National Institute Of Dental And Craniofacial Research (nidcr)

This study is testing if a drug called tofacitinib, already used for rheumatoid arthritis, is safe and can help control the symptoms of Sjogren's Syndrome. About 60 adults with mild to moderate Sjogren's will take the pill twice a day for 28 weeks to see if it reduces their disea…

This early-stage study is testing the safety of an experimental drug called resiniferatoxin (RTX) for people with severe pain from advanced cancer that other treatments cannot control. RTX is derived from a cactus-like plant and works by targeting and destroying the nerves that s…

This study aims to understand the causes and genetic patterns of facial and jaw development differences, which can be present from birth or appear during puberty. Researchers will follow 2,400 participants, including people with these conditions, their family members, and healthy…

This study collects wisdom teeth and surrounding tissue that would normally be thrown away after removal surgery. The goal is to use these samples for future dental and oral health research. Participants are people aged 16-50 who already need their wisdom teeth removed. The study…

This study aims to understand how genetic immune system problems affect oral health, particularly gum disease. Researchers will compare people with immune disorders, those with severe gum disease, and healthy volunteers by collecting samples like saliva, plaque, and blood. The go…

This National Institutes of Health study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect health information, saliva, blood, and tissue samples from people with these conditions (like Sjogren's syndrome), their fami…

This study aims to understand the long-term progression of McCune-Albright Syndrome, a rare disorder that causes abnormal bone growth, skin spots, and hormonal issues. Researchers will follow up to 500 patients over time, collecting health data and tissue samples to learn how the…

This study aims to learn more about various bone and mineral disorders by observing patients and collecting samples. Participants receive standard medical care and evaluations, but no experimental treatments. The goal is to gather information and specimens to help researchers bet…

This study aims to better understand mouth problems that can develop after a stem cell transplant from a donor, a condition called chronic graft-versus-host disease (cGVHD). Researchers will follow 500 adults—including both recent transplant patients and healthy volunteers—for up…

This study aims to learn more about what causes Sjogren's disease and how it progresses over time. Researchers will follow about 300 people with Sjogren's or similar symptoms for up to 10 years, collecting health information and samples like blood and saliva. The goal is to gathe…