National Institute Of Dental And Craniofacial Research (nidcr)

This study tests whether tofacitinib, a drug already approved for rheumatoid arthritis, is safe for people with Sjogren's disease, an autoimmune condition causing dry eyes, dry mouth, and other symptoms. Sixty adults aged 18 to 75 with mild-to-moderate Sjogren's will take the ora…

This study tests a new drug, PTH-IA, for Jansen's metaphyseal chondrodysplasia (JMC), a very rare genetic bone disease affecting about 30 people worldwide. JMC causes severe short stature, frequent fractures, bone pain, and kidney problems. The drug aims to block overactive signa…

This early-stage study tests an experimental drug called resiniferatoxin (RTX), made from a cactus-like plant, to treat severe pain in people with advanced cancer. RTX works by destroying pain-signaling nerves. Up to 45 adults with hard-to-control cancer pain will receive a singl…

This study follows people who have had or will soon have a stem cell transplant from a donor. It aims to understand how chronic graft-versus-host disease (cGVHD) affects the mouth. Researchers will collect dental exams, saliva, mouth swabs, and photos over three years. Healthy vo…

This study looks at how problems with the immune system can lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with genetic immune defects and healthy volunteers. The goal is to understand t…

This study aims to learn more about polyostotic fibrous dysplasia and McCune-Albright Syndrome by following up to 500 participants over time. Researchers will collect medical data and tissue samples to understand how the disease progresses and affects the body. No new treatments …

This study follows 300 people with Sjogren's disease (or symptoms) over time to learn how the condition starts and changes. Participants visit the NIH for exams, saliva and tear tests, and questionnaires. No new treatments are tested, but the findings may help develop better ther…

This study aims to learn more about why some people have differences in the shape of their face, head, or neck. Researchers will compare people with these conditions, their family members, and healthy volunteers. Participants will have exams, scans, and genetic tests over many ye…

This study aims to learn more about diseases that affect the salivary glands, which can impact quality of life. Researchers will collect medical information, saliva, blood, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is …

This study aims to collect bone samples and medical information from up to 1,000 people with bone or mineral disorders, such as osteomalacia or tumoral calcinosis. Participants receive standard medical evaluations and tests, but no experimental treatments. The goal is to better u…

This study collects wisdom teeth and surrounding tissue that are normally thrown away after removal surgery. Researchers will use these samples to learn more about oral health and to help train dentists. Up to 10,000 people aged 16 to 50 who need their wisdom teeth removed can jo…