Hidden thyroid cancers: how common are they in patients with thyroiditis?
NCT ID NCT07652450
First seen Jun 24, 2026 · Last updated Aug 12, 2026 · Updated 5 times
Summary
This completed study from Minia University looked at 200 patients with autoimmune thyroiditis (an inflamed thyroid) who had thyroid surgery. The goal was to see how often thyroid cancer is found by accident when examining the removed tissue. Researchers checked for cancer in patients with conditions like Hashimoto's disease and Graves' disease, and compared rates between different types of thyroiditis.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If the results show a clear link, it could help doctors better understand which patients with thyroid inflammation might need closer monitoring for cancer.
- What could go wrong
- This is an observational study, not a treatment trial, so it cannot prove cause and effect. The findings may not apply to all patients or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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98 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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May 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. All types of autoimmune thyroiditis, including: * Graves' disease * Toxic multinodular goiter (TMNG) * Toxic nodule (TN) * Hashimoto thyroiditis * Unspecified toxic nodular goiter 2. Age between 18 and 60 years 3. Underwent thyroid surgical operation (lobectomy or total thyroidectomy) Exclusion Criteria: 1. Patients with known differentiated thyroid cancer before surgery 2. Recurrent thyroid disease (previous thyroid surgery) 3. Patients unfit for operation (American Society of Anesthesiologists grade IV or V) 4. Incomplete histopathological data 5. Patients with medullary thyroid carcinoma or anaplastic thyroid cancer
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of medicine
Minya, Minya Governorate, 61611, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Two autoimmune conditions, one child: study probes hidden thyroid trouble
- Eye damage in Graves' disease: can early clues predict who is at risk?
- Why does Graves' disease leave some brains exhausted? scientists hunt for clues in blood and spinal fluid
- Hidden thyroid cancers may be more common in Graves' disease than thought
- Can a steroid shot make thyroid surgery safer?
- Targeting the immune system: a new antibody may free Graves' patients from daily drugs