Could filtered blood transfusions shield cancer Patients' immune systems?
NCT ID NCT00180869
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This trial asks whether the type of red blood cell transfusion given during cancer surgery affects the body's immune response. It compares standard transfusions with leuko-reduced ones, which have white blood cells removed. The study involves 150 cancer patients undergoing curative surgery with a high chance of needing a transfusion. Researchers will measure immune markers and track infections and survival to see if one approach is gentler on the immune system.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Two types of red blood cell transfusions: unmodified (standard) and leuko-reduced (filtered to remove white blood cells)
- What this could lead to
- If one transfusion type proves less disruptive to the immune system, it could lead to better recovery and fewer infections after cancer surgery.
- What could go wrong
- This is a mid-stage trial with 150 participants, so results may not apply to all patients. The immune effects measured are early indicators, not proof of long-term benefit.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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150 people
- Start date
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Sep 1997
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Surgery for cancer with a transfusion during surgery risk greater than 30% * Surgery in curative intent * Written informed consent Exclusion Criteria: * contraindications to the use of allogeneic unmodified red blood cell concentrate * any anti-RBC and/or anti-HLA and/or anti-granulocyte alloimmunization
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Institut Gustave Roussy
Villejuif, 94800, France
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