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Can a tiny pinhole rebuild bone lost to gum disease?

NCT ID NCT07763223

Disease control Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 13, 2026 · Last updated Aug 20, 2026 · Updated 3 times

Summary

This trial tests a new, less invasive surgical approach for treating advanced periodontitis (stage III). Instead of lifting the gum, doctors access the damaged bone through a small pinhole, clean the area, and place a bone graft to encourage regeneration. The study includes adults aged 39-61 with deep gum pockets and specific bone defects. Over six months, the researchers will measure improvements in pocket depth, gum attachment, and bone fill to see if this technique is effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A minimally invasive surgical procedure (Sub-junctional Pinhole Technique) using a xenogenic bone graft (Geistlich Bio-Oss) placed through a small pinhole without lifting the gum.
What this could lead to
If successful, this approach could offer a less invasive way to regenerate bone and gum support in advanced periodontitis, potentially saving teeth that might otherwise be lost.
What could go wrong
This is a very small early-stage trial (10 people), so results may not apply broadly. The procedure is surgical and carries risks like infection, pain, or graft failure, and long-term benefits are unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

10 people

The number who actually took part.

Started

Jun 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

39 to 61 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Patients aged 39-61 years. * Systemically healthy patients. * Diagnosed with Stage III periodontitis. * Presence of probing pocket depth (PPD) ≥ 6 mm. * Presence of clinical attachment loss (CAL) ≥ 4 mm. * Presence of at least one 2- or 3-wall interproximal intrabony defect with: * Defect depth ≥ 3 mm. * Angulation width ≥ 45°. * Each participant contributed one maxillary or mandibular single- or multi-rooted interproximal intrabony defect. Exclusion Criteria * Patients with any systemic condition contraindicating surgical intervention. * Pregnant or lactating females. * Smokers. * Alcoholic patients. * History of periodontal therapy within the previous 6 months. * History of antibiotic administration within the previous 6 months. * Patients with unacceptable oral hygiene after re-evaluation following Step 1 and Step 2 periodontal therapy. * Teeth with any degree of mobility.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal intrabony defects Stage III grade B periodontitis

Contacts and locations

Locations

  • Department of Periodontology, Faculty of Dentistry, Al-Azhar University, Cairo, Egypt

    Cairo, Nasr City, 11675, Egypt

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