PALLIATIVE CARE

This study looks at whether adding a special care program (GRACE) to regular annual check-ups can improve health and reduce hospital stays for older adults with multiple health issues. About 6,000 people aged 65 and older with complex needs will take part. The goal is to see if t…

This study tests whether a nasal spray containing midazolam can quickly reduce sudden anxiety in adults receiving palliative care. About 36 participants will receive either the drug or a placebo, and their anxiety levels will be measured before and after treatment. The goal is to…

This study is testing a new supportive care program called POISE for people with stage IV non-small cell lung cancer who are on targeted therapy. The program includes four visits with a specially trained palliative care clinician to help patients cope with uncertainty and manage …

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty terminally ill patients will receive either two doses of LSD or a very low-dose active placebo. The goal is to improve psycholog…

This early-stage study tests an experimental drug called resiniferatoxin (RTX), made from a cactus-like plant, to treat severe pain in people with advanced cancer. RTX works by destroying pain-signaling nerves. Up to 45 adults with hard-to-control cancer pain will receive a singl…

This study explores whether virtual reality (VR) can help people receiving palliative care—and their companions—achieve personal goals like relaxation or experiencing a bucket-list activity. Up to 12 patients will take part in up to 3 VR sessions at a hospice in England. Research…

This small pilot study will test whether medicinal cannabis can help ease symptoms like pain and muscle spasms in children receiving palliative care for non-cancer conditions. Ten children aged 6 months to 21 years will receive one of two cannabis products, and researchers will t…

This study tests a mobile app called ICUconnect that helps older ICU patients and their families report their needs to doctors. The goal is to improve care and reduce emotional distress. About 350 patient-family pairs will use the app or get usual care to see if it helps.

This study tests whether giving testosterone every 15 days can improve quality of life in 20 men with low testosterone who are in palliative care and have no further treatment options. Participants receive injections of Sustanon 250 and complete questionnaires about symptoms and …

This study aims to reduce suffering for adults in the intensive care unit (ICU) by having palliative care specialists consult on their care. Researchers will track how long patients stay in the ICU and whether the consultations help them leave sooner. The study involves about 2,0…

This study tests whether a structured care plan, based on patient-reported symptoms, can improve quality of life for adults with advanced cancer. Participants will either receive standard palliative care or a tailored plan that triggers specific support based on their needs. The …

This study tests a training program called ABCs that teaches healthcare providers how to have better conversations with patients facing serious illness. About 350 doctors, nurses, and other providers will take online modules and virtual workshops. The goal is to see if the traini…

This study talks to 120 adults with inflammatory arthritis (like rheumatoid arthritis) and their healthcare providers to understand how palliative and supportive care could improve quality of life. Researchers will interview patients, survey doctors, and hold group discussions. T…

This study looks at how cancer patients in palliative care feel about stopping medications that are not for their cancer. About 120 participants will fill out questionnaires, watch an educational video, and read a brochure. Then they will answer questions again to see if their vi…

This study looks at what helps or hinders creating care plans for vulnerable patients in palliative care who live in medicalized residential facilities (LAM) in Alsace, France. Researchers will interview staff and others to understand the organizational, human, and relational fac…

This study surveys 151 palliative care patients and healthcare professionals to understand oral health problems like dry mouth and infections, which can lower quality of life. The goal is to find gaps in knowledge and access to dental care, so better support can be offered. No tr…

This study looks at how people with advanced cancer feel about stopping medications that may no longer be helpful. Many patients take multiple drugs, which can cause side effects and lower quality of life. Researchers will interview about 325 patients and use questionnaires to un…