LIVER CIRRHOSIS

This study looked at whether giving two drugs together—midodrine and albumin—works better than midodrine alone to prevent serious liver-related problems in children with cirrhosis and fluid buildup in the belly (ascites). The trial involved 61 children and aimed to see if the com…

This study tested whether giving growth hormone to people with advanced liver cirrhosis could help them live longer without needing a transplant or having serious complications like fluid buildup or infections. 96 adults with decompensated cirrhosis took part. The goal was to see…

This study tested a nurse-led mobile app called ReLiver-N designed to help people with liver cirrhosis take a more active role in their care. The app provides health education, tracks symptoms, and gives personalized feedback. Researchers measured whether using the app improved p…

This study tested whether a computer program (Simcyp) could help predict the right dose of two blood pressure drugs (nebivolol and carvedilol) for 40 people with liver cirrhosis and high blood pressure. Participants were split by liver disease severity and given the closest avail…

This study looked at the long-term safety and effects of using a patient's own stem cells to treat liver cirrhosis caused by hepatitis B, C, or fatty liver disease. 700 adults with compensated cirrhosis were followed after receiving the therapy. Researchers measured liver stiffne…

This early-stage study tested a single infusion of stem cells from donated umbilical cords in 20 adults with liver cirrhosis. The main goals were to see if the treatment is safe and if it improves liver function over a year. The approach aims to control the disease and reduce liv…

This study looked at whether transplanting healthy stool bacteria (fecal microbiota transplantation) could help people with liver cirrhosis. Nineteen adults with cirrhosis received the transplant, and researchers measured liver stiffness and brain function one month later. The go…

This study tested a drug called foscenvivint in 5 adults with liver cirrhosis caused by HIV and hepatitis C co-infection who also have hemophilia. The goal was to see if the drug could improve liver function and was safe. Participants received the drug and were monitored for 24 w…

This study tested whether a combination of two drugs, zibotentan and dapagliflozin, is safe for people with liver cirrhosis. 73 adults with cirrhosis took either the combination, zibotentan alone, or a placebo. The main goal was to see if the drugs caused fluid retention, a commo…

This study tested whether a special type of ultrasound with contrast dye (CEUS) can more accurately identify liver lesions found on regular ultrasound. Researchers compared CEUS to CT, MRI, and biopsy in 878 adults with liver spots. The goal was to see if CEUS could provide a rel…

This study tested a sleep medication called lemborexant in 82 adults with liver cirrhosis who had trouble sleeping. The goal was to see if it could improve sleep quality safely. The drug works by blocking wakefulness signals in the brain to promote natural sleep.

This study tested a telemedicine platform called myLIVERcoach in 50 adults with liver cirrhosis. Participants used the app alongside standard care to answer questionnaires and track symptoms, aiming to catch complications early. The goal was to see if patients, caregivers, and do…

This study looked back at medical records of 490 patients with liver cirrhosis who also had signs of a liver-kidney syndrome. Researchers compared how well patients with and without chronic kidney disease responded to standard treatment with terlipressin and albumin. The goal was…

This study compared two methods of taking a liver biopsy: one using an endoscope with ultrasound (EUS) and the other using a needle through the skin (percutaneous). The goal was to see which method provides better tissue samples for diagnosing liver diseases like cirrhosis. 90 ad…

This study followed 100 adults hospitalized with liver cirrhosis to see how many survived 90 days after admission. Researchers also looked for factors that increased the risk of death. The goal was to better understand short-term outcomes, not to test a new treatment.

This study tested whether a computer program could help doctors choose the right dose of a statin (simvastatin) for people with liver cirrhosis and high blood pressure in the liver (portal hypertension). Twenty-two adults with mild to moderate cirrhosis took part. The goal was to…

This study looked at two different ways to screen for liver cancer in people with liver cirrhosis: ultrasound every 6 months versus MRI once a year. Researchers wanted to see which method finds cancer more accurately. A total of 211 adults over age 40 with cirrhosis took part. Th…

This study looked at how the drug zibotentan is processed in the bodies of 30 healthy adults, including both non-Asian and Japanese participants. Each person received a single dose of the drug, and researchers measured its levels in the blood over time. The goal was to gather inf…

This study tested a new ultrasound method called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to see how consistent the measurements are and how they differ between healthy and diseased livers. This i…

This study tested a special score called ICCO to see if it can predict which cirrhosis patients in the ICU are at higher risk of dying. Researchers calculated the score for 150 adults with cirrhosis admitted to the ICU and tracked their outcomes. The goal is to help doctors make …

This study looked at how the body handles four common medicines (rosuvastatin, digoxin, metformin, and furosemide) in healthy adults and in people with liver cirrhosis. Researchers measured drug levels in the blood to see if liver disease changes how these drugs are processed. Th…

This study looked at how well people with liver cirrhosis can find and understand health information online. 86 patients filled out two questionnaires about their digital skills and ability to read health-related charts and images. The goal was to learn more about patients' digit…

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 patients with liver cirrhosis and ascites (fluid buildup). Researchers wanted to understand if kidney problems change drug levels, which could affect safety and dosing. The goal is t…

This study looked at how well a combination of two drugs (Atezolizumab and Bevacizumab) works compared to standard pills (tyrosine kinase inhibitors) in 38 patients with liver cancer and cirrhosis. The goal was to see if the combo is safe and effective in everyday medical practic…

This study looked at how blood clotting works in people with liver cirrhosis, a condition that can cause dangerous bleeding. Researchers used a special machine called T-TAS to measure clotting under flow conditions, which is more realistic than standard tests. They also tested wh…

This study tested whether a computer program (Simcyp) could help doctors choose the right starting dose of warfarin, a blood thinner, for 21 patients with liver cirrhosis and a blood clot in the portal vein. The goal was to reach a safe and effective level of blood thinning more …

This study looked at how the body handles five common drugs (caffeine, warfarin, omeprazole, metoprolol, and midazolam) in healthy adults and in people with mild or moderate liver cirrhosis. Researchers measured drug levels in the blood to see if liver scarring changes how these …