Daily aspirin may slash liver cancer risk in cirrhosis patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Provide written informed consent to participate in the trial according to ICH GCP (R3) and national/local regulations. * Diagnosed with liver cirrhosis for at least 6 months * Has a current Child-Pugh score ≤6 (Child A - clinically and biochemically compensated cirrhosis) * Has been participating in ultrasound or non-ultrasound (computed tomography (CT) or magnetic resonance imaging (MRI)) based surveillance for at least 6 months prior to entry. * Has not had any focal lesions, other than haemangiomas, detected during the past 6 months. Exclusion Criteria: * Any of the following: * autoimmune liver disease. * primary biliary cholangitis. * primary sclerosing cholangitis. * prior HCC * alcohol consumption \>3 standard drinks per day in men and 2 standard drinks per day in women. * currently taking a nonsteroidal anti-inflammatory drug, anticoagulant drugs, non-vitamin K anticoagulant frugs, or other antiplatelet drugs, including aspirin, within the last 6 months. * a known bleeding disorder * a platelet count \<50 x 109/L. * known history or endoscopic evidence of high risk oesophageal (grade 2 or higher) or gastric varices or, a history of bleeding varices. * chronic iron deficiency anaemia. * a prior history of liver decompensation or liver transplantation. * known peptic ulcer disease. * chronic kidney disease with eGFR \<50ml/min; a contraindication to aspirin. * Any participant considered by the PI to be deemed unlikely to complete the study due to other comorbid conditions or poor compliance will also be excluded. Pregnancy: * Whilst low dose aspirin is considered safe in pregnancy, male and female participants of child-bearing potential are recommended use effective contraception during this trial. * Any female participants who fall pregnant during the trial will be withdrawn if their treating obstetric doctor advises that you should do so.