Can a new daily pill tame focal seizures?

NCT ID NCT06999902

Completed Disease control Sponsor: Praxis Precision Medicines Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial is testing whether an experimental medication called PRAX-628 can reduce the frequency of focal seizures in adults with epilepsy who are already taking one to three other seizure medications. Participants will receive either PRAX-628 or a placebo for 12 weeks, with the dose increasing after the first 6 weeks. The main goal is to see if PRAX-628 leads to a greater reduction in monthly seizure frequency compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PRAX-628, an experimental oral medication taken once daily
What this could lead to: If successful, PRAX-628 could offer a new treatment option to help reduce focal seizures in adults with epilepsy who still have seizures despite taking other medications.
What could go wrong: This is an early-to-mid-stage trial, so the drug may not prove more effective than placebo. As with any new medication, there is also a risk of unexpected side effects.

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Conditions

The condition(s) this trial relates to.

focal epilepsy visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOCAL SEIZURE

Contacts and locations

Locations

Praxis Research Site

DeLand, Florida, 32720, United States
Praxis Research Site

Miami, Florida, 33133, United States
Praxis Research Site

Miami Lakes, Florida, 33016, United States
Praxis Research Site

Naples, Florida, 34116, United States
Praxis Research Site

Orlando, Florida, 32825, United States
Praxis Research Site

Chicago, Illinois, 60640, United States
Praxis Research Site

Lafayette, Louisiana, 70508, United States
Praxis Research Site

Bethesda, Maryland, 20817, United States
Praxis Research Site

Boston, Massachusetts, 02131, United States
Praxis Research Site

Plymouth, Michigan, 48170, United States
Praxis Research Site

Chesterfield, Missouri, 63005, United States
Praxis Research Site

Ozark, Missouri, 65721, United States
Praxis Research Site

Hackensack, New Jersey, 07601, United States
Praxis Research Site

Amherst, New York, 14226, United States
Praxis Research Site

Middletown, New York, 10940, United States
Praxis Research Site

New York, New York, 10016, United States
Praxis Research Site

Charlotte, North Carolina, 28211, United States
Praxis Research Site

Canton, Ohio, 44718, United States
Praxis Research Site

Oklahoma City, Oklahoma, 73112, United States
Praxis Research Site

Philadelphia, Pennsylvania, 19107, United States
Praxis Research Site

Sioux Falls, South Dakota, 57105, United States
Praxis Research Site

Memphis, Tennessee, 38104, United States
Praxis Research Site

Dallas, Texas, 75206, United States
Praxis Research Site

El Paso, Texas, 79912, United States
Praxis Research Site

Frisco, Texas, 75034, United States
Praxis Research Site

Round Rock, Texas, 78681, United States
Praxis Research Site

Seabrook, Texas, 77586, United States
Praxis Research Site

Waxahachie, Texas, 75165, United States
Praxis Research Site

Virginia Beach, Virginia, 23456, United States
Praxis Research Site

Campo Comprido, Curitiba PR, Brazil
Praxis Research Site

Belo Horizonte, Minas Gerais, Brazil
Praxis Research Site

Recife, Pernambuco, Brazil
Praxis Research Site

Rio de Janeiro, Rio de Janeiro, Brazil
Praxis Research Site

Porto Alegre, Rio Grande do Sul, Brazil
Praxis Research Site

Botucatu, São Paulo, Brazil
Praxis Research Site

Campinas, São Paulo, Brazil
Praxis Research Site

Ribeirão Preto, São Paulo, Brazil
Praxis Research Site

São José do Rio Preto, São Paulo, Brazil
Praxis Research Site

São Paulo, São Paulo, Brazil
Praxis Research Site

Surrey, British Columbia, Canada
Praxis Research Site

Toronto, Ontario, Canada
Praxis Research Site

Bologna, Italy
Praxis Research Site

Lecco, Italy
Praxis Research Site

Milan, Italy
Praxis Research Site

Monserrato, Italy
Praxis Research Site

Naples, Italy
Praxis Research Site

Pavia, Italy
Praxis Research Site

Pisa, Italy
Praxis Research Site

Ponderano, Italy
Praxis Research Site

Pozzilli, Italy
Praxis Research Site

Roma, Italy
Praxis Research Site

San Lucas Tepetlacalco, Mexico
Praxis Research Site

Bydgoszcz, Poland
Praxis Research Site

Katowice, Poland
Praxis Research Site

Lublin, Poland
Praxis Research Site

Warsaw, Poland
Praxis Research Site

Valladolid, Valladolid, Spain
Praxis Research Site

Barcelona, 08003, Spain
Praxis Research Site

Barcelona, 08035, Spain
Praxis Research Site

Barcelona, 08041, Spain
Praxis Research Site

Granda, 18012, Spain
Praxis Research Site

Madrid, 28006, Spain
Praxis Research Site

Madrid, 28010, Spain
Praxis Research Site

Madrid, 28040, Spain
Praxis Research Site

Málaga, 29010, Spain
Praxis Research Site

Terrassa, 08222, Spain
Praxis Research Site

Valencia, 46026, Spain
Praxis Research Site

Phoenix, Arizona, 85032, United States
Praxis Research Site

Loma Linda, California, 92345, United States

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