adults with active trigger points and forward head posture will receive one of t…

This study tests a special fabric shoulder brace designed to mimic muscle support for people with neuromuscular disorders like muscular dystrophy, SMA, and ALS. About 30 participants will wear the brace and perform arm tasks to see if it improves movement, strength, and daily fun…

This study tests whether a 5-minute educational video about uterine fibroids and their treatments can help patients feel less conflicted when deciding on a treatment plan. About 154 women with fibroids will be randomly assigned to watch the video before their appointment or recei…

This study tested whether injecting vitamins C or E into the gums could help teeth move faster during braces treatment. 51 patients received either vitamin C, vitamin E, or a placebo injection every two weeks to a month for six months. Researchers measured tooth movement, pain, a…

This study tests whether a mouthwash made from frankincense and coconut oil can help treat mild to moderate gingivitis (gum inflammation). Researchers will compare it to a standard commercial mouthwash in 90 adults over 21 days. The goal is to see if the natural blend reduces pla…

This study looked at how well BioFlx crowns work for fixing cavities in children's back teeth. Twenty-eight kids aged 6 to 9 got the crowns and were checked for up to 24 months. The goal was to see how the crowns held up and how happy the children and parents were with them.

This trial tests whether brief mindfulness-based audio recordings can ease pain and improve jaw function in university students with painful temporomandibular disorders (TMD), a common cause of chronic jaw pain. Participants listen to the recordings three times a week for three m…

This trial tests whether adding nalbuphine to a standard numbing medicine improves pain control and reduces agitation in children aged 1 to 7 after cleft palate repair. Half of the 60 participants receive the standard nerve block with bupivacaine alone, while the other half recei…

This trial tests whether a single injection of lorecivivint into the knee can reduce pain and improve function in people with moderate to severe knee osteoarthritis. About 499 adults aged 40 to 80 will receive either the drug or a placebo injection, and researchers will compare c…

This study compares two types of nerve blocks for pain after hip replacement surgery. Sixty adults will receive either a sacral erector spinae plane block or a fascia iliaca compartment block, both using a numbing medicine through a small tube. The goal is to see which method red…

This trial tests whether coaching older adults in healthy habits or sleep habits can improve their recovery after hip or knee replacement surgery. Participants receive four hour-long sessions with a therapist, focusing either on general healthy habits like physical activity and n…

This trial tests two types of custom-made insoles for people with plantar fasciitis, a common cause of heel pain. One insole is milled from EVA foam, the other is 3D-printed from TPU plastic. Over 12 weeks, researchers measure calf muscle activity during walking, foot pressure, p…

This trial tests whether a bleaching gel fortified with tiny titanium oxide particles can whiten teeth better and cause less sensitivity than a standard gel. Sixty adults with tooth discoloration will receive either the nano-enriched gel or the conventional gel during a single se…

This study tests whether a specific exercise technique called Proprioceptive Neuromuscular Facilitation (PNF) can improve pain, posture, and muscle strength in people with upper crossed syndrome—a condition marked by forward head and rounded shoulders. Half the participants will …

This trial tests whether a nano-sized form of calcium hydroxide, placed inside the tooth after cleaning, reduces pain following root canal treatment compared to the conventional version. Adults aged 18 to 65 with a dead nerve in a single-rooted tooth and an infection at the tip o…

This trial tests a new 24-week program called COMFI that combines a cognitive behavioral approach with physical activity to help people with inflammatory arthritis manage fatigue. Participants attend group sessions, an optional individual session, and a booster session, and they …

This trial tests whether placing a nano-form of the painkiller ketorolac inside the root canal can reduce pain after root canal treatment. Adults aged 18–50 with an infected tooth nerve will receive either nano-ketorolac, regular ketorolac, or a placebo gel during the procedure. …

This trial tests whether immersive virtual reality (VR) can reduce pain, dental fear, and improve cooperation in children aged 8-12 during restorative dental treatment. Half the children will watch an age-appropriate animated video through a VR headset during local anesthesia and…

This trial compares two anti-nausea medications, palonosetron and granisetron, both given with dexamethasone, to see which better prevents nausea and vomiting after scoliosis surgery. Participants are adults and adolescents with idiopathic scoliosis undergoing posterior spinal fu…

This trial asks whether adding a mild electrical current to dry needling improves outcomes for people with neck pain caused by muscle knots, known as myofascial trigger points. Adults aged 18 to 60 with neck pain lasting at least three weeks will receive either standard dry needl…

This study tests whether blood flow restriction training (BFRT) — using pressure cuffs during low-load exercise — can help people with rheumatoid or psoriatic arthritis build muscle with less joint strain than conventional strength training. Adults with these conditions will be r…

This study tests whether a new high-intensity exercise program is feasible and can improve dynamic balance and physical activity in adolescents with cerebral palsy or spina bifida. Participants will perform a series of exercises twice a week, with researchers measuring walking sp…

This trial tests whether online educational modules or live webinars, completed before hip replacement surgery, can reduce anxiety and improve outcomes like pain, function, and quality of life. It involves adults aged 50 and older with advanced hip osteoarthritis who are schedule…

This trial tests whether children and teenagers who have just had surgery for idiopathic scoliosis can safely stand up within 6 hours after the operation. Participants will be helped by a physiotherapist to stand in an upright position, as part of an enhanced recovery program. Th…

This trial tests whether different kinesio taping methods can reduce pain and stiffness in people with myofascial pain syndrome, a condition where sensitive spots in muscles cause pain. Participants will be divided into groups receiving either a muscle-inhibition tape, a special …

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tests whether a wearable exoskeleton—a supportive device worn around the torso—can reduce physical effort and pain for nursing home staff who regularly lift, turn, and bathe residents in bed. Over 11 weeks, 35 care workers across five French nursing homes will wear the…

This study looks at how two common treatments for myofascial jaw pain—a mouth splint and lidocaine injections—affect the muscles of the jaw and neck. Researchers use ultrasound to see changes in muscle structure, like how well the muscle fibers reflect sound waves. The goal is to…

This trial tests whether adding Gua Sha—a traditional scraping therapy—to standard care can improve pain and function in people with lumbar disc herniation. The therapy is applied to the bladder meridian during the 'Shen period' (3–5 p.m.), based on traditional Chinese medicine's…

This trial tests whether giving patients an educational booklet before total knee replacement surgery improves their knowledge and beliefs about the procedure. Adults aged 55 to 75 scheduled for knee replacement will receive the booklet or standard care. Researchers will measure …

This study tests whether a gamified physical therapy software, called Yoomi, can help older hospital patients exercise safely in their beds. The goal is to see if this fun, interactive approach can preserve muscle strength and function during a hospital stay, reducing the need fo…

This trial tests whether practicing tai chi can increase overall physical activity in people with spondyloarthritis, a type of inflammatory arthritis. Participants will either take tai chi sessions for two or four months or receive no tai chi (control group). The study measures c…

This study tests whether MRI scans can predict how much people with jaw joint problems improve after a single injection of hyaluronic acid combined with platelet-rich plasma (PRP) made from their own blood. Adults aged 18–45 with TMJ internal derangement who haven't improved with…

This study tests whether an 8-week Pilates program can reduce pain and improve jaw function in women with myogenic temporomandibular disorders (TMD), a common cause of jaw pain and stiffness. Participants will be randomly assigned to either a control group receiving standard educ…

This trial tests whether a wearable suit called EXOPULSE Mollii, which sends gentle electrical pulses to muscles, can help children with cerebral palsy. The study focuses on kids aged 5 to 12 who have spasticity and some walking ability. Researchers will measure changes in balanc…

This trial asks whether a numbing injection directly into the knee works as well as a continuous nerve block for controlling pain after knee replacement surgery. Adults aged 18 to 90 with knee arthritis scheduled for a first knee replacement are randomly assigned to receive eithe…

This pilot study tests whether a technique called conditioning with open-label placebo (COLP) can help patients with spinal cord injuries, polytrauma, or burns reduce their opioid painkiller doses without losing pain relief. Participants receive a sugar pill and an essential oil …

This study tests whether a cream made with cetylated fatty acids can ease knee pain and improve function in adults with osteoarthritis. Participants apply the cream or a placebo to the affected knee twice daily for 30 days. The trial measures changes in pain during walking, physi…

This study tests whether learning Argentine tango can increase overall physical activity in people with chronic inflammatory arthritis, such as rheumatoid arthritis or spondyloarthritis. Participants will take tango sessions that focus on body awareness, movement, and connection …

This trial tests whether adding a self-management education program to a three-week spa treatment can increase physical activity levels in people with knee osteoarthritis. The program includes educational workshops and a written booklet, and the study will measure physical activi…

This trial tests three ultrasound-guided treatments for myofascial pain syndrome in the upper neck muscle: dry needling, lidocaine injection, and oxygen-ozone injection. About 76 adults with neck pain lasting at least three months will receive one of these treatments weekly for t…

This trial investigates whether eccentric isokinetic exercise — a type of controlled, lengthening muscle contraction performed on a special machine — can reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Fifty adults aged 20 to 50 with confirmed …

This trial tests whether an all-in-one dental isolation system called Isolite is more comfortable for children than the traditional rubber dam during cavity treatment. Sixty-six kids aged 8 to 12 will try both methods in random order, and researchers will measure pain, comfort, a…

This study asks whether the phase of the menstrual cycle influences pain and anxiety during a deep dental cleaning in premenopausal women with moderate gum disease. Researchers will compare pain scores and anxiety levels when treatment is done just before or just after menstruati…

This trial investigates whether histotripsy, a focused ultrasound technique, can reduce pain in people with plantar fasciitis that has not responded to standard treatments like shock waves, orthotics, or steroid injections. Participants receive two ultrasound sessions and report …

This trial compares two ultrasound-guided nerve blocks—interscalene and supraclavicular—for controlling pain after outpatient arthroscopic rotator cuff repair. About 108 adults undergoing surgery will receive one of the two blocks, and researchers will measure how much opioid pai…

This trial tests whether a corticosteroid injection given before root canal treatment can reduce pain and inflammation afterward. One hundred adults with symptomatic pulpitis (tooth nerve inflammation) are randomly assigned to receive either standard root canal treatment alone or…

This study compares two injection treatments for frozen shoulder (adhesive capsulitis). One group receives a standard steroid injection, while the other gets the same steroid plus extra saline to gently stretch the shoulder capsule. Researchers will measure pain, range of motion,…

This study compares two types of Pilates—one done in water and one on a mat—to see which better improves breathing, mobility, and quality of life in older women with a curved upper spine (kyphosis). Forty women aged 55 to 65 with mild to moderate kyphosis will follow a 12-week pr…

This study compares acute pain after partial knee replacement (unicompartmental knee arthroplasty) between patients who go home the same day and those who stay in the hospital. Researchers track pain scores and knee function in 244 adults aged 50 to 75. The goal is to see whether…

This study tests whether a mindfulness-based psychoeducation program can help people hospitalized with lumbar disc herniation. The program includes eight sessions covering mindfulness, pain education, and emotional awareness. Researchers will measure changes in mindfulness, autom…

This study tests whether an ultrasound-guided injection of local anesthetic into the space behind the knee (called the IPACK block) can reduce pain and improve function in people with advanced knee osteoarthritis. Researchers will measure pain, disability, and quality of life at …

This clinical trial tests a gel called ABIO3419, injected into the knee joint, to see if it safely reduces pain and improves function in people with knee osteoarthritis. The study compares ABIO3419 to another treatment and measures pain relief over three months. Participants are …

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tests whether adding hypnosis to standard care helps control pain and anxiety during a knee lavage procedure for people with knee osteoarthritis. About 100 participants will be randomly assigned to receive either usual care alone or usual care plus hypnosis. The main g…

This trial investigates whether jaw exercises (Rocabado programme) work better when guided by a physiotherapist through online video sessions versus doing them at home with written instructions alone. Adults aged 18-60 with jaw-joint pain and teeth grinding are randomly assigned …

This study tests whether virtual reality training can help children aged 6 to 16 with the childhood form of myotonic dystrophy type 1 (DM1) improve their ability to understand others' thoughts and emotions. Participants engage in social scenarios in a virtual environment, guided …

This pilot study tested the Atlas Knee System, a device implanted outside the knee joint to reduce pressure on the inner knee, in 50 people with medial knee osteoarthritis. The goal was to see if it safely relieves pain and improves function over 24 months. Participants were foll…

This study tests whether adding neural gliding exercises—gentle movements that help nerves slide smoothly—to standard shock wave therapy and home exercises can further reduce pain and improve foot function in people with plantar fasciitis. About 56 adults with this common cause o…

This study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joi…

This study tests two short behavioral therapies delivered over video calls for adults with chronic orofacial (jaw or face) muscle pain and insomnia. One therapy focuses on sleep habits and routines; the other uses jaw relaxation and breathing exercises. The goal is to see which a…

This trial tests whether a program combining education with high-intensity interval training (HIIT) can improve knee osteoarthritis symptoms and reduce heart disease risk better than a standard neuromuscular exercise program. About 150 adults with knee osteoarthritis and at least…

This study compares two ways to manage pain after total knee replacement: a continuous nerve block using a catheter near the femoral triangle versus tissue infiltration with a local anesthetic. The goal is to see which method better prevents long-term chronic pain and improves kn…

Knee osteoarthritis treatments vary widely, and doctors lack clear guidance on which option suits which patient. This study follows 5,000 people with knee osteoarthritis who receive usual care, recording the treatments they get and how they fare. Researchers aim to map common tre…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

Researchers are studying people who have surgery for cervical radiculopathy, a condition where a pinched nerve in the neck causes arm or hand weakness. The study follows about 2,000 patients to see how many recover full strength and whether factors like how severe the weakness wa…

This completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…

Researchers at Hacettepe University are studying people who had surgery for a massive rotator cuff tear. They want to see how the brain's signals to shoulder muscles, shoulder function, and psychological resilience relate to each other. Participants complete shoulder and mood que…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

Researchers at Giresun University are studying whether a blood protein called calprotectin changes in people with axial spondyloarthritis who complete a four-week pulmonary rehabilitation program. Thirty patients aged 25 to 65 will take part. The team will measure calprotectin al…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study followed 78 people with GNE myopathy, a rare genetic disease that causes progressive muscle weakness starting in young adulthood. Researchers collected medical history, blood samples, and muscle function tests over up to two years to understand how the disease progress…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study looks at how the muscles around the knee work together to control movement, especially in the kneecap area. Researchers temporarily numbed one muscle with lidocaine in 28 healthy volunteers and used MRI scans to see how the knee moved. The goal is to better understand …

Researchers at Gazi University are studying whether Behçet's disease, which causes mouth sores and eye inflammation, is connected to gum disease. They compare 40 people with Behçet's plus gingivitis or periodontitis against 47 people with gum disease alone. The team measures infl…

This study looks at two ways to manage pain in children having the Nuss procedure for pectus excavatum (a sunken chest). One group received standard nerve freezing (cryoanalgesia) alone, while the other also had a nerve block near the diaphragm. Researchers will compare pain scor…

Researchers at the University of Malaya are studying how COVID-19 affects muscle loss and strength in critically ill patients. They will compare quadricep muscle thickness and cross-sectional area, along with handgrip and knee extension strength, between COVID-19 and non-COVID-19…

This study looked at whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery helps preserve diaphragm movement and reduce lung problems after surgery. Sixty adults having elective coronary artery bypass surgery were randomly assigned to receive either…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This study uses MRI scans to measure amyloid protein buildup in the hearts of up to 150 people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). Participants are already enrolled in a larger treatment trial. The goal is to see how amyloid levels change over time, not …

This study looks at how oral hygiene habits and gum health affect quality of life in 160 adults. Participants will have a dental exam and fill out a questionnaire about how their mouth feels day-to-day. No treatment is given—the goal is simply to understand the connection between…

Researchers at Nantes University Hospital are studying how joint damage from bleeding affects walking in adults with moderate hemophilia. About 24 participants will have their gait measured with motion capture and force platforms during a single visit. The study also collects cli…

Researchers are studying natural killer (NK) cells in people who receive stem cell transplants for leukemia. The study follows 92 patients and their donors, looking at genes called KIR and HLA that control how NK cells work. By tracking NK cells during immune recovery, researcher…

Researchers want to learn what causes myeloproliferative neoplasms, a group of rare blood cancers. They are testing whether small incentives like pens, trolley tokens, or a £10 reimbursement encourage more people to join a case-control study. The trial includes about 100 patients…

This registry study follows 400 patients with a specific type of leukemia (non-high-risk APL) who are 70 or younger. It compares two standard treatments: ATRA plus chemotherapy versus ATRA plus arsenic trioxide. The goal is to see which approach leads to better long-term outcomes…

This study asks over 1,600 African American women aged 23-35 about their experiences during the COVID-19 pandemic. Participants fill out a short online or paper survey covering infection, vaccination, childcare, job loss, and emotional stress. The goal is to understand how the pa…

This study looks at whether non-surgical gum cleaning (scaling and root planing) can change levels of certain bone-related substances in the blood of people with advanced gum disease. Sixteen adults with stage III periodontitis will receive the treatment, and their blood will be …

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

Researchers are studying whether the shape of a spinal curve affects how teenagers with idiopathic scoliosis distribute weight through their feet. The study includes 48 adolescents aged 10 to 17 who have Lenke Type I or Type V scoliosis curves. Participants receive standard spina…

This study checks whether the Four Square Step Test (FSST) is a good way to measure balance in people with rheumatoid arthritis. Researchers will test 50 adults aged 18-65 with RA, comparing FSST results to other measures like disease activity, pain, and muscle strength. The goal…

Prosthetic joint infections are rare but serious, often causing long hospital stays and lasting disability. Researchers at a French hospital are asking adults with these infections to fill out standard quality-of-life questionnaires during their regular follow-up visits. The stud…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looks at how well a bio-inductive implant helps heal torn rotator cuff tendons in the shoulder. Researchers will use MRI scans at 3 and 6 months after surgery to check if the repair is holding and if there are any problems. About 20 people with partial or full tears wi…

This study follows 136 adults aged 50 to 85 with knee osteoarthritis who are taking the supplement Structum (chondroitin sulfate). Researchers will measure pain, stiffness, and physical function using a standard questionnaire, along with other health factors, at the start and aft…

Researchers are testing whether a type of non-invasive brain stimulation, called intermittent theta burst stimulation, can change how the brain controls hand muscles. The study includes adults with and without spinal cord injuries to compare brain-muscle connections. By measuring…

This study looked at 47 people with bullous pemphigoid, a blistering skin condition, who were treated with high-dose topical corticosteroids (clobetasol propionate) for 6 months. Researchers measured bone mineral density at the start, at 3 months, and at 6 months to see if the tr…

This study looks at whether antioxidant supplements can prevent muscle loss and blood vessel problems in older adults (ages 65-85) during five days of bed rest. Participants take either a placebo or two antioxidants (MITO-AO and PB-125) while researchers measure changes in blood …

This observational study asks whether women with lipedema, a condition that causes abnormal fat buildup in the legs, are more likely to have joint hypermobility, or unusually loose joints, compared to healthy women of similar age and weight. Researchers will measure joint loosene…

This study looks at how your sense of joint position, fear of moving, balance, and sensory processing affect recovery after knee osteoarthritis surgery. Researchers will measure these factors in 75 people aged 50-75 who had a total knee replacement 4-6 weeks ago. The goal is to b…

This study followed 39 people who needed a tooth pulled and replaced with a dental implant. After extraction, the socket was filled with a bone graft material called Bio-Oss Collagen. Researchers then placed implants at 3, 6, or 9 months later to see how the bone healed over time…

This study tests a new imaging method called MR Elastography to measure how muscles and their surrounding tissues move in people with myofascial pain syndrome. Researchers will compare results from 106 participants, including those with chronic pain and healthy volunteers. The go…

This study looked at two community-based wellness programs for adults with disabilities like spina bifida, cerebral palsy, spinal cord injury, and traumatic brain injury. Researchers measured changes in health, mood, quality of life, and healthcare costs over up to 24 months. The…

This study followed 46 children with osteogenesis imperfecta (OI), a rare connective tissue disorder that causes frequent fractures and short stature. Researchers collected medical history, physical exams, hearing and dental tests, X-rays, bone scans, and genetic samples over sev…

This study looks at how bending the knee during exercises like squats affects pain in people with patellofemoral pain syndrome (PFPS). Fifteen participants will do three types of squats with increasing range of motion and rate their pain. The goal is to understand the relationshi…

This study looks at how smoking cigarettes, e-cigarettes, or a water pipe (narghile) affects the gums and teeth of university students aged up to 25. Researchers will measure plaque, gum inflammation, pocket depth, and other signs of gum disease in 90 smokers. The goal is to see …

This study looks at whether people with lipedema, a condition that causes painful swelling in the legs, also have sarcopenia, which is age-related loss of muscle mass and strength. Researchers will measure muscle thickness, grip strength, and walking speed in 102 adults with lipe…

This study looks at children and adolescents aged 6 to 16 with inherited arrhythmias, such as long QT syndrome, to see if a controlled exercise test on a treadmill reflects their actual heart rate and activity levels during daily life. Participants will complete a routine exercis…

Researchers are studying whether a muscle-released hormone called irisin is linked to bone strength in people with spinal cord injury. They will compare irisin levels and bone density between individuals with spinal cord injury and healthy controls. Participants will also do one …

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study follows 100 people with brain or spinal cord injuries to see how their ability to judge their own memory (metacognition) changes over time. Researchers want to know if better self-awareness helps people stick with rehabilitation. Participants complete computer memory t…

This observational study looks at 103 adults with knee osteoarthritis to see if repetitive negative thinking (rumination and worry) is linked to worse pain and disability, even when X-ray damage is similar. Participants fill out questionnaires about their thoughts, pain, and dail…

This study looks at whether children with a condition called molar incisor hypomineralization (MIH), which causes weak enamel on molars and front teeth, experience more stress during dental checkups. Researchers will measure stress by testing saliva for cortisol and checking hear…

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This trial tests four ways of making upper denture bases to see which fits the mouth most accurately. Thirteen adults with no teeth in their upper jaw receive dentures made by conventional molding, fully digital 3D printing, and two hybrid methods. Researchers scan each denture a…

This study looks at what influences treatment expectations in adults with myofascial pain syndrome (MPS), a common cause of muscle pain. Researchers measure pain intensity, pain duration, quality of life, and fatigue to see which factors best predict how much benefit patients exp…

This study looks at whether using an activity tracker with motivational feedback helps people become more active after knee replacement surgery compared to using a tracker without feedback. About 152 adults aged 40-85 scheduled for knee replacement will take part. The goal is to …

This study follows adults over 60 who are having a hip replaced due to osteoarthritis. The goal is to see how the surgery affects their balance and their confidence in performing daily activities without falling. Researchers will measure balance using a detailed physical test and…

This study uses MRI scans to check how well the subscapular tendon—a key shoulder tendon—heals years after surgical repair. Researchers want to see if a new arthroscopic classification of tendon tears predicts better healing and less fatty buildup in the muscle. Adults who had th…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This trial asks whether the barbell back squat or the barbell hip thrust is better for building glute muscle and strength. About 39 young, untrained adults will train twice a week for nine weeks with one of the two exercises. Researchers will measure muscle size with MRI and stre…

This trial investigates whether combining group and individual educational sessions helps patients with chronic inflammatory rheumatism (like rheumatoid arthritis or spondyloarthritis) learn safety skills better than individual sessions alone. Participants are starting their firs…

This study explores how weight-loss surgery changes the body's protein needs and whether fast-absorbing milk proteins can help preserve muscle mass and strength. Researchers will measure nitrogen balance and muscle function in 25 adults with severe obesity before and after gastri…

This study looks at whether anxiety about climate change is linked to worse sinusitis symptoms and lower quality of life in adults with chronic rhinosinusitis. Researchers will ask about 134 adults to complete questionnaires measuring sinus symptoms, quality of life, and climate …

This study tests whether a smartphone-based digital assessment can measure rheumatoid arthritis activity as well as a standard doctor-performed exam. Adults with rheumatoid arthritis will complete a digital questionnaire, record guided videos of their joint movements, and then ha…

This observational study looks at how people with spinal cord injuries maintain balance while performing a stationary wheelchair wheelie. Participants will be asked to hold a wheelie for at least 20 seconds while sensors track their body movements and balance. The goal is to unde…

This trial tests whether taking cordyceps supplements alongside fartlek training — a type of speed-play workout — can reduce muscle damage, inflammation, and oxidative stress in competitive soccer players aged 18–20. Over four weeks, researchers measure blood markers of muscle in…

This project creates a central repository of medical records, genetic test results, and patient-reported information from people with Duchenne or Becker muscular dystrophy, as well as carriers. Anyone aged 4 weeks or older with a confirmed diagnosis can join. The goal is to provi…

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matche…

This study aims to discover new genes and mutations that cause isolated forms of amelogenesis imperfecta and dentinogenesis imperfecta—inherited conditions that affect tooth enamel and dentin. Researchers are using whole exome sequencing on participants who have these tooth disor…

This study examines nanofat—a processed form of a person's own fat—to see if it could be used as a cell therapy for rhizarthrosis, a common and painful form of thumb osteoarthritis. Researchers will collect fat samples from healthy volunteers and analyze the cells and sterility i…

This study investigates how often people with lateral epicondylitis (tennis elbow) also have posterolateral rotatory instability, a ligament problem that causes similar pain but requires different treatment. Researchers will check the elbow's lateral collateral ligament during sc…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This registry study collects detailed information from 45,000 adults undergoing fast-track hip or knee replacement at eight Danish hospitals. Researchers track patient health before surgery and complications afterward, including hospital stays, readmissions, and deaths within 90 …

This study tests three different force levels (2 kg, 5 kg, and 11 kg) of the 'crossed hands' myofascial release technique on healthy adults. The goal is to see how each force affects muscle stiffness, thickness, pain sensitivity, and lower back and hip mobility. By finding the mo…

This observational study looks at how anthracycline chemotherapy affects inflammation, oxidative stress, and heart function in adult women who had breast cancer. Researchers measure blood markers and use echocardiograms to assess heart changes about 10 years after treatment. The …

This study examines how different types of bacteria in the mouth are linked to the severity of dental cavities. Researchers will collect saliva and plaque samples from 56 people aged 3 to 45 and grade their cavities using a standard scoring system. The goal is to better understan…

This study follows head and neck cancer patients who received radiation therapy to see how many teeth they lose over two years. It also looks at other mouth problems like dry mouth and bone damage. The goal is to better understand and manage these long-term side effects.

This study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning a…

This study tested a decision algorithm to help doctors diagnose the cause of eosinophilia (high levels of a type of white blood cell). The algorithm guides which tests to do and in what order. Researchers enrolled 53 patients and measured how many followed the algorithm correctly…

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if …

This study looked at 76 children aged 3 to 15 getting dental care with nitrous oxide (laughing gas). Researchers watched for signs that kids wanted to keep the mask on longer, like hand gestures or asking to keep it. The goal was to see if there's a risk of children misusing the …

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…

This study looks at whether people with chronic inflammatory rheumatism (like spondyloarthritis) or lupus who still have pain despite treatment have low vitamin C levels. Researchers will measure vitamin C in the blood and ask about pain, fatigue, and quality of life. The goal is…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…