MALIGNANT NEOPLASM

This study tests a new approach for people with advanced cancers that have not responded to standard treatments. Doctors take a patient's own white blood cells, genetically reprogram them to recognize a protein called NY-ESO-1 found on cancer cells, and give them back along with …

This early-phase study tests a new treatment called HER2-CAR T cells for people with HER2-positive cancers that have spread to the brain or its lining. The treatment involves taking the patient's own immune cells, modifying them to recognize and attack HER2-positive cancer cells,…

This study looks at whether using virtual reality (VR) can lower pain and anxiety in cancer patients who need a bone marrow biopsy or lumbar puncture. About 60 participants will use VR during the procedure and report their pain and anxiety levels. The goal is to find a non-drug w…

This study tests whether dexamethasone, a steroid, can reduce shortness of breath in people with cancer. About 135 patients with moderate to severe dyspnea and lung involvement are being treated and monitored for two weeks. The goal is to see if the drug improves breathing and qu…

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by oxaliplatin chemotherapy in people with stage I-IV cancer. rTMS uses magnetic pulses on the scalp to change brain activity. The trial compares rTMS to a placebo and a wait…

This study tests a pre-surgical toolkit (OPTI-Surg) designed to help older cancer patients recover faster and better after major surgery. The toolkit provides recommendations before surgery to improve physical function and reduce complications. About 325 participants with planned…

This study looks at whether cancer patients can use meditation on their own to reduce anxiety and depression. About 35 patients will try techniques like deep breathing or movement for two weeks. The goal is to see if this approach is practical and helps improve emotional well-bei…

This study looks at tumor samples from 170 cancer patients who got much better with treatments that didn't work for most others. Researchers want to find genetic changes in the tumors that might explain why these patients did so well. The goal is to learn from these rare cases to…

This study compares different outreach methods to see which works best for getting African Americans to join early phase cancer treatment trials. About 134 patients and their doctors will take part. The goal is to find ways to make cancer research more inclusive.

This study is creating a web-based program to help people with hereditary cancer-causing mutations share their genetic test results with family members. The goal is to increase awareness among at-risk relatives so they can take steps to prevent cancer. The program is designed for…