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Massive study aims to settle debate on colon cancer surgery extent

NCT ID NCT02938481

Knowledge-focused Sponsor: Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study followed over 3,600 people with stage I to III colon cancer who had surgery. The goal was to learn how far cancer spreads to lymph nodes and how much bowel and tissue should be removed for the best outcome. The results could help guide surgeons in the future, but this was an observational study, not a test of a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help surgeons know exactly how much bowel and how many lymph nodes to remove during colon cancer surgery, improving outcomes.
What could go wrong
This is an observational study, not a treatment trial, so it does not test a new drug or therapy. The results may not apply to all patients or change practice directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

3,647 people

The number who actually took part.

Started

May 2013

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with colon cancer who will receive potentially curative surgery at participating institutions between 22 Jan 2015 and 22 Jan 2020.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically proven colon adenocarcinoma * Pathological stage Ⅰ, Ⅱ or Ⅲ * Potentially curative surgery * Informed consent for observational data collection Exclusion Criteria: * Tis (mucosal cancer) * Multiple colon cancers * All patients with preoperative adjuvant therapy

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Conditions

The condition(s) this trial relates to.

colon adenocarcinoma colon carcinoma colonic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colon cancer

Contacts and locations

Locations

  • Aichi Cancer Centre Hospital

    Nagoya, Aichi-ken, 464-8681, Japan

  • China Medical University Hospital

    Taichung, 40447, Taiwan

  • Fujita Health University

    Toyoake, Aichi-ken, 470-1192, Japan

  • I.M. Sechenov First Moscow State Medical University

    Moscow, Russia

  • Kanagawa Cancer Centre Hospital

    Yokohama, Kanagawa, 241-8515, Japan

  • Keiyukai Sapporo Hospital

    Sapporo, Hokkaido, 003-0027, Japan

  • Klaipeda University hospital

    Klaipėda, Lietuva, Lithuania

  • Kurume University School of Medicine

    Kurume, Hukuoka-prefecture, 830-0011, Japan

  • Kyorin University School of Medicine

    Mitaka, Tokyo, 181-8611, Japan

  • Mie University Graduate School of Medicine

    Tsu, Mie-ken, 514-8507, Japan

  • National Cancer Centre Central Hospital

    Chuo-ku, Tokyo, 104-0045, Japan

  • National Cancer Institute, Lithuania

    Vilnius, Lithuania

  • National Canser Centre Hospital East

    Chiba, Chiba, 277-8577, Japan

  • National Defense Medical College

    Tokorozawa, Saitama, 359-8513, Japan

  • National Taiwan University Hospital

    Taipei, Taiwan

  • Niigata Cancer Center Hospital

    Niigata, Niigata, Japan

  • Osaka International Cancer Institute

    Osaka, Osaka, 537-8511, Japan

  • Saisei-kai Yokohama-shi Nanbu Hospital

    Yokohama, Kanagawa, 234-0054, Japan

  • Saitama Cancer Center

    Kitaadachi-gun, Saitama, 362-0806, Japan

  • Shiga University of Medical Science

    Ōtsu, Shiga, Japan

  • Shizuoka Cancer Centre Hospital

    Sunto-gun, Shizuoka, 411-8777, Japan

  • Takano Hospital

    Kumamoto, Kumamoto, 862-0924, Japan

  • Teikyo University Chiba Medical Center

    Ichihara-shi, Chiba, Japan

  • Teikyo University School of Medicine

    Itabashi-ku, Tokyo, 173-8605, Japan

  • Tochigi Cancer Center

    Utsunomiya, Tochigi, Japan

  • Tokyo Medical and Dental University

    Bunkyo-ku, Tokyo, 113-8519, Japan

  • Tokyo Metropolitan Cancer and Infectious Disease Centre Komagome Hospital

    Bunkyo-ku, Tokyo, 113-8677, Japan

  • Tokyo Women's Medical University

    Shinjuku-ku, Tokyo, 162-8666, Japan

  • University Hospital Erlangen

    Erlangen, Bavaria, 91054, Germany

  • University of Leeds

    Leeds, West Yorkshire, LS2 9JT, United Kingdom

  • University of Ulsan College of Medicine and Asan Medical Center

    Songpa-Gu, Seoul, South Korea

  • Wakayama Medical University

    Wakayama, Wakayama, Japan

  • Yamagata Prefectural Central Hospital

    Yamagata, Yamagata, 990-2292, Japan

  • Yokohama City University Medical Center

    Yokohama, Kanagawa, 232-0024, Japan

  • Yokohama-city University

    Yokohama, Kanagawa, 236-0004, Japan

  • Yonsei University

    Seodaemun-gu, Seoul, 03722, South Korea

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