National Institute Of Dental And Craniofacial Research (nidcr)

This study tests a new drug, PTH-IA, for Jansen's Metaphyseal Chondrodysplasia (JMC), a very rare genetic bone disorder affecting about 30 people worldwide. JMC causes severe growth problems, frequent fractures, bone pain, and kidney issues, with no approved treatments. The trial…

This study tests whether tofacitinib, a pill already approved for rheumatoid arthritis, is safe for people with Sjogren's disease. About 60 adults with mild-to-moderate Sjogren's will take the drug twice daily for 28 weeks. Researchers will monitor side effects and check for impr…

This study tests an experimental drug called resiniferatoxin (RTX), made from a cactus-like plant, to treat severe pain in people with advanced cancer. RTX works by destroying pain-signaling nerves. The trial involves 45 adults whose pain is not controlled by standard treatments.…

This study collects wisdom teeth and surrounding tissue that are normally thrown away after removal surgery. Researchers will use these samples to learn more about oral health and to help train dentists. Up to 10,000 people aged 16 to 50 who need their wisdom teeth removed can jo…

This study follows 300 people with Sjogren's disease (or symptoms) over several visits to learn how the condition starts and changes. Researchers collect saliva, blood, and eye tests, and ask about symptoms. The goal is to find clues for better treatments, not to test a new thera…

This study aims to collect bone samples and medical information from up to 1,000 people with bone or mineral disorders, such as osteomalacia or tumoral calcinosis. Participants receive standard medical evaluations and tests, but no experimental treatments. The goal is to better u…

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical information, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better un…

This study follows people who have had or will soon have a stem cell transplant from a donor. It aims to understand how chronic graft-versus-host disease (cGVHD) affects the mouth. Researchers will collect saliva, mouth swabs, and photos over three years. Healthy volunteers are a…

This study looks at how problems with the immune system can lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from people with genetic immune defects, healthy people with gum disease, and healthy people without gum disease…

This study aims to learn more about abnormal development of the face, head, and neck by comparing people with these conditions to their relatives and healthy volunteers. Researchers will collect medical history, perform exams, take 3D images, and analyze DNA from blood or cheek s…

This study tracks up to 500 people with polyostotic fibrous dysplasia or McCune-Albright syndrome to learn how the disease changes over time. Researchers will collect medical data and tissue samples to better understand bone lesions and related hormone problems. The goal is to im…