Cerebral cortex disorder

This study tests an oral drug, AV078, in people aged 12 and older with tuberous sclerosis complex (TSC) whose seizures are not controlled by standard medications. Participants are randomly assigned to receive AV078 or a placebo for 12 weeks. The goal is to see if AV078 safely red…

This study tests a fun, game-based training program that teaches children with cerebral palsy how to breathe better and improve their posture. The program includes exercises like blowing out candles and floating boats, along with visual and audio cues. Researchers want to see if …

This study investigates whether a program of functional progressive resistance training—exercises like sit-to-stand, step-ups, and stair climbing with gradually increasing resistance—can improve bone mineral density and balance in children with cerebral palsy. The trial includes …

This phase III trial tests whether giving tranexamic acid continuously for 24 hours after hip surgery can reduce blood loss in non-ambulatory children with cerebral palsy. About 52 children aged 4 to 16 will be randomly assigned to receive either the drug or a placebo. The goal i…

This study tests whether a training program that pairs sounds with visual cues can help people who have lost part of their vision due to brain damage (cortical blindness). Participants will do 12 sessions where they see and hear stimuli in their blind area, plus virtual reality t…

This study tests a liquid form of the seizure drug zonisamide in children aged 1 month to 17 years who have partial-onset seizures. The goal is to find the right dose and check for side effects. About 40 children will take the medicine for up to 12 weeks, with a follow-up visit o…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This trial tests a new device called the enVVe system, a catheter-based artificial valve placed in leg veins to treat chronic venous insufficiency. The study will enroll 220 people with severe symptoms like skin changes or leg ulcers. Participants are randomly assigned to receive…

This study tests a surgical procedure to release tight muscles in the forearm of children with cerebral palsy who have a fixed elbow rotation (pronation deformity). The surgery cuts two pronator muscles to allow the arm to turn outward more easily. Researchers will measure change…

This study tests whether a special type of electrical stimulation, called reciprocal neuromuscular electrical stimulation, can improve balance and quality of life in children aged 6 to 10 with hemiparetic cerebral palsy. The 32 participants will receive either the electrical stim…

This study will test whether a gentle brain stimulation technique called tDCS, combined with task-oriented training and virtual reality, can improve movement and brain activity in 150 children with spastic cerebral palsy. Participants will be randomly assigned to receive either r…

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord can reduce spasticity (muscle stiffness) in adults with cerebral palsy. Forty participants aged 16 and older with stable, one-sided motor disability will receive the implant. Re…

This study tests a vaccine called AADvac1, which targets tau tangles in the brain, a hallmark of Alzheimer's. It will be given alone or with another drug (donanemab) to 450 adults aged 50-80 with very early Alzheimer's. The goal is to see if this approach can reduce tau buildup a…

This study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…

This study tests a wearable robotic exoskeleton called Bambini Teens in 20 children aged 5 to 14 with cerebral palsy. The device assists leg movement during walking training. Researchers will check if it is safe and easy to use, and if it improves walking speed after six 30-minut…

This pilot study will test a small screw placed in the hip bone to help correct a wide hip angle (coxa valga) in 50 children with cerebral palsy who have early hip subluxation. The goal is to see if the screw can guide bone growth and improve hip alignment, potentially preventing…

This study tests a new drug called NS101 in 15 people with semantic variant primary progressive aphasia (svPPA), a rare type of frontotemporal dementia that affects language and memory. The drug is an antibody designed to help repair connections between brain cells. The main goal…

This study tests whether combining balance exercises with thinking tasks (like math or memory games) and gentle head movement stimulation can help children with diplegic cerebral palsy improve their walking and coordination. Fifty-four children aged 6 to 12 will do these exercise…

This study tests whether videos recorded by parents at home can help doctors detect early signs of cerebral palsy in very preterm infants (born before 29 weeks). Researchers will compare the accuracy of family-led recordings to standard professional assessments. If successful, th…

This study tests whether levetiracetam, a seizure medication, works as well as magnesium sulfate to prevent seizures in pregnant people with severe preeclampsia. About 1,240 participants at 32 weeks or more will be randomly assigned to one of the two drugs. The goal is to see if …

This study tests a non-invasive technique called temporal interference stimulation to boost deep sleep in people with epilepsy. Researchers will compare 4 nights of real stimulation to 4 nights of sham (fake) stimulation in up to 16 patients. The goal is to see if better sleep ca…

This study will test whether a structured aquatic therapy program can improve balance in children aged 5 to 12 with spastic diplegic cerebral palsy. Fifty participants will be split into two groups: one receiving water-based therapy and the other continuing standard land-based ph…

This study looks at whether plyometric (jumping) exercises on the less affected leg can improve strength, movement control, and balance in children aged 6-10 with hemiplegic cerebral palsy. Forty children will either get standard physical therapy alone or standard therapy plus pl…

This small study tests whether wearing a rigid leg cast (from thigh to ankle) during treadmill training can safely improve how children with cerebral palsy walk. Six children aged 7 to 14 will take part in a 4-week walking program. Researchers will use motion cameras and muscle s…

This study tests whether watching movements in person (live) or on video helps children with spastic diplegia improve their balance and walking. About 45 children aged 4 to 7 with mild spasticity will participate. The goal is to see which method works better for improving stabili…

This study will test whether adding music therapy to standard physical therapy helps children with spastic cerebral palsy improve their concentration and walking. Forty children aged 5 to 7 will either receive physical therapy alone or physical therapy combined with rhythmic musi…

This study looks at whether a wearable garment called TheraTogs can help children and teens with cerebral palsy improve their balance and walking. Twelve participants will be tested with and without the garment to see if it makes an immediate difference. The goal is to find a sim…

This study looks at whether special balance exercises (vestibular rehabilitation) can help children aged 8 to 12 with spastic diplegia, a type of cerebral palsy, stand steadier and use less energy when walking. Researchers will measure trunk sway and heart rate during walking. Th…

This small pilot study will test whether a non-immersive virtual reality system called Rehametrics is practical and enjoyable for children with cerebral palsy aged 4 to 10. Ten participants will do balance and walking exercises using the system. The main goal is to see if kids co…

This study compares augmented reality (AR) and virtual reality (VR) during music therapy for people with cerebral palsy aged 15 to 35. Participants will use a Meta Quest 3 headset to reach for musical cubes, repeat note sequences, and play virtual instruments. The goal is to see …

This study looks at whether letting children with cerebral palsy walk sooner after calf surgery helps their foot movement and motor skills. Forty-two children aged 4 to 14 will either get a cast for 3 weeks or a brace right away, plus physical therapy. Researchers will check thei…

This study tests whether a virtual reality exercise program, done at home with telehealth coaching, can help children with cerebral palsy become more physically active. 130 kids aged 10 to 17 will either play seated arm exercise games using a VR headset for 12 weeks or continue t…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) can safely reduce chronic musculoskeletal pain in adults with cerebral palsy. Thirty-two participants will use either the active device or a sham (inactive) version at home for 30 days. Researcher…

This study tests a non-invasive brain stimulation technique called rTMS to improve motor function in 60 children with cerebral palsy. The treatment uses magnetic pulses to enhance brain plasticity and movement recovery. Researchers will measure brain activity changes to see if th…

This study tests whether combining functional electrical stimulation (gentle electrical pulses to help muscles move) with circuit training can improve balance, posture, and walking in children with cerebral palsy. Forty-six children with mild to moderate CP will be split into two…

This study tests if gentle electrical stimulation to leg muscles can help children with cerebral palsy walk more easily. About 65 children (ages 7-18) will walk on a treadmill while different stimulation settings are compared. The goal is to find which method works best to improv…

This trial compares two physiotherapy methods—Perception-Action Approach and Neurodevelopmental Therapy (Bobath)—for children aged 0 to 36 months with cerebral palsy or at high risk. Over 12 weeks, 24 participants will receive weekly therapy sessions and be assessed for motor fun…

This pilot study tests whether combining AI-assisted brain stimulation (tDCS) with hand-arm training can improve movement in children aged 6-17 with unilateral spastic cerebral palsy. Fifteen participants will receive either real or sham stimulation over 5 sessions. The goal is t…

This study will compare two common physical therapy approaches—Bobath (neurodevelopmental treatment) and functional physiotherapy—to see which one better improves upper arm strength and trunk control in children with cerebral palsy. Forty children aged 4 to 12 will receive one of…

This study compares a robotic glove to standard hand therapy for children with hemiplegic cerebral palsy, a condition where one side of the body is weaker. Seventy children aged 7-15 will receive either robotic or conventional therapy for 8 weeks. Researchers will measure hand fu…

This study tests a remote, 12-week program called PREP for teens with cerebral palsy and their caregivers. The program helps families set activity goals and overcome barriers at home, school, and in the community. Researchers will see if the program is practical and liked by fami…

This study tests a training technique that uses repeated flashes of light and bursts of sound to help people who have lost part of their vision after a stroke. The goal is to see if this training can improve how much they can see and how their brain responds. The study will inclu…

This study tests whether virtual reality training using the Nintendo Wii Fit can improve balance, walking, and agility in children aged 7-14 with cerebral palsy. Over 6 weeks, 56 kids will either play Wii Fit games or do standard physical therapy. The goal is to see if a fun, low…

This study looks at whether a combined program of 35 hours of therapy plus 15 hours of home practice works as well as 50 hours of standard therapy for improving how children aged 3 to 5 with cerebral palsy use both hands. About 66 children will take part. The goal is to make ther…

This study tests whether adding a gentle electrical stimulation to standard mouth exercises can help reduce drooling in children with cerebral palsy. About 30 children aged 4 to 17 will be split into three groups: one gets the real stimulation plus exercises, one gets exercises a…

This study tests whether an intensive 15-day summer camp can improve movement and energy use in children with cerebral palsy. Thirty children aged 6 to 13 will take part in 90 hours of fun, guided exercises for their arms and legs. Researchers will measure changes in how their bo…

This study tests whether an 8-day camp that combines sensory and motor training helps children with unilateral cerebral palsy use their affected hand better than motor training alone. About 26 children aged 5 to 15 will take part. The goal is to improve hand function and daily pa…

This study will test two different physical therapy methods in 54 children aged 6 to 12 with spastic diplegic cerebral palsy. One group will walk on a treadmill with ankle weights, and the other will practice everyday tasks like stepping and balancing. Researchers will measure ch…

This study tests whether a gamified mobile app called HEMImprove 1.0 can help adolescents with unilateral cerebral palsy improve their arm function. Thirty-six teens will be randomly assigned to use the app at home or do conventional exercises from a manual, both for 30 minutes a…

This study tests whether adding a robotic glove to standard physical therapy can improve hand function in children aged 5-12 with unilateral spastic cerebral palsy. Forty children will be randomly assigned to receive either conventional therapy alone or conventional therapy plus …

This study looks at whether adding exergaming (video games that require movement) to standard NDT-Bobath therapy can improve spinal mobility in children aged 10-15 with cerebral palsy. Forty-two participants will be split into two groups: one doing seated exergaming and the other…

This study compares two types of exercise training—task-oriented and group circuit training—to see which one helps children with quadriplegic cerebral palsy improve their movement and daily activities. About 36 children aged 7 to 12 will participate. The goal is to find better re…

This study tests two types of spiral arm straps (TheraTogs and TogRite) to see if they help children with unilateral spastic cerebral palsy use their affected arm and hand more effectively. Twenty-seven children aged 4 to 15 will be split into three groups: one gets rehab plus Th…

This pilot study tests whether a home-based telerehabilitation system can help children with cerebral palsy improve their balance and hand function. Twenty-four children aged 6 to 18 will either use a digital therapy kit at home or follow a standard home exercise program. The goa…

This study tests whether adding virtual reality (VR) to standard Bobath therapy can improve leg muscle activity, balance, and motor function in children with spastic cerebral palsy. Thirty children aged 2 to 14 will be randomly assigned to receive either VR-enhanced Bobath therap…

This study compares three types of physical therapy for 90 children aged 6-12 with mild cerebral palsy: traditional therapy, active video games (exergaming), and exergaming with real-time muscle feedback. The goal is to see which approach best improves movement, balance, and moti…

This study tests whether a training program for therapists can help them use powered mobility devices with young children (ages 12-32 months) who have severe cerebral palsy. Therapists will learn how to use the devices during everyday routines at home or in early childhood settin…

This study compares carbon fiber ankle braces to standard plastic ones in 38 children with cerebral palsy aged 8-15. Each child will try both braces for 4 weeks to see which one improves walking, running, and jumping. The goal is to find out which brace helps kids be more active …

This study tests whether a special strengthening and fatigue protocol using an isokinetic dynamometer can improve foot lift strength and walking more than standard rehab after Botox injections. Thirty adults with spastic foot drop will be randomly assigned to either the new proto…

This study will test whether walking on a treadmill with body weight support can improve motor skills in children aged 5-12 with dyskinetic cerebral palsy. Twenty children will be split into two groups: one gets the treadmill training, the other gets standard Bobath therapy. Rese…

This study will test whether robotic-assisted therapy can improve hand function, grip strength, and wrist position sense in 32 children aged 6-9 with hemiplegic cerebral palsy. Participants will use a robotic device to perform repetitive, goal-oriented hand exercises. The goal is…

This study looks at whether a common procedure for varicose veins—called endovenous ablation—can also reduce knee pain in people aged 80 and older. The researchers will follow 50 participants for one year after treatment, measuring pain and knee function. The goal is to see if im…

This study will test whether special 'brain gym' exercises can improve thinking abilities and quality of life in 60 children aged 6 to 8 with spastic hemiplegic cerebral palsy. The children will do these exercises along with standard physical therapy for 30 minutes, three times a…

This study tests a robotic exoskeleton called CLINICAL EXPLORER in 60 children aged 2 to 17 with neurodevelopmental disorders like cerebral palsy. The device supports walking during 8 therapy sessions. Researchers will check if it is safe, easy to use, and helps improve movement …

This study will use artificial intelligence and video analysis to assess how well children with cerebral palsy can walk and move. Researchers will collect data from 200 children aged 4 to 18 who can walk with or without help. The goal is to see if AI can accurately predict mobili…

This study adapts and tests a Spanish version of eTIPS, an early home-based therapy program for infants at risk of unilateral cerebral palsy after perinatal stroke. The program involves parent-delivered activities integrated into daily routines. The study will enroll 20 families …

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This study will test whether using virtual reality headsets raises the risk of seizures in adolescents and adults with epilepsy. Forty participants will wear a VR headset while their brain activity is recorded with EEG, comparing periods with the display off, on, and with hand co…

This study will look at how muscle stiffness and tone relate to balance in children aged 6 to 12 with spastic hemiplegia, a condition where one side of the body is tight and weak. Researchers will use a handheld device to measure muscle properties and a balance system to test sta…

This study will follow 42 children and teens with cerebral palsy who need surgery for scoliosis (a curved spine). Researchers want to see if the surgery helps them eat more and gain weight, since many have trouble eating and are underweight. The goal is to understand if the surge…

This early-phase study tests whether the drug Cobenfy KarXT can change brain activity linked to memory in 50 adults with epilepsy who are already scheduled for brain surgery. Participants will take either the drug or a placebo on separate days and perform memory tasks while their…

This study tests a 6-week group bootcamp for caregivers of infants (3-15 months old) diagnosed with or at high risk for cerebral palsy. The program teaches parents how to better interact with and support their baby through physical and occupational therapy techniques. The goal is…

This study looks at children born prematurely who had retinopathy of prematurity (ROP), a disease that can cause blindness. Some were treated with laser, others with injections, and some had ROP but no treatment. Researchers will compare their vision and retina structure to see w…

This observational study will follow 50 children aged 5 to 8 with non-progressive congenital ataxia, a rare condition that affects movement and coordination. Researchers will use detailed exams, brain scans, and genetic testing to better understand the disorder and its impact on …

This observational study will check if breathing strength and lung function are linked to hand use in 37 children aged 6–18 with hemiparetic cerebral palsy. Participants do simple breathing tests and hand skill tasks in one clinic visit. The goal is to see if rehab programs shoul…

This study will check how well motion-capture sensors track movements in 100 children and youth with cerebral palsy while they play active video games. Researchers will compare the sensors to a gold-standard system and a therapist's assessments. The goal is to see if these sensor…

This study looks at brain activity in children aged 5-15 with unilateral cerebral palsy (CP) compared to typically developing children. Using a special EEG cap, researchers measure brain waves while children watch and then perform simple actions like reaching for objects. The goa…

This study will follow 200 children with epilepsy to find clues—like brain scans or EEG patterns—that show which kids are likely to become resistant to standard seizure medications. The goal is to catch these cases early and consider alternative treatments such as a ketogenic die…

This study will track 139 newborns who have seizures in their first month of life to learn how common these seizures are, what causes them, and how the babies fare during their hospital stay. Researchers will use exams, blood tests, and brain scans to gather information. The goal…

This study looks at whether shifting text to a different part of the eye can help people with central vision loss read faster and more accurately. Researchers will test 100 participants with conditions like macular degeneration using various reading tasks. The goal is to find bet…

This study will follow 50 adults with varicose veins and chronic knee pain who are scheduled for standard vein treatment (laser or radiofrequency ablation). Researchers will measure changes in knee pain, stiffness, and function before and after the procedure. The goal is to see i…