National Institute Of Dental And Craniofacial Research (nidcr)

This study is testing if a drug called tofacitinib, already used for rheumatoid arthritis, is safe and can help control the symptoms of Sjogren's Syndrome. About 60 adults with mild to moderate Sjogren's will take the pill twice a day for 28 weeks to see if it reduces their disea…

This early-stage study is testing the safety of a new drug called resiniferatoxin (RTX) for people with severe pain from advanced cancer that other treatments cannot control. RTX is related to the compound in hot peppers and works by targeting and destroying the nerves that send …

This study aims to understand how genetic immune system problems affect oral health, particularly gum disease. Researchers will compare people with immune disorders, those with severe gum disease, and healthy volunteers by collecting samples like saliva, plaque, and blood. The go…

This study collects wisdom teeth and surrounding tissue that would normally be thrown away after removal surgery. Researchers will use these samples to learn more about oral health and diseases. The study also helps train dentists at the National Institutes of Health. Participant…

This National Institutes of Health study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect health information, saliva, blood, and tissue samples from people with these conditions (like Sjogren's syndrome), their fami…

This study aims to learn more about how and why certain face and jaw growth differences develop. Researchers will follow people with these conditions, their family members, and healthy volunteers over several years to collect health information, images, and genetic samples. The g…

This study aims to understand the long-term progression of McCune-Albright Syndrome, a rare disorder that causes abnormal bone growth, skin spots, and hormonal issues. Researchers will follow up to 500 patients over time, collecting health data and tissue samples to learn how the…

This study aims to learn more about various bone and mineral disorders by observing patients and collecting samples. Participants receive standard medical care and evaluations, but no experimental treatments. The goal is to gather information and specimens to help researchers bet…

This study aims to better understand mouth problems that can develop after a stem cell transplant from a donor, a condition called chronic graft-versus-host disease (cGVHD). Researchers will follow 500 adults—including both recent transplant patients and healthy volunteers—for up…

This study aims to learn more about what causes Sjogren's disease and how it progresses over time. Researchers will follow about 300 people with Sjogren's or similar symptoms for up to 10 years, collecting health information and samples like blood and saliva. The goal is to gathe…