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Liver transplant kidney mystery: biopsy study aims to uncover hidden damage

NCT ID NCT07300709

Knowledge-focused Sponsor: The University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will take small kidney tissue samples from 42 liver transplant patients who have hepatorenal syndrome (HRS), a condition where the kidneys stop working properly due to severe liver disease. Researchers want to see if the kidneys are actually damaged or just temporarily affected. By analyzing the tissue, they hope to better understand HRS and improve future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal whether kidney damage in hepatorenal syndrome is permanent, leading to better diagnosis and treatment strategies.
What could go wrong
This is a small, early-stage observational study with only 42 participants. It is not testing a new treatment, so direct patient benefits are unlikely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 42 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient must be able to understand and provide informed consent 2. Age ≥ 18 years of age at time of study entry 3. Accepted for liver transplantation (LT) 4. Fulfill the diagnostic criteria of HRS AKI according to International Club of Ascites (ICA) guidelines 3-month post transplant renal biopsy inclusion criteria: 1. Patient with adequate intraoperative renal biopsy 2. Patient must be able to understand and provide informed consent Exclusion Criteria: 1. Inability or unwillingness to give written informed consent 2. Patient with known pre-existing renal disease 3. Patient with solitary kidney 4. Re-transplantation 5. ABO-incompatible LT 6. Fail to provide 3-month post transplant renal biopsy 3-month post transplant renal biopsy exclusion criteria: 1. Graft failure after LT 2. Any condition deemed inappropriate by the PI

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Conditions

The condition(s) this trial relates to.

acute kidney injury cirrhosis of liver hepatorenal syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AKI - acute kidney injury Hepatorenal syndrome, liver regeneration Liver transplant

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Queen Mary Hospital

    Hong Kong, Hong Kong

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