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Scientists hunt for clues to why immunotherapy fails in most patients

NCT ID NCT03595813

Knowledge-focused Sponsor: Institut Paoli-Calmettes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 135 people with advanced lung cancer, lymphoma, or other tumors treated with immunotherapy drugs called checkpoint inhibitors. Researchers collected blood and tumor samples over time to measure immune cells and molecules that might predict whether the treatment works. The goal was to better understand why some patients respond and others do not, but this was an observational study, not a treatment trial.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

135 people

The number who actually took part.

Started

Jan 2018

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years * Diagnosis of locally advanced or metastatic solid tumor or lymphoma treated with Immune check blockade * Signed informed consent * Affiliated to(or beneficiary of) the French Social Security Exclusion Criteria: * Pregnant or breastfeeding woman or woman who does not apply effective contraception * Emergency * Vulnerable person or unable to provide informed consent * Emergency * Person unable to comply with required study follow up * Contraindication to the study procedure

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Conditions

The condition(s) this trial relates to.

benign urinary system neoplasm cancer lung cancer non-Hodgkin lymphoma urinary system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Locally advanced malignant neoplasm Lung cancer metastatic Non-Hodgkin lymphoma Urologic neoplasms

Contacts and locations

Locations

  • Institut Paoli-Calmettes

    Marseille, Bouches-du-Rhône, France

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Other studies related to the condition(s) this trial covers.