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Could stomach surgery raise cancer risk? new study investigates

NCT ID NCT03596411

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 100 patients who had sleeve gastrectomy for severe obesity. Researchers checked how many developed Barrett's esophagus, a condition that can lead to esophageal cancer, five or more years after surgery. They also examined whether routine endoscopy (a camera test) helps catch this early. The goal is to understand if regular screening should be recommended for these patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could show that routine endoscopy after sleeve gastrectomy helps catch early signs of esophageal cancer, leading to better prevention strategies.
What could go wrong
This is a small, retrospective study (100 patients) that only looks back at existing data. It cannot prove that screening prevents cancer, only suggest a link.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

May 2018

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Gastroesophagal reflux disease (GERD) in morbid obese after sleeve gastrectomy

Ages

18 to 60 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who had had SG with a minimum follow-up of 5 years, without signs of Barrett's esophagus before SG; * An upper GI endoscopy before the SG; * An upper GI endoscopy indicating that no Barrett's esophagus was present at the time of the SG; * An upper GI endoscopy done with the scope of searching for the endoscopic anomalies of the Barrett's esophagus according to the international guidelines for the diagnosis of Barrett's esophagus 9. * Endoscopic biopsies according to the international guidelines for the diagnosis of Barrett's esophagus 9. Exclusion Criteria: * SG as a conversional procedure from another bariatric procedure such as the gastric banding; * No upper GI endoscopy before the SG * Barrett's esophagus before the SG; * A second procedure after the SG such as the conversion to Roux-en-Y gastric bypass or duodenal switch; * An upper GI endoscopy done not following the international guidelines for the diagnosis of Barrett's esophagus9.

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Conditions

The condition(s) this trial relates to.

gastroesophageal reflux disease esophageal adenocarcinoma prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gastroesophageal reflux

Contacts and locations

Locations

  • CHU de Nice

    Nice, Alpes Maritimes, 06001, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.