Glandular cell neoplasm

This phase 1 trial tests whether a personalized vaccine made from a patient's own immune cells can safely boost the body's defenses against liver cancer. People with early-stage hepatocellular carcinoma receive either microwave ablation alone or ablation followed by seven doses o…

This early-stage study tested a vaccine called DCP-001 in 17 women with a serious type of ovarian cancer who had already completed standard treatment. The goal was to see if the vaccine is safe and can boost the immune system to recognize and fight cancer cells. Researchers measu…

This phase 2 study tested the drug erdafitinib in 316 adults and children with advanced solid tumors that have specific FGFR gene mutations or fusions. The main goal was to see if the drug could shrink tumors. Participants took erdafitinib tablets daily. The study is now complete…

This early-phase trial tested two cancer drugs—imatinib mesylate and cyclophosphamide—given daily by mouth to 26 people with rare, advanced tumors that had no standard treatment. The main goal was to find the safest dose of imatinib when combined with a fixed dose of cyclophospha…

Researchers are testing a radiation technique called PULSAR in people with metastatic cervical cancer. PULSAR delivers radiation in short bursts to pelvic tumors, guided by imaging, alongside standard systemic therapy. The trial aims to see whether this approach improves overall …

Researchers are testing an experimental immunotherapy called GNR-051 in adults with advanced lung cancer, kidney cancer, or melanoma that has returned or not responded to other treatments. The Phase 1 trial aims to find the highest dose people can tolerate and to track side effec…

This early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…

This early-phase trial tested whether adding nilotinib (a pill) to paclitaxel (a chemotherapy) is safe and tolerable for people with advanced solid tumors that no longer respond to standard treatments. The study included 47 adults and children aged 12 and older. Researchers aimed…

This study tests a mix of antibodies that help the immune system fight cancer, block tumor growth signals, and cut off the tumor's blood supply. It is for adults with head and neck cancer that did not respond to prior treatment or has no standard options. Participants receive inf…

Researchers test whether adding high-dose radiotherapy to standard chemoembolization slows tumor growth better than chemoembolization alone in adults with hepatocellular carcinoma. Participants have liver tumors up to 9 cm that cannot be removed by surgery or treated with percuta…

This phase II trial is testing an oral drug called giredestrant in 30 people with grade 1 endometrial cancer. The goal is to see if the drug can shrink or control the cancer over 6 months. Participants take one pill daily for up to 24 cycles, and doctors monitor tumor changes and…

Researchers are testing a two-step radioimmunotherapy for people with medullary thyroid cancer that has come back. Participants receive a bispecific antibody followed by a radioactive peptide. The goal is to see if this targeted radiation can shrink tumors and how safe it is.

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

This study tests a combination of two drugs, abemaciclib and ramucirumab, in people with advanced esophageal or gastroesophageal junction cancer that has spread. The goal is to see if this treatment is safe and can help control tumor growth. About 8 participants are enrolled, and…

This Phase 2 trial tests two experimental drug combinations in 63 women with a specific type of ovarian cancer (BRCA-mutant or HRD-positive) that has worsened after prior PARP inhibitor treatment. Participants receive either tuvusertib plus niraparib or tuvusertib plus larteserti…

Researchers are testing whether regorafenib, a daily oral drug, works as well as standard combination chemotherapy for people with newly diagnosed metastatic colorectal cancer. The trial enrolls adults with good performance status who have not yet received treatment for metastati…

Researchers are testing whether giving radiation therapy before sipuleucel-T, a personalized immunotherapy vaccine, works better than the vaccine alone in men with hormone-resistant prostate cancer that has spread. The trial enrolls about 51 participants and randomly assigns them…

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This study tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy and targeted therapy (trastuzumab) can better shrink HER2-positive stomach or gastroesophageal junction cancer before surgery. About 42 adults with advanced but removable tumors will rec…

This phase 2 trial tests whether simvastatin, a widely used cholesterol-lowering drug, can prevent liver cancer in 52 adults with liver cirrhosis. Participants take simvastatin and are monitored with blood tests and imaging to see if cancer-related markers change. The goal is to …

This early-phase study tests a new drug called AB680, combined with immunotherapy (zimberelimab) and two chemotherapy drugs (nab-paclitaxel and gemcitabine), in people with advanced pancreatic cancer that has spread. The main goals are to check safety and find the right dose. Abo…

This phase 1 trial is testing whether a diet that severely limits arginine—an amino acid some tumors depend on—is safe and might help control solid tumors. About 25 adults with solid tumors will follow a specially designed low-arginine liquid diet for two 3-week cycles while cont…

This early-phase trial tests a new drug, SG1827, in people with advanced solid tumors that have stopped responding to standard treatments or have no standard therapy available. The main goals are to check the drug's safety, find the best dose, and get a first look at whether it c…

This pilot study tested a wearable device that delivers low-intensity electric fields (TTFields) together with immunotherapy (atezolizumab) and two chemotherapy drugs (gemcitabine and nab-paclitaxel) in 84 people with metastatic pancreatic cancer who had not received prior treatm…

This phase II trial tests whether giving chemotherapy and proton beam radiation before surgery can help people with borderline-resectable pancreatic cancer. The goal is to shrink the tumor enough so that surgeons can remove it completely, with no cancer cells left at the edges. P…

This study tests a decision model that aims to predict whether a person with unresectable hepatocellular carcinoma, a type of liver cancer, will benefit more from transarterial chemoembolization (TACE) alone or TACE combined with atezolizumab plus bevacizumab. Researchers will de…

This study tests whether giving higher doses of radiation, guided by MRI, can help people with pancreatic cancer that cannot be removed by surgery. Participants must have already had several months of chemotherapy without the cancer spreading. The goal is to see if this approach …

This phase 3 study tests whether a new combination of two immunotherapy drugs (domvanalimab and zimberelimab) plus chemotherapy works better than the current standard (nivolumab plus chemotherapy) for people with advanced stomach, gastroesophageal junction, or esophageal cancer t…

This study tested whether adding a Chinese herbal formula (QingyiHuaji) to standard chemotherapy helps people with stage IV pancreatic cancer live longer. About 305 adults with advanced pancreatic cancer were randomly assigned to receive either the herbal formula plus chemo or a …

This phase II trial tests whether combining niraparib and dostarlimab can control metastatic pancreatic cancer in people who carry BRCA1/2 or PALB2 gene mutations. Niraparib blocks enzymes that cancer cells need to grow, while dostarlimab helps the immune system attack the tumor.…

This study looks at whether eating a high-fiber diet (over 21 grams per day) can change gut bacteria and improve the immune system's ability to fight solid tumors like colorectal cancer. About 25 adults with solid tumors will follow this diet to see if it is safe and helps with t…

This trial tests an experimental drug called zanidatamab, which targets HER2, a protein that fuels certain breast and stomach cancers. Researchers give zanidatamab alongside chemotherapy, and sometimes with the immunotherapy tislelizumab, to people with advanced HER2-positive bre…

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This trial tests whether combining the immunotherapy drug atezolizumab with precise, high-dose radiation (SABR) can better control metastatic cancers, including colorectal, lung, kidney, and sarcoma. The idea is that radiation may make tumors more visible to the immune system, wh…

This study tested two different treatment plans for people with a specific type of pancreatic cancer that is on the edge of being removable by surgery. 130 patients received either chemotherapy alone or chemotherapy plus radiation before surgery. The goal was to see which approac…

This trial tests whether giving a higher radiation dose during brachytherapy, a type of internal radiation, can improve local control in patients with locally advanced cervical cancer. Participants receive standard external beam radiation and chemotherapy, plus a boosted brachyth…

This phase 2 study is testing a combination of three drugs—paclitaxel (a chemotherapy), pembrolizumab (an immunotherapy), and olaparib (a targeted therapy)—in 36 adults with advanced gastric or gastroesophageal cancer that has worsened after one prior treatment. The goal is to se…

This trial tests whether stereotactic ablative body radiation (SAbR), a precise form of high-dose radiation, can delay the need for systemic therapy in people with oligometastatic renal cell carcinoma, meaning kidney cancer that has spread to a few limited sites. Researchers will…

This study tests whether dietary nitrate from beetroot juice can disrupt the altered metabolism of breast cancer cells. Researchers will give a concentrated beetroot juice drink for five days to patients scheduled for breast cancer surgery. Using advanced MRI scans, they will mea…

This phase 1 trial tested the combination of dasatinib (a pill) and bevacizumab (an infusion) in 50 adults with advanced solid tumors that no longer respond to standard treatments. The goal was to find the safest dose and see how well the two drugs work together to slow cancer gr…

This phase 1 trial tests an experimental drug called MRG003 in people with advanced solid tumors, including colorectal cancer, head and neck squamous cell carcinoma, and nasopharyngeal carcinoma. The study aims to find a safe dose and to see whether the drug can shrink tumors. Pa…

This study tests whether avatrombopag, a pill that boosts platelet production, can help people with gastrointestinal cancer who develop low platelets from chemotherapy. About 60 participants will receive either avatrombopag or a placebo. The goal is to see if the drug can raise p…

This study tested a special pump placed under the skin that sends chemotherapy directly to the liver through the hepatic artery. It was for people with colorectal cancer that had spread to the liver and who had already tried other chemotherapies. The goal was to see if this direc…

This phase 2 trial is testing whether adding precise, high-dose radiation (SBRT) to standard immunotherapy (ipilimumab and nivolumab) can help people with metastatic kidney cancer live longer without their disease getting worse. About 66 participants with intermediate or poor-ris…

This early-phase trial tested a shorter course of radiation for men whose prostate cancer came back after their prostate was removed. Instead of the usual 6-7 weeks of daily radiation, researchers gave higher doses over just 2-4 weeks, focusing the strongest radiation on the tumo…

This early-phase study tests an experimental drug called MK-6837, given alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug sh…

This early-phase trial tested a combination of two drugs, vandetanib and everolimus, in 151 people with advanced or metastatic cancer that had stopped responding to standard treatments. The goal was to find the safest dose and see if the combination could slow or stop cancer grow…

This early-stage study tests a new drug called WTX-124, given alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose. About 150 adults with certain…

This trial is testing whether a new form of chemotherapy called PLX038 can be safely combined with the PARP inhibitor rucaparib to shrink tumors in people with small cell lung cancer, small cell cancer outside the lungs, or other solid tumors. The study has two parts: first, find…

This large Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard trastuzumab plus chemotherapy could improve outcomes for people with advanced HER2-positive stomach or gastroesophageal junction cancer. The study enrolled 738 participants …

This study tests whether a combination of two immunotherapy drugs (nivolumab and ipilimumab) can help people with advanced liver cancer live longer than current standard treatments. About 732 participants who have not had prior systemic therapy will be randomly assigned to receiv…

This phase III trial studies whether adding the drug bevacizumab (Avastin) to standard chemotherapy after surgery helps prevent cancer from returning in people with high-risk stage II colon cancer. Over 2,400 participants were randomly assigned to receive either chemotherapy alon…

This phase 3 trial is comparing a combination of two drugs—nivolumab (an immunotherapy) and cabozantinib (a targeted therapy)—against the current standard drug sunitinib in people with advanced or metastatic kidney cancer who have not yet received systemic treatment. The main goa…

This phase III trial is investigating whether adding heated chemotherapy (HIPEC) to standard surgery improves survival for people with advanced stomach cancer. Participants are randomly assigned to receive either surgery alone or surgery plus HIPEC, where a heated chemotherapy so…

This study compares 4 months versus 6 months of chemotherapy (capecitabine and oxaliplatin) in 1024 stomach cancer patients who had surgery. The goal is to see if the shorter treatment works just as well to prevent cancer from coming back, while causing fewer side effects. Partic…

This study tests a 3-week course of radiation (using photons or protons) combined with chemotherapy for people with pancreatic cancer that hasn't spread. The goal is to see if this shorter treatment is safe and effective, either before surgery or as the main therapy. Researchers …

This trial is testing whether a chemotherapy drug called idarubicin works as well as the standard drug doxorubicin when used in a procedure called transarterial chemoembolization (TACE) for liver cancer. TACE delivers chemotherapy directly to the tumor and blocks its blood supply…

This trial is testing whether adding an experimental drug called BYL719 to standard hormone therapy (letrozole) can better fight hormone receptor-positive metastatic breast cancer in post-menopausal women. BYL719 targets a protein that helps cancer cells grow, while letrozole blo…

This trial is testing whether adding anakinra, a drug used for arthritis, to standard chemoradiotherapy is safe for people with rectal cancer. The study will include about 12 patients and will use a dose-escalation design to find the highest tolerable dose of capecitabine when co…

This trial is testing a procedure called HIPEC, where a heated chemotherapy drug (cisplatin) is delivered directly into the abdomen after surgery to remove visible cancer. The goal is to find the safest dose that can be used in patients with advanced ovarian, fallopian tube, or p…

This study looked at whether giving heated chemotherapy directly into the abdomen during a second-look surgery is possible for people with ovarian, fallopian tube, or peritoneal cancer. Ten participants who had already received standard treatment were enrolled. The goal was to se…

This early-phase trial is testing an oral drug called ATRN-119 in 132 people with advanced solid tumors that have specific DNA repair mutations. The main goals are to check safety, how the drug moves through the body, and whether it can shrink tumors. Participants must be able to…

This trial is testing whether adding an experimental antibody called XB2001 to a standard chemotherapy regimen can help people with advanced pancreatic cancer. The study has two parts: first, it finds the safest dose of XB2001, then it compares the antibody plus chemo against a p…

This phase 2 trial tests a powerful mix of short-course radiation, chemotherapy (mFOLFOX6), an immunotherapy (PD-1 antibody), and a targeted drug (cetuximab or bevacizumab, depending on genetic markers) in people with high-risk rectal cancer that is mismatch repair proficient (pM…

This study looked at whether the drug cabozantinib can help people with advanced kidney cancer that got worse after initial treatment with immunotherapy. 127 participants received cabozantinib as a second-line therapy. The main goal was to see how many patients experienced tumor …

This trial is testing a personalized treatment for people with inoperable perihilar cholangiocarcinoma, a type of bile duct cancer. The approach combines radiofrequency ablation — using heat to destroy tumor tissue — with complete drainage of bile ducts, guided by both endoscopy …

This study tested a new drug combination for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell) that had stopped responding to standard targeted pills. The trial enrolled 95 adults and gave them two different combinations of immunotherapy (atezolizum…

This study tested a new radioactive drug, 177Lu-NeoB, in 35 adults with advanced solid tumors that have a specific marker (GRPR). The goal was to check safety, find the best dose, and see if it shrinks tumors. It is an early-stage trial, so it focuses on safety and dosing, not a …

This trial is testing whether adding high-dose vitamin C (ascorbic acid) to a standard three-drug chemotherapy cocktail can safely and effectively control metastatic pancreatic cancer in people who have not yet received any treatment. The study enrolls adults with stage IV pancre…

This phase 3 trial tested whether combining sotorasib (a pill) and panitumumab (an infusion) can slow tumor growth better than standard chemotherapy in 160 adults with metastatic colorectal cancer that has a specific KRAS G12C mutation. Participants were randomly assigned to rece…

This phase 2 trial is testing whether surgery and radiation can help men whose prostate cancer has come back and spread to a few spots in the body. About 20 participants will receive either surgery to remove the spread tumors or targeted radiation, or both. The main goal is to se…

This study investigates whether combining two drugs—camrelizumab (an immunotherapy) and apatinib (a targeted therapy)—before and after surgery can improve outcomes for people with liver cancer that can be surgically removed. Participants receive the drug combination before surger…

This trial tests a device called SELENE that gives surgeons a detailed view of the tissue removed during breast-conserving surgery. The goal is to see if using this imaging helps surgeons remove all cancer cells the first time, reducing the chance that a patient needs another ope…

This early-phase trial tests a new drug called PEP-010 in people with advanced solid tumors that have spread. The study checks if PEP-010 is safe alone or with chemotherapy (paclitaxel or gemcitabine). About 57 adults with metastatic pancreatic, ovarian, or other solid cancers wi…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This trial investigates whether JX-594 (Pexa-Vec), a virus modified to attack cancer cells and boost the immune system, combined with best supportive care, can help people with advanced liver cancer live longer. The study enrolls adults whose liver cancer has progressed or who co…

This early-phase study tests a new oral drug called TT125-802 in 50 adults with advanced solid tumors (like lung cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. It is a fi…

This early-phase study tests whether adding losartan (a blood pressure medicine) to a shorter, higher-dose radiation treatment can help people with pancreatic cancer that is hard to remove surgically. The main goal is to check for side effects and find the safest dose. About 22 a…

This study tests whether a combination of ramucirumab plus FOLFIRI (a standard chemo regimen) works better than ramucirumab plus paclitaxel for people with advanced stomach or gastroesophageal junction cancer that has worsened after one prior chemo treatment. About 429 participan…

This study tests whether giving a three-part treatment before surgery can improve outcomes for people with locally advanced stomach or gastroesophageal junction cancer. The treatment combines an immunotherapy drug (tislelizumab) with standard chemotherapy and a short course of ra…

This trial investigates whether giving two immunotherapy drugs, ipilimumab and nivolumab, before liver surgery can help shrink tumors in people with liver cancer (hepatocellular carcinoma). Participants receive the drugs in the weeks leading up to their planned surgery. The study…

This large phase 3 trial tested whether taking sorafenib or sunitinib after kidney cancer surgery could prevent the cancer from coming back. Nearly 2000 patients participated. Unfortunately, neither drug improved disease-free survival compared to a placebo, and they caused side e…

This Phase 1 trial tested an investigational oral drug called CFI-402257 in 52 people with advanced solid tumors, including breast cancer, that had stopped responding to standard treatments. The main goal was to find a safe dose and check how the drug moves through the body. It w…

This study tested a new type of PET/MRI scan that uses a special tracer to find small spots of prostate cancer that standard scans miss. Men with a rising PSA after prostate surgery and radiation received targeted radiation to those spots. The goal was to see if this approach can…

This trial compares two types of surgery for pancreatic cancer in the body or tail of the pancreas: minimally invasive (laparoscopic or robot-assisted) versus traditional open surgery. The goal is to see if the less invasive approach can remove the tumor just as completely. Adult…

This study tested a fixed-dose combination of two immunotherapy drugs, tiragolumab and atezolizumab, given together as a single infusion every three weeks. The trial enrolled 64 people with advanced solid tumors that express a protein called PD-L1. The main goal was to check the …

This study tested whether a combination of two drugs (atezolizumab and bevacizumab) can prevent liver cancer from returning in people who had surgery or ablation to remove their tumor. About 668 participants at high risk of recurrence were randomly assigned to receive the drug co…

This pilot study tested whether combining high-dose radiation therapy with the immunotherapy drug pembrolizumab (Keytruda) could boost the immune system's ability to fight advanced solid tumors. Twenty-one patients with various advanced cancers received the combination either at …

This small, completed phase II study tested the safety of combining two drugs—atezolizumab (an immunotherapy) and bevacizumab (a blood vessel blocker)—in 6 people with advanced liver cancer who also had moderate cirrhosis (Child-Pugh B7 or B8). The goal was to see if this treatme…

This phase 3 trial tested whether a combination of two drugs, regorafenib and nivolumab, helps people with advanced gastro-oesophageal cancer live longer than standard chemotherapy. The study included 462 adults whose cancer had stopped responding to prior treatments. The goal wa…

This study tested whether adding a virus-based immunotherapy (Pexa-Vec) to the standard drug sorafenib helps people with advanced liver cancer live longer. About 459 adults with advanced liver cancer who had not received prior treatment took part. The approach uses a modified vir…

This phase 2 trial tested personalized immunotherapy combinations for advanced gastric cancer that had worsened after initial chemotherapy. Researchers matched treatments to tumor genetics: patients with certain genetic features received atezolizumab plus ipatasertib, while other…

This completed phase 4 trial tested whether adding SB Flavon (a blend of flavonoids, vitamin C, and L-arginine) to standard Tenofovir therapy can reverse advanced liver scarring (cirrhosis) and prevent liver cancer in 134 people with chronic hepatitis B. The study measured liver …

This study tested a combination of two drugs (atezolizumab and bevacizumab) given before surgery to people with liver cancer. The goal was to see how well the drugs shrink the tumor and how they affect the immune system. 40 participants were enrolled, and researchers also studied…

This phase 2 trial tested two drugs, osimertinib and gefitinib, in 156 people with advanced EGFR-mutant lung cancer. The goal was to see if using blood tests (liquid biopsies) to detect genetic changes could help decide when to switch treatments, compared to standard scans. The s…

This study observed 311 adults with advanced kidney cancer who received cabozantinib (a targeted therapy) plus nivolumab (an immunotherapy) as their first treatment. Researchers tracked how long patients lived and how long tumors stayed under control in real-world settings. The g…

This phase 3 trial tested whether adding a targeted drug called bemarituzumab to standard chemotherapy helps people with advanced stomach or gastroesophageal junction cancer that has a specific protein (FGFR2b). The study enrolled 547 adults whose cancer could not be removed by s…

This study tested a new X-ray monitoring technique (KIM) during prostate cancer radiation therapy. The goal was to see if it helps doctors aim more precisely at the tumor while reducing harm to healthy tissue. 49 men with low- or intermediate-risk prostate cancer took part. The a…

This early-phase trial tested whether adding a new drug called NP137 to standard chemotherapy (mFOLFIRINOX) is safe and could help shrink tumors in people with locally advanced pancreatic cancer that cannot be removed by surgery. 43 participants received the combination. The main…

This phase 2 trial tested a two-step treatment for advanced esophageal cancer that has a specific genetic marker (MGMT deficiency) and has stopped responding to standard chemotherapy. First, patients took a daily oral chemotherapy drug (temozolomide) for three months. Then, they …

This registry followed 152 patients with colorectal cancer that had spread mainly to the liver. Doctors used tiny beads called LifePearl Microspheres loaded with the chemotherapy drug irinotecan, delivered directly to the liver's blood supply. The goal was to see how and when thi…

This study tested whether placing a temporary drain in the pelvis after rectal cancer surgery reduces the risk of serious infections like leaks or abscesses. About 500 patients were randomly assigned to receive a drain or not. The main goal was to see if drainage lowered pelvic s…

This early-phase study tested a daily combination of two oral drugs, axitinib and everolimus, in 19 people with advanced solid tumors, particularly kidney cancer. The main goal was to find the safest dose by monitoring side effects in the first month. Researchers also tracked how…

This phase 3 trial tested whether adding two months of Folfirinox chemotherapy before standard radiation and chemo could help more patients with early-stage rectal cancer avoid major surgery. 218 adults with small, low-lying tumors were enrolled. The goal was to see if more patie…

This study tested the drug sunitinib (Sutent) in 71 people with advanced thyroid cancer that had spread or could not be removed by surgery. The goal was to see if the drug could shrink tumors when standard treatments like radioactive iodine no longer work. Participants took sunit…

This early-phase study tested a new drug called CCT3833 in 31 adults with advanced solid tumours, including melanoma. The main goal was to find a safe dose and check for side effects. Researchers measured how the drug moves through the body and looked for the best dose to use in …

This early-phase trial tested a new drug called PM14 in 126 people with advanced solid tumors that had no standard cure. The main goals were to find a safe dose and check for early signs of tumor shrinkage. The drug was given by IV infusion on different schedules. This is a first…

This study tested a combination of three chemotherapy drugs (paclitaxel protein bound, gemcitabine, and cisplatin) in 34 people with metastatic pancreatic cancer that had not been treated before. If the cancer got worse, a fourth drug (paricalcitol) was added. The goal was to see…

This study tested a treatment plan for locally advanced rectal cancer that uses a short course of radiation followed by chemotherapy, aiming to avoid surgery. 39 patients were enrolled. The goal was to see if the cancer could be completely controlled without an operation, using a…

This study tested whether adding the immunotherapy drug spartalizumab to standard chemotherapy (FLOT) helps shrink stomach cancer before surgery and prevent it from coming back. 67 adults with resectable stomach or gastroesophageal junction cancer received the combination before …

This early-phase study tested a drug called itacitinib in 19 adults with advanced liver cancer that had not responded to first-line treatment. The goal was to check the drug's safety and see if it could shrink tumors or slow cancer growth. Itacitinib works by blocking a protein t…

This study tested whether a short course of radiation followed by chemotherapy could eliminate the need for surgery in people with early-stage rectal cancer. 63 patients were enrolled, and the treatment aimed for a complete clinical response, meaning no tumor could be found on ex…

This study tested whether customizing chemotherapy based on specific gene mutations (EGFR and BRCA1) could improve outcomes for 153 patients with advanced lung adenocarcinoma. Participants received treatments matched to their tumor's genetic profile. The goal was to see if this p…

This study tested a new treatment for people with advanced clear cell kidney cancer that had spread and stopped responding to standard therapies. Six adults received four injections of a radioactive drug (177Lu-PSMA-1) that targets cancer cells. The goal was to check safety and s…

This study tested whether a 3-year physical activity program could help prevent colon cancer from coming back in 889 patients who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. Participants were randomly assigned to either the exercise program plus…

This study tested a newer, less invasive surgery called ETAP (done through the anus) against standard laparoscopic surgery (done through the belly) for low rectal cancer. 226 adults took part. The goal was to see if ETAP is as good at removing all cancer while possibly leading to…

This Phase 3 trial tested a new combination of chemotherapy drugs—irinotecan liposome, oxaliplatin, 5-fluorouracil, and leucovorin—against the standard treatment (nab-paclitaxel plus gemcitabine) in 770 people with metastatic pancreatic cancer who had not received prior chemother…

This study tested a triple combination treatment for advanced liver cancer that has spread. It combines a procedure called TACE (which blocks blood flow to the tumor) with immunotherapy drugs (PD-1/PD-L1 inhibitors) and targeted therapies (VEGF-TKI or bevacizumab). The goal is to…

This study tested a three-pronged approach for intermediate-stage liver cancer: a procedure that blocks blood flow to the tumor (TACE), immunotherapy drugs that help the immune system fight cancer, and targeted drugs that stop blood vessel growth. Over 900 patients participated. …

This study tested a mix of three drugs—trastuzumab deruxtecan (a targeted therapy), nivolumab (an immunotherapy), and chemotherapy—in 30 people with untreated HER2-low stomach or gastroesophageal junction cancer. The goal was to first find a safe dose and then see how well it shr…

This early-phase study tested two immunotherapy drugs (spartalizumab and canakinumab) given before surgery to 17 people with localized clear cell kidney cancer. The main goal was to see if this approach was safe and did not delay surgery. The study also looked at how the drugs af…

This study tested a chemotherapy cocktail called FOLFIRINOX in 72 patients aged 70 or older with metastatic pancreatic cancer. The doses were adjusted based on each person's genetics to reduce side effects while still fighting the tumor. The goal was to see if this approach could…

This Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine and cisplatin) helps people with advanced bile duct cancer live longer. The study enrolled 158 Chinese adults with cancer that had spread or could not be removed by…

This study tested whether a drug called ruxolitinib can reduce abnormal breast cells in people with high-risk or precancerous breast conditions like DCIS or atypical hyperplasia. Half of the 84 participants took ruxolitinib for about 15 days before surgery, and the other half too…

This study tested a combination of two drugs, AZD6738 and olaparib, in 123 women with recurrent ovarian cancer. The goal was to see if the combo is safe and how well it shrinks tumors or delays cancer growth. Participants had either platinum-sensitive or platinum-resistant cancer…

This study tested whether interferon-free drug combinations can cure hepatitis C in 150 people who had been successfully treated for liver cancer. Participants took pills like sofosbuvir and ribavirin for 12 weeks. The main goal was to see if the virus stayed undetectable 12 week…

This study tested a special type of radiofrequency ablation using two cooled needles that also release saline to treat liver cancer that came back after chemoembolization. The goal was to see if this technique could better destroy the tumor and prevent it from growing back. One h…

This study looked at how safe and effective the drug Cabozantinib is for people aged 70 and older with advanced kidney cancer. Researchers tracked side effects and tumor response in 100 participants. The goal was to see if this treatment works well in older patients who have alre…

This study looked at how the HIV drug raltegravir works in people with severe liver disease who need a liver transplant. It included 14 HIV-positive adults with end-stage liver failure. Researchers checked how the drug behaves in the body and how it interacts with anti-rejection …

This phase 3 trial tested whether a surgical procedure called laparotomy plus heated chemotherapy (HIPEC) could improve outcomes for colorectal cancer patients at high risk of cancer spreading in the abdomen. 150 patients who had already undergone surgery and chemotherapy were ra…

This phase 3 trial tested whether a single injection of radioactive lipiodol (Lipiocis) into the liver artery could prevent hepatocellular carcinoma from coming back after surgery or ablation. The study enrolled 73 adults with cirrhosis and one or two liver tumors that had been s…

This study tested a new way to reconnect the pancreas to the intestine during Whipple surgery for certain cancers. The new method uses a stent and wraps the connection with omentum (fatty tissue) to try to prevent leaks. 48 patients were split into two groups to compare the new t…

This phase 3 trial tested whether adding radiofrequency ablation (RFA) to standard transarterial chemoembolization (TACE) improves outcomes for people with intermediate-stage liver cancer. 241 participants with 2-10 liver tumors were randomly assigned to receive either TACE alone…

This study tested whether measuring drug levels in the blood can help doctors adjust doses of two common kidney cancer medications, sunitinib and pazopanib. The goal was to see if this personalized approach reduces side effects and keeps the cancer from growing longer than the st…

This study tested a new ovarian stimulation protocol using degarelix (a drug typically used for prostate cancer) to help breast cancer patients preserve their fertility before chemotherapy. The goal was to keep estrogen levels low while still collecting enough eggs for freezing. …

This study looked at 60 people with advanced pancreatic body or tail cancer that couldn't be removed by surgery. It compared a targeted treatment called splenic artery infusion chemotherapy (SAIC), which delivers chemo directly to the tumor's blood supply, with standard chemo giv…

This completed Phase 2 study tested a combination of chemotherapy (FOLFIRI) and radiation with 5-fluorouracil in 63 patients with gastric cancer. The treatment was given either before or after surgery to remove the tumor. The goal was to see if this approach is feasible and less …

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine/cisplatin) helps people with advanced bile duct or gallbladder cancer live longer. Over 1,000 participants received either the combination or chemo plus a placebo. The goal…

This study tested a new cancer drug called ERAS-007, given by mouth, together with other targeted therapies in 101 people with advanced colorectal or pancreatic cancers that have certain gene changes. The main goals were to check safety, find the best dose, and see how the drugs …

This study compared two chemotherapy regimens (FOLFOX and CarboP-pacliT) given with radiation before surgery for esophageal or junction cancer. 106 patients were enrolled to see which treatment leads to better tumor removal and fewer serious complications. The goal is to help doc…

This study tested a high-precision radiation treatment called stereotaxic radiotherapy (CyberKnife) in 44 adults with a single liver cancer tumor. The goal was to stop the tumor from growing for at least 18 months. Participants received three high-dose radiation sessions over 8-1…

This study tested a new way to give radiation to men with intermediate-risk prostate cancer. After standard radiation to the prostate and nearby glands, a precise, high-dose boost was added to the tumor. The goal was to improve cancer control while keeping side effects on the bla…

This phase 2 study tested a combination of three drugs—gemcitabine, trastuzumab, and erlotinib—as a first treatment for people with metastatic pancreatic cancer that has spread. The goal was to see if the combination could control tumor growth. 63 patients received the drugs intr…

This study tested whether giving vitamin D based on a patient's deficiency level works better than a standard dose. 215 breast cancer patients on chemotherapy received either a fixed daily supplement or a tailored dose. The goal was to see which method normalizes vitamin D levels…

This study tests whether adding a third drug, ipilimumab, to the standard two-drug combination (atezolizumab and bevacizumab) improves survival and tumor shrinkage in people with advanced liver cancer. About 229 patients will receive either the standard two drugs or all three. Th…

This early-stage trial tested a modified virus called TILT-123 in 32 people with advanced solid tumors that had not responded to standard treatments. The virus is designed to infect and kill cancer cells while releasing immune-boosting proteins. The main goal was to check safety …

This completed Phase 2 trial tested whether combining an immunotherapy drug (durvalumab) with an epigenetic drug (tazemetostat) can control advanced solid tumors like pancreatic, colorectal, and soft-tissue sarcoma. The study enrolled 164 adults and measured how well the combo sh…

This phase 2 trial tested two standard chemotherapy regimens, Folfirinox and Gemcitabine/nab-paclitaxel, in 150 patients with untreated metastatic pancreatic cancer. The goal was to see which works better and to use lab tests to personalize treatment. The study is complete, and r…

This study compared two types of surgery for stomach cancer: laparoscopic (keyhole) and open surgery. The goal was to see if keyhole surgery leads to a shorter hospital stay and fewer complications. The trial included 210 patients with resectable stomach cancer and is now complet…

This early-stage trial tested whether combining donafinib (a targeted therapy) with an anti-PD-1 antibody (an immunotherapy) can safely prevent liver cancer from coming back after surgery. It involved 30 patients with high-risk features like microvascular invasion or multiple tum…

This study tested a drug called romiplostim in 165 adults with gastrointestinal, pancreatic, or colorectal cancer who were receiving chemotherapy. The goal was to see if romiplostim could prevent low platelet counts (thrombocytopenia) that often force doctors to delay or reduce c…

This study tested whether giving chemotherapy before surgery (neoadjuvant chemo) helps people with resectable pancreatic cancer live longer. 153 patients were randomly assigned to either standard surgery followed by chemo, or one of two chemo regimens (FOLFOX or FOLFIRINOX) befor…

This early-stage trial tested an experimental drug called CyPep-1, injected directly into tumors, either alone or with the immunotherapy pembrolizumab. The study involved 60 adults with advanced solid cancers that had stopped responding to standard treatments. The main goals were…

This early-phase trial tested an experimental drug called VS-6766, given alone or with everolimus, in 104 adults with advanced solid tumors or multiple myeloma that had stopped responding to standard treatments. The goal was to find a safe, tolerable dosing schedule and measure h…

This Phase 3 study tested the drug FTD/TPI (a chemotherapy pill) against a placebo in 243 people who had surgery for colorectal cancer but still had cancer DNA in their blood. The goal was to see if the drug could prevent the cancer from coming back. Participants took the drug or…

This study tested whether adding a precise, high-dose radiation treatment (SBRT) to the hormone therapy apalutamide helps control prostate cancer that has stopped responding to standard hormone therapy and spread to a few spots. Twenty-six men with this type of cancer took part. …

This early-phase trial tested a combination of two drugs—pembrolizumab (an immunotherapy) and nintedanib (a drug that blocks blood vessel growth)—in 196 adults with advanced solid tumors that had worsened after standard treatment. The main goal was to find the safest dose of nint…

This study looked at 52 adults with advanced liver cancer to see if adding microwave ablation (MWA) to immunotherapy works better than immunotherapy alone. MWA uses heat to destroy tumors and may help the immune system fight cancer more effectively. The researchers measured how l…

This early-phase trial tested whether adding two chemotherapy drugs (6-mercaptopurine and 6-thioguanine) to an immunotherapy drug (Atezolizumab) could help treat advanced solid tumors that have stopped responding to standard treatments. The study enrolled 18 adults with metastati…

This study looked at 211 people with advanced pancreatic cancer whose first treatment (FOLFIRINOX) stopped working or caused too many side effects. Researchers compared a two-drug combination (gemcitabine and paclitaxel) against gemcitabine alone to see if the combo helped people…

This study looked at liver cancer patients whose tumors shrank completely after non-surgical treatments like chemoembolization and immunotherapy. Researchers compared those who then had surgery to remove any remaining tissue versus those who simply watched and waited. The goal wa…

This study tested whether adding a third drug (relatlimab) to a two-drug combination (nivolumab and bevacizumab) is safe and works better for people with advanced liver cancer who haven't had treatment before. The 83 participants received either the three-drug combo or the two-dr…

This phase 2 trial tested a drug called mirvetuximab soravtansine in 79 people with recurrent platinum-sensitive ovarian, peritoneal, or fallopian tube cancers that have high levels of a protein called folate receptor-alpha. The drug is given by IV every three weeks. The main goa…

This early-stage trial tested a new drug called MRX-2843 in 42 adults with advanced solid tumors that had spread or come back after other treatments. The main goal was to check safety and find the right dose. Researchers monitored side effects and how the drug moved through the b…

This early-stage trial tested a new biologic drug called ZGGS15 in 22 adults with advanced solid tumors who had no standard treatment options left. The main goals were to check safety, find the right dose, and look for early signs that the drug might control tumor growth. Partici…

This early-phase study tested an experimental oral drug called Q702 in 51 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects, while also looking at whether the drug could shrink …

This study tested a new treatment for people with liver cancer that cannot be removed by surgery. The treatment combines chemotherapy delivered directly to the liver, a procedure to block the tumor's blood supply, and two drugs (lenvatinib and tislelizumab). The goal was to see i…

This phase II trial tested two chemotherapy combinations as first-line treatment for people with advanced or metastatic pancreatic cancer. One group received a newer regimen called SLOG, while the other got a standard combo called mFOLFIRINOX. The study aimed to see which worked …

This phase II trial tested a 9-day course of whole breast radiation (hypofractionated radiotherapy) in 102 patients with early-stage breast cancer (stage 0-IIB). The goal was to see if a shorter treatment time could maintain effectiveness while reducing side effects. Researchers …

This study tested two immunotherapy drugs, nivolumab and ipilimumab, in people with advanced liver cancer that could not be treated with surgery. The goal was to see if these drugs could shrink tumors and control the disease. The trial included 657 adults and found that the treat…

This study tested whether freezing eggs (oocyte cryopreservation) could help preserve fertility in women with benign ovarian cysts that often come back, like endometriomas. The 82 participants had cysts that required multiple surgeries, which can damage the ovaries. Researchers m…

This study compared robotic-assisted pancreatic surgery to the standard open approach for people with pancreatic and related tumors. Researchers wanted to see if robotic surgery could help patients recover faster after the operation. A total of 268 patients took part across multi…

This study looked at whether removing the primary rectal tumor before starting chemotherapy helps people with rectal cancer that has spread to other organs (but cannot be cured) live longer. Only 5 people took part, and the trial was completed early. The results are too limited t…

This study tested a shorter radiation course combined with TASOX chemotherapy in 13 people with stage II/III rectal cancer before surgery. The goal was to shrink tumors and make surgery more effective. Results showed the treatment was safe and helped reduce cancer stage, but ongo…

This completed study tested whether a shorter, more intense course of radiation (1 week) works as well as the standard 3-week course for women with early breast cancer after lumpectomy. Sixty women were split into two groups to compare side effects, cosmetic results, and cancer c…

This study tested whether adding radiation to chemotherapy before surgery improves outcomes for people with locally advanced stomach or gastroesophageal junction cancer. About 204 adults with operable tumors received either chemotherapy alone or chemotherapy plus radiation before…

This early-stage study tested a fixed-dose combination of two immunotherapy drugs (relatlimab and nivolumab) in 24 Chinese patients with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, how the drugs move through the b…

This study tested two immunotherapy drugs, durvalumab and tremelimumab, given with chemotherapy before and after surgery for advanced ovarian cancer. The goal was to see if this combination is safe and feasible. About 69 women with stage IIIC to IV ovarian cancer took part. The r…

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in 160 people with a rare type of advanced kidney cancer (non-clear cell renal cell carcinoma) that had not been treated before. The goal was to see if the drugs could shrink tumors. The study found that …

This study tested whether adding fruquintinib to standard chemotherapy (paclitaxel) helps people with advanced stomach cancer live longer. It included 703 patients whose cancer had worsened after initial treatment. The goal was to see if the combination improves survival and slow…

This study looked at how safe the drug cabozantinib is for people with advanced liver cancer (hepatocellular carcinoma) who have already tried another treatment called sorafenib. A total of 110 adults took part. The main goal was to see how long patients lived after starting cabo…

This phase 3 trial tests a new drug combination, MK-4280A (favezelimab plus pembrolizumab), against standard treatments (regorafenib or TAS-102) in 94 Chinese adults with advanced, PD-L1 positive colorectal cancer that has worsened after prior therapy. The main goal is to see if …

This phase 2 trial tested whether adding a PD-1 inhibitor (Sintilimab) after standard chemoradiotherapy could improve outcomes for 30 patients with locally advanced mid-low rectal cancer. Participants received radiation and chemotherapy, then three doses of Sintilimab, followed b…

This small pilot study tested whether adding a vitamin D-like drug called paricalcitol to standard chemotherapy could help people with advanced pancreatic cancer that had stopped responding. 27 patients received chemotherapy first, then paricalcitol was added if their disease sta…

This study tested whether a stronger chemotherapy combination (mFOLFIRINOX) works better than the standard one (mFOLFOX) for people with high-risk stage III colon cancer after surgery. About 792 patients took part across multiple countries. The goal was to see if the stronger com…

This Phase 2 trial tested whether adding the immunotherapy drug durvalumab to standard chemoradiation (FOLFOX and radiation) helps patients with unresectable esophageal cancer. 112 patients were randomly assigned to receive either chemoradiation alone or chemoradiation plus durva…

This study tested a drug called tislelizumab in 50 people with advanced liver cancer who also have moderate liver damage (Child-Pugh B). The goal was to see if the drug could shrink tumors. Tislelizumab works by helping the immune system attack cancer cells. The study took place …

This study tested whether the immunotherapy drug nivolumab can help prevent esophageal cancer from coming back after surgery. About 794 people who had surgery for stage II or III cancer of the esophagus or gastroesophageal junction received either nivolumab or a placebo. The main…

This study tested whether adding special agents (FloSeal® or Surgicel®) to standard suturing during partial nephrectomy reduces bleeding and other complications. 150 patients with localized kidney tumors were randomly assigned to one of three groups. The main outcomes were bleedi…

This early-phase trial tested a new immunotherapy drug called BDB001, alone or combined with atezolizumab (Tecentriq), in 40 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find the best dose, and see if t…

This early-phase trial tested a new immunotherapy drug called BDB001, both alone and combined with pembrolizumab, in 87 adults with advanced solid tumors that had progressed after standard treatments. The main goals were to check safety and find the best dose. The study is comple…

This study offers continued access to tazemetostat for 58 people with various cancers who already benefited from the drug in earlier trials. The main goal is to monitor long-term safety and side effects. Participants must have shown clinical benefit from tazemetostat before joini…

This study tested a combination of two drugs, crizotinib and fulvestrant, in 33 people with advanced lobular breast cancer that had lost a protein called E-cadherin. It also tested crizotinib alone in people with diffuse gastric cancer, triple-negative lobular breast cancer, or o…

This early-phase trial tested different combinations of immunotherapy drugs with standard chemotherapy for people with metastatic pancreatic cancer that had not been treated before. The main goal was to check safety and see if the combinations could shrink tumors or control the d…

This study tested a new experimental therapy using special immune cells (T cells) trained to attack proteins found on pancreatic cancer cells. The trial included 37 patients whose cancer had returned or not responded to standard treatment, or who chose not to have chemotherapy. T…

This study tested a combination of an oral bacterial product (VE800) and the immunotherapy drug nivolumab in 56 people with advanced or metastatic cancers like melanoma, stomach, and colorectal cancer. The goal was to see if the bacteria could help the immune system fight tumors …

This study tested a new oral drug called RP-3500 (camonsertib), alone or combined with talazoparib or gemcitabine, in 276 adults with advanced solid tumors that have certain genetic mutations. The main goals were to find the safest dose and check for early signs of tumor shrinkag…

This study tested a shorter course of pelvic radiation (about 1 week instead of the usual 5-6 weeks) given after hysterectomy for advanced endometrial cancer. The goal was to see if this shorter treatment causes fewer side effects while still controlling the cancer. The study inc…

This study tested combinations of a new drug called etrumadenant (AB928) with other treatments in 227 people whose colorectal cancer had spread. The goal was to see if these combinations could shrink tumors or slow the cancer's growth. Participants received different drug mixes, …

This study tested whether adding an immunotherapy drug (ipilimumab or nivolumab) to niraparib, a targeted therapy, can prevent advanced pancreatic cancer from growing. It enrolled 104 adults whose cancer had not worsened after platinum-based chemotherapy. The goal was to see how …

This study tested whether a 6-day infusion of somatostatin, a drug that lowers pressure in the liver's blood vessels, could prevent ascites (fluid buildup) after liver cancer surgery. 179 patients with liver cancer and underlying liver disease took part. The goal was to see if so…

This study compared two endoscopic treatments for Barrett's esophagus, a condition that can lead to esophageal cancer. The goal was to see which procedure—radiofrequency ablation or hybrid argon plasma coagulation—causes less pain and is safer from the patient's viewpoint. Sixty-…

This phase 2 trial tested a new chemotherapy combination (Nal-IRI with 5-FU and leucovorin) against a standard treatment (gemcitabine plus cisplatin) in 93 people with advanced biliary tract cancer that could not be removed by surgery. The study aimed to see which approach better…

This study tested a new treatment plan for people with advanced pancreatic cancer that has spread. It combined chemotherapy with drugs that change how genes work and boost the immune system. The goal was to see if this approach is safe and can help control the disease. 75 patient…

This completed Phase 3 trial tested a combination of two drugs, atezolizumab and bevacizumab, in 152 people with advanced liver cancer that could not be surgically removed and had not been treated before. The goal was to check safety and how well the treatment works. The study wa…

This study looked at 24 patients with advanced liver cancer whose disease got worse after standard treatment with lenvatinib and an immunotherapy drug. Researchers added a third drug, lenalidomide, to see if it could help control the cancer again. The goal was to measure how long…

This phase 3 trial tested whether the drug everolimus could prevent kidney cancer from coming back after surgery. Over 1,500 patients with high-risk kidney cancer took either everolimus or a placebo daily for 54 weeks. The study found a small improvement in recurrence-free surviv…

This study tested a drug called ZW25 (zanidatamab) in 87 people with advanced or metastatic HER2-amplified biliary tract cancer that had worsened after standard chemotherapy. The goal was to see if the drug could shrink tumors and how long that effect lasted. The trial is now com…

This study tested a device that uses heat (radiofrequency ablation) to destroy small breast tumors (less than 2 cm). Thirty women with early-stage breast cancer received the treatment to see if it could safely eliminate the tumor. The goal was to find a less invasive option than …

This early study tested whether adding a radioactive drug (177Lu-PSMA) to standard brachytherapy is safe and feasible for men whose prostate cancer returned after initial radiation. Only 3 men took part. The goal was to see if the combination could control cancer both in the pros…

This Phase 2 trial tested whether adding afuresertib (an AKT inhibitor) to standard paclitaxel chemotherapy helps control platinum-resistant ovarian cancer better than paclitaxel alone. 150 women with this difficult-to-treat cancer participated. The study measured how long the ca…

This completed phase I trial tested whether higher doses of a precise type of radiation called stereotactic body radiotherapy (SBRT) are safe for people with pancreatic cancer. Thirty patients with inoperable or locally advanced pancreatic cancer received five targeted radiation …

This early-phase trial tested a new drug, Karonudib, in 63 people with advanced solid tumors that had not responded to standard treatments. The main goal was to check the drug's safety and find the best dose. Researchers also looked at how the drug moves through the body and any …

This study tested whether transplanting gut bacteria from people who responded well to immunotherapy could help others with advanced kidney cancer respond better. Fifty participants received either a fecal transplant or a placebo. The goal was to see if the transplant could slow …

This study tested a new way to deliver chemo directly to liver tumors using a wrist artery instead of the groin. Thirty-eight patients with liver cancer took part. The goal was to see if the wrist approach is safe, feasible, and effective, with fewer complications and faster reco…

This phase 2 trial tested a two-step surgical procedure called delayed coloanal anastomosis (2SCA) in 124 patients with medium or lower rectal cancer. The goal was to see if this technique lowers the rate of dangerous leaks at the surgical connection and reduces the need for a co…

This early-phase study tested stereotactic radiotherapy, a precise type of radiation, on 13 people with small kidney cancers (≤4 cm). The goal was to find the highest safe dose by gradually increasing the radiation in four steps. Participants were followed for up to 5 years to mo…

This early-phase trial tested an experimental immunotherapy called ELI-002 in 25 people with KRAS-mutated pancreatic, colorectal, lung, ovarian, or bile duct cancers who had signs of remaining disease after standard treatment. The therapy aims to train the immune system to attack…

This phase 3 trial tested whether removing the kidney (nephrectomy) before taking the drug sunitinib helps people with metastatic kidney cancer live longer compared to taking sunitinib alone. 452 patients were randomly assigned to either surgery plus sunitinib or sunitinib only. …

This study looked at whether taking the kidney cancer drug cabozantinib with a light breakfast changes how much drug gets into the body. Twelve patients with advanced kidney cancer took the drug both on an empty stomach and with a light breakfast, and researchers measured drug le…

This pilot study tested the safety of giving sitagliptin (Januvia) for three weeks to 14 liver cancer patients before they had surgery to remove their tumors. The idea is that sitagliptin might help immune cells get into the tumor and fight it better. The main goal was to check f…

Researchers are studying whether features from pretreatment 18F-FDG PET/CT scans can predict how well people with metastatic kidney cancer respond to first-line targeted therapy plus immunotherapy. The study reviews medical records and imaging data from 228 patients treated at a …

Researchers are testing whether a combination of PET scans with a radioactive tracer called [18F]PSMA-1007, sodium MRI, and multiparametric MRI can accurately predict where prostate cancer is and how aggressive it is. The study enrolls men who are scheduled to have their prostate…

Researchers at Hanoi Medical University are studying whether two blood markers, AFP-L3 and PIVKA-II, can accurately detect hepatocellular carcinoma, the most common form of liver cancer. The trial enrolls 200 adults, including people with liver cancer and people with benign liver…

This study tests whether a combination of serial C-reactive protein blood tests and targeted CT scans can safely identify which rectal cancer patients can skip a temporary ileostomy after laparoscopic low anterior resection. Anastomotic leakage is a serious complication, and a pr…

Researchers are testing whether a standard MRI scanner can be used to create detailed 3D maps of fat molecules in the breast. The idea is that changes in fat composition may appear before cancer develops, so this could help detect very early breast cancers. The study will compare…

Researchers are testing whether a special MRI technique that maps fat composition in breast tissue can improve early detection of breast cancer. The study compares women with a BRCA1/2 or TP53 gene mutation, who are at high risk, with women who already have invasive ductal carcin…

This study follows people with a significantly elevated risk of pancreatic cancer—due to inherited gene mutations or strong family history—who choose to undergo early detection testing. Participants receive endoscopic ultrasound (EUS) and MRI scans on an alternating schedule ever…

This trial evaluates a new biopsy needle (Micro-Tech FNB) used during endoscopic ultrasound to collect tissue samples from suspected pancreatic tumors. The goal is to see if this needle provides accurate diagnoses and yields enough high-quality tissue for genetic sequencing, whic…

This trial is testing whether a special PET/CT scan, typically used for prostate cancer, can better detect hepatocellular carcinoma (the most common type of liver cancer) compared to standard CT or MRI scans. The study will enroll about 30 adults with liver lesions suspicious for…

This completed study tested whether a special type of MRI (multiparametric MRI) can accurately tell the difference between benign and malignant small kidney tumors. About 387 adults with small solid kidney masses (1.5-4 cm) were scanned before surgery or biopsy. The goal was to s…

This study tested whether a special PET scan tracer called 18F-DOPA can better detect leftover medullary thyroid cancer in lymph nodes after surgery, compared to standard imaging. Twenty-four adults with elevated thyrocalcitonin levels (a sign of residual disease) received the tr…

This study looked at 639 adults with cirrhosis to see if a blood test called mSEPT9 can detect liver cancer (hepatocellular carcinoma) better than the current standard test (AFP). Participants gave an extra blood sample during routine care, and researchers compared how well each …

This study tested a radioactive tracer called [68Ga]FAPI-46, used with a PET scan, to see if it can better detect pancreatic cancer cells. 63 adults with early-stage pancreatic cancer received the tracer before surgery. The goal was to see how well the scan matches the actual can…

This study tested a new ultrasound technique (Side-by-Side Contrast-Enhanced Ultrasound) to see if it could accurately check whether microwave ablation fully destroyed liver tumors just 1-3 days after treatment. Researchers compared it to standard contrast-enhanced ultrasound in …

This study tested a new artificial intelligence (AI) algorithm against the standard LI-RADS criteria for diagnosing liver cancer (hepatocellular carcinoma) on CT scans. Researchers enrolled 300 people at risk for liver cancer who had a new liver nodule found on ultrasound. The go…

This study tested a new digital scope called LUMENEYE to see if it can better measure how much a rectal tumor has shrunk after chemotherapy and radiation. 82 patients who were good candidates for organ preservation were included. The goal was to see if the scope could help doctor…

This study looked at whether a breath test could help detect liver fibrosis, cirrhosis, or liver cancer. Researchers collected breath samples from 56 patients with known or suspected liver disease and analyzed them for specific chemical markers. The goal was to see if the test co…

This study tested a new blood test that looks for tiny particles (exosomes) released by cancer cells to find early liver spread in people with pancreatic cancer before they have surgery. The goal is to help doctors decide the best treatment plan by identifying patients at high ri…

This completed study tested a new blood test that looks for tiny particles called exosomal microRNAs to detect intrahepatic cholangiocarcinoma, a rare and aggressive liver cancer. Researchers analyzed blood samples from 535 adults to see how accurately the test could identify can…

This study tested a new blood test called LyMIC that looks for tiny particles (exosomes) released by cancer cells. The goal was to see if it could accurately tell whether bile duct cancer has spread to nearby lymph nodes before surgery. Researchers analyzed blood samples from 230…

This Phase 3 study tested a radioactive tracer called Copper Cu 64 PSMA I&T, given as an injection, to improve PET/CT scans in 235 men with prostate cancer that may have returned after initial treatment (surgery or radiation). The goal was to see how accurately the scan could det…

This study tested a new radioactive tracer called [18F]FAPI-74 for PET scans in people with gastrointestinal cancers, including liver, bile duct, stomach, pancreatic, and colorectal cancers. The goal was to see if the tracer can accurately detect cancer cells by comparing scan re…

This study tested a new radioactive imaging agent, 68Ga-OncoCAIX, in 20 people with a type of kidney cancer called clear cell renal cell carcinoma. The goal was to see if it is safe and how it spreads in the body. Researchers measured radiation doses to organs and checked for sid…

This study tested whether giving doctors access to a blood test called FirstLook increases lung cancer screening rates among people at high risk. The test looks for DNA fragments in the blood that may signal lung cancer. Researchers compared screening rates in practices that coul…

This study tested whether a fluorescent dye called indocyanine green (ICG) can help surgeons locate small, non-palpable breast tumors during surgery. Ten women with early-stage breast cancer received both the dye and a standard radioactive seed, and doctors compared how well each…

Researchers are testing whether low-dose tamoxifen or a 5:2 intermittent fasting diet can raise levels of a protein called sex hormone binding globulin (SHBG) in women at high risk of breast cancer. Higher SHBG levels have been linked to lower breast cancer risk. The trial enroll…

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This study tested whether a taurolidine-citrate solution (TauroLock) placed in the catheter between treatments can prevent bloodstream infections in adults with solid tumors receiving IV anti-cancer therapy. 162 patients were randomly assigned to get either the TauroLock solution…

This study looked at whether giving the Gardasil 9 HPV vaccine to women at the same time as surgery for abnormal cervical cells (CIN) can help clear the virus and prevent future infections. About 1,100 women aged 18-55 took part. The goal was to see if the vaccine reduces the cha…

This study follows up on women who took a low dose of tamoxifen (5 mg daily) for three years to see if it continues to prevent breast cancer over the long term. The original trial found a 42% reduction in breast cancer events. Researchers will also combine data from three similar…

This study tests a new way to give radiotherapy for men with intermediate-risk prostate cancer. The goal is to lower the dose to healthy parts of the prostate while boosting the dose to the tumor, using a special MRI-guided machine (MR-linac). Twenty men will take part to see if …

Researchers at Jagiellonian University are studying whether a supplement made from freeze-dried black raspberries and strawberries affects inflammation in people over 65 receiving treatment for colorectal cancer. About 70 participants take the anthocyanin-rich supplement for 21 d…

This study looked at 2,000 adults with solid tumors to find the best dose of olanzapine for preventing nausea and vomiting caused by strong chemotherapy. Researchers compared 2.5 mg, 5 mg, and 10 mg doses to see which works best with the fewest side effects like daytime sleepines…

This study tested whether a device that gently stimulates the vagus nerve through the ear could reduce delayed stomach emptying after a major pancreatic surgery (pancreaticoduodenectomy). 84 patients were randomly assigned to receive the stimulation during surgery or not. The goa…

This trial tests whether a structured patient education program can lower the risk of severe immune-related side effects in people receiving immunotherapy for certain cancers, including melanoma, lung, kidney, and head and neck cancers. Participants either attend five educational…

This study tests whether a mushroom supplement called Ganoderma lucidum spore powder can reduce depression in women who have had thyroid cancer surgery. Three hundred participants will take either the supplement or a placebo daily for three months. Researchers will measure change…

This trial tests whether an AI emotional companion app can improve depression, anxiety, and demoralization in adults with advanced cancer. Participants use a mobile app where a virtual character holds conversations, reads emotional cues, and offers a link to a human hotline if di…

This study tests whether a specialized sexual health education program can help people who have been treated for rectal, colorectal, or anal cancer improve their sexual function and emotional well-being. Participants are randomly assigned to either the new counseling program or s…

This trial tests whether laser acupuncture, a non-invasive therapy using low-intensity light on traditional acupoints, can relieve constipation in people with advanced cancer. Participants are adults with advanced cancer who have constipation despite using laxatives. The study me…

This phase 2 trial tests whether inhaling a blend of peppermint and lemon essential oils can reduce nausea and vomiting in people receiving their first chemotherapy for a solid tumor. Participants will inhale the oils four times daily and whenever nausea strikes, with symptoms tr…

This study tests whether using a virtual reality headset during PICC line placement can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to see if this non-drug appro…

This study tested whether monthly 45-minute psychological interviews over 6 months could reduce post-traumatic stress symptoms in cancer patients affected by the COVID-19 pandemic. It included 29 adults with solid tumors who had moderate to high PTSD symptoms. The goal was to see…

This phase II trial tests whether flibanserin, a drug approved for low sexual desire in women, can increase sexual interest in men with prostate cancer who are receiving androgen deprivation therapy (hormone therapy). About 44 men will be randomly assigned to take flibanserin or …

This study tested a home monitoring system for people with advanced pancreatic cancer receiving a strong chemotherapy called mFOLFIRINOX. The system tracked symptoms, activity, sleep, and weight using connected devices and an online platform. The goal was to see if early alerts c…

This study tested a 4-week exercise program before surgery (prehabilitation) in 34 women with cervical cancer. The program included aerobic, resistance, and pelvic floor exercises. Results suggest it may improve pelvic floor strength and shorten hospital stays compared to standar…

This study tests whether acupuncture using tiny, semi-permanent needles can prevent diarrhea caused by the chemotherapy drug irinotecan in children with solid tumors. About 22 children will receive the acupuncture during their second round of chemo, and researchers will measure p…

This pilot study tested a plastic stent with a retrieval string to drain bile in 40 people with resectable bile duct cancer. The goal was to see if the stent could safely reduce bile buildup before surgery. Researchers measured serious complications and how well the stent worked.

This study tested a special pain coping skills program for people with advanced solid tumor cancer who have pain that interferes with daily activities. 211 patients were randomly assigned to either the program or standard care. The program taught ways to manage pain and find mean…

This study tested whether using a 3D model of a patient's kidney before surgery could shorten the time needed for robotic-assisted partial nephrectomy (removing a kidney tumor). 370 adults with small kidney tumors took part. The goal was to see if better planning with 3D imaging …

This study tested two behavioral programs—coping skills training and general health education—to see which better improves well-being in people with ongoing pain after breast cancer surgery. About 316 participants who had surgery for breast cancer or precancerous conditions took …

This study tested whether giving a single dose of pregabalin before a liver cancer ablation procedure can reduce pain afterward. 70 adults with liver cancer were randomly assigned to receive either pregabalin or a placebo before their procedure. The main goal was to measure pain …

This study looked at whether people with early or locally advanced HER2-positive breast cancer prefer receiving their medication (a combination of pertuzumab and trastuzumab) at home versus in the hospital. About 346 participants were randomly assigned to receive the drug at home…

This study tested whether an oral iron pill (ferric maltol) can improve anemia in 40 adults after colorectal cancer surgery, compared to standard care. The main goal was to see if a larger study is possible, while also checking blood iron levels. The approach is simple and aims t…

This pilot study tested an online program called THRIVE, based on Positive Affect Training, to help breast cancer survivors feel better about taking their anti-hormonal medication. The goal was to see if the program was acceptable and feasible for women who struggle with side eff…

This study looked at whether having a palliative care team work alongside surgeons improves quality of life for patients with gastrointestinal cancers like pancreatic or liver cancer. About 379 patients and their family members took part. The main goal was to see if this team app…

This study tested a fast-recovery program for people having minimally invasive kidney surgery (laparoscopic or robotic) to remove tumors. The goal was to see if the program could safely shorten hospital stays by at least one day. Sixty patients took part, and researchers tracked …

This study tested two approaches to bring palliative care (comfort-focused care) to people with end-stage liver disease. About 1,500 adults from 19 U.S. centers took part. One group had direct access to a palliative care specialist; the other group saw a liver doctor specially tr…

This study tested a web-based program to help children aged 8-17 with cancer adjust to returning to school. The program included modules for children, parents, teachers, and peers, focusing on communication, coping, and social skills. Twenty children participated, and researchers…

This study tested whether a newer nerve block called ESP works as well as the standard PVB block for pain after breast cancer surgery. 292 women received one of the two blocks before surgery. The main goal was to see how many needed morphine in the first two hours after surgery. …

This study tested whether taking zinc supplements and applying a strong steroid cream (clobetasol) can prevent or reduce hand-foot skin reaction, a common and painful side effect of the cancer drug regorafenib. About 150 patients starting regorafenib were split into three groups:…

This study looked at whether a special PET scan (FDG-PET) can detect early whether breast cancer is responding to chemotherapy. 63 women with breast cancer had a PET scan before and after their first chemo cycle. The goal was to see if the scan could tell responders from non-resp…

This study checks for muscle loss (sarcopenia) in 25 women with advanced ovarian cancer before they start chemotherapy. Using CT scans, researchers want to see how common this condition is and if it affects treatment timing. The goal is to better understand how muscle health rela…

This completed Phase 2 trial looked at whether the sentinel lymph node technique—a less invasive way to check if cancer has spread—works for women with multifocal breast cancer (more than one tumor in the same breast). 216 women with early-stage, node-negative multifocal breast c…

This study followed 150 people with solid tumors who were starting immunotherapy (immune checkpoint inhibitors) as part of their regular care. Researchers collected data on side effects and asked patients to fill out questionnaires before each treatment. The goal was to better un…

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

This study looked at whether offering genetic testing to all young adults with cancer (ages 18-39) is better than only testing those who meet certain guidelines. About 749 participants were randomly assigned to either universal testing with a broad gene panel or standard testing …

This phase 3 trial compares a less invasive sentinel node biopsy approach to standard staging methods in 262 women with early-stage endometrial cancer at intermediate or high risk of recurrence. The goal is to see if the sentinel node policy reduces surgical complications while s…

Researchers want to learn which molecules on cancer cells the immune system attacks when checkpoint inhibitor drugs work well. They collect tumor and blood samples from adults with solid tumors who respond to these drugs, either during treatment or after surgery. The team then se…

This study is testing whether a green dye called ICG can help surgeons see tumors more clearly during surgery in children and teens with solid tumors. The dye is injected before surgery and makes tumor tissue glow under a special camera. The goal is to see if this technique helps…

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples. It will also test whether artificial intelligence (AI) can help analyze these samples faster and more accurately. Researchers will review records from 600 patients to measure diagnosis…

This study looks at whether providing cancer care at home is a good option for Black men with advanced prostate cancer. Researchers want to see if this approach can reduce healthcare disparities and improve quality of life. Participants will fill out questionnaires about their pr…

This study looks back at the medical records of 150 adults in Brazil diagnosed with adrenocortical carcinoma, a rare cancer of the adrenal glands. Researchers will collect details on age, gender, location, tumor stage, hormone activity, and treatments received since the year 2000…

This study looked at adrenal gland tumors to understand why they form, why some release extra hormones, and why some are cancerous. Researchers studied 690 people with known or suspected adrenal tumors. Participants underwent tests like blood draws, imaging scans, and urine colle…

This study tests whether a novel MRI technique called Fast Field Cycling imaging and the bacteria in the mouth and bowel can predict how well rectal cancer responds to chemoradiotherapy given before surgery. Researchers will scan 15 patients three times and collect saliva and sto…

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers want to understand how the cancer is found, what risk factors are involved, and how it is treated. The goal is to find ways to improve care and reduce …

This trial tests whether an early PET scan can help doctors choose the right treatment for people with locally advanced oesophago-gastric cancer. Patients receive one round of standard chemotherapy, then a second PET scan. If the tumor shows a strong response, they continue chemo…

This study looked at how cancer treatment changes patients' ability to stick with a Mediterranean diet. Researchers followed 116 patients starting chemotherapy or immunotherapy, checking their diet adherence and sensory changes (taste and smell) at the start and after 9 weeks. Th…

This study gathers blood, urine, stool, and tissue samples from 132 adults with primary liver cancer who are receiving or have received immunotherapy. Researchers will analyze these samples along with medical records to learn more about how liver cancer develops and responds to t…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…

This study looks at early gastric cancer, a disease where the tumor is confined to the stomach's inner layers. It asks whether the pre-surgery assessment (clinical staging) matches the actual findings after surgery (pathological staging) in a large group of Western patients. The …

This study investigates whether a protein called WT1 is present in colorectal cancer tissue and whether its presence relates to tumor characteristics like grade, spread, and invasion. Researchers will analyze tissue samples from 60 patients with colorectal adenocarcinoma using a …

This study is testing whether a special type of ultrasound, called endoscopic ultrasound elastography, can predict the texture of the pancreas and the risk of a pancreatic fistula after a major surgery called pancreaticoduodenectomy. The study will enroll 100 adults scheduled for…

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This trial explores whether a blood test measuring reticulocyte hemoglobin content (RET-He) can predict how well cancer patients with anemia will respond to intravenous iron treatment. The study involves adults with solid tumors who have functional iron deficiency. By checking RE…

This study looks at genes in men with advanced prostate cancer that has spread and is no longer responding to hormone therapy. Researchers will analyze tissue, blood, and urine samples from 92 patients receiving a drug called abiraterone. The goal is to find genetic changes that …

This study follows over 2,700 people with bladder, lung, or liver cancer who are receiving the drug atezolizumab as part of their normal treatment. Researchers are tracking how long patients live and how well the drug controls their cancer outside of a controlled clinical trial. …

This study looked at whether offering genetic counseling by phone or video could help more childhood cancer survivors get genetic testing. About 391 survivors took part, comparing remote counseling to usual care. The goal was to see if remote services increase testing uptake and …

This completed study from Minia University looked at 200 patients with autoimmune thyroiditis (an inflamed thyroid) who had thyroid surgery. The goal was to see how often thyroid cancer is found by accident when examining the removed tissue. Researchers checked for cancer in pati…

This study reviews existing medical records to understand how blood clots (VTE) are treated in people with active cancer or a history of cancer. Researchers will look at which blood thinners are used, how often clots come back, and the costs involved. No new treatments are given—…

This study reviews the medical records of 20 people treated for eyelid carcinomas at a hospital in eastern Morocco. Researchers are examining patient characteristics, tumor types, and surgical approaches to better understand how these cancers present and are managed in this regio…

This study looks at how two heat-based procedures — radiofrequency ablation and microwave ablation — affect the immune system in people with small liver cancers. Researchers will take blood samples and tissue biopsies before and after treatment to track changes in immune cells. T…

This study compares two catheters used during the mapping step before radioembolization for liver cancer. One is a standard microcatheter, the other is a pressure-enabled device (TriNav). The goal is to see if the pressure-enabled catheter delivers more radioactive tracer directl…

This study developed an artificial intelligence model that analyzes MRI scans and pathology images to predict the risk of liver cancer returning after surgery. Researchers used data from over 500 patients who had their liver cancer surgically removed. The goal is to help doctors …

This study analyzed data from 1005 liver cancer patients to see who benefits from a treatment called TACE after surgery. Using machine learning, researchers aimed to predict individual patient outcomes. The goal is to help doctors decide whether to recommend TACE or just monitor …

This study looks at whether simple, non-invasive blood test scores can predict the risk of developing liver cancer in people with advanced liver disease who have been cured of hepatitis C. Researchers analyzed data from 571 adults treated at a single hospital over ten years. The …

This completed study looked at 40,000 people with metastatic cancer who received the drug nivolumab. Researchers compared the old way of dosing (based on body weight) with a newer, simpler fixed dose. They used national health data to see if the fixed dose was just as good and mo…

This study investigates whether having an empty bladder reduces movement of the mesorectum (tissue around the rectum) during radiotherapy for rectal cancer. About 50 adults with rectal cancer receive planning CT scans and weekly CBCT scans under both empty and full bladder condit…

This completed study looked at a new antibody called anti-SIRPα as a potential immunotherapy for liver cancer. Researchers used blood and tissue samples from 30 liver cancer patients to see how the antibody affects immune cells. The goal was to understand whether blocking the SIR…

This completed study examined whether a specific variation in the VEGF gene (rs699947) is linked to a higher risk of developing kidney cancer in people who have received a kidney transplant. Researchers analyzed DNA from 272 transplant patients, some of whom had kidney cancer. Th…

This study tested a prediction tool (nomogram) to see if it could forecast how patients with metastatic clear cell renal cell carcinoma respond to the targeted therapy sunitinib. Researchers looked at 45 patients who had their kidney removed and were treated with sunitinib as the…

This study looks at the DNA of 100 children (and young adults up to age 17) who have cancer, along with the DNA of their healthy parents. The goal is to find genetic changes that may have caused the cancer. By comparing the child's DNA to both parents', researchers hope to discov…

This study looked at 100 patients who had sleeve gastrectomy for severe obesity. Researchers checked how many developed Barrett's esophagus, a condition that can lead to esophageal cancer, five or more years after surgery. They also examined whether routine endoscopy (a camera te…

This study tested whether letting patients move freely between the injection of a radioactive tracer and the PET scan affects image quality. Normally, patients must rest for an hour to avoid muscle uptake that can blur results. The trial involved 284 adults with cancer or needing…

This study looked at 180 people with liver cancer (hepatocellular carcinoma) who also had cirrhosis caused by either fatty liver disease or alcohol use. Researchers compared immune cells and gut bacteria in the liver to understand why cancer develops. The goal was to gather knowl…

This study looks at whether it's possible for people diagnosed with solid tumors to have a follow-up visit with their general practitioner within 15 days of learning their diagnosis. Researchers will track how many patients actually attend this visit and why some might not. The g…

This study followed 623 adults in France with advanced kidney cancer who were starting treatment with the immunotherapy drugs nivolumab (with or without ipilimumab) for the first time. Unlike a clinical trial, this was an observational study that simply tracked what happened in e…

This study followed 326 adults in Zambia with chronic hepatitis B for up to 5 years. Researchers tracked how the virus behaves, how many patients need treatment, and how many develop serious liver problems like cirrhosis or liver cancer. The goal was to better understand the dise…

This study enrolled 200 adults with lung adenocarcinoma that has spread to the bones. Researchers took bone biopsies, scans, and blood tests to measure bone and metabolic markers. The goal is to see if these markers are linked to how long patients live. This is an observational s…

This pilot study tested whether it's possible to adjust proton radiation plans each day while the patient is on the treatment table. Ten adults with solid tumors took part. The goal was to see if this approach is safe and practical enough to study in a larger trial.

This study looked at 10 people with liver cancer (HCC) who were getting a standard treatment called chemoembolization (c-TACE). The goal was to see if mixing the chemotherapy drug doxorubicin with salt water or a contrast dye changes how the drug spreads inside the tumor. Researc…

This study created a new tool called the SAH Index to fairly evaluate how well hospitals and surgeons perform gastric cancer surgery. Gastric cancer is serious and often requires major surgery, but comparing results is tricky because patients have different health risks. The rese…

This study looked at how lifestyle factors like obesity and muscle loss affect kidney cancer risk and survival after kidney removal. Researchers collected blood, tissue, and questionnaire data from 161 patients over up to 5 years. The goal was to understand how to personalize tre…

This study created and tested an educational website to help Black and African American cancer patients learn about personalized cancer treatments and clinical trials. Researchers interviewed 48 patients and caregivers, then tested the website with 33 patients. The goal was to se…

This study looked at whether an AI computer program could suggest cancer treatments that match what experts recommend. Researchers reviewed medical records of 30 people with stomach, colon, or pancreatic cancer. They entered key details into the AI and compared its suggestions to…

This registry followed over 1,000 liver cancer patients who received SIR-Spheres—tiny radioactive beads injected into the liver's blood supply to kill tumors. The goal was to see how this treatment is used in real hospitals and how it affects survival, side effects, and quality o…

This study aimed to improve how doctors predict whether prostate cancer has spread to nearby lymph nodes. Researchers combined patient information, MRI scans, and genetic data from 367 men who had their prostate removed. The goal was to create a more accurate tool to help decide …

This study analyzed data from nearly 3,000 patients who had surgery for esophageal cancer between 2000 and 2010. Researchers looked at factors like patient health, treatment approach, and surgical technique to see what influences cancer recurrence and survival. The goal is to bet…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study tracked 295 adults who had high-risk surgery for stomach, esophagus, pancreas, or liver cancer. Researchers measured quality of life before surgery and again at 6 and 12 months after. They also asked patients and their family members if they regretted the decision to h…

This completed study from the University of Aberdeen looked at how dietary fiber supplements might influence prostate cancer. Researchers gave mice different fibers (inulin, pectin, hemp hull) along with stool samples from healthy men over 60. They then measured changes in gut ba…

This study aimed to find biological markers (biomarkers) in pancreatic tumor cells and blood that could help predict how well a patient might respond to treatment. Researchers analyzed genetic and protein information from tumor samples collected via ultrasound-guided biopsy, as w…

This study looked at whether analyzing the DNA of a patient's tumor can help doctors pick a targeted therapy for advanced or metastatic cancer. Researchers enrolled 550 adults with various solid tumors that had spread. They took biopsy or blood samples to search for genetic chang…

This study looked at 211 people with liver cirrhosis to see which screening method works better for detecting liver cancer: an ultrasound every 6 months or an MRI once a year. Participants received both tests, and researchers measured how often each test correctly found cancer. T…

This study looked at whether giving a short, strong dose of radiation right before surgery is possible for people with pancreatic cancer. Ten patients took part to see if the approach was safe and could help surgeons remove the tumor completely. The main goal was to check for com…

This study tested whether it is safe and possible to collect a blood sample from the portal vein (a major liver blood vessel) during a routine endoscopic ultrasound in 23 people with pancreatic cancer. The goal was to find and count circulating tumor cells (cancer cells in the bl…

This study examined small RNA molecules called microRNAs in tissue samples from 57 people with pancreatic cancer. The samples were collected during a routine endoscopic ultrasound procedure. Researchers aimed to see if certain microRNA patterns are linked to how aggressive the ca…

This study looked at 74 people with metastatic colorectal cancer starting their first chemotherapy. Researchers took blood samples early in treatment to measure three markers: CEA, circulating tumor DNA, and total cell-free DNA. The goal was to see if early changes in these marke…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This completed study involved 775 women who had breast-conserving surgery and radiation for breast cancer. Researchers compared different surgery and radiation techniques to see which ones led to less breast hardening (fibrosis) and better cosmetic results. The goal was to find w…

This completed study looked at 300 cancer patients treated with immune checkpoint inhibitors to see if measuring troponin levels could help detect serious heart problems early. The goal was to prevent major cardiovascular events like heart attack or stroke without unnecessarily s…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might affect blood vessels and increase heart risks. Researchers measured blood vessel function and checked for related markers in 39 cancer patients before and after starting treatment. The goal was to…

This study tested whether 3D ultrasound can accurately measure kidney and tumor volumes compared to standard CT or MRI scans. 53 adults with chronic kidney disease or kidney tumors participated. Researchers compared 3D ultrasound measurements to those from contrast-enhanced CT or…

This study tested whether having a clinical pharmacist review medications for cancer patients before they start treatment could prevent drug-related problems. Researchers observed 440 adults with solid tumors who were about to receive chemotherapy, immunotherapy, or oral targeted…

This completed study looked at how kidney cancers are found—either because a patient had symptoms or by chance during a scan for something else. Researchers reviewed 1000 patients who had surgery for kidney lesions in the Czech Republic. The goal was to see which detection method…

This study looked at how often a muscle enzyme called CPK increases in people with solid tumors who are taking a type of targeted therapy called tyrosine kinase inhibitors (TKIs). Researchers measured CPK levels in routine blood tests from 154 patients and checked if high levels …

This study looked at how common frailty is in people aged 70 and older with solid tumors who visited a cancer center. Researchers used a short questionnaire called VES-13 to screen patients before their doctor visit. They also compared the test results with the doctor's own judgm…

This study compared anxiety, depression, and quality of life between 125 cancer patients who joined clinical trials and those who received standard treatment. Researchers used questionnaires to measure stress and emotional well-being. The goal was to understand how trial particip…

This study looked at how safe and effective a combination of two drugs (Atezolizumab and Bevacizumab) is for people with liver cancer and cirrhosis, compared to standard pills (tyrosine kinase inhibitors). Researchers followed 38 patients to see how long they lived and how their …

This study tested whether a blood test that looks at tiny particles called exosomes can find cancer that has spread but is not visible on scans in people with a type of bile duct cancer (intrahepatic cholangiocarcinoma). The goal was to help doctors know who needs stronger treatm…

This study looked at how patients with advanced kidney cancer fared when taking the drug axitinib after first trying sunitinib. Researchers did not give any new treatment—they simply observed 554 patients to see how long the drug worked and how long patients stayed on it. The goa…

This study explored whether small particles called exosomes, found in blood and urine, can help predict how well treatment works in people with advanced kidney cancer. Researchers followed 91 patients for 16 weeks, collecting samples and comparing them to imaging results. The goa…

This study watched 225 people with solid tumors who got a drug called G-CSF during chemotherapy. G-CSF can cause bone pain. Researchers measured pain levels and tracked what treatments (like pain relievers or other methods) helped. They also checked quality of life, fatigue, mood…

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This study involved 91 adults with advanced kidney cancer. Researchers collected blood and urine samples over 16 weeks to see if changes in tiny particles called exosomal miRNAs could predict whether treatment was working. The goal was to find a simple, non-invasive way to monito…

This pilot study tested whether routine genetic analysis of thyroid cancer samples could help surgeons decide how much of the thyroid to remove. Only 2 patients were enrolled. The goal was to see if a larger trial is possible, not to change treatment yet.

This study looked at 40 patients with pancreatic cancer to measure circulating tumor DNA (ctDNA) in blood from a vein near the pancreas and in the arm, as well as in fluid from the belly, during surgery. The goal was to see if these DNA levels could help predict how the disease p…

This study looked at whether liver cancer spreads differently in men and women. Researchers analyzed data from over 19,000 patients and used computer models to create separate prediction tools for each gender. The goal was to better understand risk factors for cancer spread at th…

This completed study followed over 3,600 people with stage I to III colon cancer who had surgery. The goal was to learn how far cancer spreads to lymph nodes and how much bowel and tissue should be removed for the best outcome. The results could help guide surgeons in the future,…

This completed study looked back at the medical records of 200 patients with advanced clear cell kidney cancer who received Tivozanib as their first treatment. The goal was to see how long patients went without their cancer getting worse and how long they lived overall. The study…

This study tested whether an educational session at a church could help Latino adults learn more about colorectal cancer and feel more willing to join cancer clinical trials. Sixty Spanish-speaking participants watched videos and completed surveys. The goal was to understand barr…

This study looked at whether organochlorine pesticides, which build up in body fat over time, are more common in people with pancreatic cancer. Researchers compared fat and urine samples from 56 patients undergoing surgery—some with pancreatic cancer and some without. The goal wa…

This study looked at 807 adults with adrenal tumors found by accident during scans for other reasons. Researchers compared the usual approach of repeat CT scans to a single urine steroid profile test to see which is more cost-effective for detecting cancer. The goal is to find a …

This study analyzed 2000 women who had surgery for endometriosis to see if the lesions tend to appear more on the right or left side of the pelvis. By carefully recording the location of each lesion during surgery, researchers hope to learn more about how endometriosis develops. …

This study looked at 258 adults with untreated oeso-gastric cancer to understand how factors like income, education, and personal beliefs affect the time between first noticing symptoms and seeing a doctor. Researchers measured the median delay from symptom onset to first consult…

This study looked at how chemotherapy impacts the quality of life of women treated for stage II or III endometrial cancer. Researchers asked 51 patients to fill out questionnaires about their physical, emotional, and social well-being at least two years after finishing treatment.…

This study looked at whether two easy-to-use frailty checklists (FRAIL and FiND) can predict severe side effects from chemotherapy in adults aged 65 and older with gastrointestinal cancers. Researchers followed 84 patients who had already had surgery and were receiving standard c…

This study tested a new way of helping patients breathe during a procedure that destroys liver tumors with heat or electricity. The new method, called flow-controlled ventilation, keeps the diaphragm more still than standard methods, which could help doctors place needles more ac…

This study tracked 300 cancer patients receiving their first round of chemotherapy to see how often nausea and vomiting still happen, even with standard anti-nausea medicines. Participants filled out questionnaires about their symptoms in the first 24 hours and up to 4 days after…

This completed study looked at immune cells in the blood and tumor tissue of 100 people with colon cancer. Researchers measured T cells and other white blood cells to understand the body's immune response. The goal was to gather knowledge, not to test a new treatment. Participant…

This completed study looked at the genetic makeup of liver cancer in 808 patients to better understand the disease. Researchers analyzed tumor samples from people treated with surgery, ablation, or transplant, as well as those with advanced cancer. The goal was to identify key ge…

This completed study enrolled 43 people with kidney cancer who were starting sunitinib (Sutent). Researchers measured the drug's level in the blood and checked for genetic differences that might affect how the body processes it. The goal was to understand why sunitinib levels var…

This study looked at how DNA from tumors changes in the blood before, during, and after surgery for breast, prostate, or colon cancer. Thirty adults having curative surgery provided blood samples to measure these DNA levels. The goal was to understand the natural pattern of DNA c…

This study looked at 119 children who had platinum-based chemotherapy for certain cancers. Researchers wanted to find out if certain genes make some kids more likely to develop hearing loss from the treatment. By analyzing DNA from saliva samples, they hope to identify high-risk …

This study looked at 35 people having surgery for pancreatic cancer to see if moving the tumor during the operation causes more cancer DNA to enter the bloodstream. Researchers took blood samples before, during, and after surgery to track these DNA levels. The goal was to better …

This study tested a new surgical approach for removing kidney tumors using a robot. It compared the new method to the standard one in 40 adults. The goal was to see if the new method saves time and feels better for the surgeon.

This study looked at whether measuring circulating tumor cells (CTCs) in the blood can help doctors decide when to switch chemotherapy for women with metastatic breast cancer that has worsened after two prior treatments. The trial involved 265 women and compared standard care wit…

This completed study aimed to create a biobank of 'organoids'—tiny, 3D mini-tumors grown from liver cancer tissue. Researchers collected samples from 48 patients with colorectal cancer that spread to the liver or with primary liver cancer. The goal was to see if they could reliab…

This study looked at the genes in tumors from 332 people with advanced pancreatic cancer. The goal was to see if genetic changes could help doctors choose better treatments. Researchers compared genetic information with how patients responded to their first chemotherapy. This is …

This completed observational study collected over 3,700 PillCam SB3 capsule endoscopy videos from standard care procedures. The goal was to build a large database of images showing both normal and diseased small intestine tissue. Researchers will use this data to develop and vali…

This completed study surveyed over 700 primary care doctors, gastroenterologists, and patients across seven U.S. health systems. The goal was to find out what knowledge gaps, attitudes, and practical barriers prevent people from getting screened for Barrett's esophagus, a conditi…

This study tested over 1,000 women with endometrial cancer for DNA repair problems that can be inherited (Lynch syndrome). By analyzing tumor DNA, researchers aimed to personalize cancer treatment and identify family members who might also be at risk. The goal was to improve care…

This study reviewed medical records of 300 liver cancer patients treated in Brazil between 2017 and 2022. Researchers aimed to understand patient characteristics, how the cancer was managed, and survival outcomes. No new treatments were tested; instead, the goal was to gather rea…

This study looked at whether patient navigators can help women with breast cancer in Mozambique start treatment sooner. Ninety women received support from trained navigators from admission to their first treatment. Researchers measured time delays and survival rates compared to p…

This study observed 799 adults with advanced or metastatic pancreatic cancer in Korea to see which chemotherapy treatments doctors actually use and why. Researchers tracked treatment choices, survival times, and quality of life. The goal was to understand real-world practice, not…

This study looked at 228 women with ductal carcinoma in situ (DCIS) or micro-invasive DCIS who needed a mastectomy. Researchers wanted to see if doing a sentinel lymph node biopsy upfront could help avoid a more extensive axillary lymph node dissection later. The goal was to find…

This study looked back at over 7,000 colon cancer patients who had surgery to remove their tumors. Researchers wanted to see how the cancer's stage and lymph node involvement affected whether the cancer came back and how long patients lived. By grouping patients by tumor and node…

This completed study analyzed tumor and blood samples from 166 people with advanced liver cancer who received a combination of atezolizumab and bevacizumab. The goal was to find biomarkers—biological clues—that could predict how well a patient responds to treatment and how long t…

This study looked at 314 patients with small, early-stage papillary thyroid cancer who had surgery to remove half of the thyroid. During the operation, doctors checked nearby lymph nodes for hidden cancer spread. If cancer was found, the rest of the thyroid was removed in the sam…

This study looked at whether waiting 10-12 weeks instead of the usual 4-6 weeks after chemoradiation before surgery helps patients with esophageal or gastric cardia cancer. 202 participants were randomly assigned to one of the two timing groups. The goal was to see if a longer de…