LIVER CIRRHOSIS

This study tests a procedure called endoscopic ultrasound embolization for adults with liver cirrhosis who have severe confusion (hepatic encephalopathy) that doesn't improve with standard medicines. Participants will either receive the procedure or continue medical management. T…

This early study tests a new treatment for liver cirrhosis using a patient's own bone marrow cells mixed with growth factors and exosomes. Ten adults with cirrhosis (any stage) will receive the cells through an IV. The main goal is to see if the treatment improves liver function …

This study tests a new way to use a stent (a small tube) in the liver to lower blood pressure and prevent dangerous bleeding from enlarged veins in people with cirrhosis. The new method uses a smaller balloon to open the stent, which may reduce side effects like confusion. About …

This study tests a new combination of treatments for people with liver cancer that cannot be removed by surgery and who also have high blood pressure in the liver (portal hypertension). The treatment combines a procedure called TACE with three drugs: tislelizumab (immunotherapy),…

This study tests whether adding midodrine to the standard drug carvedilol can prevent early rebleeding in people with liver cirrhosis who have had a variceal bleed. About 210 adults with moderate to severe cirrhosis will be randomly assigned to receive either both drugs or carved…

This early-phase study tests the safety of a new treatment for liver cirrhosis. The therapy uses tiny particles (extracellular vesicles) from umbilical cord stem cells, given through a vein. Up to 12 adults with moderate-to-severe liver damage will receive increasing doses to see…

This study tests a device called DIALIVE 2.0, which acts like a dialysis machine for the liver, in people with acute-on-chronic liver failure (ACLF) grades 2-4. About 72 adults aged 18-70 with liver cirrhosis and recent worsening will either receive standard care or standard care…

This study compares two medications, terlipressin and somatostatin, in 64 adults with liver cirrhosis who have both acute gastrointestinal bleeding and acute kidney injury. The goal is to see which drug better reverses the kidney damage. Participants will be randomly assigned to …

This study compares two treatments for people with liver cirrhosis who have severe bleeding from enlarged veins in the stomach or esophagus and an overactive spleen. One treatment is a surgery to remove the spleen and disconnect certain veins, and the other is a less invasive pro…

This study aims to see if using a contrast-enhanced ultrasound called Sonazoid CEUS can detect early-stage liver cancer (HCC) better than standard ultrasound in people with liver cirrhosis. About 556 participants with cirrhosis will receive both types of ultrasound every 4 to 6 m…

This study explores whether a special ultrasound technique (dynamic contrast-enhanced ultrasound) can accurately diagnose a rare liver condition called porto-sinusoidal vascular disorder (PSVD) without needing a liver biopsy. Researchers will compare ultrasound images from 100 pe…

This study tests whether taking a low-dose aspirin (100 mg) every day can prevent liver cancer in people with cirrhosis, a condition that raises cancer risk. About 890 adults from Australian hospitals will take aspirin or a placebo for 4 years while continuing their regular check…

This study tests whether adding neuromuscular electrical stimulation (NMES) to resistance exercises can improve muscle strength and physical function in hospitalized adults aged 47–70 with alcoholic liver cirrhosis and sarcopenia (muscle loss). Participants will be randomly assig…

This study follows 750 adults with liver cirrhosis whose hospitals use remote monitoring as part of standard care. Researchers will track complications like fluid buildup, bleeding, and liver failure, as well as hospital admissions. No new treatment or device is being tested—the …

This study will follow about 2,500 adults with liver cirrhosis to learn who develops dangerous blood clots in the liver's main vein. Researchers will review past cases and track new patients for two years to build a prediction tool, measure how clots affect survival, and see if b…

This study checks how many adults with cirrhosis are immune to hepatitis A and how well a single vaccine dose works for those who aren't. About 360 participants will give blood samples and some will receive the vaccine. Results will help doctors decide who needs the shot.

This study looks at children under 18 with chronic liver disease to see if they have hidden heart problems. Researchers will use simple tests like blood work, ultrasound, and heart tracings to check for conditions like high blood pressure in the lungs or changes in heart muscle f…

This study will test new scoring systems to see if they can better predict serious complications and death in people hospitalized with liver cirrhosis. Researchers will compare these new scores to standard ones in 100 adult patients. The goal is to identify high-risk patients mor…

This study looks at whether a simple, painless ultrasound can predict the risk of dangerous bleeding from enlarged veins in the esophagus (varices) in people with liver cirrhosis. Researchers will measure spleen size and a key vein's width on ultrasound and compare those results …

This study tests a new fiber-optic navigation system during a procedure called TIPS, which treats complications of liver cirrhosis like fluid buildup or bleeding. About 30 adults needing this procedure will be enrolled. The goal is to see if the technology helps doctors complete …