Ultrasound vs. MRI: which is better for catching liver cancer early?
NCT ID NCT02551250
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 211 people with liver cirrhosis to see which screening method works better for detecting liver cancer: an ultrasound every 6 months or an MRI once a year. Participants received both tests, and researchers measured how often each test correctly found cancer. The goal is to find the most effective way to catch liver cancer early in high-risk patients.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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211 people
The number who actually took part.
- Started
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Sep 2015
- Finished
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Dec 2020
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with the risk of annual HCC occurrence larger than 5%
- Ages
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40 to 99 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female subject older than 40 years of age at the enrollment * Fulfill below conditions A and B A. The evidence of cirrhosis of any etiology within 12 months prior to screening Definition of cirrhosis by any of following methods 1. Histologically by liver biopsy; 2. Non-histologically by evidence of portal hypertension in the presence of chronic liver disease; * Evidence of portal hypertension, including any of followings; * The identification of splenomegaly on ultrasonography, CT, or MRI examinations with typical features of cirrhosis * The identification of esophageal or gastric varices on endoscopic examination B. Risk Index larger than 2.33; Risk Index = 1.65 (if the prothrombin activity is \<=75%) + 1.41 (if the age is 50 years or older) + 0.92 (if the platelet count is \<=100,000/mm3) + 0.74 (if the presence of HCV is positive). Exclusion Criteria: * Presence of liver cancer or other intrahepatic malignancy * Has a history of malignancy within previous 5 years * Is pregnant or breast-feeding
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Korean University Guro Hospital
Seoul, South Korea
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Samsung Medical Center
Seoul, South Korea
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Seoul National University Hospital
Seoul, South Korea
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Seoul St.Mary's Hospital
Seoul, 06591, South Korea
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St.Vincent's Hospital
Suwon, South Korea
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Uijeongbu St.Mary's Hospital
Uijeongbu-si, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a digital platform catch liver cancer sooner?
- Can a Two-Drug combo keep cirrhosis patients out of the hospital?
- Can removing the spleen help the liver fight cancer?
- Blood test may forecast which cirrhosis patients survive after discharge
- Can a parasite drug help fight a deadly gut infection in cirrhosis?