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Could probiotics ease pain after root canal? new trial investigates

NCT ID NCT07683520

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This trial tests whether taking probiotics by mouth, along with standard root canal medications, can reduce pain and improve healing in people with chronic tooth infections. Participants will receive either a probiotic capsule or a placebo for 21 days, combined with one of three root canal treatments. The study measures pain levels and markers of bone healing to see if the combination works better than standard care alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Probiotics (Lactobacillus acidophilus, Bifidobacterium animalis) and propolis or calcium hydroxide intracanal medicaments
What this could lead to
If successful, this could point toward a simple probiotic supplement to reduce pain and improve healing after root canal treatment for chronic tooth infections.
What could go wrong
This is a small, early-phase trial with only 72 participants. Results may not apply to all patients, and the effect of probiotics on dental infections is still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

72 people

The number who actually took part.

Started

Oct 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Previously treated failed single rooted teeth with chronic apical periodontitis. * No use of antibiotic three months before treatment. * Patients are free of any systemic disease. * Positive patient acceptance for participation Exclusion Criteria: * Teeth that are badly broken down with difficult isolation. * Signs of acute infection, root fracture, root surface caries, swellings or ankylosis * Periodontally affected teeth with pockets deeper than 4mm. * Pregnant or lactating woman. * Patients who needs any prophylactic antibiotic. * Patients with allergy to pollen.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic apical periodontitis

Contacts and locations

Locations

  • Faculty of Dentistry, Ain Shams University

    Cairo, Cairo Governorate, 11566, Egypt

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