LIVER CIRRHOSIS

This study compares a procedure called TIPS (a shunt that reroutes blood in the liver) against standard treatments like water pills and fluid drainage for people with liver cirrhosis who have developed ascites (fluid buildup in the belly). The goal is to see if early TIPS placeme…

This study tests whether phycocyanin, a natural protein from spirulina, can improve liver health in adults with liver fibrosis or cirrhosis. Ten participants will take either phycocyanin or a placebo daily for at least 4 weeks. Researchers will measure changes in liver stiffness …

This study looks at how well liver transplantation works for people with severe acute-on-chronic liver failure (ACLF). Researchers will track 3,000 adults with cirrhosis who are listed for a transplant to see who survives and how to improve outcomes. The goal is to find the best …

This study tests a new medicine called BI 3802876 in 30 adults with liver scarring (cirrhosis) caused by MASH, a fatty liver disease. The goal is to see if the drug is safe and how the body processes it. Participants get either the drug or a placebo by IV infusion twice over 6 mo…

This study compares two ways of placing a stent (a small tube) in the liver to prevent dangerous bleeding from enlarged veins in the throat and stomach in people with liver scarring (cirrhosis). The standard method uses a fully opened stent, while the experimental method uses a s…

This study tests a new way to place a stent (a small tube) in the liver to treat serious complications of cirrhosis, like bleeding or fluid buildup. The new technique uses a smaller balloon to keep the stent slightly narrow at first, which may lower the risk of a brain condition …

This study tests if taking capsules containing healthy donor stool (fecal transplant) can lower the risk of serious infections and hospital visits in people with liver cirrhosis. About 300 adults with alcohol-related or fatty liver cirrhosis will receive either the real treatment…

This study is testing whether eating protein evenly throughout the day combined with exercise can improve nutrition, muscle mass, and physical function in 90 adults waiting for a liver transplant. Participants are randomly assigned to one of three groups: even protein distributio…

This study looks at whether a special ultrasound technique, combined with liver stiffness and platelet count, can accurately detect high-risk varices (enlarged veins) in the stomach and esophagus of people with liver cirrhosis. About 380 adults with cirrhosis will be tested. The …

This study is testing a new type of PET/MRI scan to see if it can give a complete picture of the liver in people with cirrhosis. The goal is to measure liver function, blood flow, and detect cancer or high blood pressure in the liver all at once. About 45 adults with cirrhosis wi…

This study tests whether a blood test (GALAD) is better than ultrasound for finding liver cancer early in 5500 people with cirrhosis or chronic hepatitis B. Participants will be randomly assigned to one of two screening methods every six months. The goal is to see which approach …

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen at high speeds) can reduce the risk of dangerously low oxygen levels during sedated gastrointestinal endoscopy in critically ill patients. About 450 adults with serious health conditions…

This study looks at how severe liver disease (cirrhosis) and liver transplant affect hardening of the arteries. Researchers will follow 95 adults who need a liver transplant. They want to see if the transplant can slow or reverse artery hardening and restore a key blood substance…

This study is creating a registry and optional biobank for 500 adults with primary biliary cholangitis (PBC) in Austria. Researchers will collect medical data and blood samples during regular clinic visits to track how the disease progresses, including complications like liver ci…

This study follows 10,000 people with advanced chronic liver disease to see how their condition changes over time. Researchers collect medical data and samples like blood, urine, and tissue to better understand cirrhosis and its complications. The goal is to learn more about the …

This study looks at why some people with liver cirrhosis develop dangerous blood clots in the portal vein (the main vein to the liver). Researchers will take blood samples from both the neck vein and the portal vein during a routine procedure called TIPS. They aim to compare clot…

This study looks at whether easy-to-measure vital signs like heart rate and blood pressure can help predict how well liver cirrhosis patients with gastrointestinal bleeding will do. Researchers will enroll 150 participants and track these signs to see if they can improve emergenc…

This study is testing a new blood test called Elecsys® GAAD to see if it can find liver cancer earlier in people with liver cirrhosis. Current methods often catch the cancer too late, leaving few treatment options. Researchers will compare the new test with standard tests in 600 …

This study follows 2,000 people with severe liver-related high blood pressure who are getting a TIPS procedure—a small tube placed in the liver to reroute blood flow. Researchers will track survival, need for liver transplant, and complications like confusion or liver failure ove…

This study looks back at medical records of 600 adults with liver cirrhosis to understand how often they use healthcare services like doctor visits, scans, and procedures. Researchers want to find patterns and factors, such as social or emotional issues, that affect healthcare us…

This study looks at how two blood thinners, rivaroxaban and apixaban, are processed by the body in people with mild to moderate liver cirrhosis (Child-Pugh class A and B). 24 participants will receive a single dose of one of the drugs, and blood samples will be taken over 12 hour…

This study aims to find early warning signs for bleeding or clotting problems in adults who receive a liver transplant from a living donor. Researchers will follow 30 people with end-stage liver cirrhosis for a short time after surgery. The goal is to create a better prevention p…

This study is gathering information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when donor livers are preserved using machine perfusion. The goal is to help doctors better understand which preservation…

This study looks at whether using a special blood test (thrombelastography) before a TIPS procedure can help doctors decide if patients with liver cirrhosis really need blood products or transfusions. The goal is to see if this approach is safe and reduces the amount of blood pro…

This study aims to create and test a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness and trouble focusing, which are often missed in regular checkups. About 230 participants will fill out th…

This study looks at 200 adults with alcohol-related liver cirrhosis to measure their health literacy (understanding health information) and self-efficacy (confidence in managing their health). Researchers will track how these factors relate to serious liver events and hospital re…

This study looks at whether handgrip strength—a simple measure of muscle function—is linked to blood flow changes in the liver's main vein (portal vein) in people with liver cirrhosis. Researchers will measure pressure, speed, and direction of blood flow using different methods (…