Cerebral cortex disorder

This study tests whether cenobamate, an experimental anti-epileptic drug, can safely reduce primary generalized tonic-clonic (PGTC) seizures when added to a person's usual seizure medications. Adults and adolescents aged 12 and older with PGTC seizures are randomly assigned to re…

This trial compares two approaches—sensory motor integration and the Bobath technique—to see which better improves hand skills in children aged 6 to 12 with hemiplegic cerebral palsy. Fifty children will receive one of the two therapies for 45 minutes, three times a week, over th…

This study tested whether combining blood flow restriction with physical therapy could improve leg muscle strength and walking in 30 children with hemiplegia (ages 3-8). The therapy involved exercises like stretching, balance training, and walking drills while blood flow to the l…

This completed Phase 2 trial tested an oral drug called LY3372689 in 327 people with early symptomatic Alzheimer's disease. The goal was to see if the drug could safely slow down declines in thinking and daily living skills compared to a placebo. The study focused on participants…

This study tested a new intensive therapy called I-ACQUIRE for infants aged 8 to 36 months who had a stroke around birth and have weakness on one side. The therapy involves guided play and movement exercises for either 3 or 6 hours a day, 5 days a week for 4 weeks. Researchers co…

This study tested a drug called cenobamate in 519 adults with partial onset seizures (focal seizures). Participants took cenobamate or a placebo alongside their usual seizure medications. The goal was to see if cenobamate could safely reduce seizure frequency. Results showed a si…

This Phase 3 trial tested a drug called XEN1101 (azetukalner) in 380 adults with focal-onset seizures that were not well-controlled by other medications. Participants took either XEN1101 or a placebo alongside their usual seizure drugs. The study measured whether XEN1101 reduced …

This study tested an early, intensive therapy program called HABIT-ILE in 36 preschool children (ages 1-4) with bilateral cerebral palsy. The therapy focuses on coordinated use of both hands and legs through structured activities. Researchers measured changes in gross motor funct…

This study tested a Norwegian intensive habilitation program for children aged 2-6 with severe cerebral palsy or similar brain damage. The program aimed to improve the child's daily living skills and empower parents. 93 children and their families took part in a randomized trial …

This study tested a 'blended care pirate group' for children aged 2.5 to 8 with unilateral cerebral palsy. The program combines on-site therapy sessions with home-based training, where children wear a sling on their less-affected arm and do play-like activities to improve use of …

This study tested an oral drug called ADX-629 in 8 people with Sjögren-Larsson syndrome, a rare inherited disorder that causes harmful fatty substances to build up in the skin, brain, and eyes. The main goals were to see if the drug is safe and can reduce these fatty aldehydes. P…

This study tested whether a single infusion of a child's own stored umbilical cord blood could improve motor skills in children with spastic cerebral palsy. Sixty-three children aged 1 to 6 years received either cord blood or a placebo, and their gross motor function was measured…

This completed trial tested whether combining a gentle brain stimulation technique called tDCS with intensive rehabilitation can improve hand function in children with hemiplegic cerebral palsy caused by perinatal stroke. 89 children participated, and the study measured changes i…

This study looked at whether physical training after a type of nerve surgery (selective dorsal rhizotomy) can improve trunk control and arm function in children aged 4-7 with severe cerebral palsy who cannot walk. The training included exercises to strengthen the trunk and improv…

This study looked at whether giving exosomes through the nose could help improve vision in 32 children with cortical visual impairment (CVI), a vision problem caused by brain injury. The children received the treatment once a month for six months and were monitored for changes in…

This study looked at whether Botox injections, combined with physical therapy, can improve selective motor control (the ability to move one joint at a time) in children with spastic diplegia cerebral palsy. Forty children aged 4-12 received Botox in their spastic muscles plus 30 …

This study tested whether intensive video game-based therapy can improve motor skills and daily living activities in children with cerebral palsy. Sixteen children aged 4-18 were randomly assigned to either video game therapy or standard bimanual therapy for two weeks. Researcher…

This study tested an investigational drug called RAP-219 in 30 adults with refractory focal epilepsy—seizures that don't respond well to current treatments. Participants took RAP-219 tablets to see if it safely reduces seizure frequency. The trial is now complete, and results wil…

This completed study tested a special balance training that uses controlled pushes or movements to help children with hemiplegic cerebral palsy improve their balance and body awareness. Thirty children aged 8 to 10 years participated. The training aims to help them react quickly …

This study tested whether multisensory environment stimulation therapy (a specially designed room with controlled lights, sounds, and textures) can improve balance in children aged 9 to 12 with spastic hemiplegic cerebral palsy. 38 children participated, and the therapy was added…

This study tested whether stem cells taken from a patient's own fat and given by IV are safe and might help the brain heal after a traumatic brain injury. 24 adults with long-term brain damage received the treatment. Researchers checked vital signs and measured inflammation marke…

This completed study tested whether adding eccentric (lengthening) exercises to standard neurodevelopmental therapy can reduce spasticity and improve walking and balance in children aged 6–18 with spastic cerebral palsy. 42 participants with mild to moderate impairment were rando…

This study tested the drug levetiracetam as the first treatment for seizures in 18 full-term newborns who had brain injury from lack of oxygen at birth. The goal was to find the right dose and check if it is safe and effective at reducing seizure activity on brain recordings. The…

This early-stage trial tested a drug called NIO752 in 59 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and balance. The drug was given as a spinal injection to see if it is safe and how the body processes it. The main goal was to ch…

This study looked at 200 women with eclampsia (a serious condition causing seizures during pregnancy) to see if giving magnesium sulphate into a vein (IV) or into a muscle (IM) works better to stop seizures from coming back. Women were randomly assigned to one of two treatment gr…

This study compared two therapies—hippotherapy (therapeutic horseback riding) and Swiss ball exercises—to see which improves trunk control and balance in children with spastic diplegic cerebral palsy. Fifty-two children aged 4 to 11 took part. The goal was to find which approach …

This study tested whether a single dose of naloxone, given right after a generalized tonic-clonic seizure, can help people with epilepsy breathe better and avoid sudden death. Researchers enrolled 485 adults with drug-resistant epilepsy who were already in the hospital for monito…

This study tested whether a special type of MRI that measures sodium levels in the brain can help locate the exact area causing seizures in people with drug-resistant epilepsy. 78 patients who were already scheduled for epilepsy surgery received a sodium MRI scan. Researchers com…

This study tested a smartphone app that guides children through deep breathing (hyperventilation) and records their face and sounds to detect absence seizures. 65 children with and without seizure history participated. The app's accuracy was compared to standard EEG monitoring. T…

This study tested whether a simple eye-tracking system can identify children with childhood absence epilepsy and related thinking problems. Researchers compared eye movement recordings from 60 participants (kids with epilepsy and healthy controls) to standard tests. The goal is t…

This study tested whether a special sitting position that centers the hip joint can prevent hip dislocation in children with severe cerebral palsy. Seventeen children aged 1-6 years participated, using either the experimental or usual sitting method for at least 5 hours daily ove…

This study tested whether giving the seizure drug levetiracetam right away can prevent seizures in people who had a brain bleed (hemorrhagic stroke). About 50 adults with a recent brain bleed received either the drug or a placebo. The goal was to see if the drug could reduce seiz…

This study tested whether lithium, a drug used for mood disorders, can prevent Alzheimer's dementia in older adults with mild cognitive impairment (MCI). 83 participants took either lithium or a placebo for a period, and researchers measured memory, thinking skills, and brain cha…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This study tested a sensorimotor program for infants with hypoxic-ischemic encephalopathy (HIE), a brain injury from lack of oxygen at birth. Eleven babies received play-based therapy sessions in the NICU and at home for the first 6 months. The goal was to see if the program was …

This pilot study tested a powered knee orthosis called Agilik in 10 people with cerebral palsy who have crouch gait. Participants walked with the device and without it to see if it improved their walking distance, speed, and knee motion. The goal was to find out if the device can…

This study tested whether task-specific electrical stimulation can improve upper limb motor skills in 30 children aged 4 to 7 with spastic quadriplegia cerebral palsy. The therapy uses mild electrical pulses to activate muscles during functional tasks. The goal was to see if this…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This study looked at whether a 10-week adapted dance program could improve balance, walking, and quality of life in 13 children with cerebral palsy. Participants attended 20 hours of dance classes designed to be accessible. The goal was to see if the program was both helpful and …

This study looked at whether an 8-week core muscle strengthening program could improve head and trunk control in 38 non-ambulatory children (ages 4-10) with spastic cerebral palsy. Children did 24 therapist-led sessions with exercises like bridging and sitting on a therapy ball. …

This study looked at whether special breathing exercises could help children with cerebral palsy (ages 5-18) breathe better, improve their balance, arm use, and swallowing. Twenty children with mild to moderate CP took part. The goal was to see if these exercises could make every…

This study tested a 6-week home stretching program for 30 children aged 4-11 with spastic cerebral palsy. The program included a 2-week casting period followed by daily stretches of the calf and hamstring muscles. Researchers measured changes in muscle length, joint flexibility, …

This study tested whether special video games controlled by muscle signals (EMG) can improve walking in children with cerebral palsy. Thirty children aged 2 to 10 with mild to moderate CP played these games alongside physical therapy. The goal was to help them better control ankl…

This study tested whether robotic gait training (using a device called Lokomat) or standard physical therapy, or a mix of both, helps children with cerebral palsy walk better. 68 children aged 5-18 participated in 16 sessions over 8-10 weeks. Researchers measured changes in motor…

This study tested a special nerve-stretching technique (neural mobilization) against standard physical therapy in 40 children aged 5-18 with cerebral palsy and leg spasticity. The goal was to see if it improves joint movement, motor function, and pain. The results may help guide …

This study tested whether adding robotic rehabilitation to standard neurodevelopmental therapy could improve leg and trunk function in children with cerebral palsy. Fifteen children participated, receiving standard therapy first, then robotic therapy added on. Researchers measure…

This study tested two exercise methods—core strengthening and movement awareness training—in 32 children with diplegic cerebral palsy (ages 4-8). Both groups did standard physical therapy plus one of the extra exercises three times a week for 12 weeks. The goal was to see which a…

This study tested whether shining a special light (photobiomodulation) on the calf muscles can reduce spasticity in children with cerebral palsy. Twelve children aged 2 to 18 received either real or placebo light therapy once a week for two months, alongside their usual care. The…

This study tested a home-based therapy program for infants and toddlers with cerebral palsy, where parents delivered daily exercises guided by a therapist. Twenty children aged 3 to 24 months participated over 18 weeks. The goal was to improve hand function and make therapy easie…

This study tested a drug called valbenazine to see if it can reduce jerky, uncontrolled movements (chorea) in people with cerebral palsy. The trial included 86 children and adults whose medical condition was stable. Participants received either valbenazine or a placebo for 14 wee…

This study looked at whether adding Epidiolex (a CBD-based medicine) to usual treatment can improve seizures, behavior, sleep, and quality of life in people aged 1 to 65 with tuberous sclerosis complex (TSC). 79 participants took the drug and were monitored for changes in symptom…

This study tested the safety and effectiveness of repeated MYOBLOC injections over one year in 187 adults with troublesome drooling caused by conditions like Parkinson's disease, stroke, or ALS. Participants received up to four treatment sessions, and researchers tracked side eff…

This study tested whether an intensive 3-week touch-based therapy program could help children with unilateral cerebral palsy use their affected arm better. Sixteen children aged 6 to 15 took part in 30 hours of therapy plus weekend activities. The goal was to see if this approach…

This study looked at using a heat-based technique called thermocoagulation in 100 children aged 1.5 to 17 years with focal epilepsy that doesn't respond to medication. During a brain monitoring procedure, doctors applied small heat lesions to the area where seizures start, aiming…

This study looked at whether aromatherapy (lavender oil foot massage) and reflexology (pressing specific points on the feet) could reduce pain and improve sleep in 90 children with cerebral palsy, aged 6 to 12. Children were split into three groups: aromatherapy, reflexology, or …

This study tested an 8-week client-centered occupational therapy program for caregivers of children with cerebral palsy. The program focused on goal setting, time management, and balancing self-care, work, and leisure. Thirty-four caregivers were randomly assigned to the program …

This study tested whether a 6-week home-based virtual reality exercise program is acceptable and beneficial for young people with cerebral palsy who are overweight and inactive. Four participants used a VR headset to play active games. Researchers measured changes in body composi…

This study tested whether a robotic walking device (Lokomat) can improve how children with cerebral palsy or other brain injuries walk. Fifty-nine children completed the program, and researchers measured changes in walking speed, step length, and other movement patterns. The goal…

This study tested whether a special video program that adds sensory exercises to hand therapy could help children with cerebral palsy use their hands better. Forty children followed either the sensory-enhanced videos or standard exercise videos at home. The goal was to see if the…

This pilot study tested a community-based group programme called 'Encompass' for parents of children under 5 with complex neurodisability. Fifteen parents in East London attended ten group sessions over six months. The study aimed to see if the programme was feasible and acceptab…

This pilot study tested a device called NaviFUS that uses focused ultrasound to stimulate the brain in 12 adults with drug-resistant epilepsy. The goal was to see if it is safe and can reduce seizure frequency. Participants kept seizure diaries and reported any side effects over …

This study tested a treatment called functional electrical stimulation (FES) in 11 children aged 3-6 who had a stroke around birth and have trouble using one arm. FES uses small electrical currents to make weak muscles move, helping kids practice reaching and grasping. Researcher…

This study looked at two different arm strengthening exercises in 14 children aged 5-12 with unilateral spastic cerebral palsy. One group did bilateral exercises based on Proprioceptive Neuromuscular Facilitation patterns, and the other did plyometric exercises. The goal was to s…

This study tested a device that sends a very mild electrical current to the brain (tDCS) to see if it can safely reduce seizures in people with epilepsy that doesn't respond to medication. 127 participants aged 9 and older received either real or fake (sham) stimulation for 10 se…

This study tested two breathing devices—a Lung Boost trainer and an incentive spirometer—to see which better improves lung function in 60 children aged 4-9 with cerebral palsy who had recovered from COVID-19. All children also received standard breathing therapy. The goal was to …

This study tested a high-intensity home exercise program for children with cerebral palsy, using rhythmic arm movements set to music. 42 children aged 6-17 participated, with parents helping to ensure safety. The goal was to see if this fun, accessible program could improve cardi…

This study tested whether Nordic walking—walking with poles like ski poles—can improve walking symmetry in children with hemiparesis due to cerebral palsy. Forty children aged 6-10 participated in a 3-month program combining physical therapy and Nordic walking. The goal was to se…

This study looked at whether strengthening breathing muscles can improve trunk control in children with spastic diplegic cerebral palsy. Thirty children aged 8 to 10 took part, doing either standard therapy plus breathing exercises or standard therapy alone for one month. The goa…

This pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…

This study tested whether adding mild, painless electrical stimulation to standard physical therapy could help children with spastic cerebral palsy. Eleven children aged 5 to 15 received 6 weeks of therapy alone, then another 6 weeks with the added stimulation. Researchers measur…

This pilot study tested the Petö Method, a comprehensive educational therapy, in 13 children aged 4 to 9 with spastic cerebral palsy. The therapy improved gross motor function, including arm and leg movement and postural control, beyond what is considered a meaningful change. The…

This study tested whether walking forward or backward is better for improving movement and balance in children with spastic cerebral palsy. Sixty children ages 6 to 9 took part in gait training sessions. Researchers measured changes in gross motor function to see which direction …

This study tested a home-based program for children with cerebral palsy who have trouble chewing. Twenty-two children did chewing exercises, and half also watched videos of chewing actions at home with a therapist's guidance. The goal was to see if adding video observation improv…

This small study looked at whether a special ballet class could help children with cerebral palsy improve their movement and thinking skills. Nine children aged 9 to 15 took part in the dance program. The goal was to see if the program was enjoyable and helpful for coordination, …

This study looked at whether adding whole body vibration training to standard physical therapy helps children with mild to moderate cerebral palsy improve their balance, walking, and leg function. 36 children were split into three groups: vibration barefoot, vibration with shoes,…

This study tested a home-based therapy program that uses sensors to help children with cerebral palsy improve the use of their arms and hands. The therapy, called Tele-HABIT, involves structured play activities done at home under remote guidance. The trial included 29 children ag…

This study tested two ways of using action observation therapy to help children with cerebral palsy improve their balance, walking, and daily movement. Twenty-two children aged 6 to 18 watched videos of motor tasks either in real time (synchronous) or with a delay (asynchronous) …

This small study looked at whether metformin, a diabetes medicine, is safe and practical for children aged 5 to 18 with cerebral palsy. Only 3 children took part, and the main goal was to see if families would join and stick with the treatment. Researchers also checked if metform…

This study tested whether adding Xbox Kinect video games to standard therapy could improve hand function and daily activity participation in 24 children aged 7-13 with hemiparetic cerebral palsy. Half received standard therapy plus gaming sessions, while the other half had standa…

This study tested whether daily probiotic supplements could improve constipation and weight gain in 30 children with cerebral palsy. Participants took either Lactobacillus reuteri or a prebiotic-enriched Lactobacillus rhamnosus for 28 days. Caregivers tracked bowel movements and …

This study tested whether combining virtual-reality cycling training with noninvasive brain stimulation could improve upper limb motor function in 36 children and young adults with cerebral palsy. Participants used a virtual-reality bike while receiving either repetitive transcra…

This study tested whether a NAO robot could make occupational therapy more engaging for children with cerebral palsy. Fifteen kids aged 5-15 took part in a 14-week program where a robot helped guide daily activities and gave motivational feedback. Researchers tracked their motor …

This study tested whether a two-week intensive physiotherapy program could help children with spastic cerebral palsy improve their posture and ability to control their arms and legs. Thirty children aged 4 to 8 years took part, with half receiving the intensive program and half r…

This study tested whether adding ultrasound or whole-body vibration to regular stretching helps children with hemiplegic cerebral palsy improve knee motion and function. Sixty children aged 4-6 years participated. The results may show which extra therapy works best for boosting m…

This study tested whether a program called PQ-ResPOND could help manage pain in children with severe neurologic disabilities like cerebral palsy. About 54 children and their parents took part, with some receiving the program (surveys plus a palliative care team consult) and other…

This study looked at whether adding special arm-reaching exercises to standard stroke rehab helps improve trunk control, balance, walking, and fall risk. 30 adults who had a stroke at least 3 months ago took part. Some did fast arm reaches to a light, others held the reach for 5 …

This small study tested a new approach for children with cerebral palsy: combining a gentle brain stimulation technique (tDCS) with treadmill walking. Five children completed ten sessions, and researchers measured changes in walking speed, endurance, and motor skills. The goal wa…

This study tested a personalized water exercise program for 12 children with cerebral palsy. Each child did both the water program and standard exercises for 16 weeks each. The goal was to see if fun, task-focused activities in water could improve their daily skills and participa…

This pilot study tested whether prolonged exposure teletherapy can help adults with psychogenic nonepileptic seizures (PNES) and PTSD. Forty-four participants received either the teletherapy or standard education about PNES. The goal was to see if the therapy reduces seizure freq…

This study tested whether combining TENS (a mild electrical stimulation) with exercises that use sight and body awareness can improve walking in children with spastic diplegic cerebral palsy. Thirty children aged 4 to 6 years old took part. The goal was to see if this approach co…

This study tested a combination of rhythmic auditory stimulation (like music or beats) and functional electrical stimulation (mild electrical pulses to muscles) to improve walking in 60 children aged 6 to 10 with hemiparesis. The goal was to see if this approach could help them t…

This study looked at whether a single session of Vojta therapy, a special type of physical therapy, could help a 15-year-old with hemiparesis (weakness on one side of the body) improve hand movement. The child's hand dexterity and brain activity were measured before and after the…

This study tested whether adding mirror therapy to Botox injections can better reduce arm spasticity in stroke survivors. Thirty patients who had a stroke at least three months earlier received Botox injections and then either mirror therapy or a sham treatment. Researchers measu…

This study tested whether serial casting (applying a series of casts) can improve ankle movement and walking in children with spastic cerebral palsy who have tight leg muscles. Forty children aged 3 to 12 took part. The goal was to see if this non-surgical approach could ease sym…

This study tested whether a 15-session physical therapy exercise camp could improve leg movement and daily function in 23 children with spastic cerebral palsy, ages 5 to 18. Kids attended 3-hour sessions and did home exercises afterward. Researchers measured strength, walking, ba…

This study tested whether a gentle electrical stimulation (NMES) to the neck muscles helps children with cerebral palsy swallow better. Twenty-six kids were split into two groups: one got real NMES plus swallowing therapy, the other got a sham device plus therapy. Researchers mea…

This study tested whether an elastic leg brace could improve walking and balance in 26 children with spastic cerebral palsy who walk on their toes. Children either received standard therapy alone or standard therapy plus the brace. The study measured changes in gait and balance a…

This study looked at whether a special exercise program called Task-Specific Circuit Training (TSCT) helps children with cerebral palsy improve their movement, balance, and quality of life. Thirty-four children aged 5-12 who could walk with or without help took part. One group di…

This study tested whether wearing a special pressure sleeve for 6 months could improve hand function in children with cerebral palsy. 101 children aged 5 to 10 took part. The sleeve, made of a stretchy material, was designed to provide gentle pressure to the arm. The main goal wa…

This study looked at whether injecting botulinum toxin into two leg muscles (rectus femoris and semitendinosus) can improve walking and reduce stiffness in children with cerebral palsy. 23 children aged 7 to 17 who could walk (with or without aids) took part. Researchers measured…

This study tested whether a technique called instrument-assisted soft tissue mobilization (IASTM) — using a special tool to massage muscles — could improve walking in children with spastic diplegic cerebral palsy. Thirty children aged 5 to 8 took part; half received IASTM plus st…

This study tested two types of exercise—moderate steady training and high-intensity interval training—in 30 children with spastic diplegia (a form of cerebral palsy) aged 3 to 5. The goal was to see which better improves walking, energy use, and daily movement. Children were spli…

This study tested whether adding a multi-component home training program to standard care helps children with cerebral palsy recover better after lower leg tendon release surgery. Forty children aged 4-18 who could walk participated. The study measured movement, pain, fear of mov…

This completed study tested whether adding sensory integration therapy to standard balance exercises could improve balance, thinking, and independence in 22 children with cerebral palsy aged 6 to 10. Participants were randomly assigned to 12 weeks of balance exercises alone or co…

This study looked at whether adding electrical muscle stimulation (EMS) to a 4-week cycling and strengthening program helps children with cerebral palsy improve their balance, walking, and mobility more than exercise alone. 26 children aged 6-10 took part. The goal was to see if …

This study tested whether watching and imitating movements (action observation therapy) improves balance, walking, and thinking in children with diplegic cerebral palsy compared to standard physical therapy. 46 children aged 5-11 years participated. The goal was to see if this ap…

This study tested whether Action Observation Therapy—watching a movement and then doing it—can reduce spasticity and improve motor skills, balance, and participation in children with cerebral palsy. 36 children aged 5-13 with spastic diplegia or hemiplegia took part. The therapy …

This study tested whether a special nerve block (erector spinae plane block) can reduce the need for strong opioid painkillers in children aged 6 to 18 with spastic cerebral palsy undergoing selective dorsal rhizotomy, a spinal surgery to reduce muscle stiffness. Thirty children …

This small study tested whether a robotic bodyweight support system combined with smart insoles that beep at the right time can help adults with cerebral palsy walk better. Five adults completed 6 training sessions. Researchers measured walking speed, endurance, and joint movemen…

This study tested whether a special exercise program using a universal exercise unit could improve arm function and strength in children with spastic hemiplegia cerebral palsy. Forty children aged 5-9 years participated, with half receiving the special program plus standard thera…

This study tested whether a daily supplement called ETAS®, made from asparagus, could improve memory, mood, and reduce inflammation in healthy adults aged 60-80 who had mild memory concerns. 45 participants took either a low or high dose of ETAS® or a placebo for 12 weeks. Resear…

This study tested whether virtual reality (VR) exposure therapy could reduce anxiety in people with epilepsy who worry about their seizures. Fourteen participants were split into two groups: one received VR therapy using 360-degree videos of social or public settings, and the oth…

This study compared a special hand therapy (mCIMT) delivered via video calls to a standard home program in 42 children with unilateral cerebral palsy. The therapy group did one-hour sessions three times a week for six weeks, plus daily activities. The goal was to see if telerehab…

This study tested a new type of mobility training (called dynamic supported mobility) for infants and toddlers with cerebral palsy. The goal was to see if it helps improve movement and balance better than standard care. 42 children aged 12 to 36 months took part. The study compar…

This study tested whether a high-intensity exercise program, run by physical therapy students, can help people with neurologic disabilities move better in everyday life. Fifteen participants with conditions like cerebral palsy, stroke, or spinal cord injury completed the program.…

This study tested a virtual reality program called MOVE-IT that kids with hemiplegia (one-sided arm weakness) can use at home. 25 children participated to see if the VR exercises improve hand and arm function better than usual care. The goal was to make therapy more engaging and …

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This study tested prefabricated carbon fiber ankle-foot orthoses (AFOs) in 65 children and teenagers with conditions like cerebral palsy, spina bifida, or spinal cord injuries that affect walking. Researchers measured stride length, walking speed, and user satisfaction by compari…

This study tested whether applying kinesiology tape (a stretchy, elastic tape) to the trunk and limbs could improve balance and motor function in 30 children with cerebral palsy. The children wore the tape for four weeks and were assessed before and after. The goal was to see if …

This study tested whether giving children a single dose of dexamethasone before a nerve block for ankle or foot surgery could extend pain relief and reduce the need for strong painkillers like opioids. 90 children took part, receiving either a small or large dose of dexamethasone…

This study tested a 3-week intensive program of play-based physical therapy for children with cerebral palsy. Seven children aged 2 to 12 took part in activities like treadmill walking and overground walking. Researchers measured changes in movement, daily skills, and quality of …

This completed study tested whether adding dry needling to standard physical therapy could reduce muscle stiffness and improve movement in 48 children with cerebral palsy. Researchers measured spasticity, walking ability, and overall motor function. The goal was to see if this si…

This study tested two different training methods—watching and imitating hand actions (action observation therapy) versus core stability exercises—to see which better improves hand function in children aged 4 to 8 with hemiplegic cerebral palsy. Fifty-two children participated, an…

This study tested two exercise programs in 50 children with spastic diplegic cerebral palsy aged 6-12. One group did exercises on unstable surfaces like gym balls and trampolines, while the other did similar exercises on stable surfaces like mats. The goal was to see which approa…

This study looks at how touch, vibration, and position sense in the hands and arms affect daily activities in children with cerebral palsy. Researchers will compare 12 children with CP to 12 typically developing kids aged 6 to 15. They use simple tests like tuning forks and monof…

This study followed 60 infants at high risk for cerebral palsy from birth to 18 months to see how they learn to move. Researchers used wearable sensors and a robotic crawler to measure leg movements, crawling, and walking. The goal was to understand how motor skills develop or ar…

This study looked at how children with cerebral palsy, their parents, and healthcare professionals experience sleep disordered breathing and its management. Researchers interviewed 24 participants to understand the challenges and what helps or hinders treatment. The goal was to g…

This study looked at 10 school-aged children with cerebral palsy to see if their hand function is related to their school grades and performance. Researchers measured hand ability using standard tests and compared them to report card grades and teacher evaluations. The goal was t…

This study tested whether a brain-computer interface (BCI) device is ready for commercial use to help people with minimal movement communicate. Researchers worked with 8 device users, plus speech therapists and support staff, to evaluate how well the device worked at home. The go…

This study looked at whether opioid use disorder and non-fatal overdoses cause a harmful protein called tau to build up in the brain. Researchers used special PET/CT scans on 12 adults, including those with opioid use disorder and healthy volunteers. The goal was to understand lo…

This study looked at how spasticity (stiff muscles) affects balance reactions in 40 children with cerebral palsy. Researchers used moving platforms to gently push kids off balance and measured their muscle activity and body movements. The goal was to better understand the link be…

This study looked at 62 children with cerebral palsy (ages 2-18) and their primary caregivers to understand how the children's sleep problems relate to caregiver burden and mental health. Researchers used questionnaires to measure sleep quality in both children and caregivers, al…

This study looked at 44 preterm infants born before 28 weeks to see if their brain activity and general movements could predict cerebral palsy. Researchers used EEG and movement recordings to find patterns linked to the condition. The goal was to improve early diagnosis and help …

Infantile spasms are a type of seizure that can harm development if not treated quickly, but they are often mistaken for normal movements. This study tested a computer program that learns from parent-recorded videos to tell the difference between these seizures and harmless movem…

This study looked at how young children with Down syndrome, cerebral palsy, and other motor delays move and explore when using a powered mobility device called the Explorer Mini and a bodyweight support system. Sixteen children who could sit upright but not walk 10 feet on their …

This completed study looked at whether healthcare professionals in Saudi Arabia received and understood safety materials about the epilepsy drug Depakine (sodium valproate). Researchers surveyed 455 doctors, pharmacists, and gynecologists to measure their knowledge and behavior. …

This study looked at whether improvements in walking from a 4-week whole-body vibration training program are kept 3 months later in children with cerebral palsy. Only 1 child took part, so results are very limited. The goal was to measure walking speed and distance before and aft…

This study tested whether a heart-rate based index (ANI) can detect pain in 17 children with cerebral palsy during injections and physical therapy. Researchers measured heart rate changes before and after painful procedures and compared them to standard pain scores. The goal was …

This study tested whether adding 10-15 minutes of leg strengthening exercises before standard physical therapy could improve hand function in 40 children aged 6-8 with unilateral cerebral palsy. The leg exercises targeted the less-affected leg, aiming to trigger brain changes tha…

This study looked at how blood pressure and heart rate change in the hour after an epileptic seizure. Researchers measured these vital signs at several time points in 1,100 people with epilepsy. The goal was to better understand the body's response right after a seizure, which ma…

This study tested two types of ankle braces in 14 children with cerebral palsy to see which better improves muscle length and function. One group wore a standard brace almost all day, while the other wore it less and used a special foot shell that allows more movement. The goal w…

This study tested a new portable, wireless EEG monitor called NeuroBell on 17 full-term newborns who already needed brain monitoring. The goal was to see if the new device records brain signals as well as standard EEG machines. The study did not treat any condition, but aimed to …

This completed study looked at 40 children with cerebral palsy to see if the quality of their early movements (around 10-20 weeks after birth) could predict how well they would move later in childhood. Researchers used video recordings to score early motor patterns and compared t…

This study tested a medicine called cenobamate in 26 children with partial-onset seizures. The goal was to see how the drug moves through the body and if it is safe. The study did not aim to cure or control seizures long-term, but to gather important information for future use.

This study looked at how walking patterns change over a 3-minute walk in 36 children with spastic cerebral palsy compared to 36 typically developing children. Researchers measured step timing and muscle activity at several points during the walk. The goal is to find the best time…

This completed study from Dijon University Hospital followed 60 parents of infants at high risk for cerebral palsy after NICU discharge. Researchers measured parental stress and healthcare use at 4, 9, and 24 months corrected age using questionnaires. The goal was to understand h…

This completed observational study enrolled 1,141 participants with mild cognitive impairment or Alzheimer's disease. Researchers tracked changes in memory tests, brain scans, and other biomarkers over time. The goal was to improve how future clinical trials measure the disease, …

This study looked at whether arm and leg muscle strength influences daily activities, social participation, and quality of life in school-age children with cerebral palsy (CP). Researchers measured muscle strength in 140 children with CP and compared them to typically developing …

This study looked at 110 children with unilateral cerebral palsy (CP) to understand how sensory issues—like touch, vibration, and joint position sense—relate to arm and hand motor skills. Researchers tested various sensory functions and motor abilities to find connections. The go…

This study tested a mobile app called OASES that guides nurses and clinical officers in rural Uganda through emergency care steps for severe diarrhea, breathing problems, and seizures. About 15 clinicians used the app during simulated patient scenarios to see if it helped them fo…

This study looked at why people who had a stroke stop getting botulinum toxin (Botox) injections for muscle stiffness. Researchers reviewed records of 81 patients over 12 years and found that most received only one injection. The main reason for stopping was that patients were no…

This study looked at whether doing virtual reality exercises with other people (multi-player) is more motivating than doing them alone. It included 86 participants: healthy teens, children with motor disorders, and older adults with conditions like stroke or COPD. Researchers mea…

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily function. The goal is to understand which children are at higher risk for conditions like cerebral palsy or intellect…

This study looked at how trunk control, balance, and upper body function are connected in children with cerebral palsy. Researchers measured these abilities in 53 children and compared them to healthy kids. The goal was to better understand these relationships to guide future the…

This study looked for early signs of epilepsy in children with autism and tested whether a structured exercise program could influence those signs. Fifty children aged 10-15 with autism, epilepsy, or both took part. Researchers analyzed blood, sleep, brain activity, and thinking …

This study measured how much energy children with cerebral palsy use while walking, with and without harness support. 34 children aged 8-17 walked on a treadmill while researchers tracked their oxygen use and movement. The goal was to understand what makes walking so tiring for t…

This completed study looked at 72 newborns who had seizures shortly after birth. Researchers measured inflammation markers in their blood and tracked whether they later developed epilepsy. The goal was to understand if inflammation plays a role in epilepsy risk after neonatal sei…

This completed study involved 84 children with cerebral palsy to see if measuring mid-upper arm circumference can help assess their nutritional status. Standard height and weight measurements are often hard to get in these children due to motor and feeding difficulties. The resea…

This study looked at 40 children with cerebral palsy, ages 4 to 8, to see if anxiety is linked to worse balance, muscle stiffness, and movement. Researchers measured anxiety, spasticity, balance, and gross motor function. The goal was to understand these connections better, not t…

This study looked at 78 children with cerebral palsy (CP) aged 6 to 12 to see how well they could sense the position of their trunk (body awareness) and how that relates to their trunk control and ability to do daily tasks independently. Researchers used simple devices to measure…

This study interviewed 26 adults who either have behavioral variant frontotemporal dementia (bvFTD) or carry a gene that puts them at risk. The goal was to learn how the condition affects daily life, emotions, and coping. No treatment or medication was tested—just listening and g…

This study tested whether two devices — a knee traction dynamometer and a non-invasive muscle sensor — can reliably measure muscle strength and activity in children with cerebral palsy. Twenty children aged 5 to 16 with mild to moderate CP took part. The goal was to see if these …

This study aims to create an algorithm that detects epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers will use data from 40 epilepsy patients who had seizures recorded during long-term video-EEG monitoring. The goal is to see how accu…

This study surveyed 219 family caregivers of people with dementia to explore how swallowing problems (dysphagia) affect their burden and needs. Caregivers completed a one-time online questionnaire about their experiences, stress, and knowledge. The goal is to better understand an…

This completed study looked at whether the sedative ketamine can cause seizure-like brain activity in people without epilepsy. Researchers monitored 300 adults undergoing a routine stomach scope procedure using EEG brain scans. They compared ketamine to two other common sedatives…

This completed study looked at whether children with neurodevelopmental disorders (like mitochondrial disease, cerebral palsy, or developmental delay) have fewer small nerve fibers in their skin, which could cause pain. Researchers took small skin biopsies from 203 children—some …

This study tested a special PET scan tracer (F-18 AV 1451) to see how much tau protein builds up in the brains of 81 people with primary progressive aphasia or frontotemporal dementia. Researchers compared these scans to those of healthy controls to find unique patterns for each …

This study tested a special light-and-sensor system (WittySEM) to measure how quickly and accurately children with cerebral palsy can react to visual cues. Twenty children completed memory tasks by touching lighted targets, while cameras tracked their movements. The goal was to s…

This study investigated why humans swing their arms during walking, a common but poorly understood movement. Researchers had 25 participants, including healthy individuals and those with conditions like stroke or Parkinson's disease, walk on a force-sensing treadmill. They measur…

This pilot study looked at how focused sound waves (shock wave therapy) reduce muscle tightness in the arm after a stroke. Twelve adults who had a stroke at least six months ago received the treatment. Researchers measured changes in muscle stiffness, nerve signals, and arm funct…

This study looked at new ways to measure and train eye movements in 21 people with macular degeneration, a condition that causes central vision loss. The goal was to see if training could help them use their remaining side vision more effectively. The research focused on understa…

This completed study looked at 97 adolescents with cerebral palsy (ages 11-18) to see how their own ratings of health-related quality of life matched those of their caregivers and physiotherapists. Everyone filled out a questionnaire about daily activities, school, movement, pain…

This study surveyed 105 Turkish pediatric physical therapists to see how often they use recommended tools to detect cerebral palsy (CP) early in babies up to 2 years old. Early detection can lead to faster treatment and better outcomes. The survey asked about awareness and use of…

This study looked at 126 children and young adults (up to age 25) with serious, non-progressive neurological diseases like cerebral palsy or brain injury. Researchers wanted to understand the best time to introduce a pediatric palliative care team. They reviewed medical records f…

This study looked at two community-based wellness programs for adults with disabilities like spina bifida, cerebral palsy, spinal cord injury, and traumatic brain injury. Researchers measured changes in health, mood, quality of life, and healthcare costs over up to 24 months. The…

This study investigates how the cerebellum influences brain plasticity in people with dystonia, a movement disorder, and in healthy volunteers. Researchers use non-invasive brain stimulation (TMS) to temporarily change cerebellar activity and measure its effects on brain plastici…