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Can a simple pill or a glue injection stop deadly stomach bleeding?

NCT ID NCT01298271

Prevention Sponsor: Taipei Veterans General Hospital, Taiwan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This trial asks whether endoscopic glue injection or the beta-blocker propranolol is better at preventing the first bleeding episode from gastric varices—enlarged veins in the stomach that can rupture in people with liver cirrhosis. Adults aged 18 to 80 with cirrhosis and gastric varices who have never bled from them are randomly assigned to one of the two treatments. The study tracks who experiences a first bleed and compares complication rates and survival between the groups.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propranolol (a beta-blocker) and endoscopic cyanoacrylate injection
What this could lead to
If successful, this could identify a better first-line strategy to prevent life-threatening gastric variceal bleeding in people with cirrhosis.
What could go wrong
This is a single-center trial with 120 participants, so results may not apply broadly. Both treatments carry risks, including bleeding, infection, or side effects from the medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

120 people

The number who actually took part.

Start date

Apr 2010

Finished

Dec 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. patients with live cirrhosis and/or hepatoma 2. Aged 18 to 80, who had endoscopy-Proven EV(-)GV(+)or EV\<GV Exclusion Criteria: 1. Patients had previous endoscopic, surgical treatment or Transjugular Intrahepatic Portosystemic Shunt 2. Had a terminal illness of any major organ system,such as heart failure, kindey failure,COPD

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bleeding gastric varices Liver cirrhosis

Contacts and locations

Locations

  • Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

    Kaohsiung City, Taiwan

  • Veteran General Hospital-Taipei

    Taipei, Taiwan, 11217, Taiwan

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