Cactus extract could zap cancer pain in new trial
NCT ID NCT00804154
First seen Jun 24, 2026 · Last updated Jun 24, 2026
Summary
This early-stage study tests a drug called resiniferatoxin (RTX), a chemical from a cactus-like plant similar to hot pepper, for people with severe cancer pain that standard treatments can't control. RTX is injected into the spine to destroy pain-transmitting nerves. The trial involves 45 adults with advanced cancer and will check safety and pain relief over several months.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
resiniferatoxin (RTX), a chemical from a cactus-like plant similar to capsaicin
What this could lead to
If it works, this could provide a new way to relieve severe cancer pain that doesn't respond to standard treatments.
What could go wrong
This is an early Phase 1 study with only 45 people, so safety and effectiveness are not yet proven. The drug destroys pain nerves, which may cause lasting numbness or other side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.