MALIGNANT NEOPLASM

This study tests a new drug, patritumab deruxtecan, in children whose liver or muscle cancer has returned or not responded to prior treatment. The drug works like a smart bomb, attaching to a protein on cancer cells to destroy them. The trial aims to check safety, how the drug mo…

This study tests an experimental pill, MK-1084, for people with advanced non-small cell lung cancer that has a specific gene change called KRAS G12C. The goal is to see if the drug can shrink tumors and how safe it is. About 130 participants will receive the drug, and researchers…

This study tests an experimental oral drug called NBM-BMX in people with advanced solid tumors or newly diagnosed glioblastoma (a type of brain cancer). In one group, the drug is given alone to patients whose cancer has stopped responding to standard treatments. In another group,…

This study tests a new medicine called MK-5684 in people with breast, ovarian, or endometrial cancer. The drug works by blocking the body from making certain hormones that can help cancers grow. Researchers want to see if MK-5684 helps people live longer without their cancer gett…

This study tests a drug called alectinib, already approved for some lung cancers, in people with other rare cancers that have a specific gene change (ALK). About 30 adults, teens, and children will receive the drug to see if it shrinks tumors or stops cancer growth for at least 2…

This study tests a new drug called MK-3120 in people with advanced solid tumors that have spread and cannot be removed by surgery. The main goal is to see if the drug is safe and tolerable. About 270 adults who have tried all available treatments will take part. The study is curr…

This study tests a new drug called TSN1611 in people with advanced solid tumors that have a specific genetic change called KRAS G12D. The study has two parts: first, finding the safest dose, and then testing how well it shrinks tumors. About 440 adults will take part. The goal is…

This study tests atezolizumab, a drug already approved for some cancers, in people with rare cancers that have high tumor mutational burden (TMB), high microsatellite instability (MSI), or a specific DNA repair defect (CMMRD). About 30 adults, teens, and children will receive the…

This study offers a bone marrow transplant using stem cells that are specially selected to remove certain immune cells. The goal is to lower the risk of the donor cells attacking the patient's body, a serious side effect called graft-versus-host disease. It is for people with can…

This study tests a drug called entrectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change (ROS1 fusion). About 30 adults and children with these rare tumors will receive the drug. Researchers will measure if tumors shrink …

This study tests whether giving focused radiation before surgery is better than after surgery for people whose cancer has spread to the brain. About 180 adults with brain metastases will be randomly assigned to one of the two timing groups. The goal is to see which approach reduc…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively treat BK and JC virus infections in 100 people with cancer, HIV/AIDS, or organ transplants. These viruses can cause serious problems like kidney damage or brain…

This early-phase study tests a new drug called MK-4716, alone or combined with other treatments, in people with advanced or metastatic solid tumors that have a KRAS mutation. The main goals are to check the drug's safety and how well people tolerate it. About 250 participants wil…

This study tests the drug pembrolizumab in Japanese children with solid tumors or lymphomas, and in Japanese adults with advanced Merkel cell skin cancer. The main goals are to check the drug's safety, how the body processes it, and whether tumors shrink. About 20 participants wi…

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if their tumors shrink or stop growing for at least 24 weeks. The goal is to fi…

This study is testing a new type of PET scan that uses a special probe (68Ga-TOI-1) to find lung tumors more accurately. The probe targets a protein called CDH3, which is only found on cancer cells. Researchers will compare this new scan with the standard FDG-PET scan in 80 adult…

This study tests whether a special dye called indocyanine green (ICG) can help surgeons see the edges of bone or soft tissue tumors during surgery. About 100 adults having tumor removal surgery will receive the dye, and doctors will use a camera to spot any leftover cancer cells.…

This study tests a weight loss program using a smartphone app and a coach for teens and young adults who are overweight after a stem cell transplant. The goal is to help them lose weight and build healthy eating habits. About 20 people will join, and researchers will track change…

This study collects blood and tumor samples from 1,100 people with rare or hard-to-treat cancers to look for genetic changes. The goal is to understand which gene mutations are most common and which ones might be targeted by existing drugs. This research does not provide a direct…

This study is developing and testing a new questionnaire system to measure how cancer and its treatments affect patients' symptoms and quality of life. Researchers will enroll about 6,500 adults, including cancer patients, healthy volunteers, and healthcare providers. The goal is…

This study aims to create an early warning system that predicts organ damage in cancer patients receiving immunotherapy. Researchers will analyze genetic, protein, and other biological data from 2,000 participants to identify warning signs of side effects. The goal is to help doc…

This study collects blood, tissue, and bone marrow samples from people with cancer or blood disorders, as well as healthy volunteers. The goal is to learn how the immune system works and how it changes with different treatments like immunotherapy. No direct treatment is given; th…

This study collects blood, tissue, and medical information from 10,000 adults with cancer or at risk for cancer. The goal is to create a large research database to help scientists understand why some cancers respond to treatment and others don't. Participants donate samples and a…

This study collects health information and leftover tumor or blood samples from children and young adults with cancer. The goal is to learn more about these diseases and find better ways to treat and care for patients over time. Up to 75,000 people will take part, and no experime…

This study collects blood and saliva samples from 2000 cancer patients to learn how inherited genetic changes influence cancer risk, tumor behavior, and response to treatment. By comparing these samples with large genetic databases, researchers hope to better understand why some …

This study is testing whether wearing a fitness tracker (like a Fitbit) can give doctors a better picture of how active advanced cancer patients are. Researchers want to see if activity levels measured by the device match up with the doctor's usual assessment of a patient's physi…

This study aims to find better ways to recruit American Indians from Southwestern tribes for cancer genome sequencing. Researchers want to understand how genetic changes cause cancer in this community, which has higher rates of certain cancers. About 1,000 adults with cancer or s…