Nasal spray could shrink polyps and reduce need for surgery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must meet all of the following criteria to be eligible for enrollment: * Male or female patients aged 18 to 70 years. * Diagnosis of chronic rhinosinusitis with nasal polyps (CRSwNP) requiring surgical treatment. * Presence of nasal polyps confirmed by clinical examination and nasal endoscopy. * Candidates for Functional Endoscopic Sinus Surgery (FESS) for removal of one or more nasal polyps. * Ability and willingness to comply with study procedures, treatment regimen, follow-up visits, and assessments. * Ability to provide written informed consent. * No treatment with antihistamines during the previous 6 months. * No ongoing treatment with topical or systemic corticosteroids at the time of enrollment. Exclusion Criteria: * Chronic maxillary sinusitis without nasal polyps. * Previous endoscopic sinonasal surgery within the preceding 12 months. * Current treatment with systemic antihistamines. * Current treatment with topical or systemic corticosteroids. * Diagnosis of asthma. * History of radiotherapy to the head and neck region within the previous 3 years. * Current or recent (within the previous 3 years) treatment for any form of cancer. * Presence of a serious neurological disorder that could interfere with study participation or outcome assessment. * Known immunodeficiency, including but not limited to Acquired Immunodeficiency Syndrome (AIDS). * Acute purulent sinusitis associated with fever requiring antibiotic therapy. * Requirement for systemic antibiotic treatment at enrollment. * Current treatment with oral anticoagulants (e.g., warfarin). * Any medical condition that, in the investigator's judgment, may compromise patient safety, adherence to the protocol, or interpretation of study results. * Development of fever or a bacterial infection requiring antibiotic therapy during the follow-up period; such patients will be withdrawn from the study after enrollment according to the protocol.