Prostate cancer

Researchers are testing a treatment called TOOKAD Soluble vascular targeted photodynamic therapy in men with localized intermediate-risk prostate cancer. The approach uses a drug activated by light to destroy cancer tissue in the prostate. The trial follows 50 men for up to 60 mo…

This phase 1 trial is testing an experimental therapeutic cancer vaccine called AST-021p in people with advanced solid tumors that no longer respond to standard treatments. The goal is to see if the vaccine is safe and can trigger an immune response against the cancer. Participan…

This study tested whether taking the drug abiraterone on an on-and-off schedule could help it work longer for men with advanced prostate cancer that no longer responds to hormone therapy. Nineteen men whose cancer had already responded to standard daily abiraterone were enrolled.…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tested two treatments for people with advanced cancer who cannot have standard therapy. One group took a low-dose chemotherapy pill (cyclophosphamide) daily, and the other took a hormone pill (megestrol). The goal was to see which treatment could slow cancer growth for…

This phase 2 study tested the drug erdafitinib in 316 adults and children with advanced solid tumors that have specific FGFR gene mutations or fusions. The main goal was to see if the drug could shrink tumors. Participants took erdafitinib tablets daily. The study is now complete…

This early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…

This early-phase trial tested whether adding nilotinib (a pill) to paclitaxel (a chemotherapy) is safe and tolerable for people with advanced solid tumors that no longer respond to standard treatments. The study included 47 adults and children aged 12 and older. Researchers aimed…

This study tests whether adding the immunotherapy drug nivolumab (Opdivo) to standard radiation and hormone therapy is safe and effective for men with a very aggressive form of prostate cancer (Gleason grade group 5). About 44 men will receive the drug combination. The goal is to…

This study tests whether adding darolutamide to standard hormone therapy (ADT) can delay cancer worsening in men with metastatic hormone-sensitive prostate cancer. About 223 men will receive darolutamide plus ADT, and their results will be compared to men from an earlier study wh…

This study tested a radioactive drug called 177Lu-PSMA-617 in 62 Chinese men with advanced prostate cancer that had spread and stopped responding to hormone therapy and chemotherapy. The drug targets a protein on cancer cells and delivers radiation directly to them. Researchers m…

This study tests a radioactive drug called 177Lu-PSMA-617 in men with advanced prostate cancer that has stopped responding to hormone therapy. The drug seeks out and delivers radiation directly to cancer cells. The trial aims to find the safest effective dose and see if it can lo…

This early-stage trial is testing a new drug called tuvusertib, given together with either lartesertib or avelumab, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see how the body pr…

Researchers are testing whether giving radiation therapy before sipuleucel-T, a personalized immunotherapy vaccine, works better than the vaccine alone in men with hormone-resistant prostate cancer that has spread. The trial enrolls about 51 participants and randomly assigns them…

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This phase 1 trial is testing whether a diet that severely limits arginine—an amino acid some tumors depend on—is safe and might help control solid tumors. About 25 adults with solid tumors will follow a specially designed low-arginine liquid diet for two 3-week cycles while cont…

This trial tests whether a steam-based treatment called Rezūm can work as well as standard surgery (TURP) for men with an enlarged prostate who need a catheter to urinate. Men aged 50 to 80 with this condition will be randomly assigned to receive either Rezūm or TURP. The main go…

This early-phase trial tests a new drug, SG1827, in people with advanced solid tumors that have stopped responding to standard treatments or have no standard therapy available. The main goals are to check the drug's safety, find the best dose, and get a first look at whether it c…

This early-stage trial tests an experimental drug called SG2918 in 17 people with advanced cancers that no longer respond to standard treatments. The main goal is to check safety and find the right dose, not yet to prove it works. Participants receive the drug by IV every three w…

This Phase 3 trial tests an oral drug called QLG1080 in men with hormone-sensitive advanced prostate cancer. The goal is to see if the drug can safely lower testosterone to castration levels, which helps slow cancer growth. Participants must be eligible for endocrine therapy and …

This study tested three flavors of Supportan® drink (Tropical Fruits, Cappuccino, and Pineapple-Coconut) in 123 cancer patients undergoing chemotherapy, radiotherapy, immunotherapy, or targeted therapy. Patients drank two bottles daily for four weeks alongside their normal diet. …

This study looks at whether eating a high-fiber diet (over 21 grams per day) can change gut bacteria and improve the immune system's ability to fight solid tumors like colorectal cancer. About 25 adults with solid tumors will follow this diet to see if it is safe and helps with t…

This study tested whether adding the immunotherapy drug pembrolizumab to standard hormone therapy (enzalutamide plus ADT) could help men with metastatic hormone-sensitive prostate cancer live longer or delay cancer growth. The trial enrolled 186 Chinese men and was stopped early …

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This trial compares two types of radiation therapy for prostate cancer: proton therapy and standard photon therapy. The main question is whether proton therapy reduces moderate to severe urinary or intestinal side effects. Researchers will also track quality of life, cancer recur…

This trial tests a structured diet and exercise program for overweight Chinese cancer survivors. The program, led by a dietitian and a cancer exercise specialist, teaches weight loss strategies, healthy eating, and physical activity. Researchers want to see if the program is prac…

This phase 1 trial tested the combination of dasatinib (a pill) and bevacizumab (an infusion) in 50 adults with advanced solid tumors that no longer respond to standard treatments. The goal was to find the safest dose and see how well the two drugs work together to slow cancer gr…

This phase 1 trial tests an experimental drug called MRG003 in people with advanced solid tumors, including colorectal cancer, head and neck squamous cell carcinoma, and nasopharyngeal carcinoma. The study aims to find a safe dose and to see whether the drug can shrink tumors. Pa…

This early-phase trial tested a shorter course of radiation for men whose prostate cancer came back after their prostate was removed. Instead of the usual 6-7 weeks of daily radiation, researchers gave higher doses over just 2-4 weeks, focusing the strongest radiation on the tumo…

This early-phase study tests an experimental drug called MK-6837, given alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug sh…

This phase 2 trial is testing a combination of two hormone-based drugs—darolutamide and high-dose testosterone—in 51 men with metastatic castration-resistant prostate cancer, a form that no longer responds to standard hormone therapy. The approach, called extreme bipolar androgen…

This early-phase trial tested a combination of two drugs, vandetanib and everolimus, in 151 people with advanced or metastatic cancer that had stopped responding to standard treatments. The goal was to find the safest dose and see if the combination could slow or stop cancer grow…

This trial is testing whether a new form of chemotherapy called PLX038 can be safely combined with the PARP inhibitor rucaparib to shrink tumors in people with small cell lung cancer, small cell cancer outside the lungs, or other solid tumors. The study has two parts: first, find…

This study compared two ways of taking prostate tissue samples: the standard transrectal method (through the rectum) and a newer transperineal method (through the skin between the scrotum and anus). Over 1,000 men participated to see if the transperineal approach causes fewer inf…

This study tests a new long-acting injection called Debio 4228 for men with advanced prostate cancer. The goal is to lower testosterone levels to control the cancer. About 55 men will receive different doses to find the best one. This is not a cure, but a way to manage the diseas…

This early-stage trial is testing whether combining two chemotherapy drugs, temozolomide and topotecan, is safe and tolerable for children and adolescents with malignant tumors that have returned or not responded to standard treatments. The study aims to find the highest safe dos…

This trial asks men with advanced prostate cancer which of two oral medications they prefer: the experimental drug ODM-201 or the approved drug enzalutamide. Both work by blocking male hormones that fuel cancer growth. Participants will take each drug for a period and then answer…

This trial tests whether using 3D on-board imaging before each radiation session improves accuracy and outcomes for men with prostate cancer compared to standard imaging. The study tracks disease-free survival, side effects, and costs over 2 to 5 years. It aims to find the best i…

This phase 3 trial is testing an investigational drug called DKF-MA102 (leuprorelin acetate) in men with advanced prostate cancer. The goal is to see if two injections, given 12 weeks apart, can safely lower testosterone levels to a target range, which may help control the cancer…

This trial tests whether a dye called indocyanine green, viewed with near-infrared imaging, can help surgeons spot pelvic lymph nodes during robot-assisted prostate removal in men with stage II prostate cancer. The dye is injected into the prostate, and the imaging system is used…

This early-stage trial is testing an investigational therapy called OH2, a modified herpes simplex virus designed to infect and destroy cancer cells while also stimulating the immune system. The study will evaluate OH2 alone or in combination with the immunotherapy drug pembroliz…

This early-stage trial is testing an experimental drug called AEB1102 in people with advanced solid tumors that have not responded to standard treatments or for which no standard treatment exists. The main goal is to find the highest dose that is safe and to understand the drug's…

This early-phase trial is testing an oral drug called ATRN-119 in 132 people with advanced solid tumors that have specific DNA repair mutations. The main goals are to check safety, how the drug moves through the body, and whether it can shrink tumors. Participants must be able to…

This trial tests whether giving the sedative dexmedetomidine during and after reconstructive microsurgery can help transplanted tissue (flaps) survive better in cancer patients. The study will compare flap health at 48 hours after surgery in patients receiving dexmedetomidine ver…

This phase 1 trial is testing an experimental drug called STP707 in people with advanced or metastatic solid tumors that have not responded to standard treatments. The study aims to find a safe dose and see whether the drug can slow or shrink tumors. Participants receive STP707 b…

This study tested a new radioactive drug, 177Lu-NeoB, in 35 adults with advanced solid tumors that have a specific marker (GRPR). The goal was to check safety, find the best dose, and see if it shrinks tumors. It is an early-stage trial, so it focuses on safety and dosing, not a …

This trial compares two common methods for placing a totally implantable vascular access device (TIVAD), a port used for chemotherapy and other treatments in cancer patients. Researchers are randomly assigning patients to have the port inserted via either the internal jugular vei…

This trial tests whether a personalized ventilation strategy, guided by electrical impedance tomography (EIT), can reduce lung complications in men undergoing robot-assisted prostate removal. During this surgery, the abdomen is inflated with gas and the patient is tilted head-dow…

This phase 3 trial tests whether a web-based physical activity program, including a wearable tracker and interactive app, can improve fitness and long-term health in children and adolescents who have completed cancer treatment. Participants are randomly assigned to receive either…

This study monitors the safety and effectiveness of the drug olaparib (Lynparza) in people with ovarian, breast, prostate, or pancreatic cancer who are prescribed it as part of routine care in South Korea. Researchers will track side effects and how long the cancer stays under co…

This early-phase trial is testing an experimental drug called SM3321 in people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to see if the drug is safe and tolerable, and to find the best dose. Participants receive SM3321 as a we…

This phase 2 trial is testing whether surgery and radiation can help men whose prostate cancer has come back and spread to a few spots in the body. About 20 participants will receive either surgery to remove the spread tumors or targeted radiation, or both. The main goal is to se…

This early-stage trial tests an experimental drug called JS015 in people with advanced solid tumors who have run out of standard treatment options. The main goal is to check the drug's safety, find the best dose, and see how the body processes it. Up to 12 participants will recei…

This trial evaluates the Bitrack robotic system, designed to assist surgeons during laparoscopic kidney removal (partial or total) and prostate removal. The study includes 15 adults scheduled for these surgeries. The goal is to check if the robot works safely and effectively, as …

This study tests a support program that brings together oncologists, pharmacists, doctors, and nurses to help cancer patients take their oral medications as prescribed. The goal is to improve treatment effectiveness and patient safety by ensuring better communication and follow-u…

This study follows nearly 1,000 prostate cancer patients taking ORGOVYX (relugolix) to see how the drug works in everyday medical practice. Researchers will track side effects, quality of life, and disease progression. The goal is to understand the drug's real-world safety and ef…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This early-phase study tests a new oral drug called TT125-802 in 50 adults with advanced solid tumors (like lung cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. It is a fi…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This trial compares three modern radiotherapy techniques—helical tomotherapy and two types of dynamic arc therapy (RapidArc and VMAT)—for treating prostate, cervical, and anal canal cancers that require pelvic lymph node irradiation. The goal is to determine which method is most …

This study tests two drugs, saruparib and darolutamide, given alone or together before prostate removal surgery in men with newly diagnosed prostate cancer. The goal is to see how these drugs affect cancer cells and check for side effects. About 120 men with localized, higher-ris…

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This Phase 1 trial tested an investigational oral drug called CFI-402257 in 52 people with advanced solid tumors, including breast cancer, that had stopped responding to standard treatments. The main goal was to find a safe dose and check how the drug moves through the body. It w…

This study tested a new type of PET/MRI scan that uses a special tracer to find small spots of prostate cancer that standard scans miss. Men with a rising PSA after prostate surgery and radiation received targeted radiation to those spots. The goal was to see if this approach can…

This study tested a fixed-dose combination of two immunotherapy drugs, tiragolumab and atezolizumab, given together as a single infusion every three weeks. The trial enrolled 64 people with advanced solid tumors that express a protein called PD-L1. The main goal was to check the …

This pilot study tested whether combining high-dose radiation therapy with the immunotherapy drug pembrolizumab (Keytruda) could boost the immune system's ability to fight advanced solid tumors. Twenty-one patients with various advanced cancers received the combination either at …

This phase 2 trial tested the chemotherapy drug carboplatin in 16 men with metastatic castration-resistant prostate cancer that has specific gene changes in the homologous recombination pathway. The goal was to see if carboplatin could shrink tumors or lower PSA levels. The study…

This study tested a drug called ARN-509 in 127 men with advanced prostate cancer that had stopped responding to standard hormone therapy. The goal was to find a safe dose and see if the drug could lower PSA levels, a marker of cancer activity. The drug works by blocking male horm…

This study looked at the long-term safety of several cancer drugs, including tislelizumab and pamiparib, in 404 people with advanced cancers. Participants had already been in an earlier trial of these drugs. The goal was to track serious side effects and see if patients could kee…

This study tested a device called NanoKnife to treat prostate cancer in 121 men with intermediate-risk disease. The goal was to safely destroy cancer tissue while avoiding major side effects. Researchers checked if the treated area was cancer-free after 12 months and tracked any …

This study tested a new X-ray monitoring technique (KIM) during prostate cancer radiation therapy. The goal was to see if it helps doctors aim more precisely at the tumor while reducing harm to healthy tissue. 49 men with low- or intermediate-risk prostate cancer took part. The a…

This early-phase study tested a daily combination of two oral drugs, axitinib and everolimus, in 19 people with advanced solid tumors, particularly kidney cancer. The main goal was to find the safest dose by monitoring side effects in the first month. Researchers also tracked how…

This trial tested whether a precise type of radiation called SBRT could slow the growth of metastatic prostate cancer in men whose disease was starting to worsen despite hormone therapy. 86 men with one or two growing tumors received SBRT while continuing their current hormone dr…

This early-phase study tested a new drug called CCT3833 in 31 adults with advanced solid tumours, including melanoma. The main goal was to find a safe dose and check for side effects. Researchers measured how the drug moves through the body and looked for the best dose to use in …

This early-phase trial tested a new drug called PM14 in 126 people with advanced solid tumors that had no standard cure. The main goals were to find a safe dose and check for early signs of tumor shrinkage. The drug was given by IV infusion on different schedules. This is a first…

This study tested a device that uses water vapor (steam) to destroy cancerous tissue in the prostate. 32 men with prostate cancer received the treatment just before their scheduled prostate removal surgery. Researchers checked how well the steam destroyed the targeted tissue and …

This study tested a single, high-dose radiation treatment for men with low-risk or low intermediate-risk prostate cancer. The goal was to see how well the body tolerates this one-time treatment by tracking side effects in the bladder and digestive system within the first 6 months…

This study tested a precise radiation implant (brachytherapy) for men with low-risk prostate cancer. Instead of treating the whole prostate, doctors placed radioactive seeds only in the tumor area. The goal was to see if this targeted approach could deliver the right radiation do…

This study tested a new way to treat intermediate-risk prostate cancer using a 3D map to guide microwaves directly to the main tumor. 76 men across Europe received the treatment, and researchers checked if the cancer was gone after 12 months. The goal is to destroy the cancer whi…

This study tested a weight management program for young adult cancer survivors (ages 18-39) who have obesity and are within 5 years of finishing cancer treatment. The program combined healthy eating, physical activity, and symptom management to help reduce cardiovascular disease …

This study looked at whether taking an oral hormone therapy called apalutamide for 6 months could slow down low-risk prostate cancer and delay the need for more aggressive treatments like surgery or radiation. 93 men on active surveillance (watching the cancer without immediate t…

This early-phase study tested a combination of two chemotherapy drugs—weekly paclitaxel given through a vein and daily oral cyclophosphamide—in 28 adults with advanced cancer who had no other treatment options. The goal was to find the safest dose of paclitaxel when used with a f…

This study tested a new way to give radiation to men with intermediate-risk prostate cancer. After standard radiation to the prostate and nearby glands, a precise, high-dose boost was added to the tumor. The goal was to improve cancer control while keeping side effects on the bla…

This early-stage trial tested a modified virus called TILT-123 in 32 people with advanced solid tumors that had not responded to standard treatments. The virus is designed to infect and kill cancer cells while releasing immune-boosting proteins. The main goal was to check safety …

This completed Phase 2 trial tested whether combining an immunotherapy drug (durvalumab) with an epigenetic drug (tazemetostat) can control advanced solid tumors like pancreatic, colorectal, and soft-tissue sarcoma. The study enrolled 164 adults and measured how well the combo sh…

This early-phase trial tested an experimental cell therapy called INKmune in 12 men with advanced prostate cancer that no longer responds to hormone therapy. The goal was to find the safest and most effective dose by measuring immune cell activity, PSA levels, and tumor changes. …

This phase 2 trial tested a drug called Lutetium-177-PSMA-617, which delivers radiation directly to prostate cancer cells. It included 58 men with prostate cancer that had spread to a few spots in bones or lymph nodes but was still hormone-sensitive. The study compared the drug t…

This study tested whether adding darolutamide to standard hormone therapy helps men with prostate cancer that has spread to other parts of the body. 669 men participated. The goal was to see if the combination delays cancer growth or death. Results showed improvement in progressi…

This study tested a treatment called focused ultrasound (HIFU) that aims to destroy only the cancerous part of the prostate, avoiding common side effects like incontinence and impotence from standard treatments. It involved 174 men aged 50-80 with intermediate-risk prostate cance…

This study tested a radioactive drug called radium-223 in 921 men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if it helps them live longer and controls the cancer. Participants received either the drug …

This study looked at whether reducing the use of strong, broad-spectrum antibiotics in cancer patients with sepsis or septic shock is as safe as continuing them. The goal is to lower the risk of creating drug-resistant bacteria. Researchers compared a de-escalation strategy to st…

This study tested a combination of high-dose radiation and hormone therapy (leuprorelin) in 74 men with prostate cancer that had returned in up to 5 pelvic lymph nodes after initial treatment. The goal was to see if this approach could delay further cancer growth or relapse. Part…

This study tested the immunotherapy drug nivolumab (Opdivo) combined with one of three other drugs (rucaparib, docetaxel, or enzalutamide) in 292 men with advanced prostate cancer that had spread and stopped responding to hormone therapy. The goal was to see if these combinations…

This early-stage trial tested an experimental drug called CyPep-1, injected directly into tumors, either alone or with the immunotherapy pembrolizumab. The study involved 60 adults with advanced solid cancers that had stopped responding to standard treatments. The main goals were…

This early-phase trial tested an experimental drug called VS-6766, given alone or with everolimus, in 104 adults with advanced solid tumors or multiple myeloma that had stopped responding to standard treatments. The goal was to find a safe, tolerable dosing schedule and measure h…

This study tested a drug called enzalutamide in 1401 men with a type of prostate cancer that has not spread to other parts of the body but is no longer controlled by standard hormone therapy. The goal was to see if enzalutamide could delay the cancer from spreading. Participants …

This study tested whether adding a precise, high-dose radiation treatment (SBRT) to the hormone therapy apalutamide helps control prostate cancer that has stopped responding to standard hormone therapy and spread to a few spots. Twenty-six men with this type of cancer took part. …

This early-phase trial tested whether adding two chemotherapy drugs (6-mercaptopurine and 6-thioguanine) to an immunotherapy drug (Atezolizumab) could help treat advanced solid tumors that have stopped responding to standard treatments. The study enrolled 18 adults with metastati…

This early-stage trial tested a new drug called MRX-2843 in 42 adults with advanced solid tumors that had spread or come back after other treatments. The main goal was to check safety and find the right dose. Researchers monitored side effects and how the drug moved through the b…

This study tested a new way to treat early-stage prostate cancer using MRI-guided ultrasound waves to destroy tumors without surgery. 25 men with low-to-intermediate risk prostate cancer received the treatment. The main goal was to see if no significant cancer remained one year l…

This phase 2 trial tested two immunotherapy drugs, ipilimumab and nivolumab, in 69 men with a specific type of advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if the combination could shrink tumors or slow disease progression. Participants…

This early-stage trial tested a new biologic drug called ZGGS15 in 22 adults with advanced solid tumors who had no standard treatment options left. The main goals were to check safety, find the right dose, and look for early signs that the drug might control tumor growth. Partici…

This study tested whether adding the drug TAK-700 to standard hormone therapy helps men with newly diagnosed prostate cancer that has spread live longer than adding the drug bicalutamide. Over 1,300 men took part. The goal was to see which combination works better for controlling…

This early-phase study tested an experimental oral drug called Q702 in 51 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects, while also looking at whether the drug could shrink …

This phase 2 trial tested whether combining two immunotherapy drugs, nivolumab and ipilimumab, could shrink tumors or slow progression in men with metastatic castration-resistant prostate cancer. 351 participants received either the combination, ipilimumab alone, or the chemother…

This study tested a drug called niraparib in 289 men with advanced prostate cancer that no longer responds to hormone therapy and has specific DNA repair issues. The goal was to see if the drug could shrink tumors or slow the disease. Results may help identify which patients coul…

This study looked at the long-term safety of the drug degarelix in 57 men with prostate cancer. Participants received a monthly injection of degarelix for up to 5 years. The goal was to monitor side effects, such as changes in blood pressure, pulse, weight, and liver function.

This study tested whether adding a radioactive drug (Radium-223) to targeted radiation (SABR) helps men with prostate cancer that has spread to a few bones or soft tissues. 64 men participated, receiving either SABR alone or SABR plus Radium-223. The goal was to see if the combin…

This large phase 3 trial tested whether adding the chemotherapy drug docetaxel to standard hormone therapy helps men with metastatic prostate cancer live longer. 790 men participated. The results showed that the combination improved overall survival compared to hormone therapy al…

This early-phase study tested a new approach for men with prostate cancer that has spread to nearby lymph nodes. The standard treatment combines radiation with 2-3 years of hormone therapy, which can cause lasting side effects. Researchers added a targeted radioactive drug (Lu-PS…

This early-stage study tested a fixed-dose combination of two immunotherapy drugs (relatlimab and nivolumab) in 24 Chinese patients with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, how the drugs move through the b…

This small pilot study tested a procedure called prostatic arterial embolization in 10 men with low-risk, one-sided prostate cancer who were already on active surveillance. The idea was to block the artery feeding the tumor, starving it of blood. Researchers checked for side effe…

This pilot study tested whether a structured exercise program is feasible for young cancer survivors (ages 18-45) who have mild heart dysfunction after cancer treatment. The program, called CORE, is like cardiac rehab and aims to improve heart health, fitness, and quality of life…

This early-phase trial tested whether injecting a man's own bone marrow stem cells into the penis could help restore erections after prostate cancer surgery. The study included 18 men who had normal erections before surgery but developed erectile dysfunction due to blood vessel d…

This Phase 3 study tested whether adding darolutamide to standard hormone therapy and chemotherapy helps men with metastatic hormone-sensitive prostate cancer live longer. Over 1,300 participants received either darolutamide or a placebo, along with standard treatments. The main …

This early-phase trial tested a new immunotherapy drug called BDB001, alone or combined with atezolizumab (Tecentriq), in 40 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find the best dose, and see if t…

This early-phase trial tested a new immunotherapy drug called BDB001, both alone and combined with pembrolizumab, in 87 adults with advanced solid tumors that had progressed after standard treatments. The main goals were to check safety and find the best dose. The study is comple…

This study offers continued access to tazemetostat for 58 people with various cancers who already benefited from the drug in earlier trials. The main goal is to monitor long-term safety and side effects. Participants must have shown clinical benefit from tazemetostat before joini…

This study tested a smartphone app to help young adult cancer survivors (ages 18-39) lose weight. The app tracked diet and activity as part of a behavioral weight loss program. The goal was to see if this approach was practical and well-liked by participants. The study involved 6…

This large phase 3 trial tested whether adding enzalutamide (Xtandi) to standard hormone therapy (ADT) helps men with metastatic hormone-sensitive prostate cancer. Over 1,100 participants received either enzalutamide plus ADT or a placebo plus ADT. The main goal was to see how lo…

This study tested a new oral drug called RP-3500 (camonsertib), alone or combined with talazoparib or gemcitabine, in 276 adults with advanced solid tumors that have certain genetic mutations. The main goals were to find the safest dose and check for early signs of tumor shrinkag…

This phase 2 trial tested whether adding a radioactive drug (I-131-1095) to standard enzalutamide therapy helps men with a specific type of advanced prostate cancer that had worsened on another treatment. The study enrolled 120 men with PSMA-positive metastatic castration-resista…

This study looked at a small implantable spacer placed between the prostate and rectum in men receiving radiation for prostate cancer. The goal was to see if the spacer reduces the radiation dose reaching the rectum, potentially lowering side effects. A total of 175 men who alrea…

This completed study tested a hydrogel spacer placed between the prostate and rectum in 20 men undergoing radiation for prostate cancer. The goal was to see if the spacer reduces radiation reaching the rectum. Researchers compared rectal radiation exposure before and after insert…

This study tested a combination of two drugs, apalutamide and abiraterone, plus prednisone, in 93 men with advanced prostate cancer that had spread and was no longer responding to hormone therapy. The goal was to see how long the cancer stayed under control and whether the drugs …

This early study tested whether adding a radioactive drug (177Lu-PSMA) to standard brachytherapy is safe and feasible for men whose prostate cancer returned after initial radiation. Only 3 men took part. The goal was to see if the combination could control cancer both in the pros…

This early-phase trial tested a new drug, Karonudib, in 63 people with advanced solid tumors that had not responded to standard treatments. The main goal was to check the drug's safety and find the best dose. Researchers also looked at how the drug moves through the body and any …

This trial tested a steroid injection called triamcinolone in 55 men with castration resistant prostate cancer, a type that no longer responds to standard hormone therapy. The goal was to see if it could extend the time before chemotherapy is needed, since current steroid treatme…

This study looked at men with advanced prostate cancer that no longer responds to hormone therapy. When the standard dose of abiraterone stopped working, some patients received a double dose to see if it could stabilize the disease. The goal was to find out if this approach is sa…

This study tested a new way to treat low-risk prostate cancer using a microwave probe inserted through the rectum. The goal was to see if it could safely destroy the main tumor while protecting nearby tissues. Eleven patients were treated, and the researchers checked for complete…

This early-phase trial tested an experimental immunotherapy called ELI-002 in 25 people with KRAS-mutated pancreatic, colorectal, lung, ovarian, or bile duct cancers who had signs of remaining disease after standard treatment. The therapy aims to train the immune system to attack…

Researchers are testing whether a combination of PET scans with a radioactive tracer called [18F]PSMA-1007, sodium MRI, and multiparametric MRI can accurately predict where prostate cancer is and how aggressive it is. The study enrolls men who are scheduled to have their prostate…

This study explores whether using only MRI-targeted prostate biopsies—instead of combining them with standard systematic biopsies—can provide enough information for doctors to decide on treatment. Men aged 50 to 75 with suspected prostate cancer and a single suspicious lesion on …

This trial tests whether a new PET/CT tracer, 64Cu-SAR-bisPSMA, can find more sites of prostate cancer recurrence than the standard 68Ga PSMA-11 scan in men whose PSA rises after prostate removal. Fifty men will receive both scans, and researchers will compare how many lesions ea…

This trial explores whether specially trained dogs can identify high-risk prostate cancer by smelling urine samples. Men with suspected prostate cancer will provide urine samples, which six dogs will sniff. The study will compare the dogs' accuracy against MRI results and biopsy …

This large registry study is testing whether a special type of PET scan, called PSMA-PET, can better detect where prostate cancer has returned after initial treatment. Thousands of men with suspected recurrent prostate cancer across Ontario will receive this scan. The goal is to …

This study tested a quick finger-prick blood test to see if cancer patients had been infected with COVID-19 in the past. Researchers enrolled 214 adults being treated for cancer. The goal was to find out how many had antibodies, including those without symptoms, to help clinics k…

This study tested a new MRI method that measures temperature changes in the prostate. The goal is to help doctors find cancer more accurately and guide laser treatments. Researchers scanned 70 men who already needed an MRI for prostate cancer diagnosis. The focus was on checking …

This study tested an AI software called Quantib Prostate to see if it can detect prostate cancer on MRI scans as accurately as expert radiologists. Researchers looked at 200 men who had prostate MRIs and biopsies. The AI's readings were compared to the radiologist's readings, usi…

This study looked at tiny particles called extracellular vesicles (EVs) found in prostate fluid from 100 men. The goal was to find unique molecular signatures that could help tell aggressive prostate cancer from slow-growing or benign conditions. Researchers used advanced techniq…

This study tested two different radioactive tracers (68Ga-RM2 and 68Ga-PSMA-617) used in PET/CT scans to see which one better detects prostate cancer in men scheduled for prostate removal surgery. Twenty-two men with low, intermediate, or high-risk prostate cancer received both s…

This study looked at two methods of taking prostate tissue samples to diagnose cancer: one through the rectum and one through the skin between the scrotum and anus. Researchers wanted to see which method causes fewer infections and less bleeding. 101 men with suspected prostate c…

This study looked at 60 men who had a prostate biopsy to check for cancer. It compared two imaging methods used to guide the biopsy: the standard multiparametric MRI and a newer scan called Ga-68 PSMA PET/CT. The goal was to see which method better finds aggressive prostate cance…

This study tested a new type of PET-CT scanner that can scan a tumor right after it is removed from the body. Patients with prostate or head and neck cancer received a small amount of radioactive tracer before surgery, which sticks to cancer cells. After removal, the specimen was…

This study tested a new imaging technique called Full Field Optical Coherence Tomography (FFOCT) to see if it can detect prostate cancer in biopsy samples as well as standard microscope analysis. Researchers compared FFOCT results to the usual pathology exam in 91 men with elevat…

This Phase 3 study tested a radioactive tracer called Copper Cu 64 PSMA I&T, given as an injection, to improve PET/CT scans in 235 men with prostate cancer that may have returned after initial treatment (surgery or radiation). The goal was to see how accurately the scan could det…

This completed registry study at Princess Margaret Cancer Centre tested whether a special PET scan tracer called 18F-DCFPyL (PSMA) can find prostate cancer that has spread to lymph nodes or other organs better than standard CT and bone scans. A total of 142 men with intermediate-…

This study tested a new radioactive imaging agent called 68Ga-OncoACP3 in 20 men with prostate cancer. The goal was to see if it is safe and to measure how much radiation the body receives. The agent helps doctors see where cancer has spread using a special scan.

This study tested whether a simple checklist and blood test (the YEARS algorithm) can safely rule out pulmonary embolism (a blood clot in the lungs) in people with active cancer, compared to the standard approach of doing a CT scan on everyone. About 700 cancer patients with susp…

This study compared two ways to biopsy the prostate in 275 men with suspected cancer. The standard method takes random samples from the gland, which can miss aggressive tumors or find harmless ones. The new method uses MRI images to guide the needle to suspicious spots. The goal …

This study tested whether new deep learning (AI) technology can make prostate MRI scans faster while still finding suspicious nodules. Researchers compared standard MRI sequences with faster, AI-enhanced versions in 34 adults referred for prostate MRI. The goal was to see if the …

This study tested whether using an MRI to guide prostate biopsies could detect cancer as well as the standard 12-sample systematic biopsy. Researchers enrolled 108 men aged 45-75 with elevated PSA levels and suspicious MRI findings. They compared the cancer detection rates of 3 t…

This study explored whether prostate cancer cells can be detected in blood samples instead of using a needle biopsy. Researchers collected blood from 127 men with suspected prostate cancer and used a special filter to isolate tumor cells. The goal was to see if this non-invasive …

This phase 2 study tested a new radioactive imaging agent called 64Cu-SAR-BBN in 53 men with prostate cancer that had returned after treatment but was not visible on standard PSMA PET scans. The goal was to see if this agent could safely and accurately detect where the cancer had…

This study tested whether a new, high-resolution ultrasound (micro-ultrasound) can find aggressive prostate cancers as well as MRI does during biopsy. Over 800 men with suspected prostate cancer were randomly assigned to one of three biopsy guidance methods. The goal was to see w…

This completed Phase 3 study tested a new radioactive tracer called [18F]CTT1057 for PET/CT scans in 190 men with prostate cancer whose PSA levels were rising after initial treatment. The goal was to see if the tracer could accurately locate where the cancer had returned. Partici…

This study tested a new imaging agent called [18F]CTT1057 for PET scans to see how well it can find prostate cancer tumors. 195 men with high-risk prostate cancer who were scheduled for surgery received the scan. The results were compared to tissue samples taken during surgery to…

This study tested a new imaging agent called 68Ga-NTA-476 for PET scans in 10 men with prostate cancer. The goal was to see how well it finds tumors compared to the standard scan, and to check for side effects. This was the first time this agent was used in humans, so safety and …

This completed study collected urine and blood samples from 80 men, including those with prostate cancer, suspected cancer, or benign prostate enlargement, as well as healthy donors. The goal was to find RNA biomarkers that could lead to a simple liquid biopsy test for diagnosing…

This study tested whether two imaging methods—Histoscanning and multiparametric MRI—can accurately detect and locate prostate cancer that comes back after radiation therapy. Thirty men with rising PSA levels or biopsy-confirmed recurrence were enrolled. Each participant received …

This trial tests whether a software tool called the hypotension prediction index (HPI) can help prevent acute kidney injury after robotic-assisted urologic surgery. The tool uses arterial pressure data to forecast drops in blood pressure during the operation, allowing doctors to …

This trial tests whether a one-hour group discussion helps Latino men aged 50 to 70 make informed decisions about PSA screening for prostate cancer. Participants receive either a printed pamphlet or an interactive session covering the benefits, risks, and controversy around PSA t…

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This study tested whether a taurolidine-citrate solution (TauroLock) placed in the catheter between treatments can prevent bloodstream infections in adults with solid tumors receiving IV anti-cancer therapy. 162 patients were randomly assigned to get either the TauroLock solution…

This phase 3 trial tested whether a biologic called IMM-101 could reduce severe respiratory infections, including COVID-19, in cancer patients at higher risk. 195 participants either received three doses of IMM-101 or were simply observed. The goal was to see if the treatment cou…

Researchers test a 10-week lifestyle program for people who have finished cancer treatment. The program combines structured exercise, nutrition counseling, and behavioral therapy. They compare it with a waitlist group to see how it affects cardiorespiratory fitness and body weigh…

This study tests whether a personalized 4-week exercise program can improve quality of life and physical function in men with metastatic prostate cancer who are receiving radiation therapy. Eighty participants will either exercise or not, and researchers will track changes in wel…

This study tests a new way to give radiotherapy for men with intermediate-risk prostate cancer. The goal is to lower the dose to healthy parts of the prostate while boosting the dose to the tumor, using a special MRI-guided machine (MR-linac). Twenty men will take part to see if …

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

This study tests a pre-surgical toolkit (OPTI-Surg) designed to help older cancer patients recover more quickly after major surgery. The toolkit provides recommendations before surgery to improve physical function and reduce complications. About 325 participants with various canc…

This study looked at 2,000 adults with solid tumors to find the best dose of olanzapine for preventing nausea and vomiting caused by strong chemotherapy. Researchers compared 2.5 mg, 5 mg, and 10 mg doses to see which works best with the fewest side effects like daytime sleepines…

This completed Phase 2 trial tested whether formal hypnosis, alongside standard care, could reduce anxiety and pain in 68 cancer patients undergoing brachytherapy. Patients received either standard care with Kalinox or standard care plus formal hypnosis. The study measured anxiet…

This study tested an experimental oral drug called Trichomylin® in 11 adults with advanced cancer who had moderate to severe pain despite taking strong opioids. The goal was to see if the drug is safe and can provide additional pain relief. Participants took the drug twice daily,…

This study tests a program that helps caregivers of teens and young adults (ages 15-26) with cancer find resources for financial and social needs. About 60 caregiver-patient pairs will take part. The goal is to see if this support reduces stress and improves well-being.

This trial tests whether wearing a grounding patch at night improves sleep quality in cancer patients who have insomnia while in the hospital. The patch is a hydrogel sticker on the forehead, connected by a cord to a true earth connection, which may lower the body's electrical vo…

This trial tests whether an AI emotional companion app can improve depression, anxiety, and demoralization in adults with advanced cancer. Participants use a mobile app where a virtual character holds conversations, reads emotional cues, and offers a link to a human hotline if di…

This trial tests whether art therapy can reduce physical and psychological symptoms in cancer patients receiving chemotherapy or immunotherapy. Over six treatment sessions, participants engage in artistic activities like painting, drawing, or clay work, guided by an art therapist…

This trial tests whether heated traditional Chinese medicine plasters can help cancer patients recover from chemotherapy-induced anemia and low blood cell counts. Participants apply the plaster to a specific point on the navel for one hour daily over two weeks. Researchers compar…

This study tests whether adding olanzapine to standard anti-nausea medicines can better control vomiting in children receiving strong chemotherapy. About 200 children will be randomly assigned to get either olanzapine or a placebo. The goal is to see if olanzapine helps more kids…

This trial tests whether regular electronic questionnaires after prostate cancer surgery can improve recovery. Men who have their prostate removed will report symptoms like incontinence and mood through an app or computer. If scores hit certain levels, a nurse calls to offer a ur…

This study looked at whether laughter yoga could help cancer patients going through chemotherapy. 55 patients were split into two groups: one did weekly 40-minute laughter yoga sessions for four weeks, while the other received standard care. After four weeks, the laughter yoga gr…

This trial tests whether the Benson Relaxation Technique, a simple 15-minute guided relaxation exercise, can reduce pain, insomnia, nausea, vomiting, and retching in adults with cancer who are admitted to intensive care. Participants will practice the technique, which involves si…

This study tested a program to help cancer survivors quit smoking and manage pain. Nineteen survivors received counseling and the medication varenicline (Chantix). The goal was to see if the program was practical and helpful, not yet to prove it works.

This study tests whether using a virtual reality headset, an aromatherapy patch, or both can help men feel less pain, fear, and embarrassment during a prostate biopsy. About 208 men will be randomly assigned to one of four groups: VR, aromatherapy, both, or standard care. The goa…

This study tests whether a conversation game called 'Hello' can help people with cancer and their loved ones discuss advance care planning—decisions about future medical care. Participants will play either the Hello game or a similar conversation game, complete questionnaires, an…

This trial tests whether a combined nerve block can provide better pain relief than standard local anesthesia for cancer patients undergoing chemoport implantation. The study will compare the two approaches in 80 adults, measuring the need for extra pain medication during the pro…

This trial tests whether laser acupuncture, a non-invasive therapy using low-intensity light on traditional acupoints, can relieve constipation in people with advanced cancer. Participants are adults with advanced cancer who have constipation despite using laxatives. The study me…

This phase 2 trial tests whether inhaling a blend of peppermint and lemon essential oils can reduce nausea and vomiting in people receiving their first chemotherapy for a solid tumor. Participants will inhale the oils four times daily and whenever nausea strikes, with symptoms tr…

This study explores whether engaging in positive activities can improve emotional well-being and quality of life for Asian American cancer patients and their caregivers. Participants, who are within a year of a cancer diagnosis and undergoing treatment, along with their caregiver…

This trial tests whether combining pranayama breathing exercises with music listening can help manage fatigue and improve quality of life in cancer patients receiving immunotherapy. Sixty participants are split into two groups: one receives the integrative therapy alongside their…

This trial tests whether a new care approach, called PediQUEST Response, can improve quality of life for children, adolescents, and young adults with advanced cancer. Participants use an app to regularly report symptoms and quality of life, and a palliative care team receives the…

This study tests whether a music-assisted mandala coloring activity can improve psychological well-being and quality of life in adults receiving their first chemotherapy treatment for cancer. Participants will color mandalas weekly for 8 weeks, guided by an instructional video, a…

This study tests whether using a virtual reality headset during PICC line placement can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to see if this non-drug appro…

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This study tested whether monthly 45-minute psychological interviews over 6 months could reduce post-traumatic stress symptoms in cancer patients affected by the COVID-19 pandemic. It included 29 adults with solid tumors who had moderate to high PTSD symptoms. The goal was to see…

This study tests whether a 12-week, drug-free exercise program can help men with metastatic prostate cancer who are starting hormone therapy. The program includes supervised sessions of aerobic, resistance, balance, and flexibility exercises. The main goal is to see if patients c…

This trial tests whether adding two surgical steps—suspending the urethra and rebuilding pelvic fascia—during robot-assisted prostate removal can help men regain urinary continence sooner. About 60 prostate cancer patients will receive the modified procedure and be followed for t…

This study tests PAfitME™, a telehealth program that uses personalized motion exergames to help young adult cancer survivors (ages 18–39) improve their physical function. The program is tailored to each person's fitness level, fatigue, and pain. Researchers will see if it is feas…

This phase II trial tests whether flibanserin, a drug approved for low sexual desire in women, can increase sexual interest in men with prostate cancer who are receiving androgen deprivation therapy (hormone therapy). About 44 men will be randomly assigned to take flibanserin or …

This study tests whether limiting food intake to a 10-hour window each day for 12 weeks can reduce persistent fatigue in cancer survivors who completed treatment 2 months to 2 years ago. Half the participants follow the eating schedule; the other half receive general healthy life…

This study tests whether graded motor imagery—a brain-based therapy involving left/right judgment, imagined movements, and mirror exercises—can relieve nerve pain and improve leg function in cancer patients with chemotherapy-induced peripheral neuropathy. Half the participants wi…

This study tests a 4-month community program called Men Moving Forward for African-American men who have finished prostate cancer treatment. The program includes twice-weekly sessions to help participants eat more fruits and vegetables, cut down on red meat, and increase physical…

This study tested a 5-week digital program called EMPOWER that teaches emotion regulation skills to adolescent and young adult cancer survivors. 352 participants completed weekly lessons and brief daily exercises. The goal was to see if the program could improve positive feelings…

This study tests whether acupuncture using tiny, semi-permanent needles can prevent diarrhea caused by the chemotherapy drug irinotecan in children with solid tumors. About 22 children will receive the acupuncture during their second round of chemo, and researchers will measure p…

This study investigates whether a 12-week program of tai chi and qigong (called Body Mind Training) can reduce fatigue in male cancer survivors aged 55 and older. Participants are randomly assigned to the mind-body training, a light exercise-only group, or a usual-care group. Res…

This study is testing whether a mobile app that combines daily symptom reports with Fitbit data can help cancer patients better manage side effects during chemotherapy. Fifty adults with solid tumors will use the app for 90 days, receiving tips for mild symptoms and alerts to con…

This study looked at whether teaching cancer patients about their portable chemotherapy pump (elastomeric pump) can make them feel more comfortable and less anxious. 70 adults receiving 5-FU treatment were split into two groups: one got extra education and a booklet, the other go…

This pilot study tested whether a 12-week exercise program designed for Punjabi-speaking South Asian cancer patients and their support persons is practical and well-liked. Twelve participants did twice-weekly exercise sessions and filled out questionnaires. The goal was to see if…

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This study tested a music therapy program called Meraki for cancer patients receiving palliative care. The goal was to see if three music sessions could improve emotional well-being, reduce anxiety and depression, and boost quality of life. Researchers enrolled 80 patients and me…

This study tested a 3-week program that helps cancer patients identify their personal strengths (like hobbies, social support, or personal qualities) and use them to cope better. 32 adults with different cancers took part in card-sorting sessions, phone calls, and home exercises.…

This study tested a 6-session therapy called Acceptance and Commitment Therapy (ACT) for cancer patients at risk of opioid misuse. 40 adults with cancer and a high score on an opioid risk tool participated. The goal was to see if the therapy was feasible and acceptable, not yet t…

This study tested whether coloring mandala patterns can reduce nausea, vomiting, and fatigue, and improve psychological well-being in cancer patients receiving chemotherapy. 85 patients were split into a coloring group and a control group. The coloring session lasted 20-30 minute…

This study tested a special pain coping skills program for people with advanced solid tumor cancer who have pain that interferes with daily activities. 211 patients were randomly assigned to either the program or standard care. The program taught ways to manage pain and find mean…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This pilot study tested whether taking a green tea extract (EGCG) plus vitamin C daily for 12 weeks is safe and feasible for older cancer survivors who are frail or pre-frail. The study enrolled 24 people aged 65 and older who had completed cancer treatment. The main goal was to …

This study tested a mobile app called SyMon-SAYS that lets children with cancer report their symptoms weekly to their doctors. The goal was to see if using the app helps manage symptoms and improve quality of life. 216 children and their parents took part, with some using the app…

This study tested whether a program called PRISM (Promoting Resilience in Stress Management) could help young adults aged 18-39 who have cancer or desmoid tumors manage anxiety and depression. The program teaches skills like stress management, goal setting, and positive thinking.…

This study tested a 9-session virtual mind-body program (SMART-3RP) to see if it helps caregivers of cancer survivors feel less stressed and more resilient. It compared the program to a standard online support group. The trial enrolled 94 participants and focused on whether the p…

This study tested an online program to help cancer patients with insomnia. It included 348 adults with cancer who had trouble sleeping. The program used cognitive-behavioral techniques and aimed to see who might need extra help from a professional.

This study tested whether using virtual reality hypnosis before chemotherapy infusions could lower anxiety in men with metastatic prostate cancer. Fifty-three patients were randomly assigned to either receive the VR hypnosis session or standard care before each docetaxel infusion…

This study tested a program to help men prepare for and manage side effects from prostate cancer treatments like surgery or radiation. The program used daily texts and emails, plus support from other men, to encourage healthy habits before treatment. The goal was to reduce distre…

This study looked at whether men with metastatic prostate cancer prefer cabazitaxel or docetaxel as their first chemotherapy. 195 patients tried both drugs in sequence and then stated their preference. The goal is to see if side effects like nerve damage or fatigue influence choi…

This study tested whether using a low-frequency laser on an acupuncture point (P6) can help prevent nausea and vomiting caused by chemotherapy in children aged 2 to 20. The 30 participants received the laser treatment alongside standard anti-nausea drugs. The goal was to see if a…

This study tested a program called YATAC, designed to help young adults (ages 18-39) recover from cancer and return to everyday life. The program covers goal-setting, managing daily life, staying active, coping with emotions, education, work, finances, relationships, and peer sup…

This study tested a 6-month program called CancerPEP that sends daily emails to cancer patients and survivors with tips on exercise, yoga, stress reduction, and healthy eating. The goal was to see if the program is practical and helps improve mental and physical health. 104 adult…

This study tested whether listening to music during radionuclide treatment helps prostate cancer patients feel less anxious and distressed. Sixty men were split into two groups: one listened to their choice of instrumental music through headphones during treatment, while the othe…

This study tested an online educational program for cancer patients receiving chemotherapy. The program included video sessions, peer discussions, and digital materials to help with symptom management and emotional coping. Researchers compared 212 patients who used the program to…

This study looked at whether cancer patients prefer doing yoga online or in a studio during their treatment. 163 people with cancer chose their preferred setting and attended weekly group yoga for 12 weeks. Researchers measured quality of life and interviewed participants about t…

This small pilot study tested whether acupuncture could help reduce hot flashes and night sweats in men with prostate cancer who are on hormone therapy. Twelve men received acupuncture sessions, and researchers measured how well the treatment was accepted and whether symptoms imp…

This study tested a stepped-care telehealth program for cancer survivors living in rural areas who experience anxiety, depression, or sleep problems. Participants received either low-intensity check-ins or high-intensity phone therapy with a licensed therapist, depending on sympt…

This study looked at whether giving a lower dose of the steroid dexamethasone before the chemotherapy drug docetaxel can prevent allergic reactions with fewer side effects. The standard high dose can cause problems like high blood sugar, mood changes, and weakened immunity. Resea…

This study tested whether buffered lidocaine (lidocaine mixed with baking soda) reduces pain during prostate biopsy. 350 men undergoing a prostate biopsy received either buffered or standard lidocaine. Researchers measured pain from the numbing injection and from the biopsy itsel…

This study tested a smartphone app called POSTHOC that helps cancer survivors manage symptoms and track healthy behaviors after finishing treatment. Fifty-one adults who recently completed cancer therapy used the app or received standard care for 12 weeks. The goal was to see if …

This completed trial tested a web-based remote monitoring platform called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Patients used the platform to report symptoms and receive alerts, aiming to improve their physical health and q…

This study tested whether asking cancer patients to complete a symptom questionnaire online before their doctor visit could help identify who might benefit from a palliative care referral. Forty adults with advanced cancer participated. The goal was to see if this approach is pra…

This study looked at whether a 12-week adapted physical activity program could help cancer patients feel less tired and improve their quality of life. 37 adults with different cancer types and treatments took part. Researchers measured fatigue, quality of life, and fear of moveme…

This study tested an 8-week phone- and app-based program designed to increase hope and reduce life disruption in young adults who have finished cancer treatment. 155 survivors participated in a randomized trial comparing the hope program to a control group. The goal was to see if…

This study tested a program called CAFÉ, where financial navigators helped cancer patients with money concerns after diagnosis. The goal was to reduce financial hardship and improve quality of life. 371 patients from two Kaiser Permanente regions took part. The program provided p…

This study tested whether a telemonitoring app called Cureety could reduce the number of phone calls hospital staff receive from cancer patients starting oral or IV treatment. 86 adults with cancer were randomly assigned to standard care or standard care plus the app. The goal wa…

This study tested whether an online program combining nutrition counseling and resistance training could improve physical function in older adults (65+) who finished treatment for breast, colorectal, or prostate cancer. 75 participants received virtual sessions with dietitians an…

This study tested whether a mobile app that lets cancer patients report their symptoms to their doctor can reduce unplanned hospital visits. 166 adults with solid cancers on systemic therapy participated. Half used the app before clinic visits, while the other half had usual care…

This study tested a special mask that uses lights and sounds to help patients relax during a prostate biopsy. The goal was to see if it reduces pain and anxiety compared to standard care. 88 men took part, and researchers measured their pain levels and satisfaction after the proc…

This study tested whether an 8-week sleep coaching program delivered through a smartphone app is practical and acceptable for cancer survivors and their bedroom partners. Forty participants were enrolled to see if they would stick with the program and find it helpful. The goal wa…

This study tested a short-term talking therapy (psychodynamic psychotherapy) for 24 adults with advanced solid tumors and high psychological distress. The goal was to see if the therapy is safe, acceptable, and feasible, not to cure the cancer. Results will help design larger stu…

This study looked at whether a walking platform with fall protection and support is practical for older cancer patients (over 70) during hospital stays. 45 patients were enrolled to see if they would use it at least twice for 6 minutes or more. The goal was to help them stay acti…

This study tested a program called PRISM that teaches stress management, goal-setting, and coping skills to adolescents and young adults (ages 12-24) with advanced cancer. Researchers wanted to see if it could improve quality of life and reduce anxiety and depression. The program…

This study tested a program to help older cancer patients get stronger before and after surgery. 148 patients aged 70+ (or 60+ with other health issues) took part. The program included exercise, nutrition advice, and education to reduce complications and improve recovery.

This study tested if the drug Akynzeo can prevent nausea and vomiting in cancer patients getting moderate chemotherapy who are at high risk based on a special prediction tool. Over 400 adults took part. The goal was to see if Akynzeo works better than standard care over three rou…

This study tested a telehealth program called Dyadic Life Review (DLR) for older adults (65+) with advanced cancer and mild cognitive impairment, along with their caregivers. The program involved 8 weekly video sessions where patients and caregivers shared memories from different…

This study tested whether mangafodipir, an MRI contrast agent with antioxidant properties, could reduce nerve damage caused by oxaliplatin chemotherapy. Researchers enrolled 23 cancer patients who already had moderate nerve problems from oxaliplatin but needed to continue treatme…

This study tested a mobile app called STAMP+CBT for advanced cancer patients with chronic pain. The app helps patients track their pain, mood, and opioid use while providing tailored education and cognitive behavioral therapy (CBT) exercises. Fifty-two patients used the app for 4…

This study tested a remote exercise program for 27 men with prostate cancer who were receiving hormone therapy (androgen deprivation therapy). The program included walking or cycling, strength training, and counseling sessions over 8 weeks. The main goal was to see if the program…

This completed pilot study tested a 12-week home-based exercise program for cancer survivors who also have diabetes or hypertension. The program used a wearable device and smartphone app to track activity and provide feedback, with options like walking, yoga, or strength exercise…

This study looked at whether a 12-week home exercise program using mobile technology could reduce fatigue in cancer survivors. 110 adults who had finished cancer treatment or were on immunotherapy took part. Some also tried acupressure or brief mindfulness exercises. The goal was…

This study tested whether using a virtual reality headset during cancer surgery under local anesthesia can reduce pain and anxiety. 42 adults with cancer were randomly assigned to receive either local anesthesia alone or local anesthesia plus VR. The VR used hypnosis and relaxati…

This study tested a patient education program for 167 cancer patients with moderate to severe pain. The program included identifying patient needs, setting goals, and tailored learning activities. Researchers measured whether the program reduced how much pain interfered with dail…

This study tested whether watching 360° virtual reality movies can reduce fear and anxiety in cancer patients about to start radiation therapy. 292 adults with breast, lung, prostate, head and neck cancer, or brain tumors participated. Patients watched a VR movie and then filled …

This study tested a web-based program to help children aged 8-17 with cancer adjust to returning to school. The program included modules for children, parents, teachers, and peers, focusing on communication, coping, and social skills. Twenty children participated, and researchers…

This study tested whether a digital platform called Cureety could reduce the number of phone calls hospital staff need to make to cancer patients before their injectable treatments. 192 adults starting injectable cancer therapy in France were randomly assigned to usual care or us…

This study tested three types of medicinal cannabis oil (with different levels of THC and CBD) against a placebo in 91 cancer patients. The goal was to see which oil, if any, helps with pain, nausea, anxiety, and sleep problems. Each patient tried multiple oils and a placebo in a…

This completed phase 3 trial tested whether taking psyllium husk fiber capsules during pelvic radiation therapy could reduce gut inflammation and urgency symptoms. 354 adults with pelvic cancers (like rectal, prostate, or gynecological) took either fiber or placebo capsules daily…

This study tested whether a numbing medicine called ropivacaine, given through a chest tube, can reduce severe pain after lung cancer surgery. 90 adults having a thoracotomy (chest opening) for cancer received either ropivacaine or a saltwater placebo every 6 hours for 2 days. Th…

This study looked at whether four well-being treatments — foot reflexology, socio-aesthetics (beauty and skincare), sophrology (a relaxation technique), and singing — can help reduce pain in people with cancer. 180 adult cancer patients took part. The goal was to see if these non…

This study tested two simple changes to hospital wheelchairs: a holder to keep IV poles attached during transport, and a more comfortable seat. Researchers wanted to see if these upgrades could shorten travel time and reduce pain for cancer patients being moved around the hospita…

This study looked at whether showing patients a dynamic video before a prostate biopsy could lower their pain and anxiety compared to just verbal instructions or static images. 223 men aged 50-80 with elevated PSA levels participated. Pain was measured with a Visual Analog Scale …

Researchers are studying whether daily step counts and other smartwatch measurements can predict which cancer patients will be readmitted to the hospital after discharge. Adults who have just left an oncology ward wear a Huawei smartwatch for 30 days to track steps, heart rate, a…

This study looked at the emotional and practical challenges faced by patients with incurable cancer and their caregivers when planning to return home for end-of-life care. Researchers measured how each person perceived the burden, using surveys and statistical analysis to find fa…

This study followed 150 people with solid tumors who were starting immunotherapy (immune checkpoint inhibitors) as part of their regular care. Researchers collected data on side effects and asked patients to fill out questionnaires before each treatment. The goal was to better un…

Researchers are testing two ways to train VA primary care clinicians to hold goals of care conversations with veterans who have serious illnesses such as cancer, heart failure, or dementia. One approach gives clinicians written materials and online training. The other adds team f…

This study looked at whether offering genetic testing to all young adults with cancer (ages 18-39) is better than only testing those who meet certain guidelines. About 749 participants were randomly assigned to either universal testing with a broad gene panel or standard testing …

Researchers at a large hospital in Seoul reviewed records from nearly 33,000 adults who had curative-intent surgery for one of seven cancers in the abdomen or pelvis: pancreatic, gastric, rectal, cervical, endometrial, kidney, or prostate. They grouped patients by whether they re…

This study looks at how Spanish-speaking Latiné men cope after prostate cancer treatment, especially with issues like erectile dysfunction and urinary problems. Researchers will survey and interview 55 survivors to understand their needs and cultural barriers. The goal is to crea…

Researchers want to learn which molecules on cancer cells the immune system attacks when checkpoint inhibitor drugs work well. They collect tumor and blood samples from adults with solid tumors who respond to these drugs, either during treatment or after surgery. The team then se…

This study is testing whether a green dye called ICG can help surgeons see tumors more clearly during surgery in children and teens with solid tumors. The dye is injected before surgery and makes tumor tissue glow under a special camera. The goal is to see if this technique helps…

Researchers in seven European and Latin American countries ask bereaved relatives to complete the CODE questionnaire about two months after a family member died of cancer in hospital. The survey asks whether patients were treated with dignity and respect and whether relatives fel…

This large observational study looks at whether getting an mRNA COVID-19 vaccine shortly before or after starting immune checkpoint inhibitor therapy is linked to longer survival in adults with cancer. Using data from nearly 100,000 patients in France, researchers are comparing t…

This study tests a digital platform called ConnectedNest that helps cancer patients find and connect with social services like housing assistance, food aid, and financial help. About 400 adults with cancer in Minnesota will use the platform for 90 days. Researchers will measure i…

This study looks at how giving fluids during robotic prostatectomy affects patient outcomes. It compares two approaches: one guided by a special monitor (LiDCO) that tracks blood flow in real time, and the other using standard clinical judgment. The researchers will measure the t…

This study looks at whether providing cancer care at home is a good option for Black men with advanced prostate cancer. Researchers want to see if this approach can reduce healthcare disparities and improve quality of life. Participants will fill out questionnaires about their pr…

This study looks at medical records from 584 men in Brazil with castration-resistant metastatic prostate cancer, a form of the disease that no longer responds to hormone therapy. Researchers aim to describe how long these patients survive and to identify their individual characte…

This study examines whether a routine blood test called Mean Platelet Volume (MPV), taken when a cancer patient is admitted to the intensive care unit (ICU), can help predict their risk of dying. Researchers will review the medical records of 425 adult cancer patients who stayed …

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study explores whether men with early prostate cancer on active surveillance would be willing to take dietary fibre supplements, such as inulin or psyllium. Previous research hints these fibres may reduce inflammation and slow tumour growth, but no one has asked patients abo…

This pilot study tests a program to help young female cancer survivors in rural Imperial County, California, get reproductive health care that matches their personal goals. The program includes a quick needs assessment during oncology visits, followed by a session with a social w…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study looked at how cancer treatment changes patients' ability to stick with a Mediterranean diet. Researchers followed 116 patients starting chemotherapy or immunotherapy, checking their diet adherence and sensory changes (taste and smell) at the start and after 9 weeks. Th…

This study tests whether a 3.5-minute educational video shown before a doctor's visit helps cancer patients understand radiation therapy better than standard verbal instructions alone. One hundred patients scheduled for radiation will be randomly assigned to receive either the vi…

This study tested a co-designed nutritional training program for 20 oncology nurses in Vietnam. The program included a three-day workshop with theory and hands-on practice, focusing on managing diet-related side effects of cancer treatment like nausea and diarrhea. Researchers me…

This study looked at skin problems caused by targeted cancer therapies. Researchers followed 141 cancer patients starting these treatments, recording any skin reactions through exams and photos. The goal was to better understand why these side effects happen and how to manage the…

This trial asks whether the type of red blood cell transfusion given during cancer surgery affects the body's immune response. It compares standard transfusions with leuko-reduced ones, which have white blood cells removed. The study involves 150 cancer patients undergoing curati…

This study looks at whether a short risk-assessment tool, called the CARG score, can predict severe side effects from chemotherapy in cancer patients aged 70 and older. Participants will answer questions about their health and daily function before starting a new chemotherapy reg…

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This trial explores whether a blood test measuring reticulocyte hemoglobin content (RET-He) can predict how well cancer patients with anemia will respond to intravenous iron treatment. The study involves adults with solid tumors who have functional iron deficiency. By checking RE…

This study looks at genes in men with advanced prostate cancer that has spread and is no longer responding to hormone therapy. Researchers will analyze tissue, blood, and urine samples from 92 patients receiving a drug called abiraterone. The goal is to find genetic changes that …

This study is testing a new smartphone app designed to help cancer patients remember to take their oral anticancer medications and report any side effects. The app also helps patients communicate with their care team and find support for financial or social needs. Researchers wil…

This study uses an online questionnaire to explore how people with past or active cancer in France use self-medication, including non-prescription drugs, herbal remedies, and supplements. It aims to understand what products they take, why, and where they get them. The findings co…

This study looks at whether the virus that causes COVID-19 can be found in the semen of men with cancer who are storing sperm before treatment. Researchers will test both the fluid and the sperm cells for the virus and compare results with nasal swabs and blood tests. The goal is…

This study looks at whether getting a yearly LDL cholesterol test could help cancer survivors avoid serious heart problems like heart attacks and strokes. Researchers will analyze health records from over a million cancer survivors in Korea, comparing those who had the test with …

This study follows about 500 men with advanced prostate cancer that still responds to hormone therapy. Researchers are comparing two drug combinations (apalutamide or enzalutamide plus standard hormone therapy) to see how well they work in real-world settings. The goal is to unde…

This study looked at 14 men with intermediate-risk prostate cancer who were scheduled for prostate removal surgery. Each man received two different types of PET scans to see which one better highlights cancer cells. The goal was to compare the scans' ability to detect and measure…

This trial investigates how a single injection of degarelix, a drug that lowers testosterone, affects prostate cancer cells when given just days before prostate removal surgery. Researchers aim to measure changes in cell growth (Ki-67 levels) by comparing biopsy and surgical tiss…

This study reviews existing medical records to understand how blood clots (VTE) are treated in people with active cancer or a history of cancer. Researchers will look at which blood thinners are used, how often clots come back, and the costs involved. No new treatments are given—…

This study examines how children under 18 with cancer or a history of a stem cell transplant do when they need a machine called ECMO to help them breathe. Researchers looked at bleeding, infections, and survival rates in children treated at one hospital, and compared survival wit…

This study looks at whether using text messages to screen for depression is practical and well-liked by cancer survivors. About 60 adults with cancer will be asked to respond to a short depression questionnaire via text. The goal is to see if this method works better than the usu…

This observational study follows cancer patients undergoing radiotherapy to understand how psychological distress changes over time and whether it affects clinical outcomes like missed appointments or hospitalizations. Participants complete weekly surveys rating their distress an…

This study collects medical information and biological samples (blood, urine, stool, etc.) from 32 cancer patients starting or restarting immunotherapy. The goal is to build a research database to better understand why some patients develop immune-related side effects and how to …

This study looks at whether a 12-week program of cooking demonstrations, recipe cards, and free fruit and vegetable bundles can help cancer survivors eat healthier. Only 11 people are taking part, and the main goal is to see if such a program is practical and keeps people interes…

This study investigates how often cancer patients with COVID-19 develop dangerous blood clots (venous thromboembolism). Researchers will screen participants using ultrasound and blood tests to detect clots, whether or not they cause symptoms. The goal is to understand the true ra…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study collects and analyzes health records from 10,000 cancer patients across multiple sites. Researchers will use this real-world data to better understand patient populations, improve clinical trial design, and support drug development. No new treatments are tested—the goa…

This study tested whether a smartphone app called QuestOnco can reliably track side effects in 134 adult cancer patients receiving active treatment. Patients used the app to report symptoms, and researchers compared those reports to standard paper questionnaires. The goal was to …

This study tested whether Pluvicto, a radioactive drug for prostate cancer, can be safely given through a permanently implanted port (TIVAP) instead of a standard IV. Researchers measured if any drug got stuck in the port in 107 patients. The goal was to see if using the port is …

This completed study looked at 80 patients with advanced prostate cancer that had stopped responding to chemotherapy. All patients received a radioactive drug called 177Lu-PSMA-617. Researchers compared two types of scans—PET and SPECT—to see which better tracks changes in tumor …

This study looks at how prostate cancer and its treatment affect quality of life three years after diagnosis. Researchers compared 900 men with prostate cancer to cancer-free men of the same age. The goal is to understand what life is like after treatment and whether patients ret…

This study looks at the DNA of 100 children (and young adults up to age 17) who have cancer, along with the DNA of their healthy parents. The goal is to find genetic changes that may have caused the cancer. By comparing the child's DNA to both parents', researchers hope to discov…

This study looked at how two prostate cancer drugs, darolutamide and enzalutamide, affect thinking and memory in men with advanced prostate cancer. About 111 men took one of the two drugs and completed computer-based cognitive tests over time. The goal was to see if one drug caus…

This study tested whether letting patients move freely between the injection of a radioactive tracer and the PET scan affects image quality. Normally, patients must rest for an hour to avoid muscle uptake that can blur results. The trial involved 284 adults with cancer or needing…

This study looks at whether it's possible for people diagnosed with solid tumors to have a follow-up visit with their general practitioner within 15 days of learning their diagnosis. Researchers will track how many patients actually attend this visit and why some might not. The g…

This pilot study tested whether it's possible to adjust proton radiation plans each day while the patient is on the treatment table. Ten adults with solid tumors took part. The goal was to see if this approach is safe and practical enough to study in a larger trial.

This study measured how two common blood thinners (rivaroxaban and apixaban) behave in 193 adults with active cancer who also had blood clots or atrial fibrillation. Researchers aimed to understand factors like age, weight, and kidney function that affect drug levels. The goal wa…

This completed study at Sohag Oncology Center tested whether a quality-of-life survey could help match cancer patients' needs with the right supportive care, like pain management or nutrition counseling. Over 4,400 adult cancer patients completed the EORTC QLQ-C30 questionnaire, …

Researchers tested a new online tool called PIPO that helps doctors estimate how long a cancer patient might live. This information can guide decisions about which patients to enroll in early-phase clinical trials. The study included 586 people who had already joined phase 1 or p…

This study tested a machine learning model that uses electronic health records to predict which cancer patients receiving infusion therapy are at risk of needing emergency care or hospitalization within 30 days. Researchers analyzed data from over 4,700 patients at UCSF. The goal…

This study looked at genetic changes in prostate cancer samples from 84 men who had surgery. The goal was to find DNA markers that could predict if the cancer would come back or spread. By identifying these markers, doctors may one day better tailor follow-up care and treatment f…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This pilot study tested a program called GUIDE, which uses a trained navigator to help cancer patients overcome social and financial barriers to joining clinical trials. The study included 100 adults with cancer who were eligible for a trial and had at least one health-related so…

This study created and tested an educational website to help Black and African American cancer patients learn about personalized cancer treatments and clinical trials. Researchers interviewed 48 patients and caregivers, then tested the website with 33 patients. The goal was to se…

This study looked at 30 men with prostate cancer to understand why MRI and PSMA-PET scans sometimes spot different tumors. Researchers used stored tissue samples to analyze the genes and molecules of these mismatched lesions. The goal was to find out if these differences mean the…

This study aimed to improve how doctors predict whether prostate cancer has spread to nearby lymph nodes. Researchers combined patient information, MRI scans, and genetic data from 367 men who had their prostate removed. The goal was to create a more accurate tool to help decide …

This study looked at 185 men with low-risk prostate cancer who chose active surveillance (monitoring instead of immediate treatment). Researchers used a genetic test called a polygenic risk score to see if it could predict which men would have their cancer get worse over time. Th…

This study tested whether a special MRI scan (31P-MRS) can detect early signs of damage to heart and muscle cells caused by chemotherapy drugs like doxorubicin. Twelve cancer patients scheduled for chemo underwent three scans over time. The goal was to see if the scan could measu…

This study looked at a new device called AE05ML that helps surgeons place clips on blood vessels and other tissues during keyhole surgery. The goal was to see if the device is safe and works well. A total of 161 adults took part in the study.

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This completed study from the University of Aberdeen looked at how dietary fiber supplements might influence prostate cancer. Researchers gave mice different fibers (inulin, pectin, hemp hull) along with stool samples from healthy men over 60. They then measured changes in gut ba…

This study looked at how prostate and colorectal cancer affect mitochondria—the energy factories in cells—and whether a 4-week home exercise program could improve them. Fifteen men awaiting surgery did either resistance or high-intensity interval training at home. Researchers mea…

This study looked at how cancer patients feel about returning to work while undergoing treatment. Researchers interviewed 20 patients to understand their needs and how work affects their sense of normalcy. The goal is to help nurses provide better support for work-related challen…

This study looked at whether analyzing the DNA of a patient's tumor can help doctors pick a targeted therapy for advanced or metastatic cancer. Researchers enrolled 550 adults with various solid tumors that had spread. They took biopsy or blood samples to search for genetic chang…

This study looked at 135 people with advanced lung cancer, lymphoma, or other tumors treated with immunotherapy drugs called checkpoint inhibitors. Researchers collected blood and tumor samples over time to measure immune cells and molecules that might predict whether the treatme…

This study tested whether taking dasatinib alone or with darolutamide for 14 days can increase PSMA levels on PET scans in men with metastatic prostate cancer. Only 4 men participated, all with low PSMA uptake on their initial scan. The goal was to learn more about how PSMA expre…

This study tested a tool built into electronic health records that prompts doctors to discuss heart health with cancer survivors during routine visits. Researchers enrolled 645 survivors of breast, prostate, colorectal, endometrial, and lymphoma cancers across 12 clinics. The goa…

This study tested two different PET-CT scanners to see which one is better at finding very small cancer spots (less than 1 cm) in patients. Twenty-four people with cancer each had two scans, one on each machine. The researchers then added virtual lesions to the images to compare …

This completed study looked at 300 cancer patients treated with immune checkpoint inhibitors to see if measuring troponin levels could help detect serious heart problems early. The goal was to prevent major cardiovascular events like heart attack or stroke without unnecessarily s…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might affect blood vessels and increase heart risks. Researchers measured blood vessel function and checked for related markers in 39 cancer patients before and after starting treatment. The goal was to…

This completed study tested a new tool called Life S-Can that quickly checks diet, exercise, sleep, and mental health in cancer survivors. 105 survivors used the tool and some received extra coaching from health experts. The goal was to see if the tool helps doctors give better s…

This study looked at how often a specific gene change (called HOXB13 c.853delT) occurs in men with prostate cancer in Martinique. Researchers tested 465 men of African descent who had prostate cancer. The goal was to find out how common this gene change is, which may help underst…

This study looked at how closely 200 adults with advanced breast or prostate cancer follow their prescribed oral cancer treatments. Participants filled out questionnaires about their medication use and gave blood samples to check certain health markers. The goal was to understand…

This study tested whether having a clinical pharmacist review medications for cancer patients before they start treatment could prevent drug-related problems. Researchers observed 440 adults with solid tumors who were about to receive chemotherapy, immunotherapy, or oral targeted…

This completed study surveyed 51 men with localized prostate cancer and their healthcare providers in Belgium, Italy, and Spain. The goal was to understand how acceptable artificial intelligence (AI) is as a tool to help diagnose prostate cancer, and whether people are willing to…

This study gathered information from nearly 3,000 cancer patients aged 65 and older to learn more about their health, living situations, and the care they receive. No new treatments were tested. The goal was to create a database that helps doctors and researchers better understan…

This study looked at how often a muscle enzyme called CPK increases in people with solid tumors who are taking a type of targeted therapy called tyrosine kinase inhibitors (TKIs). Researchers measured CPK levels in routine blood tests from 154 patients and checked if high levels …

This study looked at how common frailty is in people aged 70 and older with solid tumors who visited a cancer center. Researchers used a short questionnaire called VES-13 to screen patients before their doctor visit. They also compared the test results with the doctor's own judgm…

This study compared anxiety, depression, and quality of life between 125 cancer patients who joined clinical trials and those who received standard treatment. Researchers used questionnaires to measure stress and emotional well-being. The goal was to understand how trial particip…

This study looked at how patients with advanced cancer respond to being offered a conversation about their future care preferences. Researchers invited 71 patients to discuss their wishes and tracked who took part. The goal was to learn more about what helps patients feel ready t…

This study looked at men whose prostate cancer came back after surgery, shown by a small rise in PSA. It compared giving radiation right away versus waiting and doing another special scan when PSA rose higher. Only 4 men took part, so the main goal was to see if such a study is e…

This study tested a digital chatbot (called CATALYST) to help cancer survivors learn about genetic testing for inherited cancer risk. Fifty adults who had certain cancers (like breast, ovarian, or prostate) used the chatbot or received usual care. The goal was to see if the chatb…

This study tested a program called FinFit to help adolescent and young adult cancer survivors deal with money problems caused by their illness. Researchers interviewed 16 people from community cancer clinics to design and improve the program. The goal was to figure out the best w…

This study watched 225 people with solid tumors who got a drug called G-CSF during chemotherapy. G-CSF can cause bone pain. Researchers measured pain levels and tracked what treatments (like pain relievers or other methods) helped. They also checked quality of life, fatigue, mood…

This study looked at how financial problems affect the well-being of hospitalized cancer patients and their caregivers in Turkey. Over 750 patients filled out surveys about their finances, mood, and quality of life. The goal was to understand the link between money stress and car…

This study looked at 3820 adults with cancer who also had COVID-19. Researchers collected routine medical data to describe symptoms and identify factors affecting survival. The goal was to learn more about how COVID-19 affects cancer patients, not to test a new treatment.

This study followed 25 men who carry BRCA1 or BRCA2 gene mutations (and a control group of non-carriers) to see if they developed prostate cancer. Researchers called participants to update their medical history and check for new diagnoses. The goal is to learn how to better scree…

This study tested a new education program for men with metastatic prostate cancer who are taking next-generation hormone therapy. The program aimed to help patients better understand their disease, stick to their medication, and improve their quality of life. 18 patients took par…

This study looked at whether using a Spiritual Needs Questionnaire helps identify and address the spiritual needs of patients in palliative care. About 100 patients with cancer, heart failure, COPD, or ALS took part. The goal was to see if this approach is practical and beneficia…

This study analyzed blood samples from 33 men with advanced prostate cancer that no longer responds to hormone therapy. Researchers looked for tiny molecules called microRNAs that might predict whether a patient will resist chemotherapy or newer hormone drugs. The goal is to help…

This study tested whether showing cancer survivors real-time glucose data from a wearable sensor can encourage them to be more physically active. 60 cancer survivors at high risk for type 2 diabetes wore a Fitbit and some also wore a continuous glucose monitor for 4 weeks, receiv…

This study measured how often muscle loss (sarcopenia) happens in men aged 70 and older with prostate cancer who are treated with radiation and hormone therapy. Researchers screened 112 patients using a simple questionnaire and body scans. The goal was to understand risk factors …

This study looked at 103 diabetic adults starting chemotherapy for cancer. Researchers used a continuous glucose monitor (Freestyle Libre) to track blood sugar changes. The goal was to see how often blood sugar went too low or too high during treatment, since chemotherapy and rel…

This study looked at 33 adults who had both immune thrombocytopenia (ITP) — a condition where the immune system destroys platelets — and cancer. Researchers wanted to see if treating the cancer could also improve ITP. They also investigated whether cancer cells might mimic platel…

This study tested a web-based program called GIFT that helps cancer patients share information about inherited cancer risks with their relatives. Over 3,000 patients and their family members took part. The goal was to see if the tool encourages more relatives to get genetic testi…

This study followed 831 men aged 60 and older with prostate cancer who were starting GnRH agonist therapy (a type of hormone therapy). Researchers measured how their quality of life changed over 6 months, comparing different age groups. The goal was to understand how age affects …

This study looked at whether measuring elastin fragments in blood or urine can help assess frailty in people aged 65 and older with cancer. Frailty is hard to measure with current methods, which can be slow and subjective. The researchers hope that a biological marker could provi…

This study tested a program called KanSurvive, which uses virtual education sessions and practice support to help rural primary care clinics improve follow-up care for cancer survivors. Researchers worked with 15 rural practices to see if they could better follow guidelines for m…

This pilot study tested whether a brief educational session with a trained educator could increase the number of men with prostate cancer who agree to germline (inherited) genetic testing. The study enrolled 50 men who met national guidelines for testing but had not yet been test…

This study tested whether combining PET-CT and MRI scans (called trimodality imaging) can better define the target area for radiotherapy in high-risk prostate cancer. Twenty patients received both standard scans and the new combined scan before treatment. Researchers compared the…

This study looked at whether sending reminders to cancer patients and alerts to their nurses helps them complete regular symptom questionnaires. Over 476 patients starting a new cancer therapy were split into three groups: usual care, reminders plus nurse alerts during clinic vis…

This study looked at whether a special 3D camera can accurately measure radiation from a prostate cancer drug called lutetium. Researchers used data from 20 patients who had already received the treatment. The goal was to see if images taken at different energy levels give the sa…

This study tested a special barbed suture (Symmcora Longterm) used to reconnect the bladder after robotic prostate removal for prostate cancer. Researchers measured how long the stitching took and checked for leaks or other problems up to 6 months after surgery. The goal was to s…

This study looked at how well the Pfizer COVID-19 vaccine triggers an immune response in 196 adults with weakened immune systems (due to conditions like kidney transplant, cancer, or HIV) compared to healthy adults. Researchers measured antibody levels and their ability to neutra…

This study compared two common methods for taking a prostate biopsy: one through the rectal wall and one through the skin between the scrotum and anus. 840 men who needed a biopsy for suspected prostate cancer were randomly assigned to one of the two methods. The goal was to see …

This completed study collected MRI and 3D ultrasound images from 2 men with prostate cancer who had their prostate removed. The goal was to create a database that could later be used to train a computer system to detect cancer without needing a biopsy. This is a very early step i…

This study tracked 300 cancer patients receiving their first round of chemotherapy to see how often nausea and vomiting still happen, even with standard anti-nausea medicines. Participants filled out questionnaires about their symptoms in the first 24 hours and up to 4 days after…

This study asked 167 people with cancer (and their caregivers) what they value most during pharmacy consultations for oral cancer drugs. Using a survey method, researchers identified key preferences to help hospitals design better support services. The goal was to improve patient…

This study looked at the total cost of two types of prostate cancer surgery over 5 years: robot-assisted surgery using the da Vinci system and traditional open surgery. Researchers tracked medical expenses and patient outcomes in 90 men with localized prostate cancer. The goal wa…

This study tested a program for adults aged 65-90 who had breast, colorectal, or prostate cancer. A community health worker assessed their health and provided coaching to address issues often missed after cancer treatment. The goal was to see if the program was feasible and could…

This study looked at how DNA from tumors changes in the blood before, during, and after surgery for breast, prostate, or colon cancer. Thirty adults having curative surgery provided blood samples to measure these DNA levels. The goal was to understand the natural pattern of DNA c…

This study tested whether an automated system can grow cancer cells from patient samples (blood, fluid, or tumor tissue) inside chicken eggs. Researchers aimed to see if at least half of the samples would successfully grow. The goal is to create a better, cheaper way to study can…

This study looked at health-risk behaviors like smoking, alcohol use, diet, and exercise among 46 cancer survivors in France. The goal was to see how common these behaviors are so doctors can better help survivors avoid future health problems. The study found that many survivors …

This study tested whether showing patients videos about advance care planning and training doctors in communication skills helps cancer patients document their care wishes. Over 13,000 patients from multiple clinics took part, with most only having their medical records reviewed.…

This study followed over 1,400 men with metastatic castration-resistant prostate cancer who were already receiving Radium-223 as part of their routine care. Researchers tracked serious side effects and the development of new cancers over several years. The goal was to better unde…

This study tested a questionnaire called PO-BADO that helps doctors and nurses talk with cancer patients and their caregivers. Researchers checked if the questionnaire gives consistent and reliable results. 252 adults with cancer who have a caregiver support time took part. The g…

This study brought together experts to decide what health outcomes matter most when testing cancer treatments in older adults. Instead of focusing only on tumor shrinkage, they identified key areas like independence, memory, mood, and nutrition. The goal is to help future clinica…

This study followed 76 cancer patients over age 70 to see how geriatric tests and social factors affect their quality of life. Researchers wanted to learn how to better tailor chemotherapy and care for older adults. The goal was to improve both well-being and cost-effectiveness o…

This study looked at 700 cancer patients to understand how often dangerous blood clots occur and how blood-thinning medications affect them. Researchers tracked patients over two years, analyzing blood samples and clotting events. The goal is to improve prevention and treatment o…

This study followed 30 men aged 45-70 who had their prostate removed due to cancer. Researchers measured urine leakage by weighing pads over 24 hours and during a 1-hour activity test. The goal was to better understand how long and how severe incontinence lasts after surgery.

This study looked at whether having cancer patients report their own symptoms during radiation treatment helps doctors notice and manage side effects better. About 104 adults with lung, esophageal, or other gastrointestinal cancers took part. Doctors reviewed patient-reported sym…

This completed study looked at whether special PET scans can predict how aggressive a person's prostate cancer is. Researchers compared scan features with tumor samples from 70 patients who had surgery. The goal was to see if imaging could replace or reduce the need for invasive …

This completed study looked at 12,500 cancer patients who had a type of heart attack called NSTEMI. Researchers compared those who got invasive procedures like angiography versus those treated only with medications. The goal was to see which approach led to fewer deaths in the ho…

This completed study looked at 261 French cancer patients to understand why many do not exercise, despite evidence that physical activity improves survival and well-being. Researchers surveyed patients about their personality, motivation, anxiety, and social background. The goal …

This study followed 153 people with cancer who had or were suspected of having COVID-19. Researchers collected throat swabs and saliva samples over several weeks to see how well antibody and antigen tests work in this group. The goal was to learn more about the course of COVID-19…

This small study looked at whether special MRI scans can help doctors adjust radiation treatment for high-risk prostate cancer. Only 5 men took part, all with aggressive cancer. The goal was to see if the MRI method was reliable enough to guide changes in radiation doses. Because…