New hope: hepatitis c drugs after liver cancer treatment
NCT ID NCT02771405
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether interferon-free drug combinations can cure hepatitis C in 150 people who had been successfully treated for liver cancer. Participants took pills like sofosbuvir and ribavirin for 12 weeks. The main goal was to see if the virus stayed undetectable 12 weeks after treatment, and to check for any cancer return.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Sofosbuvir, Ribavirin, Simeprevir, Daclatasvir, Ledipasvir
- What this could lead to
- If successful, this could show that treating hepatitis C after liver cancer treatment reduces cancer recurrence and improves long-term outcomes.
- What could go wrong
- This is a completed Phase 3 trial, but results may not apply to all patients. There is a risk of virologic failure or cancer recurrence despite treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Mar 2016
- Finished
-
Jan 2018
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 70 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18-70 years old * Confirmed HCV viremia by PCR * CHILD Pugh "A" or "B7,B8" * Confirmed HCC either by laboratory ,imaging or histopathological criteria * Underwent or candidate for curative intervention for HCC (BCLC stage 0 ,A) * Willing to be treated for HCV and signing informed consent Exclusion Criteria: * Patients below 18 or above 70 years old * patients with advanced liver condition "CHILD score ≥ B9" * Patients with advanced HCC status (BCLC≥ B) * Patients with combined HBV ,HIV infection
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Amr Maged
Cairo, 11441, Egypt
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Other studies related to the condition(s) this trial covers.
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