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Can psychotherapy ease existential distress in advanced cancer?

NCT ID NCT05520281

Symptom relief Sponsor: Universitätsklinikum Hamburg-Eppendorf Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a short-term talking therapy (psychodynamic psychotherapy) for 24 adults with advanced solid tumors and high psychological distress. The goal was to see if the therapy is safe, acceptable, and feasible, not to cure the cancer. Results will help design larger studies on emotional support for people facing serious illness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

Sep 2022

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years and older * UICC stage IV solid tumor * Informed consent * Current physical condition that allows for at least 12 therapy sessions * Indication: Presence of a mental disorder with existential stress and limitations in coping capacity Exclusion Criteria: * Acute suicidality * Psychotic disorder (ICD-10: F2 diagnosis) * Substance dependence or abuse (ICD-10: F1 diagnosis) * Structural deficits that interfere with attending to regular appointments * Other psychotherapeutic treatment * Severe cognitive impairment * Severe physical impairment * Insufficient German to give informed consent and complete self-report questionnaires

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Conditions

The condition(s) this trial relates to.

cancer carcinoma Necrophobia neoplasm psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carcinoma Malignant neoplasm Palliative care

Contacts and locations

Locations

  • Clinical Institute for Psychosomatic Medicine and Psychotherapy, University Medical Center Düsseldorf

    Düsseldorf, 40225, Germany

  • Institute of Social Work, University of Kassel

    Kassel, 34127, Germany

  • Psychosomatics, Psychotherapy and Psychooncology, Medicine II, University of Würzburg

    Würzburg, 97080, Germany

  • University Medical Center Hamburg Eppendorf, Department of Medical Psychology

    Hamburg, 20246, Germany

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