Cerebral cortex disorder

This study tests whether a daily pill called BHV-7000 can reduce seizures in adults with refractory focal epilepsy—a type of epilepsy that doesn't respond well to current medications. About 390 participants will receive either a low dose, a higher dose, or a placebo for 8 weeks. …

This study tests whether adding perampanel (Fycompa) to current epilepsy medications can reduce seizures in children aged 1 month to 18 years. About 100 children with specific epilepsy syndromes or partial-onset seizures will receive the drug. The main goal is to see if at least …

This study follows 158 people in France who are prescribed Epidyolex (a cannabidiol-based medicine) for seizures as part of their normal care. Researchers will track how long people stay on the treatment, side effects, seizure frequency, and changes in daily functioning and quali…

This early-phase study tested a new drug called BHV-7000 in 5 people with epilepsy who have a brain implant (RNS) that records brain activity. The goal was to see if the drug reduces abnormal electrical activity linked to seizures. Participants took the drug for 4 weeks, and thei…

This study follows about 111 people with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex who are taking Epidyolex (a CBD oral solution) for seizures. Researchers track how many stay on the drug for a year and how many seizure-free days they have. It's an o…

This study tests the long-term safety and effectiveness of XEN1101 (azetukalner) in 880 adults with focal or tonic-clonic seizures. Participants who completed earlier studies will take XEN1101 capsules for up to 6 years. Researchers will track side effects and changes in monthly …

This early-stage trial tests a gene therapy called PBFT02 for frontotemporal dementia (FTD) in people with specific genetic mutations. The therapy delivers a working copy of the GRN gene directly into the brain. The study involves 30 adults and primarily checks for safety and sid…

This study checks the long-term safety of the drug BHV-7000 in about 660 adults whose focal epilepsy has not been controlled by other treatments. Participants who completed an earlier study will continue taking the drug while doctors watch for side effects and lab changes. The go…

This Phase 3 study tests whether fenfluramine (ZX008) can safely reduce seizures in 87 children and adults with CDKL5 deficiency disorder, a rare genetic condition causing severe epilepsy. Participants receive either the drug or a placebo, followed by an open-label extension wher…

This study looks at the long-term safety of everolimus in people with tuberous sclerosis complex (TSC) who have seizures that are hard to control. Participants are already taking everolimus and benefiting from it in an earlier study. The goal is to see if the drug remains safe an…

This phase 3 trial is testing the safety and tolerability of the drug cenobamate (Xcopri) in 140 children aged 2 to 17 with partial-onset (focal) seizures. Researchers will monitor side effects, lab results, and drug levels in the blood. The study is open-label, meaning everyone …

This study follows 25 people aged 2 to 65 with cerebral palsy or brain damage from lack of oxygen who have already received a new gene therapy given as a nose spray. The therapy delivers 15 genes meant to repair the brain, reduce inflammation, and improve movement and thinking. R…

This study tests whether adding robot-assisted walking training to standard physical therapy helps children with cerebral palsy move better and breathe easier. Twenty-four children aged 8-18 will receive either standard therapy alone or standard therapy plus robotic walking sessi…

This study tests whether cenobamate, already approved for epilepsy, works well when used alone in adults with partial-onset seizures. About 49 participants will take either 100 mg or 200 mg daily, and researchers will track how many become seizure-free for 26 weeks. The goal is t…

This study tests whether stem cells from donated umbilical cords can improve movement and thinking in children with cerebral palsy. 78 children aged 6 months to 3 years will receive either stem cells plus a special liquid (conditioned medium), stem cells alone, or standard therap…

This study tests whether a device called Sonablate can safely use high-intensity focused ultrasound (HIFU) to treat vein problems like varicose veins, leg ulcers, and certain birth defects. About 30 adults with these conditions will receive the treatment, which does not involve c…

This pilot study tests deep brain stimulation (DBS) of the medial pulvinar, a new target in the brain, for people with drug-resistant epilepsy who have not improved with other treatments. Twelve adults aged 18 to 60 will receive the stimulation and track their seizures for 12 mon…

This study tests whether a remote physiotherapy program, based on the neurodevelopmental treatment (Bobath) model, can improve gross motor skills and daily function in children with cerebral palsy. Twenty children aged 6 months to 6 years will participate, with a caregiver helpin…

This study tests a brain-responsive neurostimulation system in 24 people aged 12 and older with Lennox-Gastaut syndrome whose seizures are not controlled by medication. The device detects and responds to seizure activity in the brain to reduce drop seizures. The goal is to see if…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This phase 3 study is testing the long-term safety and effectiveness of LP352 (Bexicaserin) in 324 children and adults with developmental and epileptic encephalopathy (DEE), including Dravet and Lennox-Gastaut syndromes. Participants who completed earlier studies will receive LP3…

This study is testing the long-term safety of a once-daily drug called vormatrigine in 700 adults with focal or generalized tonic-clonic seizures. Participants must have already taken vormatrigine in a previous trial or program. The main goal is to check for side effects and chan…

This study tests whether nicorandil, a drug currently used for heart conditions, can help people with a type of dementia called hippocampal sclerosis of aging. This condition is often mistaken for Alzheimer's but has no approved treatments. The trial includes 64 older adults and …

This study compares two treatments—special exercises called PNF and music therapy—to see which helps children with ataxic cerebral palsy improve balance, coordination, and daily activities. About 29 children aged 6 to 18 will take part, receiving either PNF or music therapy along…

This study follows children with hypotonia (low muscle tone) who have obstructive sleep apnea. They use a flexible silicone nasal tube called ssNPA at night to keep the airway open. Researchers will check how well it works and if children can tolerate it over a year.

This study gave stem cell infusions to one person with severe cerebral palsy who had no other treatment options. The goal was to improve their quality of life, not to cure the condition. The person received 8 infusions of their own stem cells, taken from fat tissue.

This study compares two types of physical therapy for children aged 6 to 10 with diplegic cerebral palsy: scooter board activities and core stability exercises. The goal is to see which better improves trunk control and balance. Forty children will participate, and their progress…

This study looks at how well the drug cenobamate works for adults with focal seizures that don't improve with at least two other epilepsy medicines. Researchers are collecting data from Italian clinics and a compassionate use program to measure seizure reduction and side effects.…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study looks at whether aquatic therapy in a warm pool can help children ages 3-9 with conditions like cerebral palsy improve their swimming safety, arm function, and ability to do daily tasks. Children attend sessions twice a week for ten weeks. Researchers will measure chan…

This study tests whether augmented reality (AR) games can improve walking and balance in children with cerebral palsy. Forty children will either do exercises wearing AR goggles or receive standard physical therapy. The goal is to see if the AR approach is more effective and enga…

This study tests whether an injection of hyaluronidase can reduce muscle stiffness and spasticity in the arm after a stroke. 56 adults with moderate-to-severe stiffness will receive either the study drug or a placebo, and later switch to the other option. The goal is to improve r…

This small study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a lower electric current than standard electroconvulsive therapy (ECT), aiming to avoid memory and thinking problems. Eight adults aged 25-64 wil…

This study tests whether personalized nutrition advice can improve nutrition, reduce stomach problems, and enhance quality of life in children with cerebral palsy. Fifty children aged 6 to 12 will be randomly assigned to receive either individualized dietary counseling or routine…

This study tests two different therapies—digital mirror therapy and action observation therapy—to see which better improves arm movement and grip strength in children with hemiplegia (one-sided weakness). Forty-five children aged 6 to 8 will participate. The goal is to find a sim…

This study compares a special exercise program called Coordinative Locomotor Training (CLT) to regular physiotherapy for children aged 8 to 12 with spastic hemiplegic cerebral palsy, a condition that causes stiffness on one side of the body. CLT uses running and skating movements…

This study looks at whether a very mild, unnoticeable electrical stimulation to the legs can help children and young adults with cerebral palsy (ages 10–21) maintain balance during everyday movements like standing up, walking, and turning. Participants will perform simple tasks w…

This study tests whether wearing a virtual reality headset during laser treatment for varicose veins can lower anxiety and pain. About 100 adults will use VR during the procedure, and researchers will measure their heart rate, blood pressure, and comfort levels. The goal is to se…

This study tests whether adding a mild electrical stimulation to the diaphragm (the main breathing muscle) can improve lung function, head control, and sitting balance in children with severe cerebral palsy who cannot walk. Thirty children aged 5-18 will receive either standard r…

This study compares robotic exoskeleton training to traditional physical therapy for improving walking in adolescents and young adults with cerebral palsy. Participants undergo brain scans, mobility tests, and nerve tests before and after training. The goal is to see if the robot…

This study tests whether a structured walking therapy program can improve mobility in 120 adolescents and young adults with cerebral palsy. Participants undergo 24 gait training sessions over 8 weeks, with before-and-after tests of walking speed, brain activity, and muscle contro…

This small study tests whether adding robot-assisted walking training to regular physiotherapy can improve body composition (like muscle and fat) and daily function in children with cerebral palsy or similar conditions. Nine children will each receive both standard physiotherapy …

This study looks at whether using a passive kinesiotherapy device on the legs for 30 minutes can immediately reduce muscle stiffness (spasticity) and improve walking in people with conditions like cerebral palsy, stroke-related weakness, or spinal cord issues. About 80 participan…

This study tests whether early, intensive leg exercises, done by a physical therapist and a parent together, can improve walking and motor skills in children aged 8 months to 3 years who had a stroke around birth. The study compares this approach to usual care. The goal is to see…

This trial tests a robotic exoskeleton called the CPWalker to help children with cerebral palsy improve their walking. The device supports the child's weight and assists leg movements during walking practice. The study includes 30 participants aged 11 to 21 with spastic diplegia.…

This study looks at whether a special exercise method called blood flow restriction training can help children with hemiparetic cerebral palsy (CP) improve their hand grip strength. The method uses a cuff to lightly restrict blood flow during low-intensity exercises, which may bu…

This study tests whether 3 months of intensive leg exercise (walking, kicking, jumping, and climbing with small ankle weights) can improve walking and daily function in 60 young children with spastic diplegia caused by prematurity. The exercise is done 1 hour a day, 4 days a week…

This study looks at the cost and benefits of a two-week day camp for children with mild to moderate arm weakness (hemiparesis) from cerebral palsy or brain injury. In the first week, children wear a constraint on their stronger arm to encourage use of the weaker arm, followed by …

This study tests whether online group cognitive behavioral therapy (CBT) is a practical way to help adults with cerebral palsy who have chronic pain. Fourteen participants will attend weekly virtual therapy sessions for 12 weeks. The main goal is to see if people will stick with …

This study tests a gentle hands-on technique called Strain Counter-Strain to relax tight jaw and neck muscles in 30 children with spastic cerebral palsy, ages 4 to 8. The goal is to improve mouth opening, reduce drooling, and make eating easier. Results are measured after one mon…

This study compares two types of therapy for children aged 8 to 12 with spastic diplegic cerebral palsy. One group uses play-based activities like puzzles and arts and crafts, while the other uses standard exercises with resistance bands and weights. The goal is to see which appr…

This study tests whether an 8-week power wheelchair training program using the IndieTrainer system can help children with severe cerebral palsy improve their wheelchair skills and independence. Sixteen children who cannot walk or propel a manual wheelchair will participate. The t…

This study tests a program called MSE-PEACE, where parents and children with developmental disabilities (like autism or ADHD) attend 10 sensory sessions together. The goal is to see if it improves children's engagement and emotional control, and helps parents feel more confident …

This study compares two physical therapy approaches for children aged 8-24 months with or at high risk for cerebral palsy. One method focuses on sitting, reaching, and problem-solving, while the other targets general motor skills. The goal is to see which therapy improves sitting…

This study looks at whether walking on a path with lights that show where to step can improve how children with spastic diplegia (a type of cerebral palsy) walk. Thirty children aged 5 to 8 with mild spasticity will walk on the light pathway, and researchers will measure changes …

This study tests a dual-task training program for children aged 6-8 with unilateral cerebral palsy. About 70 participants will be split into two groups: one doing balance exercises while also performing fine motor tasks, and the other doing single-task exercises. The goal is to s…

This study looks at whether adding tolperison to botulinum toxin injections helps reduce muscle stiffness and nerve pain in stroke survivors. About 40 adults with spastic hemiplegia (one-sided paralysis) will be followed. Researchers will measure spasticity and walking speed to s…

This study tests a home-based program called HOBSCOTCH-PTE for people with epilepsy caused by a traumatic brain injury. The program aims to improve quality of life, memory, and thinking skills, and also helps support their caregivers. The study includes 160 adults with post-traum…

This study tests an intensive group physical therapy program for children aged 7-17 with cerebral palsy who can walk. The program focuses on improving muscle strength, walking speed, and daily activities like climbing stairs. Researchers will measure changes in strength, balance,…

This study looked at 60 children aged 6 to 10 with hemiplegic cerebral palsy to see which type of balance training works better: playing on a Wii Balance Board or doing reactive balance exercises. Both groups also did standard physical therapy three times a week for eight weeks. …

This study tests a 12-week play-based training program for children aged 2-5 with cerebral palsy. The program uses running frames and other assistive devices to improve mobility, fitness, and daily activity. Twenty children will participate in weekly group sessions plus home exer…

This study looks at whether doing arm exercises on a vertical surface (like a wall) or a horizontal surface (like a table) makes a bigger difference in hand skills and trunk control for children with bilateral cerebral palsy. Thirty children aged 5 to 8 will take part in a 3-mont…

This small study tests whether low-intensity focused ultrasound (LIFU) can safely reduce seizures in people with temporal lobe epilepsy that doesn't improve with medication. Six participants with implanted brain electrodes will receive both real and sham ultrasound sessions. The …

This pilot study tests whether constraint-induced movement therapy (CIMT) can be effectively delivered via video in the homes of 10 children aged 4-10 with hemiplegic cerebral palsy. The therapy involves encouraging use of the weaker arm while restraining the stronger one. Resear…

This study tests whether adding light weights to the ankles can improve balance in children aged 7 to 13 who have ataxic cerebral palsy, a condition that affects coordination and stability. Researchers will measure changes using a special balance platform. The goal is to find a s…

This study tests whether adding a gentle, non-invasive nerve stimulation on the ear (taVNS) to standard physical therapy can reduce muscle stiffness, improve movement, and boost quality of life in children with spastic cerebral palsy. Eighteen children aged 8-18 will be split int…

This study compares two ways of delivering an intensive upper limb therapy program for children with cerebral palsy, ages 3 months to 4 years 11 months, and their caregivers. The goal is to see which method works better for improving hand function. The study involves 37 children …

This study tests a pair of smart glasses called NEXA that can read brain signals through dry electrodes. The glasses aim to predict epileptic seizures in real time and alert the wearer with vibrations, lights, or sounds. Researchers will test the device on 47 adults with epilepsy…

This study looks at whether adding music to standard occupational therapy can help children aged 5-12 with conditions like cerebral palsy, encephalitis, or brain tumor recovery. Researchers will measure changes in walking, balance, and vital signs like heart rate and oxygen level…

This study tests a wearable robotic exoskeleton called EXPLORER in 15 children with movement problems from conditions like cerebral palsy. The goal is to see if it helps them walk better in their everyday environments, such as home and the community. The study focuses on safety, …

This study looks at whether virtual reality games designed for hand-arm training can improve hand function in children with hemiplegic cerebral palsy. Seventeen children will either play VR games or do standard hand exercises for 40 hours over two weeks. Researchers will measure …

This study tests a training program that teaches children with physical disabilities how to use their manual wheelchairs better. The goal is to help them move around on their own instead of relying on others, which can improve their confidence and social life. Four children aged …

This study tests a robotic feeding device called Obi for people who cannot use their arms to eat on their own. About 50 participants, including patients, caregivers, and healthcare providers, will use the device at home or in care settings for one week. Afterward, they will fill …

This study looks at how adults at risk for Alzheimer's disease react after learning their amyloid and tau biomarker test results. Researchers will track changes in distress, stigma, quality of life, and future planning over time. The goal is to understand the psychological and be…

This study follows 1,500 volunteers with normal memory, mild cognitive impairment, or Alzheimer's over several years. Researchers use brain scans, memory tests, and blood samples to track how the disease progresses. The goal is to find better ways to diagnose and treat Alzheimer'…

This study looks at how common sleep breathing problems are in children with cerebral palsy across the UK, and how often they use breathing support like CPAP machines. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to im…

This study follows 72 adults with cerebral palsy who had walking tests as children to see how their walking ability changes over time. Researchers measure joint movement, muscle activity, and blood markers related to metabolism and inflammation. The goal is to understand how walk…

This study uses a radioactive tracer called [18F]MK-6240 to take detailed pictures of tau protein clumps in the brain, a hallmark of Alzheimer's disease. Researchers will scan 200 people from families with a rare genetic form of Alzheimer's to see how tau buildup changes over tim…

This study looks at how the brain creates and recalls memories by recording brain activity in people with epilepsy who already have electrodes placed for surgery. Participants play memory games on a laptop while their brain signals are recorded, and sometimes small electrical pul…

This study looks at gene activity in brain tissue removed during surgery from 10 people with temporal lobe epilepsy and hippocampal sclerosis. The goal is to find which genes are linked to the disease and may help predict outcomes. No new treatment is being tested; instead, resea…

This study tests whether a special type of X-ray called DXA, taken while lying down, can measure spine curves as well as standard standing X-rays in people with scoliosis. About 20 participants will have both types of images taken, and researchers will compare the results and ask…

This study tests a new way to measure how children move their arms using a special camera system that tracks reflective markers placed on the skin. Researchers will check if the method is reliable and easy to use in both healthy children and those with arm movement problems. The …

This study explores whether an Apple Watch can track walking, heart rate, breathing, and sleep in people with glioblastoma, a serious brain cancer. The goal is to see if the watch can detect symptom changes before they become serious, like seizures or blood clots. Twenty-five pat…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study aims to create more sensitive cognitive tests for Huntington's disease by combining brain imaging (PET and MRI) with blood markers. Researchers will study 90 participants—healthy controls, pre-symptomatic gene carriers, and early-stage patients—to understand how brain …

This study checks whether a play-based test of arm and hand movements, called the Melbourne Assessment-2, is reliable when done through telehealth for children with hemiplegic cerebral palsy. About 35 children ages 2 to 10 will attend one in-person visit and one telehealth visit,…

This study explores why constipation is common in children with cerebral palsy and what factors might be involved, such as diet, physical activity, and caregiver stress. Researchers will observe 100 children aged 4 to 18 and their caregivers using questionnaires and diaries. No t…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study looks at how the brain changes and adapts after losing central vision, which happens in conditions like macular degeneration. Researchers are testing different training tasks in 120 healthy adults aged 18-30 to measure improvements in eye movements and focus. The goal …

This study followed 602 people who had a stroke to see how many later had seizures. Researchers looked at blood tests, brain scans, and EEG recordings to find clues that might predict who is at risk. The goal is to better understand why some stroke survivors develop epilepsy.

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study looks at whether a tiny device placed under the scalp can safely and comfortably track seizures in adults with mild to moderate intellectual disability and epilepsy. Nine participants will wear the monitor for up to 6 months, and researchers will compare the device's r…

This study tests a new computer-based visual training task for people who have lost part of their vision due to a stroke. Participants watch moving patterns on a screen and learn to detect motion direction, with the goal of improving visual abilities. The study first checks if th…

This early-stage trial tests the safety of an experimental oral drug called iQ-007 in 72 healthy volunteers. The drug is designed to help control seizures by boosting the brain's ability to clear excess glutamate, a chemical linked to epilepsy. The study does not yet test if it w…

This study looks at why people with cerebral palsy often feel very tired. Researchers will use EEG and PET scans to compare brain activity in 50 adults with mild versus severe fatigue. The goal is to find a brain network linked to fatigue, which could lead to better treatments in…

This study looks at brain tissue and lab-grown nerve cells from people with schizophrenia, depression, bipolar disorder, frontotemporal dementia, and Alzheimer's. Researchers want to find out how problems with synapses—the connections between brain cells—differ in these condition…

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This study is working to create a simple screening test to find cerebral vision impairment (CVI) in babies and young children. CVI is a leading cause of vision problems in kids, often linked to brain injuries or conditions. Researchers will study 600 children to better understand…

This study looks at whether a power wheelchair that can lift a child from sitting to standing is practical for kids with conditions like cerebral palsy, spinal cord injuries, or genetic diseases. Only 4 children aged 5-17 are taking part. The goal is to see if the chair helps the…

This study follows 300 adults with focal epilepsy who are starting an additional anti-seizure medication (ASM) alongside their current treatment. Researchers will track changes in seizure frequency and quality of life over 12 months in everyday clinical settings. The goal is to s…

This study planned to test a wearable device called EpiCare@Home that records brain activity, heart rate, and movement to detect focal seizures. It was designed for people with epilepsy, both in the hospital and at home. However, the study was withdrawn before enrolling any parti…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…